CN104887172A - Novel nonradiative OCT probe and measuring system for blood vessel detection - Google Patents
Novel nonradiative OCT probe and measuring system for blood vessel detection Download PDFInfo
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- CN104887172A CN104887172A CN201510197211.3A CN201510197211A CN104887172A CN 104887172 A CN104887172 A CN 104887172A CN 201510197211 A CN201510197211 A CN 201510197211A CN 104887172 A CN104887172 A CN 104887172A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00147—Holding or positioning arrangements
- A61B1/0016—Holding or positioning arrangements using motor drive units
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/313—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
- A61B1/3137—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes for examination of the interior of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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Abstract
The invention discloses a novel nonradiative OCT probe and measuring system for blood vessel detection and belongs to the field of medical imaging instruments. The endoscope probe is composed of a micromotor, a gear, an FC type optical fiber connector, a metal spring, an optical fiber, a Grin lens, a rectangular prism and a metal sleeve. The measuring system comprises a broadband light source, a polarizer, a coupler, an optical fiber delay line, a reflector, a polarization beam splitter, a detector, a filter, a data acquisition card, a computer and the probe. The optical fiber connector, the Grin lens and the rectangular prism are packaged in the metal sleeve; an external motor drives the metal spring so as to drive the metal sleeve to rotate to finish scanning of the probe, so that the influence of electromagnetic radiation of an internal motor is avoided, the problem that optical fibers are liable to fracture is solved, and the mechanical strength of the probe is improved. The measuring system utilizes the polarizer and the polarization beam splitter for dividing an interference signal into two signals in the perpendicular vibration directions for acquisition and processing, and the influence of a polarization effect of optical fibers is avoided.
Description
Technical field
The present invention relates to medical imaging instruments industry, be specifically related to the medical interior pry head of radiationless OCT for blood vessel detection and measuring system.
Background technology
Cardiovascular disease is class serious threat human diseases.Its atherosclerosis is gathered by lipid and compound saccharide, hemorrhage and thrombosis, proliferation of fibrous tissue and calcinosis, and have medial transformation gradually and calcification, be enough to obstructing arterial chamber once develop into, then the tissue supplied of this tremulous pulse or organ are by ischemia or necrosis.Therefore from Point of View of Clinical, need to carry out imaging to blood vessel wall, help doctor correctly to identify that endovascular speckle is to treat, be the useful tool of operation process medium-sized artery operation to the realtime imaging of blood vessel simultaneously.
Ultrasonic and nuclear magnetic resonance is the most frequently used imaging technique measured for blood vessel wall in body, but its resolution is lower, the speckle that None-identified is less.And Optical Coherence Tomography Imaging Technology (Optical Coherence Tomography, OCT) is based on low coherence interference and heterodyne detection technology, integrate not damaged, non-intervention and high-resolution, highly sensitive advantage.OCT utilizes optical coherence imaging, can detect the pathological changes of below biological tissue surface, determine size of tumor, has high-resolution image foundation for Diagnosis and Treat provides.Medical endoscopes is a kind of Wicresoft or noninvasive Medical Instruments, be the medical diagnosis on disease such as human tumor, cancer, treat indispensable instrument, but first pathological changes often occurs in the tomography of organ, and traditional medical endoscopes can only observe the pathological changes on human viscera organ surface, this makes traditional endoscope be limited by very large on Diagnosis and Treat.
OCT technology is combined with medically conventional endoscope, interior pry head can be made to be greatly improved in resolving power, sensitivity on the one hand, make OCT have greater flexibility on the other hand.Miniature OCT probe is imported human intracavity through the biopsy forceps road of endoscope and makes 360 ° of rotation sweeps, utilize light wave to the penetration capacity of tissue, realtime imaging can be carried out to the inaccessible in-vivo tissue of common imaging device, find pathological changes wherein, be hopeful the function realizing " optical biopsy " in biomedical research treatment and clinical diagnosis, thus have bright application prospect in medical diagnosis and treatment field.
