CN107137513A - The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire - Google Patents

The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire Download PDF

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Publication number
CN107137513A
CN107137513A CN201710550636.7A CN201710550636A CN107137513A CN 107137513 A CN107137513 A CN 107137513A CN 201710550636 A CN201710550636 A CN 201710550636A CN 107137513 A CN107137513 A CN 107137513A
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China
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preparation
bleeding
chinese medicinal
exuberance
medicine
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CN201710550636.7A
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马力
王维蔚
齐燕松
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

It is a kind of to be used for the compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by treating exuberance of stomach fire.Preparation by consumption by weight than agents raw material be made：Radix rehmanniae recen 12 32, Radix Angelicae Sinensis 6 15, stir-baked RADIX PAEONIAE ALBA 9 24, moutan bark 6 15, stir-baked FRUCTUS GARDENIAE 6 15, the capsule of weeping forsythia 6 15, the coptis 4 10, Asian puccoon 6 15, rattletop 4 10, licorice 4 10.Invention formulation is to boil the method for extraction using water to extract the active ingredient in material medicine, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term taking, so security is good.In addition, the preparation method technique of the present invention is simple, it is easy to operate.

Description

The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of use being made using Chinese medicine as raw material The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by treatment exuberance of stomach fire.
Background technology
The blood person's of going out name from gum slot says bleeding from the gum, also known as pingival atrophy,《Inner is passed through》Without specific considerations, it may be included in " spitting blood " Category in, be a part for a variety of heat symptom-complex bleedings, be generally divided into excess fire and the fire of deficiency type.Although being clinically used to treat bleeding from the gum at present Types of drugs it is a lot, but due to causing the factor of bleeding from the gum to have a variety of, and bleeding from the gum also divides polytype, therefore these medicines lack Weary specific aim, the course for the treatment of is relatively long, and some drugs have certain side effect or allergic reaction, so belonging to after taking for treatment Effect is undesirable for this disease of bleeding from the gum caused by exuberance of stomach fire.
The content of the invention
In order to solve the above problems, it is used for it is an object of the invention to provide a kind of in bleeding from the gum caused by treating exuberance of stomach fire Medicine compound preparation and preparation method.
In order to achieve the above object, provided by the present invention for treatment exuberance of stomach fire caused by bleeding from the gum compound Chinese medicinal preparation by Consumption by weight than agents raw material be made：
Radix rehmanniae recen 12-32 Radix Angelicae Sinensis 6-15 stir-baked RADIX PAEONIAE ALBA 9-24 moutan bark 6-15 stir-baked FRUCTUS GARDENIAEs 6-15
Capsule of weeping forsythia 6-15 coptis 4-10 Asian puccoon 6-15 rattletop 4-10 licorices 4-10
The preparation method of the described compound Chinese medicinal preparation for being used for bleeding from the gum caused by treating exuberance of stomach fire is that said medicine is former Material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue is that can be made into institute That states is used for the compound Chinese medicinal preparation of bleeding from the gum caused by treating exuberance of stomach fire.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup, Oral liquid, pill and paste.
Compound Chinese medicinal preparation provided by the present invention for bleeding from the gum caused by treatment exuberance of stomach fire is that the side of extraction is boiled using water Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution rate of active ingredient in medicine Greatly improve, and contribute to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Toxic side effect will not be produced after compound Chinese medicinal preparation, thus patient's long-term taking, so security is good.In addition, the system of the present invention Preparation Method technique is simple, easy to operate.
Embodiment
Bleeding from the gum complicated symptoms, course of disease delay, complication is more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess etc..This side Make laws in eliminating stomach-fire, cooling blood and hemostasis.Radix rehmanniae recen sweetness and bitterness is trembled with fear in side, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, is wanting for clearing heat and cooling blood hemostasis Medicine, is monarch drug in a prescription.Radix Angelicae Sinensis Gan Xinwen, enriches blood, promoting blood circulation and stopping pain；Moutan bark bitter sweet is slightly cold, clearing heat and cooling blood, promoting blood circulation；Capsule of weeping forsythia hardship is micro- It is cold, clearing heat and detoxicating, dispersing swelling and dissipating binds；Asian puccoon is sweet salty-cold, clearing heat and cooling blood, promoting blood circulation, detoxify promoting eruption, all medicines of the above, blood circulation promoting and enriching, heat-clearing Removing pattogenic heat from the blood and toxic material from the body, is altogether ministerial drug.Stir-baked RADIX PAEONIAE ALBA picric acid is slightly cold, and the moon, soft liver analgesic, suppressing liver-YANG are held back in blood-nourishing；Stir-baked FRUCTUS GARDENIAE bitter cold, purging intense heat is removed It is tired, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body；Coptis bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating is longer than clear dampness-heat in middle jiao especially；The pungent micro-sweet of rattletop is micro- Cold, inducing diaphoresis promoting eruption is clearing heat and detoxicating, rises and lifts yang-energy, and all medicines of the above, blood-nourishing yin-nourishing, soothing the liver purging intense heat is clearing heat and detoxicating, and sharp water eliminating dampness is Adjutant.Licorice is sweet flat, invigorates the spleen and benefits qi, clearing heat and detoxicating analgesic, coordinating the drug actions of a prescription, and thinking makes medicine.Our heat-clearing and damp-drying drug, promoting blood circulation is mended Blood, clearing away heat,cooling blood and removing toxin, therefore suitable for the bleeding from the gum caused by treatment exuberance of stomach fire.
With reference to embodiment to provided by the present invention for treatment exuberance of stomach fire caused by bleeding from the gum compound Chinese medicinal preparation and Its preparation method is described in detail.
Embodiment 1：
The present embodiment provide be used for treat exuberance of stomach fire caused by bleeding from the gum compound Chinese medicinal preparation by consumption be weight than Agents raw material is made：
The stir-baked FRUCTUS GARDENIAE 6 of 9 moutan bark of radix rehmanniae recen 12 Radix Angelicae Sinensis, 6 stir-baked RADIX PAEONIAE ALBA 6
The licorice 4 of 6 rattletop of the capsule of weeping forsythia 6 coptis, 4 Asian puccoon 4
The preparation method of the described compound Chinese medicinal preparation for being used for bleeding from the gum caused by treating exuberance of stomach fire is that said medicine is former Material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue is that can be made into institute That states is used for the compound Chinese medicinal preparation of bleeding from the gum caused by treating exuberance of stomach fire.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation Starch agent, oral liquid, pill and paste.
Embodiment 2：
The present embodiment provide be used for treat exuberance of stomach fire caused by bleeding from the gum compound Chinese medicinal preparation by consumption be weight than Agents raw material is made：
The stir-baked FRUCTUS GARDENIAE 15 of 24 moutan bark of radix rehmanniae recen 32 Radix Angelicae Sinensis, 15 stir-baked RADIX PAEONIAE ALBA 15
The licorice 10 of 15 rattletop of the capsule of weeping forsythia 15 coptis, 10 Asian puccoon 10
Preparation method be the same as Example 1.
Embodiment 3：
The present embodiment provide be used for treat exuberance of stomach fire caused by bleeding from the gum compound Chinese medicinal preparation by consumption be weight than Agents raw material is made：
The stir-baked FRUCTUS GARDENIAE 9 of 16 moutan bark of radix rehmanniae recen 14 Radix Angelicae Sinensis, 9 stir-baked RADIX PAEONIAE ALBA 9
The licorice 5 of 9 rattletop of the capsule of weeping forsythia 9 coptis, 5 Asian puccoon 5
Preparation method be the same as Example 1.
The compound Chinese medicinal preparation of bleeding from the gum caused by provided by the present invention for treating exuberance of stomach fire is in brown to sepia；Gas It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 338 Patient of the example with exuberance of stomach fire type bleeding from the gum has carried out system clinical observation, wherein 21-30 Sui patient 92,31-40 Sui 129 Example, 41-50 Sui 117, each medication 150ml, 3 times a day, is within 120 days 1 course for the treatment of.Cure (to go out altogether after 1 course of therapy Mass formed by blood stasis shape disappears substantially) 159, account for 47.0%；Effectively (cardinal symptom has improvement) 133,39.3% is accounted for；Invalid (main disease Shape is without improving) 46, account for 13.6%；Total effective rate is 86.4%.225 are cured altogether after 2 course of therapy, account for 66.6%； Effective 98, account for 29.0%；Invalid 15, account for 4.4%；Total effective rate is 95.6%.
Meanwhile, the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis As a result 1, table 2 is shown in Table respectively.
Table 1：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove It is bright to take the compound Chinese medicinal preparation that provides of the present invention to treat exuberance of stomach fire type bleeding from the gum, to the therapeutic effect of each age group not with year Age and change.
Table 2：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this Invent the compound Chinese medicinal preparation of offer to treat exuberance of stomach fire type bleeding from the gum, with going deep into for treatment, cure rate, effective percentage are obvious Improve.

