CN107519412A - Treat the compound preparation and preparation method of nonallergic purpura caused by excess heat compels blood - Google Patents

Treat the compound preparation and preparation method of nonallergic purpura caused by excess heat compels blood Download PDF

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Publication number
CN107519412A
CN107519412A CN201710939679.4A CN201710939679A CN107519412A CN 107519412 A CN107519412 A CN 107519412A CN 201710939679 A CN201710939679 A CN 201710939679A CN 107519412 A CN107519412 A CN 107519412A
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preparation
blood
excess heat
medicine
radix
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马力
王维蔚
齐燕松
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/804—Rehmannia
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

A kind of compound preparation and preparation method for treating nonallergic purpura caused by excess heat compels blood.Preparation by dosage by weight than agents raw material be made：Radix rehmanniae recen 12 32, radix scrophulariae 9 24, the tuber of dwarf lilyturf 9 24, honeysuckle 6 15, the capsule of weeping forsythia 9 24, radix scutellariae 6 15, the coptis 4 10, Radix Angelicae Sinensis 6 15, moutan bark 6 15, Asian puccoon 6 15, madder 6 15, the leaf of bamboo 4 10.Invention formulation is to extract the active ingredient in material medicine using the method for boiling extraction, and keeps its activity, and not only the dissolution rate of active ingredient in medicine can so improved, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, the preparation method technique of the present invention is simple, it is easy to operate.

Description

Treat the compound preparation and preparation method of nonallergic purpura caused by excess heat compels blood
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, is controlled more particularly to one kind using Chinese medicine as made of raw material Treat the compound preparation and preparation method of nonallergic purpura caused by excess heat compels blood.
Background technology
Nonallergic purpura be due to various non-allergic diseases because and disease caused by one kind characterized by aberrant angiogenesis Hemorrhagic disease clinically to show as more：Skin purpura or ecchymosis, mucous membrane or visceral hemorrhage (rare), capillary fragility Experiment can be that the inspection such as the positive, coagulation function, platelet count, platelet function is generally normal.Cause nonallergic purpura The cause of disease and disease it is a lot of, the sick record of similar traditional Chinese medicine " flesh nosebleed ".Although clinically it is used to treat nonallergic purpura at present Types of drugs it is many but a variety of due to causing the factor of nonallergic purpura to have, and nonallergic purpura also divides multiple types Type, therefore these medicine lack of targeted, the course for the treatment of is relatively long, and some drugs have certain side effect or allergic reaction, institute So that effect is undesirable for treatment belongs to this disease of nonallergic purpura caused by excess heat compels blood after taking.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide one kind to treat nonallergic purpura caused by excess heat compels blood Compound preparation and preparation method.
In order to achieve the above object, it is provided by the invention treatment excess heat compel blood caused by nonallergic purpura compound preparation by Dosage by weight than agents raw material be made：
Radix rehmanniae recen 12-32 radix scrophulariae 9-24 tuber of dwarf lilyturf 9-24 honeysuckle 6-15 capsules of weeping forsythia 9-24
Radix scutellariae 6-15 coptis 4-10 Radix Angelicae Sinensis 6-15 moutan bark 6-15 Asian puccoons 6-15
Madder 6-15 leaf of bamboves 4-10
The preparation method of the compound preparation of nonallergic purpura caused by described treatment excess heat compels blood is that said medicine is former Material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue can be made into institute The compound preparation of nonallergic purpura caused by the treatment excess heat stated compels blood.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup, Oral liquid, pill and paste.
The compound preparation of nonallergic purpura caused by treatment excess heat provided by the invention compels blood is the side using boiling extraction Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution rate of active ingredient in medicine Greatly improve, and contribute to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Compound Chinese medicinal preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, the system of the present invention Preparation Method technique is simple, easy to operate.
Embodiment
Nonallergic purpura complicated symptoms, course of disease delay, complication are more.Clinical common asthenic symptoms, real example and simulataneous insufficiency and excessive Card etc..This side makes laws in clearing heat and cooling blood.Radix rehmanniae recen sweetness and bitterness is trembled with fear in side, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, is wanting for clearing heat and cooling blood hemostasis Medicine, it is monarch drug in a prescription.Radix scrophulariae sweetness and bitterness is salty to be slightly cold, clearing heat and cooling blood, purging intense heat and detonicating, enriching yin；Honeysuckle is sweet cold, clearing heat and detoxicating；Radix scutellariae bitter cold, Heat-clearing and damp-drying drug, purging intense heat and detonicating, it is longer than clear middle dampness-heat in upper jiao especially；Radix Angelicae Sinensis Gan Xinwen, enriches blood, promoting blood circulation and stopping pain；Asian puccoon is sweet salty-cold, heat-clearing Cool blood, promoting blood circulation, promoting eruption of detoxifying, all medicines of the above, clearing heat and detoxicating, cooling blood and hemostasis, is altogether ministerial drug.The tuber of dwarf lilyturf, sweet slight bitter was slightly cold, yin-nourishing life Tianjin, moistening lung clears away heart-fire；Capsule of weeping forsythia hardship is slightly cold, clearing heat and detoxicating, dispersing swelling and dissipating binds；Coptis bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating, it is longer than especially clear Dampness-heat in middle jiao；Moutan bark bitter sweet is slightly cold, clearing heat and cooling blood, promoting blood circulation；Madder bitter cold, cooling blood and removing stasis hemostasis, stimulates the menstrual flow, the above is all Medicine, clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating, nourishing Yin and promoting production of body fluid, therefore be adjutant.The leaf of bamboo is sweet pungent light cold, clearing heat-fire, relieving restlessness, promotes the production of body fluid, diuresis, Thinking makes medicine.Our clearing heat and detoxicating, blood cooling and ecchymoses removing, therefore compel the nonallergic purpura caused by blood suitable for treatment excess heat.
With reference to embodiment to it is provided by the invention treatment excess heat compel blood caused by nonallergic purpura compound preparation and Its preparation method is described in detail.
Embodiment 1：
The present embodiment provide treatment excess heat compel blood caused by nonallergic purpura compound preparation by dosage for weight than Agents raw material is made：
The capsule of weeping forsythia 9 of 12 radix scrophulariae of radix rehmanniae recen, 9 tuber of dwarf lilyturf, 9 honeysuckle 6
The Asian puccoon 6 of 6 moutan bark of radix scutellariae 6 coptis, 4 Radix Angelicae Sinensis 6
The leaf of bamboo 4 of madder 6
The preparation method of the compound preparation of nonallergic purpura caused by described treatment excess heat compels blood is that said medicine is former Material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue can be made into institute The compound preparation of nonallergic purpura caused by the treatment excess heat stated compels blood.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup, Oral liquid, pill and paste.
Embodiment 2：
The present embodiment provide treatment excess heat compel blood caused by nonallergic purpura compound preparation by dosage for weight than Agents raw material is made：
The capsule of weeping forsythia 24 of 32 radix scrophulariae of radix rehmanniae recen, 24 tuber of dwarf lilyturf, 24 honeysuckle 15
The Asian puccoon 15 of 15 moutan bark of radix scutellariae 15 coptis, 10 Radix Angelicae Sinensis 15
The leaf of bamboo 10 of madder 15
Preparation method is the same as embodiment 1.
Embodiment 3：
The present embodiment provide treatment excess heat compel blood caused by nonallergic purpura compound preparation by dosage for weight than Agents raw material is made：
The capsule of weeping forsythia 12 of 16 radix scrophulariae of radix rehmanniae recen, 12 tuber of dwarf lilyturf, 12 honeysuckle 8
The Asian puccoon 8 of 8 moutan bark of radix scutellariae 8 coptis, 5 Radix Angelicae Sinensis 8
The leaf of bamboo 5 of madder 8
Preparation method is the same as embodiment 1.
The compound preparation of nonallergic purpura caused by treatment excess heat provided by the invention compels blood is in brown to sepia；Gas It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 315 The patient that example compels blood group nonallergic purpura with excess heat has carried out system clinical observation, wherein 21-30 year 99 cases, 31- 40 years old 114,41-50 year 102, each medication 150ml, 3 times a day, 120 days are 1 course for the treatment of.After 1 course of therapy altogether Cure (bleeding disappears substantially) 199, account for 63.2%；Effectively (cardinal symptom has improvement) 99, accounts for 31.4%%；It is invalid (cardinal symptom is without improvement) 17, accounts for 5.4%；Total effective rate is 94.6%.Cure 246 altogether after 2 course of therapy, account for 78.1%；Effective 60, account for 19.0%；No effect 9, account for 2.9%；Total effective rate is 97.1%.
Meanwhile the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis As a result 1, table 2 is shown in Table respectively.
Table 1：Compound Chinese medicinal preparation therapeutic effect provided by the invention and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove It is bright to take compound Chinese medicinal preparation provided by the invention to treat the urgent blood group nonallergic purpura of excess heat, the treatment effect to each age group Fruit does not change with the age.
Table 2：Compound Chinese medicinal preparation therapeutic effect provided by the invention and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this The compound Chinese medicinal preparation provided is provided and compels blood group nonallergic purpura to treat excess heat, with going deep into for treatment, cure rate, effectively Rate significantly improves.

