CN107519296A - 一种用于产后血症的中药组合物及其药剂 - Google Patents
一种用于产后血症的中药组合物及其药剂 Download PDFInfo
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Abstract
本发明属于中医中药领域,公开了一种用于产后血症的中药组合物及其药剂。该中药组合物包含以下重量份的组分:熟地黄25~250克,当归10~25克,炒白芍12~30克,川芎3~9克。该中药组合物改变传统四物汤药方中“熟地黄”的用量以及治疗理念,重用熟地黄滋阴补血为君,以补肾水为主要治疗方向,补血之源不是补血之本身,为水满自溢的根源性补法;当归补血养肝,生血活血,引血归经,为熟地黄之臣,把血之源头生成的血,归入血脉,为之臣;白芍养血柔肝,且助肝藏血,为佐;川芎活血行气,畅通气血为之使。四味合用,补而不滞,滋而不腻,养血活血,可使营血调和,从而针对产后常见血症可达到极为有效的治疗效果。
Description
技术领域
本发明属于中医中药领域,特别涉及一种用于产后血症的中药组合物及其药剂。
背景技术
“四物汤”是治疗妇科百病的良方,血家百病的圣药,该药方最早出现记载于唐朝的蔺道人著的《仙授理伤续断秘方》,目前应用较为广泛的药方则是来源于《太平惠民和剂局方》中的“四物汤”方,熟地15克、当归15克、白芍10克、川芎8克,为补血调经的主方备受历代医家推崇。尤其是明末清初妇科医家傅青主,更是把四物汤看作是妇科补血调经神品,并在四物汤方的基础上开发了加味四物汤等众多妇科复方,以此看出四物汤对于妇科血证的重要性以及其历史悠久性。又如张秉成在《成方便读》曰:“故一切补气诸方,皆从四君化出;一切补血诸方,又当从此四物而化也。补气者,当求之脾肺;补血者当求之肝肾。地黄入肾,壮水补阴;白芍入肝,敛阴益血。二味为补血之正药。然血虚多滞,经脉隧道,不能滑利通畅,又恐地黄、白芍纯阴之性,无温养流动之机,故必加以当归、川芎辛香温润,能养血而行血中之气以流动之。总之,调理一切血证是此方所擅长的。现代中医也多在本方的基础上,加量或加味来治疗妇科各种血症,收效良好。
产妇是一特殊群体,由于分娩时失血过多、用力、疼痛、创伤,都会导致其气、血、津液的耗损,产后容易出现各种血症。如(1)产后恶露不尽。恶露主要是指产妇产后余血和浊液从其子宫经阴道排出,产后恶露持续20天以上仍淋漓不净者为产后恶露不尽。恶露不尽是产后常见多发性疾病,主要是患者产后子宫复旧不全引起,随着时间迁徙则会影响患者身心健康。临床应用西药缩宫素和抗生素等药物治疗均难以达到满意效果且不良反应较多,且在哺乳期不宜服用。(2)产后崩漏。产后崩漏,是指妇女产后出现异常的阴道出血,是行刮宫术和口服抗早孕药物中断妊娠后的多发病。现代医学认为产后恶露不尽主要是因子宫复旧不良和宫腔内胎盘胎膜残留等所致。目前临床主要采用宫缩药物联合抗生素治疗,但缩宫药物半衰期短且存在受体饱和现象,大量使用会导致患者发生过敏反应。此外,大剂量使用后患者子宫会出现强直收缩而出现宫缩痛,进而导致患者难以耐受,不良反应大、依赖性强,在哺乳期不宜服用。然而中医临床尚无固定组方治疗产后崩漏。(3)产后气血亏耗,导致的发热、便秘、产后抑郁、痹痛也为产后常见病。(4)产后乳汁过少,指产妇在产后2~10天内没有乳汁分泌和分泌量过少;或者在产褥期、哺乳期内乳汁正行之际,乳汁分泌减少或全无,甚至不能喂养婴儿的,统称为缺乳。现代医学认为泌乳的内分泌及神经机制较复杂,孕激素、雌激素、胎盘催乳素、泌乳素、皮质醇及胰岛素,皆与乳房系统生长发育及泌乳功能有关,内分泌及神经调节失常皆可导致产后缺乳。此外,乳汁开始分泌后,若发生营养不良、精神恐惧或抑郁,可直接影响丘脑下部,使腺垂体催乳素分泌减少,而致乳汁不分泌或分泌量减少。婴儿哺乳不当,也可造成乳汁分泌不足。西医目前尚无有效临床治疗方法,中医同样也无固定成药组方可用。(5)流产后出血不止,是人流后一种常见的并发症,人流术后阴道出血不止,以血痕和气血二虚者居多。现代医学认为此病术中胚胎组织残留或子宫复旧不全所致,对其治疗多采用抗生素,益母草冲剂,当归养血丸等,但疗效欠佳。
