CN107502628A - A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity - Google Patents
A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity Download PDFInfo
- Publication number
- CN107502628A CN107502628A CN201710741021.2A CN201710741021A CN107502628A CN 107502628 A CN107502628 A CN 107502628A CN 201710741021 A CN201710741021 A CN 201710741021A CN 107502628 A CN107502628 A CN 107502628A
- Authority
- CN
- China
- Prior art keywords
- paniculate swallowwort
- paeonol
- preparation
- residue
- inflammatory activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity and its preparation method and application, comprise the steps of：1) by paniculate swallowwort residue, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtains paniculate swallowwort residue powder；2) by paniculate swallowwort residue powder, after high-temperature sterilization, black-koji mould suspension is added, fermentation 5d is carried out under the conditions of 30 DEG C；3) by the paniculate swallowwort residue powder after fermentation, add in organic solvent and stand 10h, after removing solid matter, solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.The present invention has inhibitory action to bacterium and fungi, can be controlled the oxidation balance environment of Skin Cell, so as to reach the effect of inhibiting bacteria and diminishing inflammation.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of paniculate swallowwort Paeonol and preparation with antibacterial anti-inflammatory activity
Methods and applications.
Background technology
Paniculate swallowwort, Asclepiadaceae Cynanchum herbaceos perennial is traditional Chinese medical science common drug, alias knotweed Diao Zhu, spice all over the mountain,
Compel distant bamboo, cynanchum paniculatum, leaf of bamboo asarum, to section lotus, line spices etc..This product all herbal medicine, warm-natured, acrid flavour, there are promoting qi circulation and relieving pain, wind-dispelling
The effect of wet, stopping numbness pain.
Early stage research finds that Paeonol has under 1: 15000 concentration to Escherichia coli, hay bacillus in vitro and obvious suppresses to make
With having obvious inhibiting effect, infected by influenza and Common Pathogenic skin under 1: 2000 concentration to staphylococcus aureus in vitro
Skin fungi also has inhibitory action.Jiang Gao et al. proves that Paeonol and its derivative are to tested by AGP test bacteriostatic test
Candida albicans, staphylococcus aureus, bacillus pumilus and Friedlander's bacillus 4 kinds of Gram-negative bacterias, positive bacterias
All there is obvious inhibitory action.
The research to paniculate swallowwort is concentrated mainly on component and effect at present, extracting method or patent Shen to paniculate swallowwort residue
Corresponding record is not retrieved please.
The content of the invention
Based on this, it is an object of the invention to provide a kind of paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity and preparation side
Method and application.
To achieve the above object, concrete technical scheme is as follows：
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) by paniculate swallowwort residue, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtains paniculate swallowwort residue powder；
2) by paniculate swallowwort residue powder, after high-temperature sterilization, black-koji mould suspension is added, is fermented under the conditions of 30 DEG C
5d；
3) by the paniculate swallowwort residue powder after fermentation, add in organic solvent and stand 10h, after removing solid matter, decompression
Recycling design, obtain paniculate swallowwort Paeonol.
In wherein some embodiments, the paniculate swallowwort residue is paniculate swallowwort remaining residue after water extracts.
In wherein some embodiments, the paniculate swallowwort powder in the step 1) after drying and crushing needed 50~70 mesh sieves.
In wherein some embodiments, paniculate swallowwort residue powder and the organic solvent added, solid-liquid ratio in the step 3)
For (1:20)~(1:30).
In wherein some embodiments, the organic solvent added in the step 3) is 60~80% ethanol solutions.
In wherein some embodiments, the method that solid matter is removed in the step 3) is：It is ultrasonically treated 30min,
Centrifuged under 10000r/min rotating speeds, obtain supernatant, be repeated 2 times, merge supernatant.
Present invention also offers the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity according to obtained by above-mentioned preparation method.
Present invention also offers application of the above-mentioned paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity in cosmetics are prepared.
In wherein some embodiments, the State of cosmetics includes cream, emulsion, aqua.
Present invention also offers a kind of aroma calm relaxing bath and shower cream, the component of following mass percent is included：It is above-mentioned that there is antibacterial resist
The paniculate swallowwort Paeonol 0.1~10% of scorching activity, laureth sodium sulfovinate 1~3%, laruyl alcohol phosphate potassium 1~5%,
Cocoamidopropyl betaine 5~15%, polyvinyl alcohol 1~5%, sodium lauroyl sarcosine 1~5%, Dodecyl Polyglucosides 1
~5%, glycol distearate 0.1~5%, panthenol 1~5%, guar gum 0.5~1.5%, Phenoxyethanol 0.3~
0.7%th, sodium chloride 3~5%, citric acid 0.05~0.2%, methyl hydroxybenzoate 0.1~0.3%, EDETATE SODIUM 0.05~0.15%,
Deionized water surplus.
