CN107530303A - Ras‑抑制性茚基乙酰胺化合物、组合物和用途 - Google Patents

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Publication number

CN107530303A

CN107530303A CN201480084636.7A CN201480084636A CN107530303A CN 107530303 A CN107530303 A CN 107530303A CN 201480084636 A CN201480084636 A CN 201480084636A CN 107530303 A CN107530303 A CN 107530303A

Authority

CN

China

Prior art keywords

alkyl

indenes

benzylidenei

acetamide

bases

Prior art date

2014-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• -1 indenyls acetamide compound Chemical class 0.000 title claims abstract description 170
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• 229940002612 prodrug Drugs 0.000 claims description 73
• 239000000651 prodrug Substances 0.000 claims description 73
• 150000003839 salts Chemical class 0.000 claims description 72
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• 125000000217 alkyl group Chemical group 0.000 claims description 68
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• 150000002367 halogens Chemical group 0.000 claims description 51
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• 238000011282 treatment Methods 0.000 claims description 45
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
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• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims description 24
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• XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 22
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 21
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