CN107518862A - A kind of optical fiber and imaging method of integrated optical coherence and incoherent imaging system - Google Patents
A kind of optical fiber and imaging method of integrated optical coherence and incoherent imaging system Download PDFInfo
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- CN107518862A CN107518862A CN201610441935.2A CN201610441935A CN107518862A CN 107518862 A CN107518862 A CN 107518862A CN 201610441935 A CN201610441935 A CN 201610441935A CN 107518862 A CN107518862 A CN 107518862A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00112—Connection or coupling means
- A61B1/00117—Optical cables in or with an endoscope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00112—Connection or coupling means
- A61B1/00121—Connectors, fasteners and adapters, e.g. on the endoscope handle
- A61B1/00126—Connectors, fasteners and adapters, e.g. on the endoscope handle optical, e.g. for light supply cables
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/0017—Details of single optical fibres, e.g. material or cladding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
Abstract
The invention reside in a kind of optical fiber and imaging method for providing integrated optical coherence and incoherent imaging system.Means of optical coherence tomography（Optical Coherence Tomography, abbreviation OCT）Using low-coherent light interference technique, it is necessary to be launched using single-mode fiber and reclaim optical signalling.Multimode fibre is suitable for the spectroscopy imaging of incoherent light.Single mode transport is realized on single optical fiber simultaneously with multimode transmissions, then integrates the imaging mode of two kinds or even various modes, joint imaging, the advantages of two or more imagings can be combined.The present invention proposes a kind of such triply coated fiber and imaging method.Three layers by fibre core and at least covering of optical fiber form, from inside to outside core layer, also referred to as internal layer fibre core respectively, for single mode transport；First layer covering, also referred to as internal layer covering；Second layer covering, also referred to as outer layer fibre core, for multimode transmissions；Third layer covering, also referred to as outer layer covering.
Description
Technical field
The present invention relates to single fiber based endoscopic imaging technology, more particularly to one kind to be used for integrated optical coherence chromatographic imaging and light
Triply coated fiber, triply coated fiber coupler, integrated imaging system and the dependent imaging method of spectroscopy imaging.
Background technology
Fibre Optical Sensor has the features such as small volume, imaging resolution is high with imaging technique, is quickly grown in nearly recent decades.
Especially in medical imaging field, the optical biopsy for diagnosing tissue lesion has become the one of Modern Optics Technology application
General orientation.The based endoscopic imaging technology of optical biopsy, especially micro-volume probe, have and reduce patient suffering, accurate identification disease
Stove and guiding clinical diagnosis and the effect for the treatment of.Means of optical coherence tomography（Optical
CoherenceTomography, abbreviation OCT）It is to develop a kind of faster new Tomography of most development prospect in recent years
Technology, particularly biological tissue's In vivo detection and imaging side face have tempting application prospect, attempted ophthalmology, angiocarpy and
Applied in the clinical diagnosis of disease of digestive tract.In recent years OCT using single optical fiber carry out in peep scanning, then reconstructed image can
It is the important application technology of based endoscopic imaging to realize that probe size is small.
Research and excavation for OCT and based endoscopic imaging technology is in recent years and very rapid.Conventional OCT technology can only
The morphologic information of sample is provided, shows slightly single for being permitted multifocal observation and understanding aspect.In patent CN201085617Y
Show a kind of single fiber imaging system of integrated optical coherence chromatographic imaging and laser-induced fluorescence spectroscopy.Propose in one kind
System is peeped, can provide sample morphology and while biochemical composition, the scheme that imaging probe minimizes as far as possible.
Patent US8953911 has been inquired into emphatically with reference to OCT and other noncoherence optics imaging systems, especially with reference to OCT and spectroscopy
The embodiment of imaging.These schemes to realize that multi-mode optical becomes possibility using single microstructured optical fibers.
However, the fibre core and Nei Bao that are all doubly clad optical fiber, optical fiber inevitably be present that prior art is applied to
Signal cross-talk problem between layer.The signal cross-talk problem of two adjacent light waveguide-layer of optical fiber can influence imaging system sensitivity and
Signal to noise ratio.Therefore, in order to improve image quality, this problem present in doubly clad optical fiber should be solved.
