CN109893070A - A kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring - Google Patents
A kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring Download PDFInfo
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Abstract
The invention discloses a kind of integrated optoacoustic endoscope and image processing devices for treatment of nasopharyngeal carcinoma monitoring, including semiconductor laser, pulse laser, multiwavelength laser bundling device, fiber optic bundle and sequentially connected ultrasonic detector, signal amplifier and data processing equipment, the first end of fiber optic bundle is connect with multiwavelength laser bundling device, the second end of fiber optic bundle is equipped with ultrasonic detector, and lateral light-emitting window is equipped at the position close to the second end of fiber optic bundle.The pulse laser that the continuous laser and pulse laser that semiconductor laser issues issue is incident on respectively in multiwavelength laser bundling device, enter fiber optic bundle after multiwavelength laser bundling device closes beam, it is irradiated on the inside of nasopharynx by lateral light-emitting window, realize laser immunization therapy, radiation cure in compared to the prior art has better curative effect, simultaneously, based on ultrasonic detector, signal amplifier and data processing equipment, nasopharyngeal carcinoma tumor therapeutic process can be monitored, convenient for being diagnosed and being monitored to tumour.
Description
Technical field
The present invention relates to electronic technology fields, more specifically to a kind of integration for treatment of nasopharyngeal carcinoma monitoring
Optoacoustic endoscopy device.
Background technique
Nasopharyngeal carcinoma refers to the malignant tumour betided at the top of nasopharyngeal cavity with side wall, is one of high-incidence malignant tumour in China, hair
Sick rate is that can be treated using radiation cure method to it, but its curative effect is general, poison first of ear,nose & throat malignant tumour
Side effect is big, cannot eradicate the tumour of most early stages, and the palliative treatment or preoperative, postoperative auxiliary for being chiefly used in advanced cancer are controlled
It treats.
Summary of the invention
The main purpose of the present invention is to provide a kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring, purports
Solving the technical issues of using radiation cure nasopharyngeal carcinoma tumor weak curative effect in the prior art.
To achieve the above object, the present invention provides a kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring,
Including semiconductor laser, pulse laser, multiwavelength laser bundling device, fiber optic bundle, ultrasonic detector, signal amplifier sum number
According to processing unit, the ultrasonic detector, signal amplifier and data processing equipment are sequentially connected；The first end of the fiber optic bundle
It is connect with the multiwavelength laser bundling device, the second end of the fiber optic bundle is equipped with ultrasonic detector, close to the fiber optic bundle
Second end position at be equipped with lateral light-emitting window；
The continuous laser that the semiconductor laser issues, the pulse laser issued with the pulse laser are incident respectively
Into the multiwavelength laser bundling device, enter the fiber optic bundle after the multiwavelength laser bundling device closes beam, and pass through institute
It states lateral light-emitting window to be irradiated on the inside of nasopharynx, realizes laser immunization therapy；
The pulse laser on the inside of nasopharynx is irradiated to by the lateral light-emitting window, and excitation is generated into photoacoustic signal, the ultrasound
Detector is for receiving photoacoustic signal and the photoacoustic signal being converted to electric signal；
The signal amplifier is used to receive the electric signal that the ultrasonic detector is sent, and amplifies the electric signal and will put
Electric signal after big is sent to the data processing equipment；
The data processing equipment based on the electric signal received, on the inside of nasopharynx described in graphic software platform in tumor tissues
Temperature, volume, the absorbing state of vascular distribution situation and the continuous laser and the pulse laser.
Optionally, fiber optic bundle includes the conduit of optical fiber and setting in a fiber, and the ultrasonic detector includes multiple equal
The even ultrasonic detector array element for being distributed in the duct wall.
Optionally, the wavelength for the continuous laser that semiconductor laser issues is 500nm~1500nm.
Optionally, the wavelength for the pulse laser that pulse laser issues is 500nm~1500nm.
Optionally, above-mentioned light-emitting window is cyclic annular light-emitting window.
Optionally, above-mentioned light-emitting window is lateral light-emitting window, and fiber optic bundle can be rotated with 360 °, alternatively, laterally going out on fiber optic bundle
Position where optical port can be rotated with 360 °.
