CN107530330A - 疼痛的治疗 - Google Patents

疼痛的治疗 Download PDF

Info

Publication number
CN107530330A
CN107530330A CN201680023299.XA CN201680023299A CN107530330A CN 107530330 A CN107530330 A CN 107530330A CN 201680023299 A CN201680023299 A CN 201680023299A CN 107530330 A CN107530330 A CN 107530330A
Authority
CN
China
Prior art keywords
pyridine
isopropyl
tetrahydro
pain
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680023299.XA
Other languages
English (en)
Chinese (zh)
Inventor
伊莎贝尔·冈萨雷斯
马丁·普里查德
彼得·理查森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BenevolentAI Cambridge Ltd
Original Assignee
Proximagen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proximagen Ltd filed Critical Proximagen Ltd
Publication of CN107530330A publication Critical patent/CN107530330A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680023299.XA 2015-04-24 2016-04-22 疼痛的治疗 Pending CN107530330A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1507048.5A GB201507048D0 (en) 2015-04-24 2015-04-24 Treatment of pain
GB1507048.5 2015-04-24
PCT/GB2016/051122 WO2016170353A1 (en) 2015-04-24 2016-04-22 Treatment of pain

Publications (1)

Publication Number Publication Date
CN107530330A true CN107530330A (zh) 2018-01-02

Family

ID=53488643

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680023299.XA Pending CN107530330A (zh) 2015-04-24 2016-04-22 疼痛的治疗

Country Status (22)

Country Link
US (1) US20180104223A1 (enExample)
EP (1) EP3285767B8 (enExample)
JP (2) JP2018520984A (enExample)
KR (1) KR20170139047A (enExample)
CN (1) CN107530330A (enExample)
AU (1) AU2016252237B2 (enExample)
BR (1) BR112017019337A2 (enExample)
CA (1) CA2979160A1 (enExample)
DK (1) DK3285767T3 (enExample)
EA (1) EA032512B1 (enExample)
ES (1) ES2720035T3 (enExample)
GB (1) GB201507048D0 (enExample)
HK (1) HK1249865B (enExample)
HU (1) HUE043871T2 (enExample)
IL (1) IL254155B (enExample)
MX (1) MX2017013047A (enExample)
PL (1) PL3285767T3 (enExample)
PT (1) PT3285767T (enExample)
SG (1) SG11201707870SA (enExample)
TR (1) TR201905392T4 (enExample)
WO (1) WO2016170353A1 (enExample)
ZA (1) ZA201705847B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110167932A (zh) * 2016-10-25 2019-08-23 博善人工智能剑桥有限公司 用于制备(3S，4S)-4-异丙基-6，7-二氢-3H-咪唑并[4，5-c]吡啶-5(4H)-羧酸四氢呋喃-3-基酯的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
GB201507036D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd Crystalline enzyme inhibitor compound
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms
US20180360808A1 (en) * 2015-12-07 2018-12-20 Benevolentai Cambridge Limited Vap-1 inhibitors for treating pain
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023023A1 (en) * 1992-05-15 1993-11-25 University Of Saskatchewan Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
CN102232073A (zh) * 2008-09-16 2011-11-02 普罗克西梅根有限公司 新化合物i

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1791835A2 (en) * 2004-09-09 2007-06-06 Astellas Pharma Inc. Thiazole derivatives having vap-1 inhibitory activity
EP3042668B1 (en) 2006-06-07 2018-09-19 The Board of Trustees of the Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
FI20115234A0 (fi) * 2011-03-08 2011-03-08 Biotie Therapies Corp Uusia pyridatsinoni- ja pyridoniyhdisteitä
AU2014279863A1 (en) * 2013-06-12 2016-01-28 Proximagen Limited New therapeutic uses of enzyme inhibitors
WO2015159112A1 (en) * 2014-04-15 2015-10-22 Pécsi Tudományegyetem Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation
GB201507036D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd Crystalline enzyme inhibitor compound
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023023A1 (en) * 1992-05-15 1993-11-25 University Of Saskatchewan Method for preventing endothelium damage in mammals and for alleviating pain associated with gout and arthritis
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
CN102232073A (zh) * 2008-09-16 2011-11-02 普罗克西梅根有限公司 新化合物i

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
P. H. YU等: "Deamination of aliphatic amines by type B monoamine oxidase and semicarbazide-sensitive amine oxidase; pharmacological implications", 《J NEURAL TRANSM》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110167932A (zh) * 2016-10-25 2019-08-23 博善人工智能剑桥有限公司 用于制备(3S，4S)-4-异丙基-6，7-二氢-3H-咪唑并[4，5-c]吡啶-5(4H)-羧酸四氢呋喃-3-基酯的方法

Also Published As

Publication number Publication date
EA032512B1 (ru) 2019-06-28
PT3285767T (pt) 2019-05-20
EP3285767B1 (en) 2019-03-20
IL254155B (en) 2021-02-28
JP2021073257A (ja) 2021-05-13
JP2018520984A (ja) 2018-08-02
WO2016170353A1 (en) 2016-10-27
CA2979160A1 (en) 2016-10-27
KR20170139047A (ko) 2017-12-18
US20180104223A1 (en) 2018-04-19
EP3285767A1 (en) 2018-02-28
IL254155A0 (en) 2017-10-31
BR112017019337A2 (pt) 2018-06-05
AU2016252237B2 (en) 2021-04-08
ZA201705847B (en) 2020-03-25
PL3285767T3 (pl) 2019-09-30
ES2720035T3 (es) 2019-07-17
AU2016252237A1 (en) 2017-10-05
HUE043871T2 (hu) 2019-09-30
DK3285767T3 (en) 2019-04-29
TR201905392T4 (tr) 2019-05-21
SG11201707870SA (en) 2017-11-29
EA201792123A1 (ru) 2018-03-30
MX2017013047A (es) 2017-12-08
HK1249865B (en) 2019-12-06
EP3285767B8 (en) 2019-05-22
GB201507048D0 (en) 2015-06-10

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Address after: London, England

Applicant after: Boshan AI Cambridge Co., Ltd.

Address before: Cambridge County

Applicant before: Proximagen Limited

WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180102