The content of the invention
The invention reside in provide a kind of integrated optical coherence chromatographic imaging（Optical Coherence Tomography,
Abbreviation OCT）With the multi-modal imaging optical fiber and method of other spectroscopy imaging modes.OCT uses low-coherent light interference technique, needs
To be launched using single-mode fiber and reclaim optical signalling.Multimode fibre is suitable for the spectroscopy imaging of incoherent light.Will be single
Mould transmission is realized simultaneously with multimode transmissions on single optical fiber, then integrates the imaging mode of two kinds or even various modes, joint
Imaging, the advantages of two or more are imaged can be combined.The present invention proposes a kind of such triply coated fiber.Optical fiber by fibre core and
At least 3 layers of covering composition, from inside to outside respectively core layer, also referred to as internal layer fibre core；First layer covering, also referred to as internal layer bag
Layer；Second layer covering, also referred to as outer layer fibre core；Third layer covering, also referred to as outer layer covering.It is optional outside outer layer covering
Coat, the index of refraction relationship between each layer meets：Coat refractive index>Internal layer fiber core refractive index>Outer layer fiber core refractive index>
Outer layer cladding index>Internal layer cladding index.Wherein internal layer fibre core is single mode transport, and outer layer fibre core is multimode transmissions, internal layer
Covering and outer layer covering be not guide-lighting.In order to improve signal receiving efficiency, dimensionally, the thickness of internal layer covering is arranged to, and is being protected
It is as small as possible in the case of card internal layer fibre core limitation loss is unconspicuous.In certain embodiments, the thickness of internal layer covering is, interior
10 times or so of center wavelength of light are transmitted in layer fibre core.
Another feature of triply coated fiber of the present invention is, compared with prior art, guide-lighting two optical fiber
Signal cross-talk between layer is greatly diminished（It is detailed below）.By this improvement, noise signal is suppressed, the spirit of imaging system
Sensitivity and signal to noise ratio all get a promotion.
The present invention relates to the coupled apparatus related to triply coated fiber.Separation internal layer single mode transport is realized by coupled apparatus
With outer layer multimode transmissions, and the two is independent of each other.In one embodiment, triply coated fiber and single-mode fiber are coupled, and pass through
What coupled apparatus made the internal layer fibre core in triply coated fiber is optically coupled into single-mode fiber, and the light of outer layer fibre core passes through refractive index
Matched media, optional lens and light detection device sensing.In another embodiment, the light of outer layer fibre core in triply coated fiber
Taken out by the method for peeling outer layer covering, the transmission without influenceing light in internal layer fibre core.
The present invention relates to the coupled apparatus related to triply coated fiber.Separation internal layer single mode transport is realized by coupled apparatus
With outer layer multimode transmissions, and the two is independent of each other.In one embodiment, triply coated fiber and single-mode fiber are coupled, and pass through
What coupled apparatus made the internal layer fibre core in triply coated fiber is optically coupled into single-mode fiber, and the light of outer layer fibre core passes through refractive index
Matched media, optional lens and light detection device sensing.In another embodiment, the light of outer layer fibre core in triply coated fiber
Taken out by the method for peeling outer layer covering, the transmission without influenceing light in internal layer fibre core.
Brief description of the drawings：
Fig. 1 shows the cross-sectional view of triply coated fiber and its corresponding index distribution.
Fig. 2 shows the longitudinal section of triply coated fiber and escapes the track of light.
Fig. 3 shows the cross-sectional view of conventional single-mode fiber.
Fig. 4 shows that single-mode fiber couples place's longitudinal section and effusion optical track mark with triply coated fiber.
Fig. 5, Fig. 6, Fig. 7 are respectively the embodiment schematic diagram of three kinds of triply coated fiber couplers.
Fig. 8 is to be a kind of using triply coated fiber and the endoscopic imaging system schematic diagram of triply coated fiber coupler.
Embodiment：
The present invention is further illustrated with reference to the accompanying drawings and examples.