Beneficial effect
The present invention provide it is a kind of for treatment of nasopharyngeal carcinoma monitoring integrated optoacoustic endoscope and image processing device include semiconductor laser,
Pulse laser, multiwavelength laser bundling device, fiber optic bundle, ultrasonic detector, signal amplifier and data processing equipment are described super
Detector of sound, signal amplifier and data processing equipment are sequentially connected, the first end of the fiber optic bundle and the multiwavelength laser
The second end of bundling device connection, the fiber optic bundle is equipped with ultrasonic detector, at the position close to the second end of the fiber optic bundle
Equipped with lateral light-emitting window.The continuous laser that semiconductor laser issues, the pulse laser issued with pulse laser are incident respectively
Into multiwavelength laser bundling device, enter fiber optic bundle after multiwavelength laser bundling device closes beam, and irradiate by lateral light-emitting window
On the inside of to nasopharynx, laser immunization therapy is realized.It is to be understood that the medicament that laser immunization therapy includes cooperation injection is realized
Photo-thermal therapy and topical immunotherapy can use patient's self tumor antigen as vaccine in situ, induce body and generate for a long time
Lasting anti-tumor immunity not only can effectively clear in situ tumor, but also can control and even remove metastatic tumor, compared to existing
There is the radiation cure in technology that there is better curative effect.On the other hand, the one for the treatment of of nasopharyngeal carcinoma monitoring provided by the invention
Changing optoacoustic endoscopy device further includes ultrasonic detector, signal amplifier and data processing equipment, can be controlled nasopharyngeal carcinoma tumor
Treatment process is monitored, and synthesizes the three-dimensional photoacoustic image of tumour, while can detecte the temperature change of tumour, absorption characteristic and
Vasculature part situation, convenient for being diagnosed and being monitored to tumour.In another aspect, the one for the treatment of of nasopharyngeal carcinoma monitoring provided by the invention
Body optoacoustic endoscopy device volume is small, light-weight, and the operation is stable, cost is relatively low, has to realization treatment of nasopharyngeal carcinoma huge
Promotional value.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those skilled in the art without creative efforts, can also basis
These attached drawings obtain other attached drawings.
Fig. 1 is a kind of structural representation of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring provided by the invention
Figure；
Fig. 2 is that the structure of another integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring provided by the invention is shown
It is intended to.
Specific embodiment
In order to make the invention's purpose, features and advantages of the invention more obvious and easy to understand, below in conjunction with the present invention
Attached drawing in embodiment, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, and not all embodiments.Based on the embodiments of the present invention, those skilled in the art
Member's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
The present invention provides a kind of integrated optoacoustic endoscope and image processing devices for treatment of nasopharyngeal carcinoma monitoring, which can be to nose
Pharynx cancer tumour realizes laser immunization therapy, and the integrated optoacoustic endoscope and image processing device for the treatment of of nasopharyngeal carcinoma monitoring includes semiconductor laser
101, pulse laser 102, multiwavelength laser bundling device 103, fiber optic bundle 104, ultrasonic detector 105, signal amplifier 106 with
And data processing equipment 107.
Connection relationship between each device is referring to Figure 1, wherein at ultrasonic detector 105, signal amplifier 106 and data
Reason device 107 is sequentially connected, and the first end of fiber optic bundle 104 is connect with multiwavelength laser bundling device 103, and the second of fiber optic bundle 104
End is equipped with ultrasonic detector 105, and light-emitting window 1041 is equipped at the position close to the second end of fiber optic bundle 104, it is to be understood that
, under some examples, the light-emitting window being equipped at the position of second end can be cyclic annular light-emitting window, or laterally go out light
Mouthful, shown in FIG. 1 is lateral light-emitting window.
The function of above each device is as follows:
Semiconductor laser 101 can issue high power CW laser, and continuous laser may be implemented to nasopharyngeal carcinoma tumor
Topical immunotherapy.
Pulse laser 102 can issue pulse laser, and generation light will be excited by being irradiated to the pulse laser on the inside of nasopharynx
Acoustical signal.
Multiwavelength laser bundling device 103 can will be in continuous laser and pulse laser beam combining coupled into optical fibres beam 104
Fiber optic bundle 104 is equipped with lateral light-emitting window 1041, and the laser that conjunction beam couples will be by lateral light-emitting window 1041
It is irradiated on the inside of pharynx nasalis.
