CN107519438A - Treat composition of pruitus and preparation method and application - Google Patents
Treat composition of pruitus and preparation method and application Download PDFInfo
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- CN107519438A CN107519438A CN201710773702.7A CN201710773702A CN107519438A CN 107519438 A CN107519438 A CN 107519438A CN 201710773702 A CN201710773702 A CN 201710773702A CN 107519438 A CN107519438 A CN 107519438A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The present invention relates to a kind of composition for treating pruitus and preparation method and application, the raw material components of composition by weight, including：The parts by weight of frutus cnidii 2~4, the parts by weight of golden cypress 2.5~3.5, the parts by weight of smilax 1~5, the parts by weight of corter pseudolaricis 2~3, the parts by weight of dittany bark 2~3, the parts by weight of the fruit of summer cypress 1~3, the parts by weight of borneol 1.5~2.5, the parts by weight of ilexrotunda 0.5~1.5, the parts by weight of cavalerie mosla herb 0.4~0.6, the parts by weight of the tuber of stemona 0.3~0.7, the parts by weight of pearl powder 0.4~0.6, the parts by weight of spina gleditsiae 0.3~0.8 and the parts by weight of chlorhexidine acetate 0.2~0.3.Using plurality of Chinese such as frutus cnidii, golden cypress and smilaxs, as raw material, the composition with treatment pruitus effect, evident in efficacy and quick, safe without toxic side effect is prepared by extracting its active component in the present invention；Easy to use, cost is relatively low.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of composition for treating pruitus and its preparation side
Method and application.
Background technology
Pruritus (pruritus) is one of clinically common skin disease, is especially more common in the elderly, can clinically be divided
For locality and systemic two kinds, be mainly shown as skin itch, macula, papule, or even occur oozing out, blister, chronic phase can
There is pachyderma and liver moss sample changes.The reason for causing pruitus is a lot, such as infection, food or drug allergy, intestines and stomach
Accumulated heat, indigestion, endocrinopathy and multisystem disease etc..The pathogenesis of pruitus is not fully understood at present,
But numerous studies show that histamine is a kind of important medium that can cause pruitus, and histamine is after being generated by l-histidine depickling
It is stored in the form of Heparin-binding in the mast cell of tissue and the basophil secretory granules of blood, accounts for particle content
The 10% of thing.Histamine in tissue is present in inactive mating type in the particle of mast cell and basophilic granulocyte,
It is more with content in skin, tunica mucosa bronchiorum, intestinal mucosa and nervous system.When these cells are by immunity reason or other reasons
After change factor stimulates, cell degranulation can be caused then to discharge histamine, skin and mucous membrane blood capillary are caused by H1 or H2 acceptors
Enlargement of pipe and permeability increase, and produce erythema, oedema and wheal, cause itch by stimulating nerve endings.
The clinical treatment of pruitus is more difficult, treats pruitus at present and often uses Western medicine antihistamine, calcium agent and hormone
Deng, they often initial stage it is effective, but the purpose for the treatment of pruitus can not be really achieved, and treatment cycle is long, curative effect is slow,
Easily repeatedly, that is, work of curing the symptoms, not the disease.Therefore, the novel product of pruitus can safely and effectively be treated by finding, and be skin scabies
Itch treatment in urgent problem to be solved.
The content of the invention
For in the prior art the defects of, present invention aims at provide a kind of composition and its system for treating pruitus
Preparation Method and application, to use the plurality of Chinese such as frutus cnidii, golden cypress and smilax as raw material, by extracting its active component system
It is standby to obtain the composition with treatment pruitus effect, evident in efficacy and quick, safe without toxic side effect；It is easy to use,
Cost is relatively low, has good commercial promise.
