CN107530368A - 抗癌组合物及其用途 - Google Patents

抗癌组合物及其用途 Download PDF

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Publication number
CN107530368A
CN107530368A CN201680021393.1A CN201680021393A CN107530368A CN 107530368 A CN107530368 A CN 107530368A CN 201680021393 A CN201680021393 A CN 201680021393A CN 107530368 A CN107530368 A CN 107530368A
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pgg
methanol
compound
cell
gnmt
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CN201680021393.1A
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陈宜民
颜嘉宏
卢重光
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Kaohsiung Medical University
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Kaohsiung Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明揭示一种抗癌组合物及其用途，该组合物具有抑制致癌物的作用。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201680021393.1A 2015-04-16 2016-04-14 抗癌组合物及其用途 Pending CN107530368A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562148238P 2015-04-16 2015-04-16
US62/148,238 2015-04-16
PCT/CN2016/079289 WO2016165630A1 (zh) 2015-04-16 2016-04-14 抗癌组合物及其用途

Publications (1)

Publication Number Publication Date
CN107530368A true CN107530368A (zh) 2018-01-02

Family

ID=57125647

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680021393.1A Pending CN107530368A (zh) 2015-04-16 2016-04-14 抗癌组合物及其用途

Country Status (5)

Country Link
US (1) US11000535B2 (zh)
JP (1) JP6692830B2 (zh)
CN (1) CN107530368A (zh)
TW (1) TWI626051B (zh)
WO (1) WO2016165630A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807318A (zh) * 2021-02-22 2021-05-18 广东盛普生命科技有限公司 1,2,3,4,6-o-五没食子酰葡萄糖在制备预防和/或治疗肺纤维化药物中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107325135A (zh) * 2017-09-05 2017-11-07 中国林业科学研究院林产化学工业研究所 一种1,2,3,4,6‑o‑五没食子酰葡萄糖标准样品的制备方法
CN112770714B (zh) 2018-08-03 2024-05-24 奈克塞罗医学有限公司 纯化的五没食子酰葡萄糖和递送装置
CN112444590B (zh) * 2019-09-02 2022-12-02 江阴天江药业有限公司 一种五倍子药材的uplc指纹图谱的构建方法、通过该方法构建的指纹图谱及其应用
CN113823364B (zh) * 2021-10-08 2023-08-01 武汉轻工大学 一种基于网络药理学分析1,2,3,4,6-o-五没食子酰葡萄糖治疗肝癌机制的方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN101525357A (zh) * 2008-03-07 2009-09-09 首都医科大学 一种从中药中分离制备五没食子酰基葡萄糖的方法
CN102526046A (zh) * 2010-12-14 2012-07-04 复旦大学 含有表没食子儿茶素没食子酸酯与索拉非尼的抗肿瘤药物组合物及其应用
CN103012510A (zh) * 2012-12-03 2013-04-03 北京工业大学 一种1,2,3,4,6-五没食子酰葡萄糖对照品的制备方法
CN103520229A (zh) * 2013-06-11 2014-01-22 浙江大学 一种芒果提取物在制备抗肿瘤药物中的应用

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* Cited by examiner, † Cited by third party
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WO2008101079A1 (en) * 2007-02-15 2008-08-21 Yale University Herbal-composition phy906 and its use in chemotherapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101525357A (zh) * 2008-03-07 2009-09-09 首都医科大学 一种从中药中分离制备五没食子酰基葡萄糖的方法
CN102526046A (zh) * 2010-12-14 2012-07-04 复旦大学 含有表没食子儿茶素没食子酸酯与索拉非尼的抗肿瘤药物组合物及其应用
CN103012510A (zh) * 2012-12-03 2013-04-03 北京工业大学 一种1,2,3,4,6-五没食子酰葡萄糖对照品的制备方法
CN103520229A (zh) * 2013-06-11 2014-01-22 浙江大学 一种芒果提取物在制备抗肿瘤药物中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GILLIAN M. KEATING等: "Sorafenib A Review of its Use in Advanced Hepatocellular Carcinoma", 《DRUGS 2009》 *
YINHUI DONG等: "Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D-glucose-induced senescence-like growth arrest in human cancer cells", 《AUTOPHAGY》 *
李惠晨等: "五没食子酰基葡萄糖抗肿瘤的作用研究进展", 《现代肿瘤医学》 *
赵勇等: "中药水解类鞣质PGG的研究进展", 《临床和实验医学杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807318A (zh) * 2021-02-22 2021-05-18 广东盛普生命科技有限公司 1,2,3,4,6-o-五没食子酰葡萄糖在制备预防和/或治疗肺纤维化药物中的应用
CN112807318B (zh) * 2021-02-22 2022-08-02 广东盛普生命科技有限公司 1,2,3,4,6-o-五没食子酰葡萄糖在制备预防和/或治疗肺纤维化药物中的应用

Also Published As

Publication number Publication date
JP6692830B2 (ja) 2020-05-13
US20180214469A1 (en) 2018-08-02
JP2018517671A (ja) 2018-07-05
WO2016165630A1 (zh) 2016-10-20
TW201637657A (zh) 2016-11-01
TWI626051B (zh) 2018-06-11
US11000535B2 (en) 2021-05-11

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Application publication date: 20180102