CN106138738A - A kind of Chinese medicine composition with white-skinned face function and its preparation method and application - Google Patents
A kind of Chinese medicine composition with white-skinned face function and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The present invention discloses a kind of Chinese medicine composition with white-skinned face function and its preparation method and application, the composition of raw materials of this Chinese medicine composition, in percentage by weight, it is made up of 18～27 parts of Ligusticum wallichiis, 6～11 parts of peppermints, 22～32 parts of safflowers, 5～8 parts of edible tulips, 12～21 parts of fire spine.The Chinese medicine composition of the present invention be by Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine grind respectively after mixing, again mixture is put into soaking at room temperature 30 days in ethanol solution, filtrate is taken after filtration, pH value with acetum regulation filtrate is pH=2 again, after last room temperature stands 24 hours, filter, collect filter residue, be prepared after filter residue is dried.The Chinese medicine composition of the present invention, its raw material all select the Chinese medicine material of green natural, natural releive, and gentle to skin, excitant is little, and preparation method is simple, and can suppress the activity of tyrosinase well, improves pigmentation, has good whitening effect.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition with white-skinned face function and preparation method thereof
And application.
Background technology
In state-owned sentence common saying " one hide in vain thousand ugly ", since ancient times people seeking beauty to blond require just very high, especially
It is as increasing of living standards of the people, and people seeking beauty is more fanatic to the pursuit of whitening.
Melanin is the arch-criminal causing skin obscure, is present in a kind of protein of everyone skin base layer,
Tyrosinase is then that enzyme is built in the pass of synthesis of melanin, therefore suppresses tyrosinase activity thus suppresses the melanic generation can be effective
Reach whitening purpose.
At present, the method for whitening is varied, such as concealer, foundation cream, whitening cream, cleawhite over-night essences etc., but because of
Cause human skin problem to occur more and more for environment, and a large amount of chemical compositions contained in whitening product more can be stung
Swashing increasing the weight of of skin problem, therefore, a lot of people occur using the unconformable situation of skin after whitening product.
Chinese medicine is the distinctive medical Culture of China, and its character is gentle, does not stimulates, and no side effects, therefore therefrom
The related whitening product of medicine angle research and development, is paid close attention to by consumers in general more and more.
Content of the invention
The problem that it is an object of the invention to exist for prior art, provides a kind of nontoxic, non-stimulated, has tyrosinase
There is notable inhibitory action, it is thus possible to effectively suppression melanin ground generates, reach the Chinese medicine composition of fine whitening effect.
It is a further object to provide the preparation method of above-mentioned Chinese medicine composition.
It is a further object to provide application in preparation whitening class product for the above-mentioned Chinese medicine composition.
The above-mentioned purpose of the present invention is achieved by following scheme:
A kind of Chinese medicine composition with white-skinned face function, its composition of raw materials is made up of each component of following parts by weight:
Ligusticum wallichii 18～27 parts；
Peppermint 6～11 parts；
Safflower 22～32 parts；
Edible tulip 5～8 parts；
Fire spine 12～21 parts.
In the composition of raw materials of above-mentioned Chinese medicine composition, Ligusticum wallichii has good regulation effect, its infusion to microcirculqtory system
Stronger restraint is had to some pathogenic dermatophyte.Ligusticum wallichii also has the effect that antivitamin E lacks.Additionally, Ligusticum wallichii can also
The activity of suppression tyrosinase, thus therapeutic action can be played to blackspot, freckle, senile plaque expelling.
In the composition of raw materials of above-mentioned Chinese medicine composition, containing factors such as menthols inside peppermint, the skin of people can be allowed to produce
Refrigerant effect, therefore can be with anti-inflammatory analgesic, anti-itch detoxification and dispelling wind and heat from the body.
In the composition of raw materials of above-mentioned Chinese medicine composition, safflower, by promoting blood circulation and removing blood stasis, accelerate blood circulation, promotes newly old looking for
Thank, increase and get rid of melanin produced by melanocyte, promote that being stranded in internal melanin decomposes, and is allowed to precipitate formation
Color spot, or make the pigment decomposition in shallow lake excrete, reach nti-freckle profit face, the effect treating sore stagnation resolvation.
In the composition of raw materials of above-mentioned Chinese medicine composition, edible tulip contains colchicin, has clearing heat and detoxicating, the carbuncle that disappears dissipating bind, loses
Anticancer, the effect of dispersing swelling and dissipating binds of poison, can remove skin toxins.
In the composition of raw materials of above-mentioned Chinese medicine composition, fire spine has whitening curative effect, and " histamine " can be suppressed to stimulate pigment female
Cell produces too much melanin, has magical effect of desalination Mai Laning pigment and moisturizing.