To achieve the above object, technical scheme provided by the invention is：
In a first aspect, the invention provides a kind of composition for treating pruitus, the raw material components of composition are by weight
Part meter, including：The parts by weight of frutus cnidii 2~4, the parts by weight of golden cypress 2.5~3.5, the parts by weight of smilax 1~5, the weight of corter pseudolaricis 2~3
Part, the parts by weight of dittany bark 2~3, the parts by weight of the fruit of summer cypress 1~3, the parts by weight of borneol 1.5~2.5, the parts by weight of ilexrotunda 0.5~1.5,
The parts by weight of cavalerie mosla herb 0.4~0.6, the parts by weight of the tuber of stemona 0.3~0.7, the parts by weight of pearl powder 0.4~0.6, the weight of spina gleditsiae 0.3~0.8
Measure part and the parts by weight of chlorhexidine acetate 0.2~0.3.
In the further embodiment of the present invention, the raw material components of composition also include：The parts by weight of dried orange peel 10~15, tangerine
The parts by weight of shell 6~8, the parts by weight of Sculellaria barbata 5~10, the parts by weight of rhizoma cyperi 8~12, the parts by weight of ligusticum sinense oliver 5~10 and the weight of fructus viticis 3~7
Measure part.
The present invention further embodiment in, the raw material components of composition by weight, including：The weight of frutus cnidii 3
Measure part, the parts by weight of golden cypress 3, the parts by weight of smilax 3, the parts by weight of corter pseudolaricis 2.5, the parts by weight of dittany bark 2.25, the weight of the fruit of summer cypress 2
Part, the parts by weight of borneol 2, the parts by weight of ilexrotunda 1, the parts by weight of cavalerie mosla herb 0.5, the parts by weight of the tuber of stemona 0.5, the parts by weight of pearl powder 0.5, soap
0.5 parts by weight, the parts by weight of chlorhexidine acetate 0.25, the parts by weight of dried orange peel 12, the parts by weight of tangerine shell 7, the parts by weight of Sculellaria barbata 6, perfume (or spice) are pierced in angle
Attached 10 parts by weight, the parts by weight of ligusticum sinense oliver 8 and the parts by weight of fructus viticis 5.
Second aspect, the invention provides the preparation method of the composition for the treatment of pruitus, comprise the following steps：S1：
Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain the first mixing
Thing；S2：Smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb are soaked in water, then adjust pH value to 8.1~8.3, then
Decoction extraction is carried out, is filtered after extraction, collects the first filtrate；S3：Other surplus stock components are added into ethanol water
In, regulation pH value to 5.3~5.5, refluxing extraction is then carried out, is filtered after extraction, collect the second filtrate；S4：By first
Filtrate and the second filtrate merge, and then heating concentration, obtains medicinal extract；S5：First mixture and medicinal extract are well mixed, obtain group
Compound.
In the further embodiment of the present invention, in S2, the quality of water is smilax, corter pseudolaricis, dittany bark, ilexrotunda
With 15~18 times of the gross mass of cavalerie mosla herb.
In the further embodiment of the present invention, in S2, the time of immersion is 5~6h, and the temperature of immersion is 55~65
℃；The time for decocting extraction is 1~1.5h.
In the further embodiment of the present invention, in S3, in ethanol water, the volume fraction of ethanol for 40%~
50%.
In the further embodiment of the present invention, in S3, the number of refluxing extraction is 3~4 times, the time extracted every time
For 50~60min；Every time during extraction, the addition quality of ethanol water is the 8~10 of the gross mass of other surplus stock components
Times.
In the further embodiment of the present invention, in S4, the temperature of heating is 45~50 DEG C, and liquid extract is in 25 DEG C of measure
Relative density be 1.2~1.25.
The third aspect, the invention provides application of the above-mentioned composition in the medicine for preparing treatment pruitus.
It should be noted that the above method prepare composition can be further prepared into as needed it is pharmaceutically acceptable
Formulation.In addition, fall within protection scope of the present invention by medicine made of active component of above-mentioned composition.By by above-mentioned medicine
Compositions, prepared after directly preparing or adding pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable dose
Type.Include by taking external preparation as an example：Solution, patch, vina, tincture, gel, liniment, aerosol, spray, ointment
And plastics.The medicine of above-mentioned various formulations can be prepared according to the conventional method of pharmaceutical field.
