CN107519086A - A kind of black hair additive and its application - Google Patents
A kind of black hair additive and its application Download PDFInfo
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- CN107519086A CN107519086A CN201710762039.0A CN201710762039A CN107519086A CN 107519086 A CN107519086 A CN 107519086A CN 201710762039 A CN201710762039 A CN 201710762039A CN 107519086 A CN107519086 A CN 107519086A
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- China
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- black hair
- hair
- extraction
- additive
- tribulus terrestris
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
Abstract
The invention discloses a kind of black hair additive and its application, the black hair additive is made up of the component of following mass percent：Paeoniflorin 0.2 2.1%, Radix Gentianae extract 0.1 2.4%, tribulus terrestris extraction 0.2 2.0%.It is applied in hair conditioner, can effectively activates melanocyte, activate tyrosinase activity, promotes the generation of hair melanin, and then the effect of black hair.Long-term use, healthy hair can be made pitch-black smooth, healthy submissive.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of black hair additive and its application.
Background technology
While continuous improvement along with the continuous progress of society, living standard, the quickening of people's rhythm of life, work and
The various reasons such as the increase of life stress, diet be irregular cause the hair such as exception, the white hair occurred too early, alopecia of hair
Disease brings serious influence to work and life.Modern medicine is thought：White hair is because melanocyte forms black in ball top
The hypofunction of element, the activity of tyrosinase lower or lost, lack melanin in hair shaft and cause.
In view of the above-mentioned problems, many treatment white hairs occurs in the market, improve the hair products of hair quality, but these products
There is the shortcomings that certain, the product using effect unobvious included；Some product using effects are single；Product price also
Costly, it is difficult to accepted extensively by people.
The content of the invention
Based on this, it is an object of the invention to provide a kind of black hair additive, and it has good black hair effect, and uses
Conveniently, price is less expensive.
To achieve these goals, the present invention adopts the following technical scheme that：
A kind of black hair additive includes the component of following mass percent：Paeoniflorin 0.2-2.1%, Radix Gentianae extract
0.1-2.4%, tribulus terrestris extraction 0.2-2.0%.
Preferably, described black hair additive includes the component of following mass percent：Paeoniflorin 0.3-1.8%, rough gentian
Careless extract 0.3-2.0%, tribulus terrestris extraction 0.4-1.6%.
Optimal, described black hair additive includes the component of following mass percent：Paeoniflorin 0.5-1.2%, rough gentian
Careless extract 0.5-1.6%, tribulus terrestris extraction 0.6-1.0%.
Further, the preparation method of described Paeoniflorin is as follows：Chinese herbaceous peony cleaning, drying are weighed, are crushed to 40 mesh, according to
Solid-liquid ratio 1:25 (g/ml) add 50% ethanol, ultrasonic extraction 2h, cool down, filtering, and filter residue continues to repeat extraction 2 times, every time
1h, merging filtrate, obtain Paeoniflorin.
Further, the preparation method of described Radix Gentianae extract is as follows：Felwort is weighed, cleaning, drying, is ground into
60 mesh, obtain Chinese Gentian Root；The acetone for adding 10 times of amounts carries out degreasing decoloring, after filtering, according to solid-liquid ratio 1：10 add 95%
Ethanol extracted, Extracting temperature be 90 DEG C, extraction time 1.5-2h, cooled and filtered, filter residue repeat extraction 2 times, close
And filtrate, concentrate, dry, obtain Radix Gentianae extract.
Further, the preparation method of described tribulus terrestris extraction is as follows：Tribulus terrestris is weighed, cleaning, drying, is ground into
40 mesh, according to solid-liquid ratio 1:15 (g/ml) add 80% ethanol, refluxing extraction 3 times at 75-80 DEG C, each 2h, filter, and close
And filtrate, it is evaporated under reduced pressure recovery ethanol；Add appropriate absolute ethyl alcohol and carry out ultrasonic dissolution, and add Silon absorption, in
Ethanol is flung in 50 DEG C of water-baths, is then transferred to chromatographic column；Eluted with the petroleum ether of 5 times of amounts, discard eluent, obtain tribulus terrestris extraction
Thing.
Present invention also offers application of the above-mentioned black hair additive in cosmetics are prepared, and described cosmetics are hair care
Element.
Further, described hair conditioner includes the component of following mass percent：Above-mentioned black hair additive 1.6-
3.8%th, stearic acid 2.1-3.8%, glycerine 3.5-7.1%, serine 1.2-2.7%, cetostearyl alcohol 1.1-3.4%, behenyl
Alcohol 3.1-4.7%, 1,3-PD 1.15-2.3%, avocado oil 0.8-1.3%, glycine betaine 1.1-2.17%, polyquaternium-
223.7-6.2%, citric acid 0.1-0.5%, EDETATE SODIUM 0.03-0.15%, hydroxyethyl cellulose 0.1-0.3%, oxybenzene first
Ester 0.1-0.25%, Nipasol 0.1-0.3%, Sodium Hyaluronate 0.01-0.03%, deionized water surplus.