It is the device have the advantages that as follows：The present invention, which is largely tested by inventor, and experience is preferred prepares
The various conditions of method, the preparation method optimized, make full use of paniculate swallowwort residue to carry out secondary operation, effectively avoid providing
The waste in source；The paniculate swallowwort Paeonol obtained using preparation method of the present invention, content is high, and properties of product are stable, can add
In a variety of skin-protection products, such as cream, emulsion, aqua.The present invention has inhibitory action to bacterium and fungi, and skin can be made thin
The oxidation balance environment of born of the same parents is controlled, and preferably plays antibacterial action；And can enough reduces capillary permeability simultaneously, presents
Go out stronger antiinflammatory action, so as to reach the effect of inhibiting bacteria and diminishing inflammation.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated：
All the components appeared in text are INCI (International Nomenclature Cosmetic
Ingredient), i.e., international cosmetic raw material is obviously said to its defined title.
Embodiment 1
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) remaining paniculate swallowwort residue after water is extracted, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtained 60 mesh sieve paniculate swallowworts
Residue powder；
2) the paniculate swallowwort residue powder of 60 mesh sieves will be crossed, after high-temperature sterilization, black-koji mould suspension is added, under the conditions of 30 DEG C
Carry out fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 1:10h is stood in 25 70% ethanol solutions of addition, is surpassed
Centrifuged under sonication 30min, 10000r/min rotating speed, obtain supernatant, be repeated 2 times, merge supernatant；After removing solid matter,
Solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
Embodiment 2
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) remaining paniculate swallowwort residue after water is extracted, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtained 50 mesh sieve paniculate swallowworts
Residue powder；
2) the paniculate swallowwort residue powder of 50 mesh sieves will be crossed, after high-temperature sterilization, black-koji mould suspension is added, under the conditions of 30 DEG C
Carry out fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 1:10h is stood in 30 60% ethanol solutions of addition, is surpassed
Centrifuged under sonication 30min, 10000r/min rotating speed, obtain supernatant, be repeated 2 times, merge supernatant；After removing solid matter,
Solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
Embodiment 3
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：1) water is extracted
Remaining paniculate swallowwort residue afterwards, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtained 70 mesh sieve paniculate swallowwort residue powder；
2) the paniculate swallowwort residue powder of 70 mesh sieves will be crossed, after high-temperature sterilization, black-koji mould suspension is added, under the conditions of 30 DEG C
Carry out fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 15:10h is stood in 30 80% ethanol solutions of addition,
30min is ultrasonically treated, is centrifuged under 10000r/min rotating speeds, is obtained supernatant, be repeated 2 times, merges supernatant；Remove solid matter
Afterwards, solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
Comparative example 1
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) remaining paniculate swallowwort residue after water is extracted, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtained 80 mesh sieve paniculate swallowworts
Residue powder；
2) the paniculate swallowwort residue powder of 80 mesh sieves will be crossed, after high-temperature sterilization, black-koji mould suspension is added, under the conditions of 30 DEG C
Carry out fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 10:10h is stood in 36 50% ethanol solutions of addition,
30min is ultrasonically treated, is centrifuged under 10000r/min rotating speeds, is obtained supernatant, be repeated 2 times, merges supernatant；Remove solid matter
Afterwards, solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
Comparative example 2
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) remaining paniculate swallowwort residue after water is extracted, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtained 60 mesh sieve paniculate swallowworts
Residue powder；
2) the paniculate swallowwort residue powder of 60 mesh sieves will be crossed, after high-temperature sterilization, mould bacteria suspension is added, enters under the conditions of 30 DEG C
Row fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 1:10h is stood in 25 70% ethanol solutions of addition, is surpassed
Centrifuged under sonication 30min, 10000r/min rotating speed, obtain supernatant, be repeated 2 times, merge supernatant；After removing solid matter,
Solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
Comparative example 3
A kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, is comprised the steps of：
1) remaining paniculate swallowwort residue after water is extracted, it is placed in 60 DEG C of baking ovens and dry, pulverize, obtained 30 mesh sieve paniculate swallowworts
Residue powder；
2) the paniculate swallowwort residue powder of 30 mesh sieves will be crossed, after high-temperature sterilization, black-koji mould suspension is added, under the conditions of 30 DEG C
Carry out fermentation 5d；
3) by the paniculate swallowwort residue powder after fermentation, according to solid-liquid ratio 3:8h is stood in 15 45% ethanol solutions of addition, is surpassed
Centrifuged under sonication 30min, 10000r/min rotating speed, obtain supernatant, be repeated 2 times, merge supernatant；After removing solid matter,
Solvent is recovered under reduced pressure, obtains paniculate swallowwort Paeonol.