Technical scheme provided by the invention, there is following beneficial effect：(1) composition provided by the invention, selection
It is the Chinese medicinal material containing active skull cap components, prescription proportioning science, does not add any hormonal components, safe without toxic side effect；
(2) composition provided by the invention has the function of excellent treatment pruitus, evident in efficacy；And it is easy to use, cost compared with
It is low, there is good commercial promise；(3) preparation method provided by the invention is used, each raw material can retained to greatest extent
While medicine active component, the active ingredient in each raw medicinal material can be fully discharged, so that being finally prepared
Composition not only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for the treatment of pruitus.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore be intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, it is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with three
Secondary to repeat to test, data are to repeat the average value or mean+SD of experiment three times.
Frutus cnidii used, golden cypress, smilax, corter pseudolaricis, dittany bark, the fruit of summer cypress, ilexrotunda, seven-star in following embodiments
Sword, the tuber of stemona, spina gleditsiae, dried orange peel, tangerine shell, Sculellaria barbata, rhizoma cyperi, ligusticum sinense oliver and fructus viticis meet one each medicinal material of text of Chinese Pharmacopoeia
Pertinent regulations under.Before feeding intake, by identification, ingredients material object is consistent with title, and quality meets standard.
The present invention provides a kind of composition for treating pruitus, the raw material components of composition by weight, including：Snake
The parts by weight of machine tool 2~4, the parts by weight of golden cypress 2.5~3.5, the parts by weight of smilax 1~5, the parts by weight of corter pseudolaricis 2~3, dittany bark 2~
3 parts by weight, the parts by weight of the fruit of summer cypress 1~3, the parts by weight of borneol 1.5~2.5, the parts by weight of ilexrotunda 0.5~1.5, cavalerie mosla herb 0.4~
0.6 parts by weight, the parts by weight of the tuber of stemona 0.3~0.7, the parts by weight of pearl powder 0.4~0.6, the parts by weight of spina gleditsiae 0.3~0.8 and acetic acid
The parts by weight of Chlorhexidine 0.2~0.3.
Preferably, the raw material components of composition also include：The parts by weight of dried orange peel 10~15, the parts by weight of tangerine shell 6~8, Sculellaria barbata 5
~10 parts by weight, the parts by weight of rhizoma cyperi 8~12, the parts by weight of ligusticum sinense oliver 5~10 and the parts by weight of fructus viticis 3~7.
In addition, present invention also offers the preparation method of above-mentioned treatment pruitus, comprise the following steps：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 55~65 DEG C of 5~6h of immersion of water, then adjust
PH value is saved to 8.1~8.3, then carries out decocting 1~1.5h of extraction, is filtered after extraction, collects the first filtrate；Wherein, water
Quality is 15~18 times of the gross mass of smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 40%~50%, adjust pH value
To 5.3~5.5, refluxing extraction is then carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is
3~4 times, the time extracted every time is 50~60min；Every time during extraction, the addition quality of ethanol water is that other are remaining former
Expect the gross mass of component 8~10 times；
S4：First filtrate and the second filtrate are merged, then in 45~50 DEG C of heating concentrations, obtain the phase in 25 DEG C of measure
To the medicinal extract that density is 1.2~1.25；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Composition and preparation method thereof for the treatment of pruitus provided by the invention is made with reference to specific embodiment into
One step explanation.