Ultrasonic detector 105 is for receiving photoacoustic signal and photoacoustic signal being converted to electric signal.
Signal amplifier 106 is used to receive the electric signal of the transmission of ultrasonic detector 105, and amplification electric signal simultaneously will be amplified
Electric signal is sent to data processing equipment 107.
Data processing equipment 107 is used for based on the electric signal received, on the inside of graphic software platform nasopharynx in tumor tissues
Temperature, volume, the absorbing state of vascular distribution situation and continuous laser and pulse laser.
At work, the continuous laser that semiconductor laser 101 issues is and described for the nasopharynx integration optoacoustic endoscope and image processing device
The pulse laser that pulse laser 102 issues is incident on respectively in the multiwavelength laser bundling device 103, is swashed through the multi-wavelength
Combiner device 103 enters the fiber optic bundle 104 after closing beam, and is irradiated on the inside of nasopharynx by the lateral light-emitting window 1041, real
Existing laser is immune to be controlled.Laser immunization therapy includes the photo-thermal therapy and topical immunotherapy of joint targeting, can use patient certainly
Body tumour antigen induces the anti-tumor immunity that body generates long duration, not only can effectively clear original position as vaccine in situ
Tumour, and can control and even remove metastatic tumor.
It should be noted that being irradiated to the pulse laser on the inside of nasopharynx by lateral light-emitting window 1041 generates optoacoustic for excitation
Signal, ultrasonic detector 105 will receive photoacoustic signal and be sent to signal amplification after the photoacoustic signal is converted to electric signal
Device 106, signal amplifier 106 are sent to data processing equipment 107 after amplifying electric signal, data processing equipment 107 is based on electricity
Signal shows temperature, volume, vascular distribution situation and the continuous laser of tumor tissues on the inside of nasopharynx in a manner of patterned
With the absorbing state of pulse laser.
Referring to fig. 2, it is shown in Fig. 2 be treatment of nasopharyngeal carcinoma monitoring integrated optoacoustic endoscope and image processing device showing in a state of use
It is intended to.
The integrated optoacoustic endoscope and image processing device for the treatment of of nasopharyngeal carcinoma monitoring provided by the invention can provide laser immunization therapy, phase
There is better curative effect compared with radiation cure in the prior art.On the other hand, treatment of nasopharyngeal carcinoma monitoring provided by the invention
Integrated optoacoustic endoscope and image processing device further include ultrasonic detector 105, signal amplifier 106 and data processing equipment 107, can be with
Nasopharyngeal carcinoma tumor therapeutic process is monitored, the three-dimensional photoacoustic image of tumour is synthesized, while the temperature that can detecte tumour becomes
Change, absorption characteristic and vasculature part situation, convenient for being diagnosed and being monitored to tumour.In another aspect, nose provided by the invention
The integrated optoacoustic endoscope and image processing device of pharynx cancer treatment monitoring is small in size, and light-weight, the operation is stable, cost is relatively low, to realization nose
Pharynx cancer treatment has huge promotional value.
It is to be understood that fiber optic bundle 104 includes the conduit of optical fiber and setting in a fiber, the ultrasonic detector
105 include multiple 105 array elements of ultrasonic detector for being evenly distributed on the duct wall, and 105 array element of ultrasonic detector can be visited
The photoacoustic signal for surveying all angles is transferred in data processing equipment 107 after the amplification of signal amplifier 106, is believed by optoacoustic
Temperature change, absorption characteristic, the vasculature part situation of monitoring tumor tissues number may be implemented, can also be calculated using filtered back projection
Method realizes the photoacoustic imaging to tumour large area, and based on photoacoustic imaging and adjustable semiconductor laser 101 issues and continuously swashs
The power of light optimizes photo-thermal effect, convenient for being diagnosed and being monitored to tumour.
Under some examples, the wavelength for the continuous laser that semiconductor laser 101 issues is 500nm~1500nm, pulse
The wavelength for the pulse laser that laser 102 issues is 500nm~1500nm.
Under some examples, the light-emitting window on fiber optic bundle is cyclic annular light-emitting window, and semiconductor laser issues continuous sharp
Light, the pulse laser issued with pulse laser, can project from cyclic annular light-emitting window, and 360 ° be irradiated on the inside of nasopharynx is realized
Laser immunization therapy.