Fig. 1 is the refractive index profile corresponding to the cross-sectional view of triply coated fiber and each covering and fibre core.In the present invention
Among, optical fiber 100 is divided into core layer 101, also referred to as internal layer fibre core from inside to outside；First layer covering 102, also referred to as internal layer bag
Layer；Second layer covering 103, also referred to as outer layer fibre core；Third layer covering 104, also referred to as outer layer covering.It is outside outer layer covering
Selectable coat（It is not drawn into）, in actual applications, the optical fiber without coat is immersed has class with the coat
Like the matched media of refractive index（Such as certain solution）In, identical practical function can also be reached.111 in diagram, 112,
113rd, 114 be respectively internal layer fibre core, internal layer covering, outer layer fibre core, wherein the refractive index situation of outer layer covering, coat refractive index
>Internal layer fiber core refractive index>Outer layer fiber core refractive index>Outer layer cladding index>Internal layer cladding index.Refractive index shown in it
111st, 112,113,114 be this layer of overall index situation, or perhaps mean refractive index situation.That is, respectively for
Wherein any one layer of inside, refractive index can be step or gradual change.Internal layer fibre core and outer layer fibre core are as guide-lighting logical
Road, and internal layer covering, outer layer covering and coat are not as guide-lighting path.
This index distribution so that the signal cross-talk problem between internal layer fibre core and outer layer fibre core, obtained well
Solve.As shown in Fig. 2 when fiber optic materials it is uneven, or optical fiber bending to a certain extent when, partly in internal layer fibre core 101
The light 201 of middle propagation, internal layer fibre core 101 is escaped out because not reaching total reflection condition, into internal layer covering 102.For these
The light of escape, because the refractive index of outer layer fibre core 103 is bigger than internal layer covering 102, internal layer covering 102 will not produce effectively
Fiber waveguide, light is subsequently into outer layer fibre core 103.And because the refractive index of outer layer covering 104 is more than or equal to internal layer covering 102
Refractive index, this escape light will not also form effective fiber waveguide in outer layer fibre core 103, and light 201 continues to enter with corresponding angle
Enter outer layer covering.And coat or ambient refractive index matched media（It is not drawn into）There is bigger refractive index than outer layer covering 104, enter
Enter the light of outer layer covering 104 also can not effectively transmit in outer layer covering 104, go successively to coat.Overlay has high-transmission
Loss, therefore the light for entering coat disappears quickly.Therefore, the light escaped from internal layer fibre core 101 can not be in other any layers biography
It is defeated.This, which is just effectively reduced from the transmission signal of internal layer fibre core 101, enters the generation crosstalk of outer layer fibre core 103.
In optical sensing imaging field, internal layer fibre core is commonly used to the transmission channel as transmission signal.The light of transmitting passes through
The probe of triply coated fiber end is pointed into testing sample, the optical signal returned from testing sample, is reclaimed through probe, and fine in internal layer
Propagated in core and outer layer fibre core.Pop one's head in the organic efficiency of light is one and sample distance, internal layer fibre core numerical aperture, outer layer fibre
The core numerical aperture complicated equation related to probe end lens group parameter, with optical waveguide layer occupied area in cross section of optic fibre just
It is related.Because internal layer covering can not effectively carry out fiber waveguide, then in order that the collection efficiency of return signal is higher, it is necessary to interior
The thickness of layer covering is as far as possible small.On the other hand, in order to ensure internal layer fibre core can effective fiber waveguide, prevent evanescent wave from penetrating internal layer
Covering, internal layer covering will have certain thickness.Therefore, the thickness of internal layer covering is often arranged to conduct light wave in internal layer fibre core
Between long 5-15 times.
Fig. 3 is that the cross-sectional view 301 of common single-mode fiber is fibre core, and 302 be covering.In certain embodiments,
In order to increase the compatibility of triply coated fiber, enable with common Single-Mode Fiber Coupling, two kinds of optical fiber are standing be set to it is consistent
External diameter, while the fibre core of internal layer fibre core and single-mode fiber is all mutually matched in refractive index and diametrically.It is illustrated in figure 4 such one
Individual embodiment.In this example, triply coated fiber 410 by alignment or fused fiber splice or waits means and single-mode fiber 420
It is coupled in coupling surface 430.Now the light in internal layer fibre core 401 and single-mode fiber fibre core 301 can couple completely, with common two
Single-Mode Fiber Coupling face is not different.And because the covering of single-mode fiber 420 can not carry out effective fiber waveguide, along outer layer fibre core
403 light propagated, optical fiber 420 can be left with circular cone track.If necessary to which this part of light is collected, then need corresponding
Outer layer fibre core light collecting device, that is, the triply coated fiber coupler being detailed below.