Several components in above-mentioned black hair additive are introduced below：
Chinese herbaceous peony cold nature, bitter acid, there are nourishing blood and liver, slow middle analgesic, hold back the cloudy function of receiving sweat.Paeoniflorin is improved antioxygen
Change the vigor of enzyme, effect of scavenging radical.The melanocyte system that Paeoniflorin acts in vitro culture can promote melanocyte
Propagation, and contrasted with 8-MOP, obvious toxic action is not produced to cell yet in higher concentration.Paeoniflorin can raise junket
Propylhomoserin enzymatic activity and promotion melanin genesis.
Felwort also known as rough gentian, according to《Sheng Nong's herbal classic》Record, " fever and chills, frightened epilepsy perverse trend, continue wound absolutely to rough gentian between main bone, fixed
The five internal organs, kill cup poison.Felwort function mainly has eight：Including clearing heat-fire, heat-clearing and damp-drying drug, it is clearing heat and detoxicating, clear liver and improve vision, the infantile malnutrition due to digestive disturbances or intestinalparasites that disappears,
Tranquilizing and allaying excitement, cooling blood and hemostasis, desinsection.Felwort has stronger to the human melanoma cell's tyrosinase activity and melanogenesis of culture
Dosage correlation activation.Felwort makees to tyrosinase activity in people's A375 melanoma cells in dose-dependent activation
With.
Chinese medicine tribulus terrestris is zygophyllaceae puncture vine platymiscium, annual herb, is typically born in barren hillock, Tian Bian, roadside, is distributed in
All parts of the country, North of Yangtze River are most universal.The plant is a traditional Chinese medicine, tool promoting blood circulation by removing wind, flat liver solution strongly fragrant, improving eyesight, itching-relieving efficacies,
For treating the diseases such as headache, dizziness, the more tears of hot eyes, tracheitis, hypertension, pruitus, rubella.Tribulus terrestris is thin to external melanocyte
The activity of born of the same parents and tyrosinase is respectively provided with high concentration activation, the dual regulation that low concentration suppresses.
Compared with prior art, it is the device have the advantages that as follows：(1) present invention is carried using Paeoniflorin, felwort
Thing, tribulus terrestris extraction compounding use in specific proportions are taken, mainly by activating melanocyte, activates tyrosinase activity,
To promote the generation of hair melanin, and then the effect of black hair.(2) wherein, Paeoniflorin can promote melanocyte proliferation,
And then promote melanin genesis, while tyrosinase activity can be raised；Human melanoma cell tyrosinase of the felwort to culture
Activity and melanogenesis have stronger dosage correlation activation；Activity of the tribulus terrestris to external melanocyte and tyrosinase
It is respectively provided with high concentration activation, the dual regulation that low concentration suppresses.(3) hair conditioner of the present invention not only has black hair effect, also
Energy moisturizing hair, hair care, it is long-term use of, healthy hair can be made pitch-black smooth, healthy submissive.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated：
The hair conditioner embodiment 1~5 of the present invention is formulated, and is shown in Table 1.
Table 1
1. the preparation method of Paeoniflorin is as follows：
Chinese herbaceous peony cleaning, drying are weighed, are crushed to 40 mesh, according to solid-liquid ratio 1:25 (g/ml) add 50% ethanol, ultrasound
2h is extracted, is cooled down, filtering, filter residue continues to repeat extraction 2 times, each 1h, merging filtrate, obtains Paeoniflorin.
2. the preparation method of Radix Gentianae extract is as follows：
Felwort is weighed, cleaning, drying, 60 mesh is ground into, obtains Chinese Gentian Root；The acetone for adding 10 times of amounts carries out degreasing
Decolourize, after filtering, according to solid-liquid ratio 1：10 ethanol for adding 95% are extracted, and Extracting temperature is 90 DEG C, extraction time 1.5
~2h, cooled and filtered, filter residue repeat extraction 2 times, merging filtrate, concentrated, dry, obtain Radix Gentianae extract.3. tribulus terrestris carries
Take the preparation method of thing as follows：
Tribulus terrestris is weighed, cleaning, drying, is ground into 40 mesh, according to solid-liquid ratio 1：15 (g/ml) add 80% ethanol,
Refluxing extraction 3 times at 75~80 DEG C, each 2h, filter, merging filtrate, be evaporated under reduced pressure recovery ethanol；Add appropriate anhydrous second
Alcohol carries out ultrasonic dissolution, and adds Silon absorption, flings to ethanol in 50 DEG C of water-baths, is then transferred to chromatographic column；Measured with 5 times
Petroleum ether elutes, and discards eluent, obtains tribulus terrestris extraction.
