CN109106340A - A kind of insertion type optical acoustic imaging and laser thermal treatment system - Google Patents
A kind of insertion type optical acoustic imaging and laser thermal treatment system Download PDFInfo
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- CN109106340A CN109106340A CN201811096996.5A CN201811096996A CN109106340A CN 109106340 A CN109106340 A CN 109106340A CN 201811096996 A CN201811096996 A CN 201811096996A CN 109106340 A CN109106340 A CN 109106340A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
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- A61N5/067—Radiation therapy using light using laser light
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
- A61N2005/0627—Dose monitoring systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
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Abstract
The present invention provides a kind of insertion type optical acoustic imagings and laser thermal treatment system, including laser subsystem, light wavelength division multiplexing module, optical fiber probe module, photoacoustic imaging subsystem and ultrasonic listening unit.Laser subsystem includes: pulse excitation light of the pulsed light emission module transmitting for acousto-optic imaging；Continuous optical transmitter module transmitting is used for the continuous treatment light of laser heat cure；Optical fiber sensing module emits and receives the sense light for temperature monitoring；Indicate that optical module emits the visible light being used to indicate.Each module of laser subsystem is connected to optical fiber probe by light wavelength division multiplexing module.Optical fiber probe includes temperature sensor, light diverging angle controller and protective coating, for intervening and conveying continuous treatment light, pulse excitation light and sense light to treatment region.The light activated part photoacoustic waves signal of pulse excitation enters ultrasonic listening unit.The system realizes the integration of laser therapy, monitoring temperature, high-resolution imaging.
Description
Technical field
The present invention relates to a kind of insertion type optical acoustic imaging and laser thermal treatment system, which may be implemented laser intervention and controls
Treatment, photoacoustic imaging and the real time monitoring to temperature at interventional therapy.Belong to benign, malignant tumour, tumour, hyperplasia, tubercle
Deng the field for carrying out interventional therapy.
Background technique
Insertion type laser heat cure (ILITT:Interventional Laser Induced Thermal Therapy)
It is the another oncotherapy mode at present other than traditional operation, chemotherapy, the big oncotherapy means of radiotherapy three.Laser heat cure
Laser ablation (high power) and photothermal laser treatment (low-power) two major classes can be divided into.The laser heat cure side of optical fiber insertion type
Formula has many advantages, such as minimally invasive, accurate.Using the Photothermal characterisation of near-infrared laser (700nm-1100nm), implementing insertion type operation can
To carry out precisely heating ablation to tumor locus, to reach the killing tumour cell of most limits without destroying health tissues
Purpose.The nano material (such as nanogold) absorbed for infrared laser specific wavelength, it might even be possible to use the red of more low energy
The heating tumour cell of outer laser selective and do not destroy healthy cell completely, to achieve the purpose that insertion type targeted therapy.
Multimode fibre is mainly sent to therapentic part by intervention metal needle tubing by insertion type laser heat cure.However multimode light
Fibre output Laser beam energy distribution is uneven, leads to speckle effect due to local spatial coherence effect, is easy to produce local energy
Hot spot, and the bending of transmission fiber also results in the variation of output laser energy hot spot, this therapeutic effect for tumor locus
Control can generate sizable discreteness.
On the other hand, when implementing laser heat cure, precise measurement, the temperature for controlling treatment region are essential.Example
Such as, the temperature for the treatment of region can be measured using MRI real-time monitoring, however is supervised during laser heat cure using real time MRI
Control will greatly improve operation cost；And the temperature monitoring method be it is opposite, rung vulnerable to treatment shadow, precision not can guarantee.
Real-time ultrasonic image can monitor treatment region temperature, equally exist similar problems.In addition, being encapsulated simultaneously in intervention metal needle tubing
Can the thermocouple of thermometric and the method for optical fiber be also able to achieve the point monitoring for the treatment of region, however be packaged with optical fiber and thermocouple
Metal needle pipe diameter is too big, considerably increases patient suffering.