The embodiment that Fig. 5-Fig. 7 shows 3 kinds of triply coated fiber couplers.These three schemes can be fine by internal layer
The core layer optically coupling to monokaryon optical fiber of core, while by corresponding collection optics of arranging in pairs or groups, triply coated fiber can be collected
The light propagated in middle outer layer fibre core.In Fig. 5, left side is triply coated fiber 501, and right side is monokaryon optical fiber 502, and the two is coupled in end
Face 503.Fiber coupler region wraps a kind of index-coupling medium 504, and the refractive index of matched media 504 allows light to escape
Effusion right side optical fiber 502.The light transmitted from fibre core is not much loss and produced from left side to right side.And from multi-clad
The light transmitted in 501 outside fibre core then have left optical fiber 502.The cone angle 505 of optical fiber escape is by triply coated fiber 501
The refractive index of outer layer fibre core numerical aperture, the cladding index for coupling optical fiber and matter of matching together decides on.Therefore existed originally
The light propagated in the outer layer fibre core of multi-clad 501 have left optical fiber, and without influence on internal layer fibre core.Leave optical fiber
Light is detected by the annular detector 506 being arranged in light path.By contrast, it with the addition of optics in the embodiment in Fig. 6
Device 601 is with more efficient and convenient collection light.In this embodiment, the light for escaping optical fiber passes in index-coupling medium
After having broadcast certain distance, reflected via a face speculum 602, then lens 601 focus the light into, and are oriented to light detection device（Not
Draw）.It is noted that speculum 602 can also be moved within index-coupling medium 603.Wound fiber is shown in Fig. 7
Index-coupling medium 701 effusion propagation path of light on edge be in a curved surface 702, the curved surface makes it through processing such as plated films
There is the function of condenser lens and speculum simultaneously.Light after line focus and reflection is transmitted to light detection device 703.
It is described above, it is optical coupling and collection method at single-mode fiber and triply coated fiber coupling.These methods, equally
Suitable for the situation for taking out the light the outer layer fibre core of one section of triply coated fiber.Now need rotten by mechanical lapping or chemistry
The means such as erosion carefully remove the outer layer covering of one section of suitable length, and retain the complete of internal layer fibre core and internal layer cladding structure.This
When internal layer fibre core and internal layer covering formed waveguide properties it is unaffected.Then use the method as shown in Fig. 5, Fig. 6 or Fig. 7 will
The triply coated fiber for eliminating outer layer covering is placed among index-coupling medium, you can is not influenceing internal layer fibre core light propagation
Under the premise of, the light in outer layer fibre core is taken out from triply coated fiber.
Fig. 8 shows that an application triply coated fiber 906 and triply coated fiber coupler 905 carry out double mode complex imaging
System.This imaging system includes a light source 901, OCT subsystems 902, and single-mode optical-fibre coupler part 903 is selectable
Rotary optical connector 904, triply coated fiber coupler 905, the conduit link block 906 comprising triply coated fiber, probe
907, photoelectric detector 908 and computer and electronic system 909 form.Wherein, OCT subsystems 902, which are one, includes ginseng
Examine arm, the subsystem of the complete function such as sample arm and photoelectric detection module.In certain embodiments, rotary optical connector 904
Can not have, now often probe 907 containing scan module with the two dimension of complete paired samples, 3-D scanning.In some embodiments
In, rotary optical connector 904 is placed in the side of close probe 907 of triply coated fiber coupler 905.Incoherent imaging system
The light of the light of light source 901 and the light source of coherence imaging system 902 is combined by optics.Two kinds of light pass through monokaryon optical fiber
Fibre core is propagated, and by triply coated fiber coupler 905, is propagated in the triply coated fiber of conduit 906, and sample is pointed into from probe 907
Product.Two fibre core Es-region propagations from the light that sample returns by triply coated fiber, the light propagated by internal layer fibre core return to OCT subsystems
902, then collected and handled by interferometric measuring means.And the light that outer layer fibre core is collected coupling at triply coated fiber coupler 905
Optical fiber is closed out, detecting signal immediately by photoelectric detector 908 enters computer and the collection of electronic system 909 processing.Electronics
System is used to realizing the signal control of whole system, synchronization, scanning probe, is shown as picture etc. function.