Comparative example 1：
Paeoniflorin is not added in difference with embodiment 3 only, and remaining each material addition, conditions and technology of preparation does not occur
Change.
Comparative example 2：
Radix Gentianae extract is not added in difference with embodiment 3 only, remaining each material addition, and conditions and technology of preparation is equal
Do not change.
Comparative example 3：
Tribulus terrestris extraction is not added in difference with embodiment 3 only, remaining each material addition, and conditions and technology of preparation is equal
Do not change.
Comparative example 4：
Compared with Example 3, Paeoniflorin, Radix Gentianae extract, tribulus terrestris extraction do not add, remaining each material addition
Amount, conditions and technology of preparation do not change still.
Dark hair efficacy validation：
In order to illustrate the effect of the hair conditioner of the present invention, rabbit tragus melanin granule has been carried out to the hair conditioner of the present invention
The zoopery of synthesis.
First, some rabbit are divided into 9 groups, shave off the tragus of its auris dextra exterior feature ear table, then uniformly applied and spread respectively
Embodiment and comparative example are stated, and left ear compares without any processing as consubstantiality.After medication 60 days, animal is put to death, takes house
There is speed and the ratio containing a large amount of melanin hair shafts in hair shaft sum in the hard of hearing skin of rabbit, observation melanin.
As control, equally to independent one group of rabbit, 15% alcohol solvent is smeared, rather than smear made from above-mentioned formula
Hair conditioner, processing method is with process with embodiment 3.
(1) there is the influence of speed to rabbit melanin：
In shaving the 7th day, it was tested ear and all starts point-like melanin pigmentation occur for the rabbit of embodiment each group, and the 14th~18
My god, then there is large stretch of melanin pigmentation in experiment ear, and untreated ear also has the appearance of point-like melanin pigmentation, at the same time comparative example 1
~3 groups of experiment ear starts point-like melanin pigmentation occur.
In contrast, control group is showed no melanin pigmentation with 4 groups of ears of comparative example.
(2) ratio of the hair shaft containing a large amount of melanin in hair shaft sum at Histological section's observation pore：
The synthesis of hair melanin granule is relevant with the growth cycle of the function of melanocyte and hair.This experiment is with hair shaft
How much middle melanin amount, which represents, is in asynchronous hair.So as to understand nutrition of the present composition to Mao mother's chromatophore and
The effect of functional rehabilitation.
The results are shown in table 2.
Table 2
From the results showed that of table 2 smeared embodiment sample experimental subjects experiment terminate rear melanin ratio compared with
Height, it is even more of the invention black apparently higher than not adding completely higher than the comparative example 1~3 for not exclusively adding black hair additive of the present invention
Send out the basic hair conditioner formula comparative example 4 of additive and the control group using ethanol.
And from practical manifestation it has also been discovered that, generation time of the embodiment to hair melanin is significantly shorter than comparative example 1
~3, and fail to find that obvious melanin generates for comparative example 4 and control group are then interior at the trial.
It was found from the experimental result of table 2, melanin is more in the animal hair shaft of embodiment, and pigment time of occurrence is significantly faster than that
Control group rabbit.
(2) human body effect experiment：
In order to prove the facilitation that is synthesized naturally to human hair melanin granule of hair conditioner of the present invention, dialogue originator
The using effect observation of 2~12 months is carried out.
Effectively：After use, have newborn dark hair or the black tip of root it is white turn melanotrichia growth naturally, hair color development deepens or has hair dyed
Interval time extends before relatively using, and hair quality improves obvious.
It is invalid：It is not any change after use.
The results are shown in table 3.
Table 3
From the content of above-mentioned table 3 it can be found that the comparative example 4 without black hair additive component of the present invention, the group after use
The white hair of member does not have improved sign substantially.And add the comparative example 1~3 of fractions, then the effect for having certain dark hair, but
It is ineffective, it is impossible to reach and allow most people all to produce dark hair effect.Add in proportion black hair additive of the present invention all into
The embodiment divided, then there is obvious dark hair to show, preferable dark hair effect, and the effect can be produced for most of test individual
The influence relation of fruit and individual age is little.
Above example is merely to illustrate embodiment of the present invention, does not have any formal limit to the present invention
System；It is any to be engaged in professional and technical personnel, all have the ability using the technology contents having revealed that, some are made to it and changes or repaiies
Decorations, turn into the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (9)
1. a kind of black hair additive, it is characterised in that described black hair additive includes the component of following mass percent：Chinese herbaceous peony
Glycosides 0.2-2.1%, Radix Gentianae extract 0.1-2.4%, tribulus terrestris extraction 0.2-2.0%.
2. a kind of black hair additive according to claim 1, it is characterised in that described black hair additive includes following matter
Measure the component of percentage：Paeoniflorin 0.3-1.8%, Radix Gentianae extract 0.3-2.0%, tribulus terrestris extraction 0.4-1.6%.