In the composition of raw materials of above-mentioned Chinese medicine composition, Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine all use commercially available
Chinese medicinal material.
Above-mentioned a kind of Chinese medicine composition with whitening function, the preferred version of its composition of raw materials is by following parts by weight
Each component composition:
Ligusticum wallichii 24 parts；
Peppermint 8 parts；
Safflower 30 parts；
Edible tulip 6 parts；
Fire spine 18 parts.
The present invention also provides the preparation method of above-mentioned a kind of Chinese medicine composition with whitening function, and it specifically includes as follows
Step:
Step 1. is according to the composition of raw materials of above-mentioned Chinese medicine composition, by Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine respectively
It is mixed to get Chinese medicine mixture after grinding, then this Chinese medicine mixture is joined in ethanol solution, soaking at room temperature 30 days,
Filtrate is taken after filtration；
Step 2. adds acetum in filtrate prepared by step 1 while stirring, and regulating whole system pH value is pH=
2, after then room temperature stands 24 hours, filter, collect filter residue, after filter residue is dried, then obtain Chinese traditional medicine composition needed for the present invention
Thing.
In above-mentioned steps 1, the concentration of ethanol solution is 50%(mass percent concentration)；The present inventor is sent out by research
Existing: the too high meeting of concentration of alcohol has injury to skin, concentration too low then cannot by the extracts active ingredients in Chinese medicine out,
How to ensure that the concentration of ethanol both will not injure skin, the active ingredient in Chinese medicine can be extracted to greatest extent again
Come, for this problem, after the present inventor has done substantial amounts of conceptual design and assay optimization, select to soak Chinese medicine mixture
In the ethanol solution that mass percent concentration is 50%, soaking at room temperature 30 days, then the Chinese medicine composition finally giving is not only
Can skin whitening well, and the injuries such as drying, allergy will not be caused to skin.
In above-mentioned steps 1, Chinese medicine mixture is 300:1(g/L with the mass volume ratio of ethanol solution).
In above-mentioned steps 2, the present inventor is found by research, with the Chinese medicine mixture to the present invention for the ethanol solution
Active ingredient extract after, then acid environment process is carried out to this ethanol extract, the Chinese medicine composition finally giving, it is beautiful
White effect is significantly better than the Chinese medicine composition processing without acid environment；Therefore, the pH to acid environment for the present inventor is carried out greatly
After the conceptual design of amount and assay optimization, the pH value selecting acid environment is pH=2；Inventor considers sulfuric acid, hydrochloric acid, nitre
The common acid such as acid can have certain stimulation to skin, and acetic acid is not only non-stimulated, and itself all has certain bactericidal action, because of
The acetum that this inventor selects concentration to be 1mol/L.It in concrete operations, is 1mol/L's by concentration while stirring
Acetum joins in the filtrate of step 1 preparation, monitors the pH of whole system simultaneously, until the pH value of whole system
For pH=2, then stop adding acetum.
Proving through experimental study, the Chinese medicine composition of the present invention has good inhibiting effect to tyrosinase, thus can
Effectively suppress melanic generation, play good whitening effect.
The Chinese medicine composition of the present invention can make various formulation with skin care item, the acceptable auxiliary material combination of cosmetic field
External application whitening product, as can be made into face cream, emulsion, toner, mildy wash, spray or essence etc..
Compared with prior art, there is advantages that
1. the Chinese medicine composition of the present invention, its raw material all select the Chinese medicine material of green natural, natural releive, to skin temperature
With excitant is little, and can suppress the activity of tyrosinase well, improves pigmentation, has good whitening effect；
2. the Chinese medicine composition of the present invention, its raw material obtains simple, and preparation method is convenient, it is easy to accepted by consumers in general, tool
Have application prospect and market prospects well.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described through, but the present invention is not appointed by specific embodiment
What limits.
Embodiment 1
A kind of Chinese medicine composition with white-skinned face function of the present embodiment, its composition of raw materials is by each component of following parts by weight
Composition:
Ligusticum wallichii 24 parts；
Peppermint 8 parts；
Safflower 30 parts；
Edible tulip 6 parts；
Fire spine 18 parts.
In the composition of raw materials of above-mentioned Chinese medicine composition, Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine all use commercially available
Chinese medicinal material.
The preparation method of above-mentioned a kind of Chinese medicine composition with white-skinned face function, it specifically includes following steps:
Step 1. is according to the composition of raw materials of above-mentioned Chinese medicine composition, by Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine respectively
It is mixed to get Chinese medicine mixture after grinding, then this Chinese medicine mixture is joined the second that mass percent concentration is 50%
In alcoholic solution (Chinese medicine mixture is 300:1 with the mass volume ratio g/L of ethanol solution), soaking at room temperature 30 days, filters
After take filtrate；
The acetum that concentration is 1mol/L is joined in filtrate prepared by step 1 by step 2. while stirring, regulation
Whole system pH is to pH=2, after then room temperature stands 24 hours, filters, collects filter residue, then obtains this after drying filter residue
Chinese medicine composition needed for embodiment.
