CN107334967A - Compound Chinese medicinal preparation and preparation method for nosebleed epistaxis caused by treating liver-fire flaming - Google Patents
Compound Chinese medicinal preparation and preparation method for nosebleed epistaxis caused by treating liver-fire flaming Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 49
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- 239000003814 drug Substances 0.000 claims abstract description 32
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- 210000004185 liver Anatomy 0.000 claims description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/539—Scutellaria (skullcap)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/884—Alismataceae (Water-plantain family)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
A kind of compound Chinese medicinal preparation and preparation method for being used for nosebleed epistaxis caused by treating liver-fire flaming.Preparation by dosage by weight than agents raw material be made：Rough gentian 4 10, radix scutellariae 6 15, stir-baked FRUCTUS GARDENIAE 6 15, rhizoma alismatis 6 15, plantain seed 9 24, caulis clematidis armandii 4 10, moutan bark 6 15, Asian puccoon 6 15, wolf's milk 9 24, hairyvein agrimony 18 48, rhizoma imperatae 18 48, radix bupleuri 4 10.Invention formulation is to extract the active ingredient in material medicine using the method for boiling extraction, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, preparation method technique is simple, it is easy to operate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, is used more particularly to one kind using Chinese medicine as made of raw material
In the compound Chinese medicinal preparation and preparation method for the treatment of nosebleed epistaxis caused by liver-fire flaming.
Background technology
Nosebleed epistaxis refers to that blood flows out from nostril, is common one kind disease, can be caused by a variety of illness.The record of nosebleed epistaxis is earliest
See《The Yellow Emperor's Canon of Internal Medicine》, studied through ancient Chinese medicine doctor, it is believed that its morbidity is relevant with " heat ", " cold ", liver tuberculosis and internal lesion caused by overexertion.Although at present
Clinically be used for treat nosebleed epistaxis types of drugs it is more but a variety of due to causing the factor of nosebleed epistaxis to have, and nosebleed epistaxis also divide it is a variety of
Type, therefore these medicine lack of targeted, the course for the treatment of is relatively long, and some drugs have certain side effect or allergic reaction,
So effect is undesirable for this disease of nosebleed epistaxis caused by treatment belongs to liver-fire flaming after taking.
The content of the invention
In order to solve the above problems, it is used for it is an object of the invention to provide a kind of in nosebleed epistaxis caused by treating liver-fire flaming
Medicine compound preparation and preparation method thereof.
In order to achieve the above object, provided by the present invention for treatment liver-fire flaming caused by nosebleed epistaxis compound Chinese medicinal preparation by
Dosage by weight than agents raw material be made：
Rough gentian 4-10 radix scutellariae 6-15 stir-baked FRUCTUS GARDENIAE 6-15 rhizoma alismatis 6-15 plantain seeds 9-24
Caulis clematidis armandii 4-10 moutan bark 6-15 Asian puccoon 6-15 wolf's milk 9-24 hairyvein agrimonies 18-48
Rhizoma imperatae 18-48 radix bupleuri 4-10
The preparation method of the described compound Chinese medicinal preparation for being used for nosebleed epistaxis caused by treating liver-fire flaming is according to the following steps
Order is carried out:
(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；
(b) the other medicines raw material in said medicine raw material in addition to plantain seed is weighed and mixed according to proportioning,
The Chinese herbaceous peony attached bag being put into step (a), then soak 25 minutes, decoct 30 minutes, filter and remove residue can be made into described
Compound Chinese medicinal preparation for nosebleed epistaxis caused by treating liver-fire flaming.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup,
Oral liquid, pill and paste.
Compound Chinese medicinal preparation provided by the present invention for nosebleed epistaxis caused by treatment liver-fire flaming is the side using boiling extraction
Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution rate of active ingredient in medicine
Greatly improve, and contribute to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure
Compound Chinese medicinal preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, the system of the present invention
Preparation Method technique is simple, easy to operate.