3. a kind of black hair additive according to claim 2, it is characterised in that described black hair additive includes following matter
Measure the component of percentage：Paeoniflorin 0.5-1.2%, Radix Gentianae extract 0.5-1.6%, tribulus terrestris extraction 0.6-1.0%.
A kind of 4. black hair additive according to claim any one of 1-3, it is characterised in that the preparation of described Paeoniflorin
Method is as follows：Chinese herbaceous peony cleaning, drying are weighed, are crushed to 40 mesh, according to solid-liquid ratio 1:25 (g/ml) add 50% ethanol, ultrasound
2h is extracted, is cooled down, filtering, filter residue continues to repeat extraction 2 times, each 1h, merging filtrate, obtains Paeoniflorin.
A kind of 5. black hair additive according to claim any one of 1-3, it is characterised in that described Radix Gentianae extract
Preparation method it is as follows：Felwort is weighed, cleaning, drying, 60 mesh is ground into, obtains Chinese Gentian Root；Add the acetone of 10 times of amounts
Degreasing decoloring is carried out, after filtering, according to solid-liquid ratio 1：10 ethanol for adding 95% are extracted, and Extracting temperature is 90 DEG C, extraction
Time is 1.5-2h, and cooled and filtered, filter residue repeats extraction 2 times, merging filtrate, concentrated, dry, obtains Radix Gentianae extract.
A kind of 6. black hair additive according to claims any one of 1-3, it is characterised in that described tribulus terrestris extraction
The preparation method of thing is as follows：Tribulus terrestris is weighed, cleaning, drying, is ground into 40 mesh, according to solid-liquid ratio 1:15 (g/ml) add 80%
Ethanol, refluxing extraction 3 times at 75-80 DEG C, each 2h, filter, merging filtrate, be evaporated under reduced pressure recovery ethanol；Add appropriate
Absolute ethyl alcohol carry out ultrasonic dissolution, and add Silon absorption, fling to ethanol in 50 DEG C of water-baths, be then transferred to chromatographic column；
Eluted with the petroleum ether of 5 times of amounts, discard eluent, obtain tribulus terrestris extraction.
A kind of 7. application of black hair additive in cosmetics are prepared according to claim any one of 1-6.
8. application according to claim 7, it is characterised in that described cosmetics are hair conditioner.
9. a kind of hair conditioner with black hair effect, it is characterised in that described hair conditioner includes the group of following mass percent
Point：Black hair additive 1.6-3.8%, stearic acid 2.1-3.8%, glycerine 3.5-7.1%, serine as claimed in claim 1
1.2-2.7%, cetostearyl alcohol 1.1-3.4%, docosyl alcohol 3.1-4.7%, 1,3- propane diols 1.15-2.3%, avocado oil 0.8-
1.3%th, glycine betaine 1.1-2.17%, Merquat 280 3.7-6.2%, citric acid 0.1-0.5%, EDETATE SODIUM 0.03-
0.15%th, hydroxyethyl cellulose 0.1-0.3%, methyl hydroxybenzoate 0.1-0.25%, Nipasol 0.1-0.3%, Sodium Hyaluronate
0.01-0.03%, deionized water surplus.
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| CN201710762039.0A CN107519086A (en) | 2017-08-30 | 2017-08-30 | A kind of black hair additive and its application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113633585A (en) * | 2020-04-27 | 2021-11-12 | 美慕(北京)科技有限公司 | External hair care composition and preparation with effects of preventing alopecia, growing hair and blackening hair and preparation method thereof |
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| CN101288732A (en) * | 2008-05-26 | 2008-10-22 | 赵振江 | Hair-growing liquid |
| CN105496878A (en) * | 2015-12-25 | 2016-04-20 | 青岛玻莱莫斯新材料技术有限公司 | Conditioning shampoo |
| CN107050131A (en) * | 2016-12-23 | 2017-08-18 | 彭祥丽 | A kind of Chinese medicine black hair composition and preparation method |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101288732A (en) * | 2008-05-26 | 2008-10-22 | 赵振江 | Hair-growing liquid |
| CN105496878A (en) * | 2015-12-25 | 2016-04-20 | 青岛玻莱莫斯新材料技术有限公司 | Conditioning shampoo |
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| CN113633585A (en) * | 2020-04-27 | 2021-11-12 | 美慕(北京)科技有限公司 | External hair care composition and preparation with effects of preventing alopecia, growing hair and blackening hair and preparation method thereof |
| CN113633585B (en) * | 2020-04-27 | 2024-01-30 | 美慕(北京)科技有限公司 | External hair care composition and preparation with effects of preventing alopecia, promoting hair growth and blackening hair and preparation method thereof |
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Application publication date: 20171229 |