On the other hand, the aid imaging of insertion type treatment include magnetic resonance, computed tomography and real-time ultrasound at
Picture.Ultrasound is applied widely as low cost, real-time imaging mode.Although the tissue depth that ultrasound can detect reaches
10cm or more, but its resolution ratio is lower, with the increase of depth, resolution ratio decline, therefore, it is difficult to observe more complicated tissue
And subtleer lesion, and then influence the assessment to insertion type laser heat cure effect.Therefore it needs a kind of while can be
The method of real-time perfoming high-resolution imaging in deeper pathological tissues.A kind of mode of novel raising imaging resolution be optoacoustic at
Picture, it can be realized the scanning to specific organization's higher resolution (up to tens microns).The optoacoustic excitation light of photoacoustic imaging system
Source is infrared (700-1100nm) pulse laser to the relative transparent of biological tissue, and percutaneous radiation utilizes light by imaging position
The biological tissue of pulse excitation certain depth forms light scattering, generates elastic mechanical wave, and ultrasonic probe captures the elasticity of return
Wave signal is to carry out fine ultrasonic imaging.1064nm is currently mainly used and mixes rubidium garnet (Nd:YAG) solid laser
Device generates nanosecond light pulse.The spectrum of 1064nm is to the more shallow of the penetration effect ratio 800-900nm of skin, therefore to deep group
Knit to penetrate effect weaker so that high-resolution ultrasound image can only differentiate tissue surface 1cm or less even several millis
The range of rice, practical application effect are limited.In addition, the probe designs of photoacoustic imaging are different from conventional ultrasound probe, structure is more
It is complicated.
Summary of the invention
For the disadvantages mentioned above of present laser thermal treatment device, laser heat can be carried out simultaneously the present invention provides one kind and is controlled
Treat the system with photoacoustic imaging.Insertion type optical acoustic imaging and laser thermal treatment system of the invention, has the feature that laser system
System can not only provide continuous treatment light, additionally it is possible to provide the pulse excitation laser of photoacoustic imaging, while can also provide temperature
The sense light of monitoring；Different from the external pulse laser excitation mode of traditional photoacoustic imaging system, pulse laser of the invention
From internal excitation and receive transmission photoacoustic signal；Multifunctional optical fiber probe is used to convey the same of continuous treatment light and pulse excitation light
When be able to achieve monitoring temperature at intervention again；In order to achieve the above-mentioned object of the invention, The technical solution adopted by the invention is as follows:
According to the first aspect of the invention, insertion type optical acoustic imaging and laser thermal treatment system, including laser are provided
Subsystem (1), light wavelength division multiplexing module (1 '), optical fiber probe module (2), photoacoustic imaging subsystem (3) and ultrasonic wave are visited
It surveys unit (4)；Wherein,
Laser subsystem (1) includes pulsed light emission module (11), pulse excitation light (20) of the transmitting for acousto-optic imaging；
Continuous optical transmitter module (12), transmitting are used for the continuous treatment light (19) of laser heat cure；Optical fiber sensing module (13), hair
It penetrates and receives the sense light (21) for temperature monitoring；And instruction optical module (14), emit the visible light (22) being used to indicate；
Light wavelength division multiplexing module (1 ') include pulsed light wave division multiplexer (15), sensing light wavelength division multiplexing (16) and
It indicates light wavelength division multiplexing (17), respectively by pulsed light emission module (11), continuous optical transmitter module (12), optical fiber sensing
Module (13) and instruction optical module (14) pass through single mode optical fiber (10) and are connected to optical fiber probe module (2), act on treatment region
(6)；
Optical fiber probe module (2) includes insertion type needle tubing (23) and optical fiber probe (24)；Wherein insertion type needle tubing (23) is used
Enter treatment region (6) in assistance optical fiber probe (24)；
Photoacoustic imaging subsystem (3) includes pulsed light emission module (11), ultrasound emission-detecting module (31) and image
Processing-display module (32)；Wherein, the pulse excitation light (20) that pulsed light emission module (11) issues passes through optical fiber probe module
(2) enter treatment region (6), the photoacoustic waves signal (7) that a part is excited enters ultrasonic listening unit (4)；Ultrasonic listening
Unit (4) emits ultrasonic signal (8) and receives the ultrasonic signal (9) of return simultaneously.
Continuous optical transmitter module (12) and pulsed light emission module (11) are rare earth doped fiber laser or quasi- phase
Matched crystal intracavity frequency doubling-parameter oscillation laser；Launch wavelength range 800-1200nm；Pulsed light emission module (11) connects
Continuous optical transmitter module (12) and optical fiber sensing module (13) are all using the optical fiber to operation wavelength single mode.
According to the second aspect of the invention, a kind of insertion type optical fiber probe (24) is provided, including single mode optical fiber (10),
Temperature sensor (25), light diverging angle controller (26) and protective coating (27) are used for transmission continuous treatment light (19), pulse
Excitation light (20), sense light (21) and visible light (22)；Single mode optical fiber (10) includes covering (101) and sandwich layer (102), temperature
Sensor (25) is used to sense the temperature for the treatment of region (6).
