CN107158194A - The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by for treating deficiency of kidney-YIN - Google Patents
The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by for treating deficiency of kidney-YIN Download PDFInfo
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- CN107158194A CN107158194A CN201710550625.9A CN201710550625A CN107158194A CN 107158194 A CN107158194 A CN 107158194A CN 201710550625 A CN201710550625 A CN 201710550625A CN 107158194 A CN107158194 A CN 107158194A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
It is a kind of to be used for the compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by treating deficiency of kidney-YIN.Preparation by consumption by weight than agents raw material be made：Radix rehmanniae recen 18 48, Chinese yam 9 24, Fructus Corni 6 15, Poria cocos 9 24, rhizoma alismatis 6 15, moutan bark 6 15, Asian puccoon 6 15, hairyvein agrimony 18 48, the fruit of glossy privet 6 15, eclipta 6 15, golden cypress 6 15, licorice 4 10.Invention formulation is to boil the method for extraction using water to extract the active ingredient in material medicine, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term taking, so security is good.In addition, the preparation method technique of the present invention is simple, it is easy to operate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of use being made using Chinese medicine as raw material
The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by treatment deficiency of kidney-YIN.
Background technology
Nosebleed epistaxis refers to that blood flows out from nostril, is common one kind disease, can be caused by a variety of illness.The record of nosebleed epistaxis is earliest
See《The Yellow Emperor's Canon of Internal Medicine》, studied through ancient Chinese medicine doctor, it is believed that its morbidity is relevant with " heat ", " cold ", liver tuberculosis and internal lesion caused by overexertion.Although at present
The types of drugs for being clinically used to treat nosebleed epistaxis is more, but due to causing the factor of nosebleed epistaxis to have a variety of, and nosebleed epistaxis also divides a variety of
Type, therefore these medicine lack of targeted, the course for the treatment of is relatively long, and some drugs have certain side effect or allergic reaction,
So effect is undesirable for this disease of nosebleed epistaxis caused by treatment belongs to deficiency of kidney-YIN after taking.
The content of the invention
In order to solve the above problems, it is used for it is an object of the invention to provide a kind of in nosebleed epistaxis caused by treating deficiency of kidney-YIN
Medicine compound preparation and preparation method thereof.
In order to achieve the above object, provided by the present invention for treatment deficiency of kidney-YIN caused by nosebleed epistaxis compound Chinese medicinal preparation by
Consumption by weight than agents raw material be made：
The preparation method of the described compound Chinese medicinal preparation for being used for nosebleed epistaxis caused by treating deficiency of kidney-YIN is according to the following steps
Order is carried out：Described preparation method is that said medicine raw material is weighed and mixed according to proportioning, then soaks 25
Minute, decoct 30 minutes afterwards, filter and remove residue is the Chinese medicine compound prescription that can be made into described nosebleed epistaxis caused by for treating deficiency of kidney-YIN
Preparation.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup,
Oral liquid, pill and paste.
Compound Chinese medicinal preparation provided by the present invention for nosebleed epistaxis caused by treatment deficiency of kidney-YIN is that the side of extraction is boiled using water
Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution rate of active ingredient in medicine
Greatly improve, and contribute to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure
Toxic side effect will not be produced after compound Chinese medicinal preparation, thus patient's long-term taking, so security is good.In addition, the system of the present invention
Preparation Method technique is simple, easy to operate.
Embodiment
Nosebleed epistaxis complicated symptoms, course of disease delay, complication is more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess etc..This side
Make laws in enriching yin and nourishing kidney, fall fire hemostasis.Radix rehmanniae recen sweetness and bitterness is trembled with fear in side, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, is wanting for clearing heat and cooling blood hemostasis
Medicine, is monarch drug in a prescription.Chinese yam is sweet flat, and tonifying spleen nourishing the stomach is the good merchantable brand of chronic prolonged illness harmonizing the spleen and stomach；Poria cocos is sweet light flat, clearing damp and promoting diuresis, invigorating the spleen
Resolving sputum, antitoxic heart-soothing and sedative；Moutan bark bitter sweet is slightly cold, clearing heat and cooling blood, promoting blood circulation；Hairyvein agrimony bitterness is flat, astringing to arrest bleeding, qi-restoratives；Ink
Non-irrigated lotus sweet acid is trembled with fear, nourishing liver and kidney, cooling blood and hemostasis, all medicines of the above, sharp water invigorating the spleen, filling liver kidney, and clearing heat and cooling blood hemostasis, is altogether ministerial drug.