The present invention proposes a kind of medical interior pry head of Novel non radiation OCT of detecting for blood vessel and measuring system, by OCT technology with interiorly peep probe incorporated, give full play to both advantages.External motor is adopted to drive interior pry head to rotate, the situation of the electromagnetic interference human body cell avoiding conventional internal motor to bring and the environment of body fluid, adopt metal spring rotating drive, solve frangibility, the problem such as damage and cost increase that optic fibre turning in traditional design brings, simultaneously by optical fiber head, Green lens and corner cube prism are encapsulated in metal canula, improve the mechanical strength of probe, ensure the stability of probe work.Use the polarizer and polarization beam apparatus in measuring system, be divided into by the interference signal of measurement the vertical signal of two bundle direction of vibration to carry out acquisition process, avoid because fibre-optical bending reverses the polarization effect brought.
Summary of the invention
The invention provides a kind of in conjunction with OCT technology and conventional medical endoscope, the Novel non radiation OCT that detects for blood vessel pops one's head in and measuring system, probe adopts external motor to drive probe rotation sweep, effectively can avoid electromagnetic radiation, measuring system adds the polarizer and polarization beam apparatus, be divided into by the interference signal of measurement the vertical signal of two bundle direction of vibration to carry out acquisition process, avoid because fibre-optical bending reverses the polarization effect brought.
The technical solution used in the present invention is: a kind of Novel non radiation OCT for blood vessel detection pops one's head in and measuring system, wherein, described Novel non radiation OCT probe is made up of micro machine, gear, FC type fibre-optical splice, metal spring, optical fiber, Green lens, corner cube prism and metal canula.
Micro motor for driving pinion rotation, drives spring pivotal by FC type fibre-optical splice and then drives probe to carry out rotation sweep.Optical fiber is placed in spring center, optical fiber connector with bond with the Green lens of focused ray and corner cube prism for collimating, be placed in the lump in rotatable metal canula.
A kind of Novel non radiation OCT measuring system detected for blood vessel, comprise wideband light source, the polarizer, splitting ratio be 50: 50 fiber coupler, fibre delay line, reflecting mirror, be provided with pry head, polarization beam apparatus, detector, wave filter and computer in New O CT simultaneously.The signal that wave filter exports transfers to computer via data collecting card and processes.The broadband light that wideband light source sends obtains polarized light after the polarizer, polarized light separates through bonder, a part is from the fiber exit of spring center, successively by Green lens and corner cube prism, blood vessel is radiated at through collimation with after focusing on, the reflection of biological tissue is by reflected incident light, and reflected light successively by corner cube prism and Green lens, returns optical fiber again; Another part is through fibre delay line, and after reflecting mirror reflection, return to bonder place, two parts light converges at bonder place, interferes.Interference signal is divided into the two-beam that direction of vibration is vertical after polarization beam apparatus, detect through detector respectively and pass through filter process, filtered two-beam sends into data collecting card, and transfers to computer, and software processing obtains the real time imaging of tested blood vessel.
Compared with prior art, the present invention has following characteristics:
Adopt the polarizer and polarization beam apparatus in the present invention, the two bundle signals being divided into direction of vibration vertical interference signal carry out acquisition process, can avoid the polarization effect because fibre-optical bending brings.
A kind of Novel non radiation OCT of the present invention pops one's head in and adopts external motor but not built-in miniature motor, and in testing process, human body is interior without the signal of telecommunication, is beneficial to the miniaturization of probe simultaneously.
The medical interior pry head of a kind of Novel non radiation OCT of the present invention, adopts metal spring to be socketed in outer fiber, uses metal spring transmission, solves the problems such as frangibility that optic fibre turning in traditional design brings, damage and cost increase.
The medical interior pry head of a kind of Novel non radiation OCT of the present invention, is encapsulated in rotatable metal canula after optical fiber head, Green lens and corner cube prism being bondd, improves the mechanical strength of probe, ensure the stability of probe work.
The medical interior pry head of a kind of Novel non radiation OCT of the present invention, changes probe rotational scan rate, to make to realize different scanning speeds in different surveyed areas by the rotating speed controlling external motor.
Beneficial effect of the present invention is OCT technology and medical endoscope to combine; give full play to both advantages; external motor is adopted to drive interior pry head to rotate; the situation of the electromagnetic interference human body cell avoiding conventional internal motor to bring and the environment of body fluid; adopt metal spring rotating drive; solve frangibility, the problem such as damage and cost increase that optic fibre turning in traditional design brings; metal canula can protect the probe optical fiber head of front end, Green lens and corner cube prism; improve the mechanical strength of probe, ensure the stability of probe work.Use the polarizer and polarization beam apparatus in measuring system, be divided into by the interference signal of measurement the vertical signal of two bundle direction of vibration to carry out acquisition process, avoid because fibre-optical bending reverses the polarization effect brought.