Embodiment one
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 3
Parts by weight, the parts by weight of golden cypress 3, the parts by weight of smilax 3, the parts by weight of corter pseudolaricis 2.5, the parts by weight of dittany bark 2.25, the weight of the fruit of summer cypress 2
Part, the parts by weight of borneol 2, the parts by weight of ilexrotunda 1, the parts by weight of cavalerie mosla herb 0.5, the parts by weight of the tuber of stemona 0.5, the parts by weight of pearl powder 0.5, soap
0.5 parts by weight and the parts by weight of chlorhexidine acetate 0.25 are pierced in angle.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 60 DEG C of immersion 5.5h of water, pH value is then adjusted
To 8.2, then carry out decocting extraction 1.2h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, soil
Rose of Sharon skin, dittany bark, 16 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 45%, regulation pH value to 5.4,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 4 times, is carried every time
The time taken is 55min；Every time during extraction, the addition quality of ethanol water is the 9 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 48 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.22；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Embodiment two
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 2
Parts by weight, the parts by weight of golden cypress 3.5, the parts by weight of smilax 1, the parts by weight of corter pseudolaricis 3, the parts by weight of dittany bark 2, the parts by weight of the fruit of summer cypress 3,
The parts by weight of borneol 1.5, the parts by weight of ilexrotunda 1.5, the parts by weight of cavalerie mosla herb 0.4, the parts by weight of the tuber of stemona 0.7, the parts by weight of pearl powder 0.4,
The parts by weight of spina gleditsiae 0.8 and the parts by weight of chlorhexidine acetate 0.2.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 55 DEG C of water immersion 5h, then adjust pH value to
8.1, then carry out decocting extraction 1h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, the native rose of Sharon
Skin, dittany bark, 15 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 40%, regulation pH value to 5.3,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 3 times, is carried every time
The time taken is 50min；Every time during extraction, the addition quality of ethanol water is the 8 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 45 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.2；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Embodiment three
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 4
Parts by weight, the parts by weight of golden cypress 2.5, the parts by weight of smilax 5, the parts by weight of corter pseudolaricis 2, the parts by weight of dittany bark 3, the parts by weight of the fruit of summer cypress 1,
The parts by weight of borneol 2.5, the parts by weight of ilexrotunda 0.5, the parts by weight of cavalerie mosla herb 0.6, the parts by weight of the tuber of stemona 0.3, the parts by weight of pearl powder 0.6,
The parts by weight of spina gleditsiae 0.3 and the parts by weight of chlorhexidine acetate 0.3.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 65 DEG C of water immersion 6h, then adjust pH value to
8.3, then carry out decocting extraction 1.5h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, the native rose of Sharon
Skin, dittany bark, 18 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 50%, regulation pH value to 5.5,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 4 times, is carried every time
The time taken is 60min；Every time during extraction, the addition quality of ethanol water is the 10 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 50 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.25；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Example IV
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 3
Parts by weight, the parts by weight of golden cypress 3, the parts by weight of smilax 3, the parts by weight of corter pseudolaricis 2.5, the parts by weight of dittany bark 2.25, the weight of the fruit of summer cypress 2
Part, the parts by weight of borneol 2, the parts by weight of ilexrotunda 1, the parts by weight of cavalerie mosla herb 0.5, the parts by weight of the tuber of stemona 0.5, the parts by weight of pearl powder 0.5, soap
0.5 parts by weight, the parts by weight of chlorhexidine acetate 0.25, the parts by weight of dried orange peel 12, the parts by weight of tangerine shell 7, the parts by weight of Sculellaria barbata 6, perfume (or spice) are pierced in angle
Attached 10 parts by weight, the parts by weight of ligusticum sinense oliver 8 and the parts by weight of fructus viticis 5.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 60 DEG C of immersion 5.5h of water, pH value is then adjusted
To 8.2, then carry out decocting extraction 1.2h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, soil