Tepor that Fructus Corni is sour and astringent, tonifies the liver and kidney, and convergence is astringent or styptic treatment for spontaneous sweating, for the key medicine of flat tonifying yin sun；Rhizoma alismatis is sweet cold, and inducing diuresis for removing edema, excreting dampness expels the heat-evil；
Asian puccoon is sweet salty-cold, clearing heat and cooling blood, promoting blood circulation, promoting eruption of detoxifying；Fruit of glossy privet sweetness and bitterness is cool, nourishing liver and kidney, and crow must improving eyesight；Golden cypress bitter cold, clearly
Hot eliminating dampness, purging intense heat, except steaming, detoxification sore treatment, all medicines of the above, filling liver kidney, heat-clearing and damp-drying drug, removing toxic substances, cooling blood and hemostasis is adjutant.Licorice
Gan Ping, invigorates the spleen and benefits qi, clearing heat and detoxicating analgesic, coordinating the drug actions of a prescription, and thinking makes medicine.Our invigorating the spleen, filling liver kidney, cooling blood and hemostasis of detoxifying, therefore
Suitable for the nosebleed epistaxis caused by treatment deficiency of kidney-YIN.
With reference to embodiment to provided by the present invention for treatment deficiency of kidney-YIN caused by nosebleed epistaxis compound Chinese medicinal preparation and
Its preparation method is described in detail.
Embodiment 1：
The present embodiment provide be used for treat deficiency of kidney-YIN caused by nosebleed epistaxis compound Chinese medicinal preparation by consumption be weight than
Agents raw material is made：
The preparation method of the described compound Chinese medicinal preparation for being used for nosebleed epistaxis caused by treating deficiency of kidney-YIN is that said medicine is former
Material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue is that can be made into institute
That states is used for the compound Chinese medicinal preparation of nosebleed epistaxis caused by treating deficiency of kidney-YIN.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation
Starch agent, oral liquid, pill and paste.
Embodiment 2：
The present embodiment provide be used for treat deficiency of kidney-YIN caused by nosebleed epistaxis compound Chinese medicinal preparation by consumption be weight than
Agents raw material is made：
Preparation method be the same as Example 1.
Embodiment 3：
The present embodiment provide be used for treat deficiency of kidney-YIN caused by nosebleed epistaxis compound Chinese medicinal preparation by consumption be weight than
Agents raw material is made：
Preparation method be the same as Example 1.
The compound Chinese medicinal preparation of nosebleed epistaxis caused by provided by the present invention for treating deficiency of kidney-YIN is in brown to sepia；Gas
It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 327
Patient of the example with kidney-yin deficiency type nosebleed epistaxis has carried out system clinical observation, wherein 21-30 Sui patient 92,31-40 Sui 118
Example, 41-50 Sui 117, each medication 150ml, 3 times a day, is within 120 days 1 course for the treatment of.Cure (to go out altogether after 1 course of therapy
Mass formed by blood stasis shape disappears substantially) 157, account for 48.0%；Effectively (cardinal symptom has improvement) 134,41.0% is accounted for；Invalid (main disease
Shape is without improving) 36, account for 11.0%；Total effective rate is 89.0%.213 are cured altogether after 2 course of therapy, account for 65.1%；
Effective 89, account for 27.2%；Invalid 25, account for 7.6%；Total effective rate is 92.4%.
Meanwhile, the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis
As a result 1, table 2 is shown in Table respectively.
Table 1：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove
It is bright to take the compound Chinese medicinal preparation that provides of the present invention to treat kidney-yin deficiency type nosebleed epistaxis, to the therapeutic effect of each age group not with year
Age and change.
Table 2：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this
Invent the compound Chinese medicinal preparation of offer to treat kidney-yin deficiency type nosebleed epistaxis, with going deep into for treatment, cure rate, effective percentage are obvious
Improve.
Claims (3)
1. a kind of be used for the compound Chinese medicinal preparation of nosebleed epistaxis caused by treating deficiency of kidney-YIN, it is characterised in that：It is described to be used to treat kidney
The compound Chinese medicinal preparation of nosebleed epistaxis caused by yin deficiency is empty by consumption by weight than agents raw material be made：
2. a kind of preparation method of the compound Chinese medicinal preparation as claimed in claim 1 for being used for nosebleed epistaxis caused by treating deficiency of kidney-YIN,
It is characterized in that：Described preparation method is that said medicine raw material is weighed and mixed according to proportioning, is then soaked
25 minutes, decoct 30 minutes afterwards, filter and remove residue is that can be made into the described Chinese medicine for being used for nosebleed epistaxis caused by treating deficiency of kidney-YIN to answer
Square preparation.
3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine
Granule, tablet, capsule, syrup, oral liquid, pill and paste are made of auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710550625.9A CN107158194A (en) | 2017-07-07 | 2017-07-07 | The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by for treating deficiency of kidney-YIN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710550625.9A CN107158194A (en) | 2017-07-07 | 2017-07-07 | The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by for treating deficiency of kidney-YIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107158194A true CN107158194A (en) | 2017-09-15 |
Family
ID=59823200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710550625.9A Withdrawn CN107158194A (en) | 2017-07-07 | 2017-07-07 | The compound Chinese medicinal preparation and preparation method of nosebleed epistaxis caused by for treating deficiency of kidney-YIN |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107158194A (en) |
-
2017
- 2017-07-07 CN CN201710550625.9A patent/CN107158194A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 焦中华等: "《实用中医血液病学》", 30 June 1989, 青岛出版社出版 * |
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Application publication date: 20170915 |