目前,临床使用的四物汤及加量或加味四物汤,用途很普遍,适合所有妇科血症,尤其是血虚症,所以其以补血生血为主,无不以当归为君,因为当归入血分,具有补血活血,调和血脉的作用。熟地黄为臣,是因为当归容易生热上火。而熟地虽性温,却补益肾精,有凉性特点,既能生精化血辅助当归生血,又能降低当归热性,所以为臣。白芍性凉,生血补血,入肝经血分,所以有辅佐生血作用,性凉又能约制当归,白芍为佐。川芎性温,善走善行,活血化瘀,引药入肝,所以川芎为使位。但是,妇科血症多以经血不调为主,如经期时间超前或错后或先后不定期等,原因多为外感内伤所致气血虚弱或气滞血瘀;产后血症多以产后出血为主,如产后血崩、恶落不尽、产后漏下等,原因多为血虚、脏腑不和、血不归经为主。因此,传统四物汤虽然对于妇科血症有极好疗效,但是对于产后血症的治疗则针对性不强,无法单用于产后或者崩漏。
发明内容
为了克服上述现有技术的缺点与不足,本发明的首要目的在于提供一种用于产后血症的中药组合物。
本发明的另一目的在于提供一种用于产后血症的中药组合物的药剂。
本发明的目的通过下述方案实现:
一种用于产后血症的中药组合物,其所含组分及组分重量配比为:熟地黄25~250克,当归10~25克,炒白芍12~30克,川芎3~9克。
优选的,所述的中药组合物,其所含组分及组分重量配比为:熟地黄25~50克,当归10~15克,炒白芍12~30克,川芎6~9克。
所述的炒白芍优选为醋炒白芍,又称醋芍为白芍片用米醋喷淋,用文火微炒入药。偏于敛肝止痛,养血止血。
一种采用上述的用于产后血症的中药组合物制成的药剂,该药剂除了上述中药组合物外,还可包括可接受的辅料。
所述的可接受的辅料可为赋形剂、填充剂、粘合剂、湿润剂、吸收促进剂或润滑剂。
所述的药剂可为汤剂、片剂、胶囊剂、针剂、粉针剂、颗粒剂、冲剂、口服液或糖浆剂,或者采用微纳米技术制成的片剂、胶囊剂、针剂、粉针剂或颗粒剂。该药剂可由本领域常规的方法制备得到,例如:
所述的采用上述的用于产后血症的中药组合物制成的汤剂,具体由以下步骤制备得到:
1.先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
2.加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
3.武火烧开后,文火煎煮30~60分钟后,倒出药汤;
4.再加入药物总重量2~6倍体积的水,武火烧开后,文火煎煮30~60分钟;
5.合并两次所得药汤,得汤剂。
所述的采用上述的用于产后血症的中药组合物制成的片剂,具体由以下步骤制备得到:
1.先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
2.加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
3.加热回流30~60分钟后过滤,得滤液1;
4.后再加入药物总重量2~6倍体积的水,回流30~60分钟后过滤,得滤液2;
5.合并滤液1和2,蒸干水分后得浸膏;
6.提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过50~80目筛;
7.将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;
