CN107519300A - The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat - Google Patents
The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
It is a kind of treat stagnation of blood stasis and heat caused by anaphylactoid purpura compound Chinese medicinal preparation and preparation method.Preparation by dosage by weight than agents raw material be made：Radix rehmanniae recen 12 32, the radix paeoniae rubrathe 9 24, Radix Angelicae Sinensis 6 15, peach kernel 6 15, moutan bark 6 15, radix scutellariae 6 15, prepared RADIX ET RHIZOMA RHEI with wine 6 15, stir-baked FRUCTUS GARDENIAE 6 15, garden burnet 6 15, schizonepeta 6 15, cicada slough 4 10, licorice 4 10.Invention formulation is to extract the active ingredient in material medicine using the method for boiling extraction, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, preparation method technique is simple, it is easy to operate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, is controlled more particularly to one kind using Chinese medicine as made of raw material
The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat.
Background technology
Anaphylactoid purpura is a kind of blood vessel allergy hemorrhagic disease, that is, immunity vascular conditions.It is fallen ill
Mainly due to body to Cucumber allergy occurs for mechanism, and the permeability and fragility for causing capillary wall increase, and
With polyangitis.This disease can be caused by many factors, may with bacterium, virus protein, parasite metabolite, food and
Some drugses etc. are relevant.Its clinical manifestation is mainly skin or mucosal bleeding, arthritis, stomachache, ephritis etc..According to the traditional Chinese medical science
Theory, anaphylactoid purpura belong to the categories such as " flesh nosebleed ", " febrile virulent maculae ", " ecchynosis " more.Although current clinical treatment mistake
The types of drugs of HSP is more, but a variety of due to causing the factor of anaphylactoid purpura to have, and anaphylactoid purpura also divide it is more
Type, therefore these medicine lack of targeted, the course for the treatment of is relatively long, and some drugs have certain side effect or allergy anti-
Should, so effect is undesirable for this disease of anaphylactoid purpura caused by treatment belongs to stagnation of blood stasis and heat after taking.
The content of the invention
In order to solve the above problems, it is an object of the invention to provide it is a kind of treat stagnation of blood stasis and heat caused by anaphylactoid purpura
Compound Chinese medicinal preparation and preparation method thereof.
In order to achieve the above object, the compound Chinese medicinal preparation of anaphylactoid purpura caused by treatment stagnation of blood stasis and heat provided by the invention
By dosage by weight than agents raw material be made：
Radix rehmanniae recen 12-32 radix paeoniae rubrathe 9-24 Radix Angelicae Sinensis 6-15 peach kernel 6-15 moutan barks 6-15
Radix scutellariae 6-15 prepared RADIX ET RHIZOMA RHEI with wine 6-15 stir-baked FRUCTUS GARDENIAE 6-15 garden burnet 6-15 schizonepeta 6-15
Cicada slough 4-10 licorices 4-10
The preparation method of the compound Chinese medicinal preparation of described treatment anaphylactoid purpura caused by stagnation of blood stasis and heat is by said medicine
Raw material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue can be made into
The compound Chinese medicinal preparation of anaphylactoid purpura caused by described treatment stagnation of blood stasis and heat.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup,
Oral liquid, pill and paste.
The compound Chinese medicinal preparation of anaphylactoid purpura caused by treatment stagnation of blood stasis and heat provided by the invention is extracted using boiling
Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution of active ingredient in medicine
Degree greatly improves, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is
Pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term use, so security is good.In addition, the present invention
Preparation method technique is simple, easy to operate.