Accompanying drawing explanation
Below in conjunction with accompanying drawing and detailed description of the invention, the present invention is described further.
Fig. 1 is the schematic diagram of the described Novel non radiation OCT measuring system for blood vessel detection;
Fig. 2 is described schematic diagram of popping one's head in for the Novel non radiation OCT of blood vessel detection.
In figure: 1, wideband light source, 2, the polarizer, 3, bonder, 4, described probe, 5, blood vessel, 6, fibre delay line, 7, reflecting mirror, 8, polarization beam apparatus, 9, detector 1,10, wave filter 1,11, detector 2,12, wave filter 2,13, data collecting card, 14, computer, 15, micro machine, 16, gear, 17, FC type fibre-optical splice, 18, metal spring, 19, single-mode fiber, 20, Green lens, 21, corner cube prism, 22, metal canula.
Detailed description of the invention
Below in conjunction with accompanying drawing, a kind of Novel non radiation OCT probe for blood vessel detection of the present invention and measuring system are described further.
As shown in Figure 1, a kind of Novel non radiation OCT measuring system detected for blood vessel of the present invention, comprise bonder 3, fibre delay line 6, reflecting mirror 7, polarization beam apparatus 8, first detector 9, second detector 11 and wave filter 10,12 corresponding respectively that the wideband light source 1, the polarizer 2, the splitting ratio that set gradually are 50: 50.Described Novel non radiation OCT probe 4 imports blood vessels 5 and carries out rotation sweep, and wave filter 10,12 output signal is gathered by data collecting card 13 and sends PC 14 to.
Wherein for pry 4 in Novel non radiation OCT blood vessel detection system, be made up of micro machine 15, gear 16, FC type fibre-optical splice 17, metal spring 18, single-mode fiber 19, Green lens 20, corner cube prism 21 and rotatable metal canula 22, single-mode fiber 19 is placed in spring 18, optical fiber connector with bond with the Green lens 20 of focused ray and corner cube prism 21 for collimating, be placed in the lump in rotatable metal canula 22.
Measuring system operation principle is as follows: as shown in Figure 2, the broadband light that wideband light source 1 sends is after the polarizer 2, the polarized light obtained is divided into two-way by bonder 3, and a road is through fibre delay line 6 and reflect Hou Yuan road by reflecting mirror 7 and return, and this light path is as with reference to light path; Another road connects Novel non radiation OCT probe and is radiated on blood vessel, and because blood vessel returns the former road of reflected light that the reflection of light produces, this light path is as signal light path.The light of signal light path, from single-mode fiber 19 outgoing at spring 18 center, successively by Green lens 20 and corner cube prism 21, focuses on blood vessel, and gained reflected light successively by corner cube prism 20 and Green lens 21, returns optical fiber again.
Pop one's head in rotation sweep process at OCT, micro machine 15 driven gear 16 rotates, spring 18 is driven to rotate by FC type fibre-optical splice 17, thus drive the rotation of probe front end to carry out rotation sweep, the fibre delay line 6 of continuous adjustment reference path makes two-way reflected light in an optical path difference, like this, the flashlight of biological tissue's information is carried and the reference light of reference arm constantly interferes at bonder 3 place.Interference signal after bonder 3 by obtaining the vertical two-beam of direction of vibration after polarization beam apparatus 8, processed by wave filter 10,12 after detector 9, detector 11 respectively, after signal after process is gathered by data collecting card 13, the real time imaging of blood vessel is obtained, for Diagnosis and Treat after routine processes by PC 14.
Claims (6)
1., for spying upon a head in Novel non radiation OCT blood vessel detection system according to claim 1, be made up of micro machine, gear, FC type fiber connector, metal spring, single-mode fiber, Green lens, corner cube prism, metal canula.Optical fiber is placed in metal spring, and optical fiber connector bonds with the Green lens focused on for collimate light and corner cube prism, is placed in rotatable metal canula in the lump.
2. as claimed in claim 1 for the Novel non radiation OCT measuring system of blood vessel detection, it is characterized in that, use the polarizer and polarization beam apparatus, interference signal is divided into the signal that two bundle direction of vibration are vertical, detected respectively by two detectors and carry out acquisition process, the polarization effect that measurement result is not brought by fibre-optical bending, torsion affects.