8.干浸膏颗粒与微晶纤维素(质量比为4:1~2:1)混合后压片,得片剂。
所述的采用上述的用于产后血症的中药组合物制成的胶囊剂,具体由以下步骤制备得到:
1.先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
2.加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
3.加热回流30~60分钟后过滤,得滤液1;
4.后再加入药物总重量2~6倍体积的水,回流30~60分钟后过滤,得滤液2;
5.合并滤液1和2,蒸干水分后得浸膏;
6.提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过50~80目筛;
7.将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;
8.将干浸膏颗粒装胶囊。
本方以四物汤药方为基础,治疗营血亏虚,血行不畅,淤血、出血,一方多用。出血则止,淤血则行,兼具养血、补血,调和肝肾,补益冲任,一举多得。本方中改变“熟地黄”的用量以及治疗理念,重用熟地黄滋阴补血为君,以补肾水为主要治疗方向,补血之源不是补血之本身,为水满自溢的根源性补法;当归补血养肝,生血活血,引血归经,为熟地黄之臣,把血之源头生成的血,归入血脉,为之臣;白芍养血柔肝,且助肝藏血,为佐;川芎活血行气,畅通气血为之使。四味合用,补而不滞,滋而不腻,养血活血,可使营血调和,从而针对以上几种产后常见血症可达到极为有效的治疗效果。因肝肾主生殖,产后血症属于生殖后产生的疾病,补益肝肾养血活血为重点,行气活血为辅,川芎行气活血,归肝、心经,引药入肝,为使。
熟地黄,性味甘微温,归肝、肾经。功效补血养阴,填精益髓。本品甘温质润,补阴益精以生血,为养血补虚益肾之要药。在此方中熟地为君意义在于调补肝肾,使肾精充足化生血脉。又因为肾主冲任,冲任者主胞宫,肾气健壮冲任不虚,胞宫生殖功能正常。所以说肾主生殖就是这个意思。同时,肝肾为母子关系,肾气充足能生养肝木,肝木健康能藏血,不致血漏脉外;又因为肝主疏泄一身气血,肝经疏畅能疏活气血,使气血不致淤滞不前出现闭经不行,或者因为肝血瘀滞出现产后恶落不净。熟地滋阴能使肾水充足,可使肾中水满自愈补中有泻,对治疗血虚、血淤引起的闭经及产后恶落不净,出血不止疗效突出。
白芍(炒),性味苦,酸,微寒,归肝经、脾经。养血和营,缓急止痛,敛阴平肝。主治:月经不调,经行腹痛,崩漏,自汗,盗汗,胁肋脘腹疼痛,四肢挛痛,头痛,眩晕。在本方中白芍为佐位,具有辅佐熟地生血,肝肾同补的作用。又因白芍柔肝止痛,所以可以收敛肝阳上亢,助肝藏血不致迫血妄行,又能治疗肝血淤滞引起的癥瘕积聚经来腹痛。因此熟地配白芍为补血探源,补血之正药也。
既然熟地、白芍是补血妙方,为何又用当归、川芎?因为,方中当归性味甘、辛、温,归肝、心、脾经。具有补血、活血、调经止痛、润燥滑肠,主血虚诸证,如月经不调、经闭、痛经、症瘕结聚、崩漏、虚寒腹痛等。在本方中当归为臣助熟地产生的血液顺利归入血分,兼顾因熟地白芍性寒引起血寒淤滞,起到温化疏通血脉之功。所以当归是妇科良药,在方中为臣位。
另外,方中川芎性味辛温,归肝、脾、心包经,具有活血行气、祛风止痛的作用,可以温化血脉、通行肝脾心包之气血,使生成之血脉不致淤滞。与当归配伍,能补中有行,使血脉通畅无阻。因川芎辛散力较强,多用恐伤气血,与补血养血之法相搏,所以方中用川芎起到引药归经,通活血脉的作用即可,因此在本方中川芎为佐使位。
全方尽属血分药,但组合得体,补血而不滞血,行血而不破血,补中有散,散中有收,构成治血要剂。诸药合用补益肝肾生成血脉,又能主冲任脉虚,引起的女子经血量少,经期不调,崩中漏下;肝血淤滞出现的,癥瘕积聚经来腹痛,产后恶露不尽等妇科血症。尤其对生产后血虚引起的各类症状,对于兼有旁症者,辅以其他药物,效果事半功倍。
