CN107261030A - Damp and hot accumulate the compound Chinese medicinal preparation and preparation method spitted blood caused by stomach for treating - Google Patents

Damp and hot accumulate the compound Chinese medicinal preparation and preparation method spitted blood caused by stomach for treating Download PDF

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Publication number
CN107261030A
CN107261030A CN201710550367.4A CN201710550367A CN107261030A CN 107261030 A CN107261030 A CN 107261030A CN 201710550367 A CN201710550367 A CN 201710550367A CN 107261030 A CN107261030 A CN 107261030A
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preparation
damp
medicine
stomach
chinese medicinal
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马力
王维蔚
齐燕松
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

It is a kind of to be used to treat the damp and hot compound Chinese medicinal preparation and preparation method accumulate and spitted blood caused by stomach.Preparation by consumption by weight than agents raw material be made：Poria cocos 9 24, rhizoma alismatis 6 15, plantain seed 9 24, radix scutellariae 6 15, the coptis 4 10, prepared RADIX ET RHIZOMA RHEI with wine 4 10, stir-baked FRUCTUS GARDENIAE 6 15, cacumen biotae 6 15, caulis bambusae in taenian 4 10, bletilla 6 15, smilax 9 24, licorice 4 10.Invention formulation is to boil the method for extraction using water to extract active ingredient in material medicine, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, medicine is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term taking, so security is good.In addition, the preparation method technique of the present invention is simple, it is easy to operate.