Light diverging angle controller (26) includes covering (261) and sandwich layer (262), for controlling treatment light (19) in treatment region
The angle of divergence in domain；The hot spot (28) issued from diverging angle controller (26) is with the angle of divergence (281) propagation.Light dissipates angle controller
(26) multimode graded index fiber is used.Protective coating (27) is used to wrap up the head of optical fiber probe (24) to improve its machinery
Intensity.For temperature sensor (25) using the single mode optical fiber with light sensitive characteristic, sandwich layer is fiber bragg grating (251).
Photoacoustic imaging and laser thermal treatment system of the invention, by pulsed light emission module (11), continuous optical transmitter module
(12), optical fiber sensing module (13) and instruction optical module (14) are fully integrated as the laser subsystem of an all -fiber
(1), collection is treated, is motivated, sensing, being instructed in one, enormously simplifies subsystem structure.Multifunctional optical fiber probe module (2) tool
Have the characteristics that design parameter is flexible, vdiverse in function, cooperate photoacoustic imaging subsystem (3), the treatment system realize real-time diagnosis,
It mediates, imaging, the integration treated.
Detailed description of the invention
Fig. 1 is photoacoustic imaging-laser thermal treatment system schematic diagram of first aspect present invention；
Fig. 2 is the laser system schematic diagram of first aspect present invention；
Fig. 3 a is the schematic diagram of the optical fiber probe module of second aspect of the present invention；
Fig. 3 b is the structural schematic diagram of the optical fiber probe of second aspect of the present invention.
Specific embodiment
The following describes the present invention in detail with reference to the accompanying drawings and embodiments.
Referring to Fig.1, according to the first aspect of the invention, a kind of insertion type optical acoustic imaging and laser heat cure system are provided
System, including laser subsystem (1), light wavelength division multiplexing module (1 '), optical fiber probe module (2), photoacoustic imaging subsystem (3) with
And ultrasonic listening unit (4).Each subsystem and module section structure are as follows:
Laser subsystem (1) includes pulsed light emission module (11), pulse excitation light (20) of the transmitting for acousto-optic imaging；
Continuous optical transmitter module (12), transmitting are used for the continuous treatment light (19) of laser heat cure；Optical fiber sensing module (13), hair
It penetrates and receives the sense light (21) for temperature monitoring；And instruction optical module (14), emit the visible light (22) being used to indicate.
Laser used by pulsed light emission module (11) and continuous optical transmitter module (12) needs to select according to treatment,
The respectively wavelength continuous and pulse laser that is 800-1200nm, such as 1064nm mixes rubidium garnet laser, 800-
Semiconductor laser, the selectable titanium-doped sapphire laser of 700-900nm wavelength of 1200nm etc..In a preferred embodiment
In, for the single mode optical fiber structure compatible with other parts of the present invention, the preferred optical maser wavelength Yb dosed optical fiber that is 1000-1100nm
Laser.Using mixing ytterbium Active Optical Fiber and a pair of of fiber reflector constitutes optical fiber laser.Active Optical Fiber core diameter is having a size of 6-
20um, cladding diameter 125-400um.In order to reach the problems of mechanical strength of all optical fibre structure, especially optical fiber probe part
Problems of mechanical strength, the preferred 250-400um of fibre cladding diameter.Launch wavelength is reflected by the fiber reflector of optical fiber laser
Wavelength determines.Fiber reflector is made of fiber grating, reflection wavelength 1000-1100nm, reflectivity 10%-99%；Power 1-
50W, preferably 1-20W.In another preferred embodiment, in order to reduce volume, continuous optical transmitter module (12) and pulse
Optical transmitter module (11) is quasi-phase-matching crystals intracavity frequency doubling-parameter oscillation laser, the preferred 800-1200nm of launch wavelength.
Photoacoustic imaging subsystem (3) includes pulsed light emission module (11), ultrasound emission-detecting module (31) and image
Processing-display module (32).Pulsed light emission module (11) issue pulse excitation light (20) by optical fiber probe module (2) into
Enter treatment region (6).Pulsed light emission module (11) is common to laser subsystem (1) and photoacoustic imaging subsystem (3).Pulse swashs
Light pulsewidth preferred 1-100ns, repetition rate 10-100kHz.Pulse laser treatment region (6) and tissue (5) in generate it is each to
The elastic mechanical wave of propagation, i.e. photoacoustic waves；The photoacoustic waves signal (7) that a part is excited enters ultrasonic wave by transmission mode and visits
It surveys unit (4).On the other hand, ultrasonic listening unit (4) emits ultrasonic signal (8) simultaneously and receives the ultrasonic wave letter of return
Number (9).The photoacoustic waves of transmission and the ultrasonic laminated of reflection are added in processing in image procossing-display module (32), form more high score
Real-time ultrasound-photoacoustic image of resolution.