The light source 901 can be that super continuous spectrums produce light source, superradiance white light source, SLED, broad band laser etc..With
Exemplified by white light source, it is photochromic that spectroscopy caused by depth information and white light source from OCT systems can be obtained simultaneously
Multimedia message.The color information of every scan line is covered into depth information head end, depth information can be observed after three-dimensional reconstruction
And the color image on surface, realize the combination of two kinds of information.In order to lift picture quality, the light that outer layer fibre core filters out, Ke Yitian
Add filtration module, to filter out the related light of OCT signals.A wavelength selectivity photoelectricity insensitive to OCT light can also be passed through
Sensitive detection parts, carry out the color light of a detecting light spectrum.The light of internal layer fibre core enters OCT systems, is formed and interfered with reference light, produces
OCT signals, and the color light of spectroscopy and reference arm are irrelevant, so can not be made a significant impact on OCT interference signals.
Can be by OCT systems, filtration module being added before into photodetector, to filter out the color light of spectroscopy, to subtract
The background noise of few OCT image.So, each OCT signal for containing depth direction information can match one accordingly
Top layer spectroscopy colouring information.By image procossings such as computerized three-dimensional reconstructions, can reach vivid in peep effect.
Above-described embodiment is to add real surface color information with white light source and the OCT system integrations.According to detected sample
The spectral absorption property of product changes light source launch wavelength, is effective based endoscopic imaging detection means.For example, cholesterol exists
1700nm wave bands have characteristic absorption, and lipidosis region can be clearly distinguished using corresponding wave band when peeping in the blood vessels, with inspection
Look into corresponding lesion situation.The image now obtained should be the pseudo-colours information mapped by color.Certainly light source also may be used herein
To be the mixing of various light sources, optical fiber is coupled into by wavelength-division multiplex technique, return light is again through solving wavelength-division multiplex afterwards respectively
Handled.Although the light source i.e. in said system embodiment is used for the color information for adding spectroscopy, it passes through a little adjustment
It can also be used for detecting the optical detection of fluorescence imaging, two photon imaging, Raman image and other similar principles.Therefore it is one more than
Kind citing, and should not be used as the limitation for the present invention.
Claims (9)
- A kind of 1. triply coated fiber for optical fiber optical sensing, it is characterised in that including：Core region, is single mode transport, refractive index n1；First cladding regions, it surrounds and directly closes on core region, refractive index n2；Second cladding regions, it surrounds and directly closes on the first cladding regions, refractive index n3；Triple clad region, it surrounds and directly closes on the second cladding regions, refractive index n4；And n1> n3 > n4 ≥ n2 .
- A kind of 2. triply coated fiber for optical fiber optical sensing according to claim 1, it is characterised in that：Observed in cross section, the fibre core of the triply coated fiber and the external diameter of covering are concentric circles, and the fibre core of the optical fiber is straight Footpath is 8-10 microns, a diameter of 35-55 microns of the first cladding regions, a diameter of 90-110 microns of the second cladding regions, the 3rd A diameter of 125-250 microns of cladding regions.
- A kind of 3. method to the thin imaging data of sample collection Optical coherence tomography and Spectral data, it is characterised in that do not limit Order includes procedure below：The light propagated to sample direction has the first refractive index in the fibre core of optical fiber；Receive scattering of the light from sample；The scattering light from sample propagated to first detector direction has the first pattern in the fibre core of the optical fiber；The scattering light from sample propagated to second detector direction has second in the second layer covering of the optical fiber Pattern；With the image of the first schema creation optical coherent chromatographic imaging of the scattering light from sample, and by Spectral data The surface of the image of optical coherent chromatographic imaging is covered, the Spectral data passes through second that scatters light from sample Pattern obtains.
- 4. according to a kind of described in claim 3 to the thin imaging data of sample collection Optical coherence tomography and Spectral data Method, it is characterised in that：The first pattern and second of pattern of scattering light from sample, fibre core and second layer bag respectively along the optical fiber Layer, propagation coaxial with each other.
- 5. according to a kind of described in claim 3 to the thin imaging data of sample collection Optical coherence tomography and Spectral data Method, it is characterised in that：Optical fiber is rotating.
- 6. according to a kind of described in claim 3 to the thin imaging data of sample collection Optical coherence tomography and Spectral data Method, it is characterised in that：The image that Optical coherence tomography is fine into picture is three-dimensional, and spectroscopic data is used for representative sample surface color.
- 7. according to a kind of described in claim 3 to the thin imaging data of sample collection Optical coherence tomography and Spectral data Method, it is characterised in that：Signal collection efficiency is calculated, to ensure that Optical coherence tomography is fine into the image focal point alignment of picture.