本发明相对于现有技术,具有如下的优点及有益效果:
(1)本方中重用熟地黄滋阴补血为君,当归补血养肝为之臣,白芍养血柔肝和营为佐,川芎活血行气,畅通气血为之使。
(2)本方以补肾水为主要治疗方向,大补肾水,水满自溢,既能补血生血,又能活血止血,适应症更有针对性,且效果更好,尤其针对产后恶露不尽、产后崩漏、产后血虚、产后乳汁过少或流产后出血不止等产后血症具有极好疗效。
(3)此发明完善了中国现有中医体系中,根据治疗理念不同,利用不同君臣佐使配伍,从而获得更有效治疗方案。以及方剂中各成分使用理论依据,使中医中药更具科学性。用本发明的中药制剂治疗所涉及的产后血症,有效率高,且疗程短,见效快,安全无毒副作用。
具体实施方式
下面结合实施例对本发明作进一步详细的描述,但本发明的实施方式不限于此。
实施例中所用试剂如无特殊说明均可从市场常规购得。
实施例一:产后恶露不尽,熟地50克,醋炒白芍15克,当归15克,川芎8克,煎汤服用。先将四种中药材原料按重量份数比称重,粉碎成细粉,过20目筛;加水至药物总量的6倍,并冷水浸泡30分钟;武火烧开后,文火煎煮45分钟后,倒出药汤;再加入药物总重量4倍体积的水,武火烧开后,小火煎煮30分钟;合并两次所得药汤。
樊XX,女,26岁,河北省石家庄藁城区塔元庄人。于2015年5月1日来诊。自诉三个月前突然毫无征兆的流产后,就出现了月经断断续续的现象。用益母草等中药已经三个月无法治愈。现在除了月经不断外没有其他症状。在医院做过刮宫说没有胎盘残留,但是就是月经隔几天就会来些,然后就没了,颜色发黑粘稠成块。观察体征,面色黑红,眼袋色重发黑,下腹胀满拒按疼痛。舌质紫暗,舌苔黄厚干燥颗粒状,脉象细沉略带弦象。诊断为产后气血瘀滞,呈现恶露不尽之症。用本实施例的汤剂治之,每日一剂早晚服用。连服15剂后患者自行中止了服药。四个月后复诊,自诉症状减轻,但是月经量少,经期十天左右。诊断为没有彻底治愈,就自行中止,致使肝经瘀滞未通。随又按原方取15副药治疗,随访多年没有复发。
实施例二:产后崩漏,熟地50克,当归15克,醋炒白芍15克,川芎8克。先将四种中药材原料按重量份数比称重,粉碎成细粉,过20目筛;加水至药物总量的6倍,并冷水浸泡30分钟;加热回流45分钟后过滤,得滤液1;后再加入药物总重量4倍体积的水,回流30分钟后过滤,得滤液2;合并滤液1和2,蒸干水分后得浸膏;提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过60目筛;将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;干浸膏颗粒与微晶纤维素(3:1)混合后压片,得片剂。
靳xx,女,27岁,河南商丘人士,在大同村人造板厂打工。与1997年4月11日,在租住处顺产一名女婴,母子健康平安。但产妇自生产婴儿后就大量出血,本以为三天后就可自行止血,但是已经四日了出血还是没有减少,且血块量多,现在出现心烦心悸失眠,食欲不振,头晕身倦乏力,身体发冷的表现。检查:患者面色苍白但是两颧潮红,口唇无血色,说话有气力正常,神情尚好,体温37.4度,舌质淡,舌苔黄厚,脉象芤。说明产妇平素身体健壮,此为生产时用力过度,损伤胞宫经脉,损耗肝肾,致肝不藏血,脾不统血,血不归经。出血量大,四日以内说明阳气未损,而阴血伤。用本实施例的片剂治之,补血生血,引血归经,从而止崩定血。早晚各服用一次,每次5片。服用一天后,出血量减少,还是血块多,体温恢复正常。服用二天后出血量明显减少,还是有血块,其他症状未减轻。服用三天后出血量基本消失,偶有血块,面色基本恢复,食欲增加,基本恢复正常。