Indicate optical module (14) be used as auxiliary system of the invention, transmitting visible light (22), by single mode optical fiber (10) into
Enter to indicate that light wavelength division multiplexing (17) enters optical fiber probe module (2) afterwards, acts on treatment region (6), be used to indicate interventional therapy
Orientation.It is preferred that using the visible light of 450-650nm, the feux rouges of optimal selection 635nm, the preferred 1-10mW of fiber power.
The function of optical fiber sensing module (13) is emission temperature sense light (21), by sensing light wavelength division multiplexing
(16) enter optical fiber probe module (2), the temperature sensing light (21) for carrying the temperature information for the treatment of region (6) passes through optical fiber probe mould
Block (2), which is back in optical fiber sensing module (13), carries out temperature demodulation.The temperature that optical fiber sensing module (13) obtains
Parameter (18) feeds back to near-infrared laser transmitting module (11), for adjusting its transmission power, to reach temperature required for treatment
Spend parameter.The wavelength of temperature sensing light (21) preferably uses communication wavelengths, such as 1300-1600nm.Various Fibre Optical Sensors and solution
Conditioning technology can use, it is preferred that the present invention uses short fiber Bragg grating as sensing unit, uses Distributed Feedback Laser
As transmitting light source.Being scanned by way of adjusting the electric current of Distributed Feedback Laser to output wavelength, from the reflection of fiber grating
Power is synchronized by the optical detector in optical fiber sensing module (13) also with the scanning of wavelength and is received, to demodulate treatment
The temperature in area (6).
With reference to Fig. 3 a, according to the second aspect of the invention, the optical fiber probe module for being used for transmission laser is provided
(2), insertion type needle tubing (23) therein is for assisting optical fiber probe (24) to enter treatment region (6).With reference to Fig. 3 b, fiber optic temperature is passed
For sensor (25) using the single mode optical fiber with light sensitive characteristic, geometric parameter is consistent with the connection parameter of single mode optical fiber (10)；Its
Sandwich layer is fiber bragg grating (251), in a preferred embodiment, the reflectivity 10%- of fiber grating (261)
99%, reflection bandwidth 0.1-1nm, length 0.5-5mm, optimization length < 1mm.The end face of optical fiber probe (24) uses angle of divergence control
Device (26) processed, including covering (261) and sandwich layer (262), for controlling treatment light (6) in the angle of divergence for the treatment of region.It is preferred that making
With graded index fiber, hot spot dispersion angle is controlled by adjusting the length (i.e. pitch) of graded index fiber.One
In a preferred embodiment, core diameter 50-62.5um, the graded index fiber of cladding diameter 125-400nm, length are used
100um-3mm.The hot spot (28) issued from diverging angle controller (26) is with the angle of divergence (281) propagation；Specific dispersion angle it is close
Infrared light forms the optical field distribution of specific shape, such as elliposoidal light field in treatment tissue, to reach and treat tissue most
Good covering.The single mode optical fiber (10) of optical fiber probe (24), fibre optic temperature sensor (25) and pass through from diverging angle controller (26)
The mode of welding links together；The head of protective coating (27) package optical fiber probe (24) is for improving its mechanical strength；It is excellent
Choosing uses the coat of metal or polymer, optimal to use gold, silver, chromium, thickness 10-200um.
Finally, have the shortcomings that speckle and the output beam angle of divergence are uncontrollable for multimode fibre output facula, this hair
It is bright to have used the optical fiber that single mode is formed to continuous treatment light (19) and pulse excitation light (20) and temperature sensing light (21), output
Laser facula is uniform Gaussian distribution, thus avoids the output facula problem of non-uniform of multimode fibre.It is preferred real at one
It applies in example, which uses core diameter 5-20um, cladding diameter 125-400um, the treatment laser to 800-1200nm
(5) optical fiber of single mode is formed.The size of the single mode optical fiber (6) and the Yb dosed optical fiber laser in near-infrared laser transmitting module (2)
Parameter is consistent, so as to efficient coupling；Also consistent with the optical fiber parameter of fiber sensing module (13).