Embodiment
Anaphylactoid purpura complicated symptoms, course of disease delay, complication are more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess
Deng.This side makes laws in Qingre Quyu.Radix rehmanniae recen sweetness and bitterness is trembled with fear in side, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, is wanting for clearing heat and cooling blood hemostasis
Medicine, therefore be monarch drug in a prescription.Radix paeoniae rubrathe hardship is slightly cold, clearing heat and cooling blood, blood stasis removing analgesic, is apt to clearing liver fire, cooling blood and hemostasis；Peach kernel bitter sweet is put down, promoting blood circulation
Dissolving stasis；Radix scutellariae bitter cold, heat-clearing and damp-drying drug, purging intense heat and detonicating, it is longer than clear middle dampness-heat in upper jiao especially；Stir-baked FRUCTUS GARDENIAE bitter cold, purging intense heat relieving restlessness, heat-clearing profit
It is wet, removing pattogenic heat from the blood and toxic material from the body, hemostasis；The pungent tepor of schizonepeta, is expelled pathogenic wind from the body surface, and promoting eruption disappears sore, and hemostasis, all medicines of the above, clearing heat and detoxicating, cool blood is stopped
Blood, it is promoting blood circulation and removing blood stasis, it is altogether ministerial drug.Radix Angelicae Sinensis Gan Xinwen, enriches blood, promoting blood circulation and stopping pain；Moutan bark bitter sweet is slightly cold, and clearing heat and cooling blood, promoting blood circulation is dispelled
The stasis of blood；Prepared RADIX ET RHIZOMA RHEI with wine bitter cold, heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, preferably for blood stasis symptom；Garden burnet picric acid is puckery micro-
It is cold, cooling blood and hemostasis, removing toxic substances sore；Cicada slough is sweet cold, dispelling wind and heat from the body, and relieving sore-throat opens sound, promoting eruption, Inflammation Zhijing, all medicines of the above, promoting blood circulation benefit
Blood, cool blood of detoxifying, stagnation resolvation is stimulated the menstrual flow, and is adjutant.Licorice is sweet flat, invigorates the spleen and benefits qi, clearing heat and detoxicating analgesic, coordinating the drug actions of a prescription, thinking makes
Medicine.Our Qingre Quyu, promoting blood circulation and cooling blood, therefore suitable for the anaphylactoid purpura caused by treatment stagnation of blood stasis and heat.
Compound Chinese medicinal preparation with reference to embodiment to anaphylactoid purpura caused by treatment stagnation of blood stasis and heat provided by the invention
And preparation method thereof be described in detail.
Embodiment 1：
The compound Chinese medicinal preparation for treatment anaphylactoid purpura caused by stagnation of blood stasis and heat that the present embodiment provides is weight ratio by dosage
Agents raw material be made：
The moutan bark 6 of 6 peach kernel of radix rehmanniae recen 12 radix paeoniae rubrathe, 9 Radix Angelicae Sinensis 6
The schizonepeta 6 of 6 garden burnet of radix scutellariae 6 prepared RADIX ET RHIZOMA RHEI with wine, 6 stir-baked FRUCTUS GARDENIAE 6
The licorice 4 of cicada slough 4
The preparation method of the compound Chinese medicinal preparation of described treatment anaphylactoid purpura caused by stagnation of blood stasis and heat is by said medicine
Raw material is weighed and mixed according to proportioning, is then soaked 25 minutes, is decocted 30 minutes afterwards, filter and remove residue can be made into
The compound Chinese medicinal preparation of anaphylactoid purpura caused by described treatment stagnation of blood stasis and heat.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation
Starch agent, oral liquid, pill and paste.
Embodiment 2：
The compound Chinese medicinal preparation for treatment anaphylactoid purpura caused by stagnation of blood stasis and heat that the present embodiment provides is weight ratio by dosage
Agents raw material be made：
The moutan bark 15 of 15 peach kernel of radix rehmanniae recen 32 radix paeoniae rubrathe, 24 Radix Angelicae Sinensis 15
The schizonepeta 15 of 15 garden burnet of radix scutellariae 15 prepared RADIX ET RHIZOMA RHEI with wine, 15 stir-baked FRUCTUS GARDENIAE 15
The licorice 10 of cicada slough 10
Preparation method is the same as embodiment 1.