Embodiment 2
A kind of Chinese medicine composition with whitening function of the present embodiment, its composition of raw materials is by each component of following parts by weight
Composition:
Ligusticum wallichii 27 parts；
Peppermint 11 parts；
Safflower 29 parts；
Edible tulip 5 parts；
Fire spine 12 parts.
In the composition of raw materials of above-mentioned Chinese medicine composition, Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine all use commercially available
Chinese medicinal material.
The preparation method of above-mentioned a kind of Chinese medicine composition with white-skinned face function, it specifically includes following steps:
Step 1. is according to the composition of raw materials of above-mentioned Chinese medicine composition, by Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine respectively
It is mixed to get Chinese medicine mixture after grinding, then this Chinese medicine mixture is joined the second that mass percent concentration is 50%
In alcoholic solution (Chinese medicine mixture is 300:1 with the mass volume ratio g/L of ethanol solution), soaking at room temperature 30 days, filters
After take filtrate；
The acetum that concentration is 1mol/L is joined in filtrate prepared by step 1 by step 2. while stirring, regulation
Whole system pH is to pH=2, after then room temperature stands 24 hours, filters, collects filter residue, then obtains this after drying filter residue
Chinese medicine composition needed for embodiment.
The inhibitory action research to tyrosinase for the embodiment 3
A. laboratory sample
The present embodiment is divided into three sample sets, specific as follows shown:
1. sample 1: the Chinese medicine composition of embodiment 1 preparation；
2. sample 2: the Chinese medicine composition of embodiment 2 preparation；
3. sample 3: the Chinese medicine composition of sample 3, its composition of raw materials in parts by weight, be by 18 parts of Ligusticum wallichiis, 6
Part peppermint, 25 parts of safflowers, 8 portions of edible tulips and 20 parts of fire spine compositions；The preparation method of the Chinese medicine composition of sample 3 is: press
It according to the composition of raw materials of aforementioned Chinese medicine composition, is mixed to get after Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine are ground respectively
Chinese medicine mixture, then this Chinese medicine mixture joins the ethanol solution that mass percent concentration is 50%, and (Chinese medicine mixes
Compound is 300:1 with the mass volume ratio g/L of ethanol solution) in, soaking at room temperature 30 days, take filtrate after filtration, by this filter
Obtaining powder after liquid vacuum drying, this powder is then for the Chinese medicine composition of sample 3.
B. experimental technique
The phosphate buffer solution that sample the 1st, sample 2 and sample 3 add PH value 6.8 respectively dilutes 10 times, accurately inhales
Take sample solution, the phosphate buffer solution of PH6.8 and 0.01mol/L DOPA solution, fully mixed in 10mL colorimetric cylinder
Close, after standing 10min at room temperature, add 0.35mol/L tyrosinase liquid to mix, be quickly transferred in cuvette,
Measuring absorbance at 475nm, each group reactant liquor composition is shown in Table 1.With the phosphate buffer of PH=6.8 as reference.
Table 1 reactant liquor forms table
Inhibiting rate by equation below calculating tyrosinase activity:
Inhibiting rate (I%)=((ODA-ODB)-(ODC-ODD))/(ODA-ODB) × 100%
In formula: A does not has sample solution for there being tyrosinase；B is for both without tyrosinase and n.s solution；C is same
When have tyrosinase and sample solution；D does not has tyrosinase for there being sample solution.
C. experimental result
By testing and calculating:
The inhibiting rate to tyrosinase for the sample 1 is 90.89%, and the inhibiting rate to tyrosinase for the sample 2 is 88.59%, sample
The inhibiting rate to tyrosinase for the product 3 is 72.8%.
By the above results it can be seen that the Chinese medicine Ligusticum wallichii of present invention selection, peppermint, safflower, edible tulip and fire spine are true
Real have preferable inhibition to tyrosinase, and sample 1 and sample 2 are because of ratio sample more than 3 one step acid treatment,
So sample 1 and the inhibiting rate to tyrosinase for the sample 2 are significantly larger than sample 3, inhibiting rate all reach 85% with
On.
Embodiment 4 human body whitening is tested
A. laboratory sample
The laboratory sample of the present embodiment uses the Chinese medicine composition of embodiment 1 preparation, and this Chinese medicine composition water is made into matter
Amount percent concentration is the solution of 30%.
The control sample of the present embodiment is water.