Description

Damp and hot accumulate the compound Chinese medicinal preparation and preparation method spitted blood caused by stomach for treating
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of use being made using Chinese medicine as raw material In treating the damp and hot compound Chinese medicinal preparation and preparation method spitted blood caused by stomach of accumulateing.
Background technology
Spit blood in also known as and be defeated in battle.All blood goes out from mouth, and its color is scarlet, and it is haematemesis that blood, which goes out noiseless person,；If blood goes out sound, color purple Secretly, or the person that held swill under the arm, blood is referred to as vomitted.Due to spitting blood be all blood from stomach, spued by mouth, both are not Easily difference, therefore commonly referred to collectively as spit blood.The card has weight Do, and the lighter is occasionally told once, and severe one is spitted blood repeatedly, notably blood such as spring Gush.Spitting blood, a card not be solely shown in by stomach internal organs illness itself, can also be damaged stomach network caused by other internal organs lesions, or his dirty blood overflows and noted Enter stomach internal organs and again discharge person, also fall within haematemesis category.Although the types of drugs for being clinically used to treat haematemesis at present is more, due to The factor spitted blood is caused to have a variety of, and haematemesis also divides polytype, therefore these medicine lack of targeted, and the course for the treatment of is relatively It is long, and some drugs have certain side effect or allergic reaction, thus after taking for treatment belong to it is damp and hot accumulate caused by stomach tell Effect is undesirable for this disease of blood.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide it is a kind of be used to treating it is damp and hot accumulate spit blood caused by stomach Medicine compound preparation and preparation method.
In order to achieve the above object, provided by the present invention for treat it is damp and hot accumulate the compound Chinese medicinal preparation spitted blood caused by stomach by Consumption by weight than agents raw material be made：
Poria cocos 9-24 rhizoma alismatis 6-15 plantain seed 9-24 radix scutellariae 6-15 coptiss 4-10
Prepared RADIX ET RHIZOMA RHEI with wine 4-10 stir-baked FRUCTUS GARDENIAE 6-15 cacumen biotae 6-15 caulis bambusae in taenian 4-10 bletillas 6-15
Smilax 9-24 licorices 4-10
The described preparation method for being used to treat the damp and hot compound Chinese medicinal preparation accumulate and spitted blood caused by stomach is according to the following steps Order is carried out:
(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；
(b) other medicines in said medicine raw material in addition to plantain seed are weighed and mixed according to proportioning, be put into Chinese herbaceous peony attached bag in step (a), is then soaked 25 minutes, is decocted 30 minutes, filter and remove residue is that can be made into described be used for Treatment is damp and hot to accumulate the compound Chinese medicinal preparation spitted blood caused by stomach.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup, Oral liquid, pill and paste.
It is that the side of extraction is boiled using water provided by the present invention for treating the damp and hot compound Chinese medicinal preparation spitted blood caused by stomach of accumulateing Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution rate of active ingredient in medicine Greatly improve, and contribute to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Toxic side effect will not be produced after compound Chinese medicinal preparation, thus patient's long-term taking, so security is good.In addition, the system of the present invention Preparation Method technique is simple, easy to operate.
Embodiment
Haematemesis complicated symptoms, course of disease delay, complication is more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess etc..This side Make laws in clearing away heat and eliminating dampeness, cooling blood and hemostasis.Poria cocos is sweet light flat in side, clearing damp and promoting diuresis, strengthening the spleen and reducing phlegm, antitoxic heart-soothing and sedative, therefore is monarch drug in a prescription.Pool Rush down sweet cold, inducing diuresis for removing edema, excreting dampness expels the heat-evil；Radix scutellariae bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating is longer than clear middle dampness-heat in upper jiao especially；Prepared RADIX ET RHIZOMA RHEI with wine Bitter cold, heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, preferably for blood stasis symptom；Cacumen biotae bitterness is cold, cooling blood and hemostasis, Preventing phlegm from forming and stopping coughing；Bletilla bitter sweet is puckery cold, astringing to arrest bleeding, and detumescence and promoting granulation is the key medicine of astringing to arrest bleeding, can control inside and outside it is all go out blood trouble, All medicines, promoting diuresis to remove toxic substance, clearing heat and cooling blood, stagnation resolvation disperse accumulations, stop blooding, are altogether ministerial drug above.Plantain seed is sweet to be slightly cold, inducing diuresis for treating strangurtia, excreting dampness Antidiarrheal, improving eyesight eliminating the phlegm；Coptis bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating is longer than clear dampness-heat in middle jiao especially；Stir-baked FRUCTUS GARDENIAE bitter cold, purging intense heat is removed It is tired, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, hemostasis；Caulis bambusae in taenian is sweet to be slightly cold, and clearing heat and eliminating phlegm relieves restlessness and prevents vomiting, cooling blood and hemostasis；Smilax is sweet light flat, Removing toxic substances, dehumidifying, easing joint movement, all medicines of the above, clearing damp and promoting diuresis is clearing heat and detoxicating, cooling blood and hemostasis, and preventing or arresting vomiting is adjutant.Licorice is sweet It is flat, invigorate the spleen and benefit qi, clearing heat and detoxicating analgesic, coordinating the drug actions of a prescription, thinking makes medicine.Our clearing heat and detoxicating, eliminate dampness and have diuretic effect, while cool blood is stopped Blood, therefore suitable for treating the damp and hot haematemesis accumulate caused by stomach.
With reference to embodiment to provided by the present invention for treat it is damp and hot accumulate the compound Chinese medicinal preparation spitted blood caused by stomach and Preparation method is described in detail.
Embodiment 1：
What the present embodiment was provided be used for treat it is damp and hot accumulate the compound Chinese medicinal preparation spitted blood caused by stomach by consumption be weight than Agents raw material is made：
The coptis 4 of 9 radix scutellariae of Poria cocos 9 rhizoma alismatis, 65 plantain seed 6
The bletilla 6 of 6 caulis bambusae in taenian of prepared RADIX ET RHIZOMA RHEI with wine 4 stir-baked FRUCTUS GARDENIAE, 6 cacumen biotae 4
The licorice 4 of smilax 9
The described preparation method for being used to treat the damp and hot compound Chinese medicinal preparation accumulate and spitted blood caused by stomach is according to the following steps Order is carried out:
(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；
(b) other medicines in said medicine raw material in addition to plantain seed are weighed and mixed according to proportioning, be put into Chinese herbaceous peony attached bag in step (a), is then soaked 25 minutes, is decocted 30 minutes, filter and remove residue is that can be made into described be used for Treatment is damp and hot to accumulate the compound Chinese medicinal preparation spitted blood caused by stomach.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation Starch agent, oral liquid, pill and paste.
Embodiment 2：
What the present embodiment was provided be used for treat it is damp and hot accumulate the compound Chinese medicinal preparation spitted blood caused by stomach by consumption be weight than Agents raw material is made：
The coptis 10 of 24 radix scutellariae of Poria cocos 24 rhizoma alismatis, 15 plantain seed 15
The bletilla 15 of 15 caulis bambusae in taenian of prepared RADIX ET RHIZOMA RHEI with wine 10 stir-baked FRUCTUS GARDENIAE, 15 cacumen biotae 10
The licorice 10 of smilax 24
Preparation method be the same as Example 1.
Embodiment 3：
What the present embodiment was provided be used for treat it is damp and hot accumulate the compound Chinese medicinal preparation spitted blood caused by stomach by consumption be weight than Agents raw material is made：
The coptis 5 of 12 radix scutellariae of Poria cocos 12 rhizoma alismatis, 9 plantain seed 9
The bletilla 9 of 9 caulis bambusae in taenian of prepared RADIX ET RHIZOMA RHEI with wine 5 stir-baked FRUCTUS GARDENIAE, 9 cacumen biotae 5
The licorice 5 of smilax 12
Preparation method be the same as Example 1.
Provided by the present invention for treating the damp and hot compound Chinese medicinal preparation spitted blood caused by stomach of accumulateing in brown to brown color；Gas It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 350 Example has carried out system clinical observation, wherein 21-30 Sui patient 104,31-40 Sui 145 with the damp and hot patient for accumulateing gastric pattern haematemesis Example, 41-50 Sui 101, each medication 150ml, 3 times a day, is within 120 days 1 course for the treatment of.Cure (to go out altogether after 1 course of therapy Mass formed by blood stasis shape disappears substantially) 149, account for 42.6%；Effectively (cardinal symptom has improvement) 145,41.4% is accounted for；Invalid (main disease Shape is without improving) 56, account for 16.0%；Total effective rate is 84.0%.266 are cured altogether after 2 course of therapy, account for 76.0%； Effective 71, account for 20.3%；Invalid 13, account for 3.7%；Total effective rate is 96.3%.
Meanwhile, the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis As a result 1, table 2 is shown in Table respectively.
Table 1：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove It is bright the compound Chinese medicinal preparation that provides of the present invention is provided to be spitted blood to treat the damp and hot gastric pattern that accumulates, to the therapeutic effect of each age group not with year Age and change.
Table 2：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this Invent the compound Chinese medicinal preparation provided to spit blood to treat the damp and hot gastric pattern that accumulates, with going deep into for treatment, cure rate, effective percentage are obvious Improve.