3. the Novel non radiation OCT detected for blood vessel as claimed in claim 2 pops one's head in, and it is characterized in that, adopt external motor to replace traditional built-in miniature motor to drive, during detection, human body is interior without the signal of telecommunication.
4. the Novel non radiation OCT detected for blood vessel as claimed in claim 2 pops one's head in, and it is characterized in that, external motor driven wheel rotates, and drives FC type fibre-optical splice and metal spring to rotate, drives probe to carry out rotation sweep.
5. the Novel non radiation OCT detected for blood vessel as claimed in claim 2 pops one's head in, and it is characterized in that, is encapsulated in rotatable metal canula after optical fiber head, Green lens and corner cube prism bonding.
6. the Novel non radiation OCT detected for blood vessel as claimed in claim 2 pops one's head in, and it is characterized in that, by controlling the rotating speed of external micro machine, can realize scanning speeds different in different surveyed area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510197211.3A CN104887172A (en) | 2015-04-22 | 2015-04-22 | Novel nonradiative OCT probe and measuring system for blood vessel detection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510197211.3A CN104887172A (en) | 2015-04-22 | 2015-04-22 | Novel nonradiative OCT probe and measuring system for blood vessel detection |
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| CN104887172A true CN104887172A (en) | 2015-09-09 |
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| CN201510197211.3A Pending CN104887172A (en) | 2015-04-22 | 2015-04-22 | Novel nonradiative OCT probe and measuring system for blood vessel detection |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105105717A (en) * | 2015-09-15 | 2015-12-02 | 中国科学院光电技术研究所 | Endoscopic OCT imaging system adopting optical path difference external compensation common-path interference probe |
| CN106419803A (en) * | 2016-08-31 | 2017-02-22 | 华南师范大学 | Intravascular opto-acoustic absorption, elasticity, viscosity multimode imaging integrated endoscopy and imaging method |
| CN106691364A (en) * | 2016-12-20 | 2017-05-24 | 哈尔滨医科大学附属第二医院 | High strength probe used for optical coherence tomography imaging |
| CN106937863A (en) * | 2017-03-21 | 2017-07-11 | 上海市第妇婴保健院 | A kind of built-in micro- gynecatoptron |
| CN107468283A (en) * | 2017-07-25 | 2017-12-15 | 北华航天工业学院 | A kind of hand-held optical biopsy instrument |
| CN107518862A (en) * | 2016-06-20 | 2017-12-29 | 魏晋 | A kind of optical fiber and imaging method of integrated optical coherence and incoherent imaging system |
| CN115089118A (en) * | 2022-06-20 | 2022-09-23 | 暨南大学附属第一医院（广州华侨医院） | Bimodal fusion blood vessel imaging system |
-
2015
- 2015-04-22 CN CN201510197211.3A patent/CN104887172A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105105717A (en) * | 2015-09-15 | 2015-12-02 | 中国科学院光电技术研究所 | Endoscopic OCT imaging system adopting optical path difference external compensation common-path interference probe |
| CN105105717B (en) * | 2015-09-15 | 2017-11-24 | 中国科学院光电技术研究所 | The endoscopic OCT imaging system popped one's head in using optical path difference external compensation common path interference |
| CN107518862A (en) * | 2016-06-20 | 2017-12-29 | 魏晋 | A kind of optical fiber and imaging method of integrated optical coherence and incoherent imaging system |
| CN106419803A (en) * | 2016-08-31 | 2017-02-22 | 华南师范大学 | Intravascular opto-acoustic absorption, elasticity, viscosity multimode imaging integrated endoscopy and imaging method |
| CN106691364A (en) * | 2016-12-20 | 2017-05-24 | 哈尔滨医科大学附属第二医院 | High strength probe used for optical coherence tomography imaging |
| CN106937863A (en) * | 2017-03-21 | 2017-07-11 | 上海市第妇婴保健院 | A kind of built-in micro- gynecatoptron |
| CN107468283A (en) * | 2017-07-25 | 2017-12-15 | 北华航天工业学院 | A kind of hand-held optical biopsy instrument |
| CN115089118A (en) * | 2022-06-20 | 2022-09-23 | 暨南大学附属第一医院（广州华侨医院） | Bimodal fusion blood vessel imaging system |
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