Rose of Sharon skin, dittany bark, 16 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 45%, regulation pH value to 5.4,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 4 times, is carried every time
The time taken is 55min；Every time during extraction, the addition quality of ethanol water is the 9 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 48 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.22；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Embodiment five
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 2
Parts by weight, the parts by weight of golden cypress 3.5, the parts by weight of smilax 1, the parts by weight of corter pseudolaricis 3, the parts by weight of dittany bark 2, the parts by weight of the fruit of summer cypress 3,
The parts by weight of borneol 1.5, the parts by weight of ilexrotunda 1.5, the parts by weight of cavalerie mosla herb 0.4, the parts by weight of the tuber of stemona 0.7, the parts by weight of pearl powder 0.4,
The parts by weight of spina gleditsiae 0.8, the parts by weight of chlorhexidine acetate 0.2, the parts by weight of dried orange peel 15, the parts by weight of tangerine shell 6, the parts by weight of Sculellaria barbata 10,
The parts by weight of rhizoma cyperi 8, the parts by weight of ligusticum sinense oliver 10 and the parts by weight of fructus viticis 3.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 55 DEG C of water immersion 5h, then adjust pH value to
8.1, then carry out decocting extraction 1h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, the native rose of Sharon
Skin, dittany bark, 15 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 40%, regulation pH value to 5.3,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 3 times, is carried every time
The time taken is 50min；Every time during extraction, the addition quality of ethanol water is the 8 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 45 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.2；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Embodiment six
The present embodiment provides a kind of composition for treating pruitus, raw material components by weight, including：Frutus cnidii 4
Parts by weight, the parts by weight of golden cypress 2.5, the parts by weight of smilax 5, the parts by weight of corter pseudolaricis 2, the parts by weight of dittany bark 3, the parts by weight of the fruit of summer cypress 1,
The parts by weight of borneol 2.5, the parts by weight of ilexrotunda 0.5, the parts by weight of cavalerie mosla herb 0.6, the parts by weight of the tuber of stemona 0.3, the parts by weight of pearl powder 0.6,
The parts by weight of spina gleditsiae 0.3, the parts by weight of chlorhexidine acetate 0.3, the parts by weight of dried orange peel 10, the parts by weight of tangerine shell 8, the parts by weight of Sculellaria barbata 5, perfume (or spice)
Attached 12 parts by weight, the parts by weight of ligusticum sinense oliver 5 and the parts by weight of fructus viticis 7.
By above-mentioned raw material, using the preparation method of the composition for the treatment of pruitus provided by the invention, treatment is prepared
The composition of pruitus：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 65 DEG C of water immersion 6h, then adjust pH value to
8.3, then carry out decocting extraction 1.5h, filtered after extraction, collect the first filtrate；Wherein, the quality of water is smilax, the native rose of Sharon
Skin, dittany bark, 18 times of gross mass of ilexrotunda and cavalerie mosla herb；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 50%, regulation pH value to 5.5,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 4 times, is carried every time
The time taken is 60min；Every time during extraction, the addition quality of ethanol water is the 10 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 50 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.25；
S5：First mixture and medicinal extract are well mixed, obtain composition.
Comparative example one
This comparative example provides a kind of composition, raw material components by weight, including：The parts by weight of frutus cnidii 3, the weight of golden cypress 3
Measure part, the parts by weight of smilax 3, the parts by weight of corter pseudolaricis 2.5, the parts by weight of dittany bark 2.25, the parts by weight of the fruit of summer cypress 2, the weight of borneol 2
Part, the parts by weight of ilexrotunda 1, the parts by weight of cavalerie mosla herb 0.5, the parts by weight of the tuber of stemona 0.5, the parts by weight of pearl powder 0.5, the weight of spina gleditsiae 0.5
Part, the parts by weight of chlorhexidine acetate 0.25, the parts by weight of dried orange peel 12, the parts by weight of rhizoma cyperi 10, the parts by weight of ligusticum sinense oliver 8 and the parts by weight of fructus viticis 5.
The same example IV of preparation method.
Comparative example two
This comparative example provides a kind of composition, the same example IV of raw material components.