As a result：Embodiment 1-3 and comparative example 1-3 preparation condition obtain the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity
Content such as table 1 below.
From the data of table 1：What is obtained under embodiment 1-3 preparation condition has the paniculate swallowwort root bark of tree peony of antibacterial anti-inflammatory activity
What the content of phenol was substantially obtained under the preparation condition than comparative example 1-3 has the content of the paniculate swallowwort Paeonol of antibacterial anti-inflammatory activity
It is substantially higher；Comparative example 2 is in addition to the Penicillium notatum that step 2 adds, and other preparation conditions are same as Example 1, but Comparative result
The content that example 2 obtains paniculate swallowwort Paeonol is significantly lower than embodiment 1, illustrates the aspergillus niger strain added, can effectively improve Xu
The recovery rate of long minister in ancient times's Paeonol.
The paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity prepared under the preparation condition of embodiment 1 is applied to shower
In dew, table 2 specific as follows.
Table 2
The crowd of 50 inflammation skin is selected to try out shower cream obtained above, it is desirable to which experimenter is daily using above-mentioned
Shower cream, usage time are one month, carry out self-appraisal to product effect at the 30th day, as a result have 45 trier's inflammation skin to fully recover from an illness
More, and think shower cream can effective antibacterial anti-inflammatory, maintain the health status of skin, there are 4 application on human skin states to tend to improve, small wound
Face is repaired, and has 1 people, without significant change, to illustrate that the paniculate swallowwort Paeonol prepared by embodiment 1 is being made up using rear skin
Also good antibacterial anti-inflammatory effect can be played in product.
In order to further verify bacteriostasis efficacy, using following experiment：
Method：Disk diffusion method；
Step：(1) it is the molten of 0.5mol/ml the paniculate swallowwort Paeonol that the preparation condition of embodiment 1 obtains to be configured into concentration
Liquid, the shower cream dilution of above-mentioned preparation are standby；Cultured Escherichia coli, staphylococcus aureus, bacillus subtilis,
Unusual denaturation bacillus, pseudomonas aeruginosa are standby；(2) that No. 1 qualitative filter paper of Xinhua is made into circular filter paper piece with card punch is (straight
Footpath 6mm), then put into the flat board of clean dried, after 120 DEG C of dry roasting 20min, choose the sterilized filter paper of right quantity
8h is soaked in above-mentioned stock solution, obtains the antibacterial scraps of paper；(3) bacterium solution prepared is drawn with cotton swab, even spread is seeded in M-H
Agar-agar surface, cover plate device, drying at room temperature 5min；(4) 3 Antibiotic discs and 1 process are taken respectively with aseptic nipper
The filter paper that 75% ethanol soaked is affixed on the test bacterium agar-agar being inoculated with, and after posting the scraps of paper, flat board room temperature places 15min,
12-18h is cultivated at 37 DEG C；(5) inhibition zone diameter D (mm) including scraps of paper diameter is measured from the back side with ruler, repeats 3
It is secondary, as a result such as table 3 below.
Table 3
From the data analysis of table 3：Paniculate swallowwort Paeonol has excellent fungistatic effect, is applied in shower cream
In, it can also play significant fungistatic effect.From the data analysis of antibacterial circle diameter in table 3, the antibacterial circle diameter of shower cream is than Xu
Long minister in ancient times's Paeonol antibacterial circle diameter is somewhat small, and, because after shower cream dilution, the concentration of the paniculate swallowwort Paeonol contained reduces for this, but
The bacteriostasis efficacy for not influenceing to evaluate shower cream is evaluated.
Above example only shows several embodiments of the present invention, therefore its description is more specific and detailed, but can not be
And it is interpreted as the limitation scope to patent of the present invention.It should be noted that：It is any to be engaged in professional and technical personnel, all have the ability
Using the technology contents having revealed that, some are made to it and changes or modifies, turns into the equivalent embodiment of equivalent variations.According to this hair
Bright technical spirit, simple modification, equivalent change and modification is carried out to the present invention, belonged in the range of technical solution of the present invention.