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of insertion type optical acoustic imaging and laser thermal treatment system, it is characterised in that: include: laser subsystem (1), light wave point
Multiplexer module (1 '), optical fiber probe module (2), photoacoustic imaging subsystem (3) and ultrasonic listening unit (4)；Wherein:
Laser subsystem (1) includes pulsed light emission module (11), pulse excitation light (20) of the transmitting for acousto-optic imaging；Continuously
Optical transmitter module (12), transmitting are used for the continuous treatment light (19) of laser heat cure；Optical fiber sensing module (13), transmitting is simultaneously
Receive the sense light (21) for being used for temperature monitoring；And instruction optical module (14), emit the visible light (22) being used to indicate；
Light wavelength division multiplexing module (1 ') includes pulsed light wave division multiplexer (15), sensing light wavelength division multiplexing (16) and indicates
Light wavelength division multiplexing (17), respectively by pulsed light emission module (11), continuous optical transmitter module (12), optical fiber sensing module
(13) and instruction optical module (14) passes through single mode optical fiber (10) and is connected to optical fiber probe module (2), acts on treatment region (6)；
Optical fiber probe module (2) includes insertion type needle tubing (23) and optical fiber probe (24)；Wherein insertion type needle tubing (23) is for assisting
Optical fiber probe (24) are helped to enter treatment region (6)；
Photoacoustic imaging subsystem (3) includes at pulsed light emission module (11), ultrasound emission-detecting module (31) and image
Reason-display module (32)；Wherein, the pulse excitation light (20) that pulsed light emission module (11) issues passes through optical fiber probe module
(2) enter treatment region (6), the photoacoustic waves signal (7) that a part is excited enters ultrasonic listening unit (4)；Ultrasonic listening
Unit (4) emits ultrasonic signal (8) and receives the ultrasonic signal (9) of return simultaneously.
2. treatment system according to claim 1, it is characterised in that: continuous optical transmitter module (12) and pulsed light emission mould
Block (11) is rare earth doped fiber laser or quasi-phase-matching crystals intracavity frequency doubling-parameter oscillation laser；Launch wavelength
Range 800-1200nm；Pulsed light emission module (11), continuous optical transmitter module (12) and optical fiber sensing module (13)
All using the optical fiber to operation wavelength single mode.
3. treatment system according to claim 1, it is characterised in that: optical fiber probe (24) includes single mode optical fiber (10), temperature
Sensor (25), light diverging angle controller (26) and protective coating (27) are spent, is used for transmission continuous treatment light (19), pulse swashs
Encourage light (20), sense light (21) and visible light (22)；Single mode optical fiber (10) includes covering (101) and sandwich layer (102), and temperature passes
Sensor (25) is used to sense the temperature for the treatment of region (6).
4. treatment system according to claim 3, it is characterised in that: it includes covering (261) that light, which dissipates angle controller (26),
With sandwich layer (262), light (19) are treated in the angle of divergence for the treatment of region for controlling；The hot spot issued from diverging angle controller (26)
(28) with the angle of divergence (281) propagation.
5. treatment system according to claim 4, it is characterised in that: light diverging angle controller (26) is rolled over using multimode gradual change
Penetrate rate optical fiber.
6. treatment system according to any one of claims 1-5, it is characterised in that: protective coating (27) is for wrapping up light
The head of fine probe (24) is to improve its mechanical strength.
7. treatment system according to any one of claims 1-5, it is characterised in that: temperature sensor (25) use has
The single mode optical fiber of light sensitive characteristic, sandwich layer are fiber bragg grating (251).
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Cited By (6)
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| CN112704476A (en) * | 2020-12-30 | 2021-04-27 | 南方科技大学 | Photoacoustic microscopic imaging diagnosis and treatment device and using method thereof |
| TWI741355B (en) * | 2019-08-28 | 2021-10-01 | 國立清華大學 | Photoacoustic system for increasing light fluence |
| CN114271936A (en) * | 2021-12-29 | 2022-04-05 | 烟台龙驰光电技术有限公司 | Laser ablation needle capable of automatically regulating and controlling temperature |
| CN114796888A (en) * | 2022-05-25 | 2022-07-29 | 海南大学 | Portable oral treatment device and control method |
| CN117618104A (en) * | 2024-01-25 | 2024-03-01 | 广州信筑医疗技术有限公司 | Laser surgery system with intraoperative monitoring function |
| WO2024060314A1 (en) * | 2022-09-21 | 2024-03-28 | 上海超光微医疗科技有限公司 | Medical treatment device and treatment probe |
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