- A kind of 8. method to the thin imaging data of sample collection Optical coherence tomography and Spectral data, it is characterised in that do not limit Order includes procedure below：The light propagated to sample direction is along the core layer of optical fiber first；The reception light of sample scattering light is come from along optical fiber the second fibre core Es-region propagations, without being propagated along innermost layer covering, and the Two core layers and innermost layer covering are coaxial；The scattering light from sample propagated to first detector direction has the first in the first core layer of the optical fiber Pattern；The scattering light from sample propagated to second detector direction has second of pattern；It is respectively intended to the first pattern of scattering light and the optical coherent chromatographic imaging of second of schema creation sample from sample Image and Spectral data, and the latter is covered in the former surface.
- 9. according to a kind of described in claim 8 to the thin imaging data of sample collection Optical coherence tomography and Spectral data Method, it is characterised in thatSecond of pattern of the scattering light from sample leaves at an angle before second detector is reached Two core layers.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109893070A (en) * | 2019-03-15 | 2019-06-18 | 深圳大学 | A kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring |
| CN111202500A (en) * | 2019-03-26 | 2020-05-29 | 科特有限责任公司 | System and method for combined optical coherence tomography and pressure measurement |
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| CN112089404A (en) * | 2020-10-10 | 2020-12-18 | 南京航空航天大学 | Endoscopic OCT-Raman dual-mode imaging device and imaging method |
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Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4252403A (en) * | 1979-11-06 | 1981-02-24 | International Telephone And Telegraph Corporation | Coupler for a graded index fiber |
| EP0105461A2 (en) * | 1982-09-30 | 1984-04-18 | International Standard Electric Corporation | Concentric core optical fiber with crosstalk barrier |
| CN1683945A (en) * | 2004-04-14 | 2005-10-19 | 古河电气工业株式会社 | Optical amplification fiber, optical fiber amplifier, and optical communication system |
| CN101147669A (en) * | 2007-10-25 | 2008-03-26 | 浙江大学 | Integrated optical coherence chromatographic imaging and laser inducing fluorescent-spectrum single optical fiber endoscopy system |
| EP1929939A2 (en) * | 2006-09-28 | 2008-06-11 | JenLab GmbH | Method and assembly for microscopic high-resolution reproduction or processing the laser endoscopy |
| JP2008292660A (en) * | 2007-05-23 | 2008-12-04 | Fujikura Ltd | Optical fiber and optical communication module |
| WO2008154460A1 (en) * | 2007-06-08 | 2008-12-18 | Prescient Medical, Inc. | Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry |
| CN102043194A (en) * | 2009-10-14 | 2011-05-04 | 住友电气工业株式会社 | Optical fiber and method of manufacturing optical fiber |
| CN102393182A (en) * | 2011-10-31 | 2012-03-28 | 南京大学 | Narrow-bandwidth Brillouin optical timedomain reflectometer (OTDR) based on sensing optical fiber of three-layer structure |
| JP2014219474A (en) * | 2013-05-02 | 2014-11-20 | 日立金属株式会社 | Optical fiber |
| CN104483735A (en) * | 2014-11-10 | 2015-04-01 | 武汉锐科光纤激光器技术有限责任公司 | All-fiber mode converter and light system |
| CN104887172A (en) * | 2015-04-22 | 2015-09-09 | 中国计量学院 | Novel nonradiative OCT probe and measuring system for blood vessel detection |
| CN105022117A (en) * | 2015-07-23 | 2015-11-04 | 江苏大学 | Double-core fiber based long-period FBG mode-field converter |
| CN105411509A (en) * | 2014-09-02 | 2016-03-23 | 乐普（北京）医疗器械股份有限公司 | OCT (optical coherence tomography) endoscopic imaging probe, manufacturing method of endoscopic imaging probe and OCT imaging catheter |
| WO2016064937A1 (en) * | 2014-10-22 | 2016-04-28 | Corning Incorporated | Double clad light diffusing fiber, connector system and illuminaire |