Claims (10)
1. a kind of preparation method of the paniculate swallowwort Paeonol with antibacterial anti-inflammatory activity, it is characterised in that comprise the steps of：
1) by paniculate swallowwort residue, it is placed in 45 DEG C of baking ovens and dry, pulverize, obtains paniculate swallowwort residue powder；
2) by paniculate swallowwort residue powder, after high-temperature sterilization, black-koji mould suspension is added, fermentation 5d is carried out under the conditions of 30 DEG C；
3) by the paniculate swallowwort residue powder after fermentation, add in organic solvent and stand 10h, after removing solid matter, be recovered under reduced pressure
Solvent, obtain paniculate swallowwort Paeonol.
2. preparation method according to claim 1, it is characterised in that the paniculate swallowwort residue is that paniculate swallowwort extracts by water
Remaining residue afterwards.
3. preparation method according to claim 1, it is characterised in that in step 1), the paniculate swallowwort powder after drying and crushing
Needed 50~70 mesh sieves.
4. preparation method according to claim 1, it is characterised in that in step 3), paniculate swallowwort residue powder and addition
Organic solvent, solid-liquid ratio are (1:20)~(1:30).
5. preparation method according to claim 1, it is characterised in that in step 3), the organic solvent of addition for 60~
80% ethanol solution.
6. preparation method according to claim 1, it is characterised in that in step 3), the method for removing solid matter is：It is super
Centrifuged under sonication 30min, 10000r/min rotating speed, obtain supernatant, be repeated 2 times, merge supernatant.
7. according to the paniculate swallowwort root bark of tree peony with antibacterial anti-inflammatory activity obtained by any one of claim 1~6 preparation method
Phenol.
8. application of the paniculate swallowwort Paeonol according to claim 7 with antibacterial anti-inflammatory activity in cosmetics are prepared.
9. application of the paniculate swallowwort Paeonol according to claim 7 with antibacterial anti-inflammatory activity in cosmetics are prepared,
Characterized in that, the State of cosmetics includes cream, emulsion, aqua.
10. a kind of aroma calm relaxing bath and shower cream, it is characterised in that the aroma calm relaxing bath and shower cream includes the component of following mass percent：Right
It is required that described in 7 have antibacterial anti-inflammatory activity paniculate swallowwort Paeonol 0.1~10%, laureth sodium sulfovinate 1~3%,
Laruyl alcohol phosphate potassium 1~5%, Cocoamidopropyl betaine 5~15%, polyvinyl alcohol 1~5%, sodium lauroyl sarcosine 1
~5%, Dodecyl Polyglucosides 1~5%, glycol distearate 0.1~5%, panthenol 1~5%, guar gum 0.5~
1.5%th, Phenoxyethanol 0.3~0.7%, sodium chloride 3~5%, citric acid 0.05~0.2%, methyl hydroxybenzoate 0.1~0.3%,
EDETATE SODIUM 0.05~0.15%, deionized water surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710741021.2A CN107502628A (en) | 2017-08-25 | 2017-08-25 | A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710741021.2A CN107502628A (en) | 2017-08-25 | 2017-08-25 | A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107502628A true CN107502628A (en) | 2017-12-22 |
Family
ID=60693426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710741021.2A Withdrawn CN107502628A (en) | 2017-08-25 | 2017-08-25 | A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107502628A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111116422A (en) * | 2019-12-30 | 2020-05-08 | 西南大学 | Paeonol etherified urea compound with anti-inflammatory activity and application thereof |
| CN111840171A (en) * | 2020-08-26 | 2020-10-30 | 王鹏 | Cynanchum paniculatum essence and preparation method thereof |
| CN113545994A (en) * | 2021-06-16 | 2021-10-26 | 广州艾卓生物科技股份有限公司 | Plant source composite bacteriostatic agent and application thereof |
| CN116350563A (en) * | 2023-05-12 | 2023-06-30 | 广东迪美新材料科技有限公司 | Plant co-fermentation composition and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005015472A (en) * | 2003-06-02 | 2005-01-20 | Nippon Menaade Keshohin Kk | Melanin expression-enhancer |
| CN1947776A (en) * | 2006-10-10 | 2007-04-18 | 刘良韡 | External use traditional Chinese medicien for treating infantile eczema and dermatitis and cosmetics therewith |