Embodiment
Nosebleed epistaxis complicated symptoms, course of disease delay, complication are more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess etc..This side
Make laws in clearing liver-fire, cooling blood and hemostasis.Rough gentian bitter cold in side, heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire, it is apt to clear damp-heat in lower-JIAO, is monarch drug in a prescription.It is yellow
A kind of reed mentioned in ancient books bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating, it is longer than clear middle dampness-heat in upper jiao especially；Rhizoma alismatis is sweet cold, and inducing diuresis for removing edema, excreting dampness expels the heat-evil；Caulis clematidis armandii
Bitter cold, inducing diuresis for treating strangurtia, clearing away the heart-fire, stimulate the menstrual flow；Asian puccoon is sweet salty-cold, clearing heat and cooling blood, promoting blood circulation, promoting eruption of detoxifying；Hairyvein agrimony is bitter flat, convergence
Hemostasis, qi-restoratives, all medicines of the above, clearing heat-fire cool blood, eliminating dampness removing toxic substances Li Shui, is altogether ministerial drug.Stir-baked FRUCTUS GARDENIAE bitter cold, purging intense heat relieving restlessness, clearly
Hot dampness removing, removing pattogenic heat from the blood and toxic material from the body；Plantain seed is sweet to be slightly cold, inducing diuresis for treating strangurtia, excreting dampness antidiarrheal, improving eyesight eliminating the phlegm；Moutan bark bitter sweet is slightly cold, and heat-clearing is cool
Blood, promoting blood circulation；Wolf's milk is pungent flat, clearing heat and detoxicating, cooling blood and hemostasis；Rhizoma imperatae is sweet cold, cooling blood and hemostasis, reducing fever and causing diuresis, clearing lung-heat stomach
Heat, all medicines of the above, clearing away heat and promoting diuresis, cooling blood and hemostasis, it is adjutant.Bitter put down of radix bupleuri is slightly cold, and soothing liver-qi stagnation, rises and lifts yang-energy, thinking makes medicine.
Our clearing away the liver-fire, detoxify Li Shui, cooling blood and hemostasis, therefore suitable for the nosebleed epistaxis caused by treatment liver-fire flaming.
With reference to embodiment to provided by the present invention for treatment liver-fire flaming caused by nosebleed epistaxis compound Chinese medicinal preparation and
Its preparation method is described in detail.
Embodiment 1：
The present embodiment provide be used for treat liver-fire flaming caused by nosebleed epistaxis compound Chinese medicinal preparation by dosage be weight than
Agents raw material is made：
The plantain seed 9 of 6 rhizoma alismatis of rough gentian 4 radix scutellariae, 6 stir-baked FRUCTUS GARDENIAE 6
The hairyvein agrimony 18 of 6 wolf's milk of caulis clematidis armandii 4 moutan bark, 6 Asian puccoon 9
The radix bupleuri 4 of rhizoma imperatae 18
The preparation method of the described compound Chinese medicinal preparation for being used for nosebleed epistaxis caused by treating liver-fire flaming is according to the following steps
Order is carried out:
(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；
(b) other medicines in said medicine raw material in addition to plantain seed are weighed and mixed according to proportioning, be put into
Chinese herbaceous peony attached bag in step (a), then soak 25 minutes, decoct 30 minutes, filter and remove residue can be made into described be used for
The compound Chinese medicinal preparation of nosebleed epistaxis caused by treating liver-fire flaming.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation
Starch agent, oral liquid, pill and paste.
Embodiment 2：
The present embodiment provide be used for treat liver-fire flaming caused by nosebleed epistaxis compound Chinese medicinal preparation by dosage be weight than
Agents raw material is made：
The plantain seed 24 of 15 rhizoma alismatis of rough gentian 10 radix scutellariae, 15 stir-baked FRUCTUS GARDENIAE 15
The hairyvein agrimony 48 of 15 wolf's milk of caulis clematidis armandii 10 moutan bark, 15 Asian puccoon 24
The radix bupleuri 10 of rhizoma imperatae 48
Preparation method is the same as embodiment 1.