Claims (3)

  1. A kind of 1. compound preparation for treating nonallergic purpura caused by excess heat compels blood, it is characterised in that：Described treatment excess heat is compeled The compound preparation of nonallergic purpura caused by blood by dosage by weight than agents raw material be made：
    Radix rehmanniae recen 12-32 radix scrophulariae 9-24 tuber of dwarf lilyturf 9-24 honeysuckle 6-15 capsules of weeping forsythia 9-24
    Radix scutellariae 6-15 coptis 4-10 Radix Angelicae Sinensis 6-15 moutan bark 6-15 Asian puccoons 6-15
    Madder 6-15 leaf of bamboves 4-10.
  2. 2. a kind of preparation method of the compound preparation of nonallergic purpura caused by treatment excess heat as claimed in claim 1 compels blood, It is characterized in that：Described preparation method is that said medicine raw material is weighed and mixed according to proportioning, is then soaked 25 minutes, decoct 30 minutes afterwards, filter and remove residue is that can be made into answering for nonallergic purpura caused by described treatment excess heat compels blood Square preparation.
  3. 3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine Granule, tablet, capsule, syrup, oral liquid, pill and paste is made with auxiliary material.
CN201710939679.4A 2017-09-30 2017-09-30 Treat the compound preparation and preparation method of nonallergic purpura caused by excess heat compels blood Withdrawn CN107519412A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王启政: "《实用中医血液病治疗学》", 31 March 1994, 中国中医药出版社 *

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