| CN105801392A (en) * | 2016-04-14 | 2016-07-27 | 重庆大学 | Extracting method of 2'-hydroxy-4'-methoxyacetopheone |
-
2017
- 2017-08-25 CN CN201710741021.2A patent/CN107502628A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005015472A (en) * | 2003-06-02 | 2005-01-20 | Nippon Menaade Keshohin Kk | Melanin expression-enhancer |
| CN1947776A (en) * | 2006-10-10 | 2007-04-18 | 刘良韡 | External use traditional Chinese medicien for treating infantile eczema and dermatitis and cosmetics therewith |
| CN105801392A (en) * | 2016-04-14 | 2016-07-27 | 重庆大学 | Extracting method of 2'-hydroxy-4'-methoxyacetopheone |
Non-Patent Citations (3)
| Title |
|---|
| 王立红等: "超临界CO2 萃取徐长卿中丹皮酚的工艺", 《沈阳药科大学学报》 * |
| 邵作敏: "牡丹皮中丹皮酚提取工艺优化及药理作用的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 雷学军: "丹皮酚的提取及其在化妆品中的应用", 《香料香精化妆品》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111116422A (en) * | 2019-12-30 | 2020-05-08 | 西南大学 | Paeonol etherified urea compound with anti-inflammatory activity and application thereof |
| CN111840171A (en) * | 2020-08-26 | 2020-10-30 | 王鹏 | Cynanchum paniculatum essence and preparation method thereof |
| CN113545994A (en) * | 2021-06-16 | 2021-10-26 | 广州艾卓生物科技股份有限公司 | Plant source composite bacteriostatic agent and application thereof |
| CN113545994B (en) * | 2021-06-16 | 2022-09-16 | 广州艾卓生物科技股份有限公司 | Plant source composite bacteriostatic agent and application thereof |
| CN116350563A (en) * | 2023-05-12 | 2023-06-30 | 广东迪美新材料科技有限公司 | Plant co-fermentation composition and preparation method and application thereof |
| CN116350563B (en) * | 2023-05-12 | 2023-08-04 | 广东迪美新材料科技有限公司 | Plant co-fermentation composition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107502628A (en) | A kind of paniculate swallowwort Paeonol and preparation method and application with antibacterial anti-inflammatory activity | |
| CN103432047B (en) | Natural preservative composition and application thereof in cosmetics | |
| CN103040718A (en) | Anti-corrosion composition, preparation method thereof and cosmetic | |
| CN101692837A (en) | Pure Chinese medicine disinfectant and process for preparing same | |
| Verma et al. | Evaluation of antibacterial activity of different parts of Tagetes erecta | |
| CN106109367A (en) | A kind of toothpaste with antibacterial action containing bamboo leaf flavone and preparation method thereof | |
| CN103913564A (en) | Method for testing bacteriostatic activity of spire wampee extractive | |
| CN102440937A (en) | Healthcare wet tissue with antimicrobial and anti-acne functions | |
| CN106420466A (en) | Plant bacteriostatic composition and application thereof in daily necessities | |
| CN107737070A (en) | Sterilization, skin care hand cleaning liquid | |
| CN106726758A (en) | A kind of sedge volatile oil and its application | |
| CN108498436A (en) | A kind of skin care bacteriostatic hand sanitizer and preparation method thereof | |
| CN104523538A (en) | Preparation method for mask containing loach synovia | |
| CN105602768A (en) | Prinsepia utilis royle soap and preparation method thereof | |
| CN109097216B (en) | Prickly ash bacteriostatic soap and preparation method thereof | |
| CN104622732B (en) | A kind of hair washing for child water containing natural plant preservative | |
| CN110402969A (en) | A kind of environmental type plant source thimerosal | |
| CN107375025A (en) | A kind of anti-acne toner and preparation method thereof | |
| Das et al. | Evaluation of in-vitro antibacterial potential of ripe fruits of Aegle marmelos | |
| CN106038398A (en) | Method for preparing cortex phellodendri extract and application of cortex phellodendri extract composition prepared from cortex phellodendri extract in bacteriostatic agent | |
| TWI655000B (en) | Body health care material composition, method of producing the same, and use thereof | |
| CN109939022A (en) | A kind of plant bacteriostatic skin-care composition | |
| CN108553571A (en) | One kind is based on pure plant extraction type skin antiseptic and preparation method thereof | |
| CN108379349A (en) | Antibacterial anti-inflammatory oral cavity flushing washing lotion and its preparation method and application | |
| CN107440965A (en) | A kind of deep layer purifies mildy wash |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20171222 |
|
| WW01 | Invention patent application withdrawn after publication |