Embodiment 3：
The present embodiment provide be used for treat liver-fire flaming caused by nosebleed epistaxis compound Chinese medicinal preparation by dosage be weight than
Agents raw material is made：
The plantain seed 16 of 9 rhizoma alismatis of rough gentian 5 radix scutellariae, 9 stir-baked FRUCTUS GARDENIAE 9
The hairyvein agrimony 25 of 9 wolf's milk of caulis clematidis armandii 5 moutan bark, 9 Asian puccoon 16
The radix bupleuri 5 of rhizoma imperatae 25
Preparation method is the same as embodiment 1.
Provided by the present invention for nosebleed epistaxis caused by treatment liver-fire flaming compound Chinese medicinal preparation in brown to sepia；Gas
It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 280
Patient of the example with flaming-up of the liverfire type nosebleed epistaxis has carried out system clinical observation, wherein 21-30 year patient 56,31-40 year 117
Example, 41-50 year 107, each medication 150ml, 3 times a day, 120 days are 1 course for the treatment of.Cure (to go out altogether after 1 course of therapy
Mass formed by blood stasis shape disappears substantially) 136, account for 48.6%；Effectively (cardinal symptom has improvement) 117, accounts for 41.8%；Invalid (main disease
Shape is without improving) 27, account for 9.6%；Total effective rate is 90.4%.Cure 188 altogether after 2 course of therapy, account for 67.1%；Have
Effect 83, accounts for 29.6%；No effect 9, account for 3.2%；Total effective rate is 96.8%.
Meanwhile the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis
As a result 1, table 2 is shown in Table respectively.
Table 1：Compound Chinese medicinal preparation therapeutic effect provided by the invention and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove
It is bright to take compound Chinese medicinal preparation provided by the invention to treat flaming-up of the liverfire type nosebleed epistaxis, to the therapeutic effect of each age group not with year
Age and change.
Table 2：Compound Chinese medicinal preparation therapeutic effect provided by the invention and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this
The compound Chinese medicinal preparation provided is provided and treats flaming-up of the liverfire type nosebleed epistaxis, it is cure rate, efficient obvious with going deep into for treatment
Improve.
Claims (3)
- A kind of 1. compound Chinese medicinal preparation for being used for nosebleed epistaxis caused by treating liver-fire flaming, it is characterised in that：It is described to be used to treat liver On fire it is scorching caused by nosebleed epistaxis compound Chinese medicinal preparation by dosage by weight than agents raw material be made：
- 2. a kind of preparation method of the compound Chinese medicinal preparation as claimed in claim 1 for being used for nosebleed epistaxis caused by treating liver-fire flaming, It is characterized in that：Described preparation method is carried out according to the following steps order:(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；(b) the other medicines raw material in said medicine raw material in addition to plantain seed is weighed and mixed according to proportioning, be put into Chinese herbaceous peony attached bag in step (a), then soak 25 minutes, decoct 30 minutes, filter and remove residue can be made into described be used for The compound Chinese medicinal preparation of nosebleed epistaxis caused by treating liver-fire flaming.
- 3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine Granule, tablet, capsule, syrup, oral liquid, pill and paste is made with auxiliary material.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710550377.8A CN107334967A (en) | 2017-07-07 | 2017-07-07 | Compound Chinese medicinal preparation and preparation method for nosebleed epistaxis caused by treating liver-fire flaming |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710550377.8A CN107334967A (en) | 2017-07-07 | 2017-07-07 | Compound Chinese medicinal preparation and preparation method for nosebleed epistaxis caused by treating liver-fire flaming |
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| Publication Number | Publication Date |
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| CN107334967A true CN107334967A (en) | 2017-11-10 |
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| CN201710550377.8A Withdrawn CN107334967A (en) | 2017-07-07 | 2017-07-07 | Compound Chinese medicinal preparation and preparation method for nosebleed epistaxis caused by treating liver-fire flaming |
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| Country | Link |
|---|---|
| CN (1) | CN107334967A (en) |
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2017
- 2017-07-07 CN CN201710550377.8A patent/CN107334967A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 焦中华等: "《实用中医血液病学》", 30 June 1989, 青岛出版社出版 * |
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Application publication date: 20171110 |