Under other examples, light-emitting window on fiber optic bundle is lateral light-emitting window, and in that case, fiber optic bundle can be with
360 ° of rotations just can guarantee semiconductor laser alternatively, the position on fiber optic bundle where lateral light-emitting window can be rotated with 360 ° in this way
The continuous laser that device issues, the pulse laser issued with pulse laser can be projected from side to light-emitting window, and be sent out in fiber optic bundle
In the case that position where raw rotation, or lateral light-emitting window rotates, by continuous laser and 360 ° of pulse laser of photograph
It is mapped on the inside of nasopharynx, realizes laser immunization therapy.
It should be noted that for the various method embodiments described above, describing for simplicity, therefore, it is stated as a series of
Combination of actions, but those skilled in the art should understand that, the present invention is not limited by the sequence of acts described because
According to the present invention, certain steps can use other sequences or carry out simultaneously.Secondly, those skilled in the art should also know
It knows, the embodiments described in the specification are all preferred embodiments, and related actions and modules might not all be this hair
Necessary to bright.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, there is no the portion being described in detail in some embodiment
Point, it may refer to the associated description of other embodiments, meanwhile, the serial number of the above embodiments of the invention is only for description, does not represent
The superiority and inferiority of embodiment, those skilled in the art under the inspiration of the present invention, are not departing from present inventive concept and right is wanted
It asks under protected ambit, can also make many forms, all of these belong to the protection of the present invention.
Claims (6)
1. a kind of integrated optoacoustic endoscope and image processing device for treatment of nasopharyngeal carcinoma monitoring, which is characterized in that in the integration optoacoustic
Endoscope devices include semiconductor laser, pulse laser, multiwavelength laser bundling device, fiber optic bundle, ultrasonic detector, signal amplification
Device and data processing equipment, the ultrasonic detector, signal amplifier and data processing equipment are sequentially connected；The fiber optic bundle
First end is connect with the multiwavelength laser bundling device, and the second end of the fiber optic bundle is equipped with ultrasonic detector, close to described
Light-emitting window is equipped at the position of the second end of fiber optic bundle；
The continuous laser that the semiconductor laser issues, the pulse laser issued with the pulse laser are incident on institute respectively
It states in multiwavelength laser bundling device, the fiber optic bundle is entered after the multiwavelength laser bundling device closes beam, and pass through the side
It is irradiated on the inside of nasopharynx to light-emitting window, realizes laser immunization therapy；
The pulse laser on the inside of nasopharynx is irradiated to by the lateral light-emitting window, and excitation is generated into photoacoustic signal, the supersonic sounding
Device is for receiving photoacoustic signal and the photoacoustic signal being converted to electric signal；
Amplified electric signal is sent at the data by the signal amplifier for receiving and amplifying the electric signal
Manage device；
The data processing equipment based on the electric signal received, on the inside of nasopharynx described in graphic software platform in tumor tissues temperature
Degree, volume, the absorbing state of vascular distribution situation and the continuous laser and the pulse laser.
2. integration optoacoustic endoscope and image processing device as described in claim 1, which is characterized in that the fiber optic bundle includes optical fiber and sets
Conduit in a fiber is set, the ultrasonic detector includes multiple ultrasonic detector battle arrays for being evenly distributed on the duct wall
Member.
3. such as the described in any item integrated optoacoustic endoscope and image processing devices of claims 1 or 2, which is characterized in that the semiconductor laser
The wavelength for the continuous laser that device issues is 500nm~1500nm.
4. such as the described in any item integrated optoacoustic endoscope and image processing devices of claims 1 or 2, which is characterized in that the pulse laser
The wavelength of the pulse laser of sending is 500nm~1500nm.
5. such as the described in any item integrated optoacoustic endoscope and image processing devices of claims 1 or 2, which is characterized in that the light-emitting window is ring
Shape light-emitting window.
6. such as the described in any item integrated optoacoustic endoscope and image processing devices of claims 1 or 2, which is characterized in that the light-emitting window is side
To light-emitting window, the fiber optic bundle can be rotated with 360 °, alternatively, position on the fiber optic bundle where the lateral light-emitting window can be with
360 ° of rotations.
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