| EP3004730B1 (en) * | 2013-05-31 | 2020-06-24 | Corning Incorporated | Uniform illumination light diffusing fiber device |
-
2016
- 2016-06-20 CN CN201610441935.2A patent/CN107518862A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4252403A (en) * | 1979-11-06 | 1981-02-24 | International Telephone And Telegraph Corporation | Coupler for a graded index fiber |
| EP0105461A2 (en) * | 1982-09-30 | 1984-04-18 | International Standard Electric Corporation | Concentric core optical fiber with crosstalk barrier |
| CN1683945A (en) * | 2004-04-14 | 2005-10-19 | 古河电气工业株式会社 | Optical amplification fiber, optical fiber amplifier, and optical communication system |
| EP1929939A2 (en) * | 2006-09-28 | 2008-06-11 | JenLab GmbH | Method and assembly for microscopic high-resolution reproduction or processing the laser endoscopy |
| JP2008292660A (en) * | 2007-05-23 | 2008-12-04 | Fujikura Ltd | Optical fiber and optical communication module |
| WO2008154460A1 (en) * | 2007-06-08 | 2008-12-18 | Prescient Medical, Inc. | Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry |
| CN101147669A (en) * | 2007-10-25 | 2008-03-26 | 浙江大学 | Integrated optical coherence chromatographic imaging and laser inducing fluorescent-spectrum single optical fiber endoscopy system |
| CN102043194A (en) * | 2009-10-14 | 2011-05-04 | 住友电气工业株式会社 | Optical fiber and method of manufacturing optical fiber |
| CN102393182A (en) * | 2011-10-31 | 2012-03-28 | 南京大学 | Narrow-bandwidth Brillouin optical timedomain reflectometer (OTDR) based on sensing optical fiber of three-layer structure |
| JP2014219474A (en) * | 2013-05-02 | 2014-11-20 | 日立金属株式会社 | Optical fiber |
| EP3004730B1 (en) * | 2013-05-31 | 2020-06-24 | Corning Incorporated | Uniform illumination light diffusing fiber device |
| CN105411509A (en) * | 2014-09-02 | 2016-03-23 | 乐普（北京）医疗器械股份有限公司 | OCT (optical coherence tomography) endoscopic imaging probe, manufacturing method of endoscopic imaging probe and OCT imaging catheter |
| WO2016064937A1 (en) * | 2014-10-22 | 2016-04-28 | Corning Incorporated | Double clad light diffusing fiber, connector system and illuminaire |
| CN104483735A (en) * | 2014-11-10 | 2015-04-01 | 武汉锐科光纤激光器技术有限责任公司 | All-fiber mode converter and light system |
| CN104887172A (en) * | 2015-04-22 | 2015-09-09 | 中国计量学院 | Novel nonradiative OCT probe and measuring system for blood vessel detection |
| CN105022117A (en) * | 2015-07-23 | 2015-11-04 | 江苏大学 | Double-core fiber based long-period FBG mode-field converter |
Non-Patent Citations (2)
| Title |
|---|
| MADORE,WENDY-JULIE;ET.AL: "Asymmetric double-clad fiber couplers for endoscopy", 《OPTICS LETTERS》 * |
| 孟卓，梁雨，姚晓天等: "光学相干层析系统色散的在线测量及补偿", 《光电子·激光》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109893070A (en) * | 2019-03-15 | 2019-06-18 | 深圳大学 | A kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring |
| CN111202500A (en) * | 2019-03-26 | 2020-05-29 | 科特有限责任公司 | System and method for combined optical coherence tomography and pressure measurement |
| CN111202500B (en) * | 2019-03-26 | 2023-10-20 | 科特有限责任公司 | System and method for combined optical coherence tomography and pressure measurement |
| CN111552026A (en) * | 2020-04-10 | 2020-08-18 | 桂林电子科技大学 | Optical fiber and system for human body intervention visual photodynamic therapy |
| US20220009027A1 (en) * | 2020-07-07 | 2022-01-13 | Panasonic Intellectual Property Management Co. Ltd | Step-core fiber structures and methods for altering beam shape and intensity |
| CN112089404A (en) * | 2020-10-10 | 2020-12-18 | 南京航空航天大学 | Endoscopic OCT-Raman dual-mode imaging device and imaging method |
| CN112089404B (en) * | 2020-10-10 | 2022-04-05 | 南京航空航天大学 | Endoscopic OCT-Raman dual-mode imaging device and imaging method |
| CN113180576A (en) * | 2021-04-30 | 2021-07-30 | 哈尔滨医科大学 | Catheter using special optical fiber |
| CN113180576B (en) * | 2021-04-30 | 2022-02-15 | 哈尔滨医科大学 | Catheter using special optical fiber |
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