实施例三:产后气血亏虚,熟地35克,当归15克,醋炒白芍12克,川芎6克,煎汤服用。先将四种中药材原料按重量份数比称重,粉碎成细粉,过30目筛;加水至药物总量的5倍,并冷水浸泡30分钟;武火烧开后,文火煎煮45分钟后,倒出药汤;再加入药物总重量5倍体积的水,武火烧开后,文火煎煮45分钟;合并两次所得药汤。
李xx,女,24岁,石家庄长安区人氏,与1997年9月2日顺产一名女婴,生产时出血量大,出现面色苍白,唇色爪甲淡白无华,头晕目眩,肢体麻木,筋脉拘挛,心悸怔忡,失眠多梦,皮肤干燥,头发枯焦,以及大便燥结,少气懒言、语言低微、疲倦乏力、气短自汗等气虚症状。服用阿胶补血口服液症状加重,于10月1日就诊。检查:面色苍白,身体怠倦无力,说话声地气弱,长吁短叹,舌质淡,舌苔薄白,脉象沉细,尺脉弱。此为产后出血量大,耗伤气血,致气血双虚症。中医认为,血为气之母,气赖血以附,血载气以行。血虚,气无以附,遂因之而虚,故血虚常伴随气虚,病人不仅有血虚的症状,而且还有少气懒言、语言低微、疲倦乏力、气短自汗等气虚症状。此为常见的血虚而致气虚的慢性气血双虚症。适合中药调理诊治,方用本实施例的汤剂治疗,取三幅,每日一副,分早晚服用。三日后症状减轻,用此方取9幅继续服用。九日后基本恢复,就是身倦无力还是存在。随取10副巩固疗效。
实施例四:产后乳汁过少,熟地35克,醋炒白芍30克,当归15克,川芎8克。先将四种中药材原料按重量份数比称重,粉碎成细粉,过20目筛;加水至药物总量的6倍,并冷水浸泡30分钟;加热回流45分钟后过滤,得滤液1;后再加入药物总重量4倍体积的水,回流30分钟后过滤,得滤液2;合并滤液1和2,蒸干水分后得浸膏;提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过60目筛;将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;将干浸膏颗粒装胶囊。
高xx,女,28岁,河北省藁城区清流村人,生下婴儿后,乳汁一直清稀量少,平时主要还要给孩子添补奶粉才行。检查:面色正常,舌质淡红,舌苔薄白,脉象沉细略带弦象,尺脉细弱。问诊:患者食欲不振,失眠多梦,烦躁易怒,头晕乏力,月经量少错后,大便干燥,两乳没有奶水充足感,奶水量少略稀。用补气养血的中药后出现头晕加重,口舌唇部生疮肿疼症状。此为阴血不足,血虚不宜肝阳,所致的肝脾不和,不生气血,血虚不化乳汁。随用本实施例的胶囊剂进行治疗,以补养阴血,平肝潜阳,调和肝肾脾胃。取三天用量的胶囊,每日早晚饭后各服用一次,每次3粒胶囊。三日后奶水开始增多,有了奶水充足的憋胀感。随取10日量巩固疗。直致孩子两周半断奶一直奶水充足。
实施例五:流产后出血不止,熟地35克,当归12克,醋炒白芍30克,川芎9克,煎汤服用。先将四种中药材原料按重量份数比称重,粉碎成细粉,过30目筛;加水至药物总量的6倍,并冷水浸泡30分钟;武火烧开后,文火煎煮45分钟后,倒出药汤;再加入药物总重量4倍体积的水,武火烧开后,文火煎煮30分钟;合并两次所得药汤。
姚xx,女22岁,河北省藁城区二大队人氏,因意外怀孕,自行买药流产,自从顺利排出妊娠物后,一直出血不止,虽然量不大,但是淋漓不断。偶有下腹疼痛,没有血块,其他症状无。检查:面色发白没有光泽,舌质淡,无舌苔,脉象芤。此为流产后,没有调养身体,致肝血虚,肝不藏血,血不归经所致。遂用本实施例的汤剂补益肝肾,收敛肝气主治。取三幅,每日一副,饭后早晚服用。第四天基本止血,偶有白带量少带血丝。此为血以归经,但是由于肝血虚肝阴不足,乘克脾胃,致脾虚带下,脾不统血,血漏脉外所致。又取三幅药,每日一副,饭后早晚服用。三日后一切恢复正常。若同时辅以白术山药粥以调补脾胃,效果更佳。