By above-mentioned raw material, the composition for the treatment of pruitus is prepared, is comprised the following steps：
S1：Crushed after frutus cnidii, golden cypress, the fruit of summer cypress and borneol are mixed, then add pearl powder and chlorhexidine acetate, obtain
To the first mixture；
S2：By smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb 60 DEG C of immersion 5.5h of water, then decocted
1.2h is extracted, is filtered after extraction, collects the first filtrate；Wherein, the quality of water is smilax, corter pseudolaricis, dittany bark, iron winter
16 times of blue or green and cavalerie mosla herb gross mass；
S3：Other surplus stock components are added in the ethanol water that volume fraction is 45%, regulation pH value to 5.4,
Then refluxing extraction is carried out, is filtered after extraction, collects the second filtrate；Wherein, the number of refluxing extraction is 4 times, is carried every time
The time taken is 55min；Every time during extraction, the addition quality of ethanol water is the 9 of the gross mass of other surplus stock components
Times；
S4：First filtrate and the second filtrate are merged, then in 48 DEG C of heating concentrations, obtained in the relatively close of 25 DEG C of measure
Spend the medicinal extract for 1.22；
S5：First mixture and medicinal extract are well mixed, obtain composition.
The composition for the treatment pruitus that the embodiment of the present invention one to embodiment six is prepared, is tried by function assessment
Test and carry out system evaluation its effect, and control is used as using the composition that comparative example one and comparative example two are prepared.
1st, toxicity test
The small white mouse 20 (each 10 of male and female) for selecting body weight to be 18~22g, is divided into 2 groups, each 5 of every group of male and female.Will be each small
White mouse back shaving, every shaving area are 5cm × 8cm, and then in back shaving area coating, it is about 2.0g/ to apply dose, point
Not Tu Mo the composition for the treatment of pruitus that is prepared of the embodiment of the present invention one and embodiment three in skin of back, it is continuous to apply
Medicine 30 days.When during coating and 1 week after drug withdrawal, white mouse growth conditions and activity and diet, identification hematology, blood biochemical are observed
, organ tissue structure and routine urinalysis etc..As a result the health existence of all small white mouses is found, it is without any side effects；Dissection
Observe blood picture, liver function, each organs and tissues state, the indifference compared with normal small white mouse.It is demonstrated experimentally that provided by the invention control
The composition for treating pruitus has no toxic side effect, and can use safely.
2nd, the fungistatic effect of the composition of pruitus is treated
Test method：The composition for the treatment pruitus that 100g embodiments one and example IV are prepared is weighed respectively
The composition being prepared with comparative example one, comparative example two, the 1st week in experiment, the 3rd week and the 5th week are carried out respectively plus bacterium is grasped
Make (including the various bacteria such as staphylococcus aureus, Escherichia coli and Candida albicans and fungi), each refinement bacterium amount be 1 ×
(107~108), mould amount is 1 × (106~107), the 0th day, the 1st day, the 5th day and the 10th day sampling analysis sample after bacterium is added
Bacteria containing amount in product.
Evaluation method：(1) antiseptic effect is excellent, i.e., three times plus after bacterium, the 5th day or 10 days every time plus after bacterium, survival
Bacterium amount reduces excellent to 0.01% not higher than initial concentration, the antiseptic effect of sample.(2) antiseptic effect is fine, i.e., adds three times
After bacterium, the 5th day or 10 days every time plus after bacterium, survival bacterium amount was reduced to 0.1% not higher than initial concentration, and sample passes through survey
Examination.(3) antiseptic effect is poor, i.e., three times plus after bacterium, the 5th day or 10 days every time plus after bacterium, survival bacterium was more than 0.1%, sample
Test is not passed through.
Result of the test：Concrete outcome is as shown in table 1 below.
Table 1 treats the fungistatic effect of the composition of pruitus
2nd, the effect of pruitus is treated
Test method：The people of patient 400 with pruitus is recruited, is randomly divided into eight groups, every group 50, by first
The patient of group to the 6th group smears the composition for the treatment pruitus that embodiment one is prepared into embodiment six, medicine respectively
Cream is 0.5~1mm in the thickness of skin surface coating, is smeared 3 times daily；It is right that 7th to the 8th group of patient is smeared into the present invention
The composition that ratio one is prepared to comparative example two, ointment are 0.5~1mm in the thickness of skin surface coating, smear 3 daily
It is secondary.Continuous smearing diagnoses curative effect after 10 days.