Embodiment 3：
The compound Chinese medicinal preparation for treatment anaphylactoid purpura caused by stagnation of blood stasis and heat that the present embodiment provides is weight ratio by dosage
Agents raw material be made：
The moutan bark 8 of 8 peach kernel of radix rehmanniae recen 15 radix paeoniae rubrathe, 12 Radix Angelicae Sinensis 8
The schizonepeta 8 of 8 garden burnet of radix scutellariae 8 prepared RADIX ET RHIZOMA RHEI with wine, 8 stir-baked FRUCTUS GARDENIAE 8
The licorice 5 of cicada slough 5
Preparation method is the same as embodiment 1.
The compound Chinese medicinal preparation of anaphylactoid purpura caused by treatment stagnation of blood stasis and heat provided by the invention is in brown to sepia；Gas
It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 280
Patient of the example with stagnation of blood stasis and heat type anaphylactoid purpura has carried out system clinical observation, wherein 21-30 year patient 56,31-40
Year 117,41-50 year 107, each medication 150ml, 3 times a day, 120 days are 1 course for the treatment of.Controlled altogether after 1 course of therapy
More (bleeding disappears substantially) 136, accounts for 48.6%；Effectively (cardinal symptom has improvement) 117, accounts for 41.8%；It is invalid (main
Symptom is wanted without improving) 27, account for 9.6%；Total effective rate is 90.4%.Cure 188 altogether after 2 course of therapy, account for
67.1%；Effective 83, account for 29.6%；No effect 9, account for 3.2%；Total effective rate is 96.8%.
Meanwhile the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis
As a result 1, table 2 is shown in Table respectively.
Table 1：Compound Chinese medicinal preparation therapeutic effect provided by the invention and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove
It is bright to take compound Chinese medicinal preparation provided by the invention to treat stagnation of blood stasis and heat type anaphylactoid purpura, to the therapeutic effect of each age group
Do not change with the age.
Table 2：Compound Chinese medicinal preparation therapeutic effect provided by the invention and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this
The compound Chinese medicinal preparation provided is provided and treats stagnation of blood stasis and heat type anaphylactoid purpura, with going deep into for treatment, cure rate, effective percentage
Significantly improve.
Claims (3)
1. it is a kind of treat stagnation of blood stasis and heat caused by anaphylactoid purpura compound Chinese medicinal preparation, it is characterised in that：Described treatment stagnant heat
Mutually knot caused by anaphylactoid purpura compound Chinese medicinal preparation by dosage by weight than agents raw material be made：
Radix rehmanniae recen 12-32 radix paeoniae rubrathe 9-24 Radix Angelicae Sinensis 6-15 peach kernel 6-15 moutan barks 6-15
Radix scutellariae 6-15 prepared RADIX ET RHIZOMA RHEI with wine 6-15 stir-baked FRUCTUS GARDENIAE 6-15 garden burnet 6-15 schizonepeta 6-15
Cicada slough 4-10 licorices 4-10.
A kind of 2. preparation side of the compound Chinese medicinal preparation of anaphylactoid purpura caused by treatment stagnation of blood stasis and heat as claimed in claim 1
Method, it is characterised in that：Described preparation method is that said medicine raw material is weighed and mixed according to proportioning, then adds water logging
Bubble 25 minutes, decoct 30 minutes afterwards, filter and remove residue is in anaphylactoid purpura caused by can be made into described treatment stagnation of blood stasis and heat
Medicine compound preparation.
3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine
Granule, tablet, capsule, syrup, oral liquid, pill and paste is made with auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710939678.XA CN107519300A (en) | 2017-09-30 | 2017-09-30 | The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710939678.XA CN107519300A (en) | 2017-09-30 | 2017-09-30 | The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107519300A true CN107519300A (en) | 2017-12-29 |
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ID=60684834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710939678.XA Withdrawn CN107519300A (en) | 2017-09-30 | 2017-09-30 | The compound Chinese medicinal preparation and preparation method of anaphylactoid purpura caused by treating stagnation of blood stasis and heat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107519300A (en) |
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2017
- 2017-09-30 CN CN201710939678.XA patent/CN107519300A/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| 叶进等: "加味犀角地黄汤治疗儿童过敏性紫癜52例", 《江苏中医》 * |
| 欧阳晓勇等: "刘复兴学术思想点滴", 《云南中医中药杂志》 * |
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