Claims (3)

1. a kind of be used for the compound Chinese medicinal preparation of bleeding from the gum caused by treating exuberance of stomach fire, it is characterised in that：It is described to be used to treat stomach Heated contain caused by bleeding from the gum compound Chinese medicinal preparation by consumption by weight than agents raw material be made：
Radix rehmanniae recen 12-32 Radix Angelicae Sinensis 6-15 stir-baked RADIX PAEONIAE ALBA 9-24 moutan bark 6-15 stir-baked FRUCTUS GARDENIAEs 6-15
Capsule of weeping forsythia 6-15 coptis 4-10 Asian puccoon 6-15 rattletop 4-10 licorices 4-10.
2. a kind of preparation method of the compound Chinese medicinal preparation as claimed in claim 1 for being used for bleeding from the gum caused by treating exuberance of stomach fire, It is characterized in that：Described preparation method is that said medicine raw material is weighed and mixed according to proportioning, is then soaked 25 minutes, decoct 30 minutes afterwards, filter and remove residue is that can be made into the described Chinese medicine for being used for bleeding from the gum caused by treating exuberance of stomach fire to answer Square preparation.
3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine Granule, tablet, capsule, syrup, oral liquid, pill and paste are made of auxiliary material.
CN201710550636.7A 2017-07-07 2017-07-07 The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire Withdrawn CN107137513A (en)

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CN201710550636.7A CN107137513A (en) 2017-07-07 2017-07-07 The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire

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Application Number Priority Date Filing Date Title
CN201710550636.7A CN107137513A (en) 2017-07-07 2017-07-07 The compound Chinese medicinal preparation and preparation method of bleeding from the gum caused by for treating exuberance of stomach fire

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CN107137513A true CN107137513A (en) 2017-09-08

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Country Status (1)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
焦中华等: "《实用中医血液病学》", 30 June 1989, 青岛出版社 *

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Application publication date: 20170908