The all cases of cutaneous pruritus described in the embodiment of the present invention meet《Clinical dermatology》Pruritus is examined
Disconnected standard, exclusion standard：(1) diabetes, chronic liver disease, chronic kidney disease, renal failure, internal tumor, autoimmune disease etc.
Itch caused by viscera disease；The immunodepressant such as tripterygium wilfordii are taken in (2) 4 weeks；Take used corticosteroid hormone orally within (3) 1 weeks；
(4) there are medicine or food hypersenstivity history person.
Result of the test：By the improvement degree of pruitus patient be divided into completely take a turn for the better (100%), turn for the better by and large (80%),
Somewhat take a turn for the better (40%) and without take a turn for the better (0%) four degree, the composition for the treatment of pruitus prepared by the present invention on probation
Patient's number of cases is recorded in following table corresponding to improvement situation, specific as shown in table 2：
Table 2 treats the effect of pruitus
| Group | Take a turn for the better completely | Turn for the better by and large | Somewhat take a turn for the better | Without improvement |
| Embodiment one | 25 | 14 | 11 | 0 |
| Embodiment two | 23 | 15 | 12 | 0 |
| Embodiment three | 22 | 14 | 14 | 0 |
| Example IV | 46 | 4 | 0 | 0 |
| Embodiment five | 42 | 8 | 0 | 0 |
| Embodiment six | 43 | 7 | 0 | 0 |
| Comparative example one | 0 | 16 | 24 | 10 |
| Comparative example two | 18 | 19 | 10 | 3 |
It should be noted that except the situation that above-described embodiment one is enumerated to embodiment six, from other raw material components
And its proportioning or preparation method parameter are also feasible.
Technical scheme provided by the invention, there is following beneficial effect：(1) composition provided by the invention, selection
It is the Chinese medicinal material containing active skull cap components, prescription proportioning science, does not add any hormonal components, safe without toxic side effect；
(2) composition provided by the invention has the function of excellent treatment pruitus, evident in efficacy；And it is easy to use, cost compared with
It is low, there is good commercial promise；(3) preparation method provided by the invention is used, each raw material can retained to greatest extent
While medicine active component, the active ingredient in each raw medicinal material can be fully discharged, so that being finally prepared
Composition not only there is good drug effect, and be easy to absorb, and then be rapidly achieved the purpose for the treatment of pruitus.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among protection scope of the present invention.
Claims (10)
1. a kind of composition for treating pruitus, it is characterised in that the raw material components of the composition by weight, wrap
Include：
It is the parts by weight of frutus cnidii 2~4, the parts by weight of golden cypress 2.5~3.5, the parts by weight of smilax 1~5, the parts by weight of corter pseudolaricis 2~3, white
The parts by weight of moss skin 2~3, the parts by weight of the fruit of summer cypress 1~3, the parts by weight of borneol 1.5~2.5, the parts by weight of ilexrotunda 0.5~1.5, seven-star
The parts by weight of sword 0.4~0.6, the parts by weight of the tuber of stemona 0.3~0.7, the parts by weight of pearl powder 0.4~0.6, the parts by weight of spina gleditsiae 0.3~0.8
With the parts by weight of chlorhexidine acetate 0.2~0.3.
2. the composition for the treatment of pruitus according to claim 1, it is characterised in that the raw material components of the composition
Also include：
The parts by weight of dried orange peel 10~15, the parts by weight of tangerine shell 6~8, the parts by weight of Sculellaria barbata 5~10, the parts by weight of rhizoma cyperi 8~12, ligusticum sinense oliver 5~
10 parts by weight and the parts by weight of fructus viticis 3~7.