B. experimental technique
Selecting the small white mouse 100 of skin health, 7-8 week old, female, small white mouse back wool removes selection 3 × 3cm region is
Recipient site, the side of this recipient site is test block, smears laboratory sample, and side is check plot, smears control sample.
Smear every day once, totally 30 days, checked that in skin, melanin contained every 5 days with dermal melanin tester
Amount, and calculate melanic inhibiting rate as follows.
Dermal melanin inhibiting rate=(check plot dermal melanin content-test block dermal melanin content)/comparison
District's dermal melanin content × 100%
C. experimental result
The experimental result of the present embodiment is as shown in table 2.
Table 2 laboratory sample is on impact melanic in mouse skin
From table 2 it can be seen that the Chinese medicine composition of the present invention can reduce dermal melanin content significantly, and over time
Gradually reduce；And tested small white mouse generally do not occur dry skin cast off a skin, the bad reaction such as allergy.
Claims (7)
1. a Chinese medicine composition with white-skinned face function, it is characterised in that the composition of raw materials of this Chinese medicine composition is by as follows
The each component composition of parts by weight:
Ligusticum wallichii 18～27 parts；
Peppermint 6～11 parts；
Safflower 22～32 parts；
Edible tulip 5～8 parts；
Fire spine 12～21 parts；
The preparation method of described Chinese medicine composition includes,
Step 1. is mixed to get Chinese medicine mixture after grinding Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine respectively, then
This Chinese medicine mixture is added in ethanol solution, soaking at room temperature 30 days, after filtration, take filtrate；
Step 2. adds acetum in filtrate prepared by step 1 while stirring, and regulating whole system pH value is pH
=2, after then room temperature stands 24 hours, filter, collect filter residue, after filter residue is dried, then obtain described Chinese medicine composition.
2. a kind of Chinese medicine composition with white-skinned face function according to claim 1, it is characterised in that: described Chinese drug-treated group
The composition of raw materials of compound is made up of each component of following parts by weight:
Ligusticum wallichii 24 parts；
Peppermint 8 parts；
Safflower 30 parts；
Edible tulip 6 parts；
Fire spine 18 parts.
3. the preparation method of a kind of Chinese medicine composition with white-skinned face function according to any one of claim 1 or 2, it is special
Levy and be: this preparation method comprises the steps:
Step 1. is mixed to get Chinese medicine mixture after grinding Ligusticum wallichii, peppermint, safflower, edible tulip and fire spine respectively, then
This Chinese medicine mixture is added in ethanol solution, soaking at room temperature 30 days, after filtration, take filtrate；
Step 2. adds acetum in filtrate prepared by step 1 while stirring, and regulating whole system pH value is pH
=2, after then room temperature stands 24 hours, filter, collect filter residue, after filter residue is dried, then obtain described Chinese medicine composition.
4. the preparation method of a kind of Chinese medicine composition with white-skinned face function according to claim 3, it is characterised in that: institute
State the ethanol solution that ethanol solution is that mass percent concentration is 50%.
5. the preparation method of a kind of Chinese medicine composition with white-skinned face function according to claim 3, it is characterised in that: institute
The mass volume ratio g/L stating Chinese medicine mixture with ethanol solution is 300:1.
6. the preparation method of a kind of Chinese medicine composition with white-skinned face function according to claim 3, it is characterised in that: institute
State the acetum that acetum is that concentration is 1mol/L.
7. a kind of Chinese medicine composition with white-skinned face function according to any one of claim 1 or 2 protects in preparation whitening class
Application in skin product or cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610707079.0A CN106138738A (en) | 2016-08-23 | 2016-08-23 | A kind of Chinese medicine composition with white-skinned face function and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610707079.0A CN106138738A (en) | 2016-08-23 | 2016-08-23 | A kind of Chinese medicine composition with white-skinned face function and its preparation method and application |
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ID=57342445
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420513A (en) * | 2016-12-28 | 2017-02-22 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine extraction composition with effects of whitening skin and dispelling speckle and preparation method and application of traditional Chinese medicine extraction composition |
| CN113476372A (en) * | 2021-08-02 | 2021-10-08 | 云南英格生物技术有限公司 | Whitening composition containing pyracantha fortuneana fruit extract and preparation method and application thereof |
-
2016
- 2016-08-23 CN CN201610707079.0A patent/CN106138738A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420513A (en) * | 2016-12-28 | 2017-02-22 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine extraction composition with effects of whitening skin and dispelling speckle and preparation method and application of traditional Chinese medicine extraction composition |
| CN113476372A (en) * | 2021-08-02 | 2021-10-08 | 云南英格生物技术有限公司 | Whitening composition containing pyracantha fortuneana fruit extract and preparation method and application thereof |
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Application publication date: 20161123 |