Claims (3)

1. a kind of be used to treat the damp and hot compound Chinese medicinal preparation accumulate and spitted blood caused by stomach, it is characterised in that：Described Chinese medicine compound prescription system Agent by consumption by weight than agents raw material be made：
2. a kind of preparation method as claimed in claim 1 for being used to treat the damp and hot compound Chinese medicinal preparation accumulate and spitted blood caused by stomach, It is characterized in that：Described preparation method is carried out according to the following steps order:
(a) plantain seed is weighed by proportioning, with gauze wrapped and sealed；
(b) other medicines in said medicine raw material in addition to plantain seed are weighed and mixed according to proportioning, be put into step (a) the Chinese herbaceous peony attached bag in, is then soaked 25 minutes, is decocted 30 minutes, and filter and remove residue is that can be made into described to be used to treat It is damp and hot to accumulate the compound Chinese medicinal preparation spitted blood caused by stomach.
3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine Granule, tablet, capsule, syrup, oral liquid, pill and paste are made of auxiliary material.
CN201710550367.4A 2017-07-07 2017-07-07 Damp and hot accumulate the compound Chinese medicinal preparation and preparation method spitted blood caused by stomach for treating Withdrawn CN107261030A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
焦中华等: "《实用中医血液病学》", 30 June 1989, 青岛出版社出版 *

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