上述实施例为本发明较佳的实施方式,但本发明的实施方式并不受上述实施例的限制,其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化,均应为等效的置换方式,都包含在本发明的保护范围之内。
Claims (10)
1.一种用于产后血症的中药组合物,其特征在于所含组分及组分重量配比为:熟地黄25~250克,当归10~25克,炒白芍12~30克,川芎3~9克。
2.根据权利要求1所述的用于产后血症的中药组合物,其特征在于所含组分及组分重量配比为:熟地黄25~50克,当归10~15克,炒白芍12~30克,川芎6~9克。
3.根据权利要求1或2所述的用于产后血症的中药组合物,其特征在于:
所述的炒白芍为醋炒白芍。
4.一种采用权利要求1~3中任意一项所述的用于产后血症的中药组合物制成的药剂。
5.根据权利要求4所述的用于产后血症的中药组合物制成的药剂,其特征在于还包括可接受的辅料。
6.根据权利要求5所述的该药剂用于产后血症的中药组合物的药剂,其特征在于:所述的可接受的辅料为赋形剂、填充剂、粘合剂、湿润剂、吸收促进剂或润滑剂。
7.根据权利要求4或5所述的用于产后血症的中药组合物制成的药剂,其特征在于该药剂为汤剂、片剂、胶囊剂、针剂、粉针剂、颗粒剂、冲剂、口服液或糖浆剂,或者采用微纳米技术制成的片剂、胶囊剂、针剂、粉针剂或颗粒剂。
8.根据权利要求7所述的用于产后血症的中药组合物制成的药剂,其特征在于所述的汤剂由以下步骤制备得到:
(1)先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
(2)加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
(3)武火烧开后,文火煎煮30~60分钟后,倒出药汤;
(4)再加入药物总重量2~6倍体积的水,武火烧开后,文火煎煮30~60分钟;
(5)合并两次所得药汤,得汤剂。
9.根据权利要求7所述的用于产后血症的中药组合物制成的药剂,其特征在于所述的片剂由以下步骤制备得到:
(1)先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
(2)加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
(3)加热回流30~60分钟后过滤,得滤液1;
(4)后再加入药物总重量2~6倍体积的水,回流30~60分钟后过滤,得滤液2;
(5)合并滤液1和2,蒸干水分后得浸膏;
(6)提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过50~80目筛;
(7)将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;
(8)干浸膏颗粒与微晶纤维素按质量比4:1~2:1混合后压片,得片剂。
10.根据权利要求7所述的用于产后血症的中药组合物制成的药剂,其特征在于所述的胶囊剂由以下步骤制备得到:
(1)先将四种中药材原料按重量份数比称重,粉碎成细粉,过20~40目筛;
(2)加水至药物总量的4~8倍,并冷水浸泡30~60分钟;
(3)加热回流30~60分钟后过滤,得滤液1;
(4)后再加入药物总重量2~6倍体积的水,回流30~60分钟后过滤,得滤液2;
(5)合并滤液1和2,蒸干水分后得浸膏;
(6)提取物浸膏再冷冻干燥后粉碎机粉碎为细粉,过50~80目筛;
(7)将干浸膏细粉置包衣锅中,边转动边将无水乙醇以雾状喷入,逐渐地湿粘成粒,再继续转动至干燥,得干浸膏颗粒;
(8)将干浸膏颗粒装胶囊。
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