3. the composition for the treatment of pruitus according to claim 2, it is characterised in that the raw material components of the composition
By weight, including：
The parts by weight of frutus cnidii 3, the parts by weight of golden cypress 3, the parts by weight of smilax 3, the parts by weight of corter pseudolaricis 2.5, the parts by weight of dittany bark 2.25,
The parts by weight of the fruit of summer cypress 2, the parts by weight of borneol 2, the parts by weight of ilexrotunda 1, the parts by weight of cavalerie mosla herb 0.5, the parts by weight of the tuber of stemona 0.5, pearl powder
0.5 parts by weight, the parts by weight of spina gleditsiae 0.5, the parts by weight of chlorhexidine acetate 0.25, the parts by weight of dried orange peel 12, the parts by weight of tangerine shell 7, half
The parts by weight of lotus 6, the parts by weight of rhizoma cyperi 10, the parts by weight of ligusticum sinense oliver 8 and the parts by weight of fructus viticis 5.
4. the preparation method of the composition of the treatment pruitus described in any one of claims 1 to 3, it is characterised in that including
Following steps：
S1：Will frutus cnidii, golden cypress, the fruit of summer cypress and borneol mix after crush, then add pearl powder and chlorhexidine acetate, obtain the
One mixture；
S2：Smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb are soaked in water, then regulation pH value to 8.1~8.3,
Decoction extraction is carried out again, is filtered after extraction, collects the first filtrate；
S3：Other surplus stock components are added in ethanol water, then regulation pH value carries out backflow and carried to 5.3~5.5
Take, filtered after extraction, collect the second filtrate；
S4：First filtrate and second filtrate are merged, then heating concentration, obtains medicinal extract；
S5：First mixture and the medicinal extract are well mixed, obtain the composition.
5. the preparation method of the composition for the treatment of pruitus according to claim 4, it is characterised in that：
In the S2, the quality of the water is the gross mass of the smilax, corter pseudolaricis, dittany bark, ilexrotunda and cavalerie mosla herb
15~18 times.
6. the preparation method of the composition for the treatment of pruitus according to claim 4, it is characterised in that：
In the S2, the time of the immersion is 5~6h, and the temperature of the immersion is 55~65 DEG C；It is described decoct extraction when
Between be 1~1.5h.
7. the preparation method of the composition for the treatment of pruitus according to claim 4, it is characterised in that：
In the S3, in the ethanol water, the volume fraction of ethanol is 40%~50%.
8. the preparation method of the composition for the treatment of pruitus according to claim 4, it is characterised in that：
In the S3, the number of the refluxing extraction is 3~4 times, and the time extracted every time is 50~60min；Every time during extraction,
The addition quality of ethanol water is 8~10 times of the gross mass of other surplus stock components.
9. the preparation method of the composition for the treatment of pruitus according to claim 4, it is characterised in that：
In the S4, the temperature of the heating is 45~50 DEG C, the liquid extract 25 DEG C of measure relative densities for 1.2~
1.25。
10. application of the composition in the medicine for preparing treatment pruitus described in claim any one of 1-3.
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| CN109200232A (en) * | 2018-10-23 | 2019-01-15 | 唐德坤 | A kind of antipsoriatics object |
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| KR20030055154A (en) * | 2001-12-24 | 2003-07-02 | 주식회사 하니로 | A composition for treating a dermatitis and a method of preparing the same |
| CN106215058A (en) * | 2016-08-23 | 2016-12-14 | 彭友莲 | A kind of lotion treating skin pruritus and preparation method thereof |
| CN106806712A (en) * | 2017-03-03 | 2017-06-09 | 贵州都匀市剑江药业有限公司 | Skin bacteria inhibiting composition and preparation method thereof |
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| KR20030055154A (en) * | 2001-12-24 | 2003-07-02 | 주식회사 하니로 | A composition for treating a dermatitis and a method of preparing the same |
| CN106215058A (en) * | 2016-08-23 | 2016-12-14 | 彭友莲 | A kind of lotion treating skin pruritus and preparation method thereof |
| CN106806712A (en) * | 2017-03-03 | 2017-06-09 | 贵州都匀市剑江药业有限公司 | Skin bacteria inhibiting composition and preparation method thereof |
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| CN109200232A (en) * | 2018-10-23 | 2019-01-15 | 唐德坤 | A kind of antipsoriatics object |
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