CN107502488A - Preparation method of antibiotic skin-care soap and products thereof - Google Patents
Preparation method of antibiotic skin-care soap and products thereof Download PDFInfo
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- CN107502488A CN107502488A CN201710667634.6A CN201710667634A CN107502488A CN 107502488 A CN107502488 A CN 107502488A CN 201710667634 A CN201710667634 A CN 201710667634A CN 107502488 A CN107502488 A CN 107502488A
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- soap
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/02—Compositions of detergents based essentially on soap on alkali or ammonium soaps
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/06—Inorganic compounds
- C11D9/08—Water-soluble compounds
- C11D9/10—Salts
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/225—Polymers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of preparation method of antibiotic skin-care soap, including the preparation of multi function shell glycan and its derivates nanometer grain and the preparation of antibiotic skin-care soap.Its antibacterial mechanisms is to utilize chitosan/metal ion composite antibacterial performance, and this organic/inorganic complex antimicrobials possess excellent broad spectrum antibacterial, the bacteriostatic activity of various pathogens is greatly improved;Its skin care principle is to utilize hyaluronic acid and nano effect, absorption of the increase active component in human body.Soap sample is made as the additive of soap in this multifunctional nano grain by hyaluronic acid decorated chitosan nano and complexing of metal ion by the preparation method of the antibiotic skin-care soap.The technology preparation method is simple, the product of the properties of product of gained apparently higher than existing market.
Description
Technical field
The present invention relates to preparation method of antibiotic skin-care soap and products thereof, belong to the preparation field of high polymer material.
Background technology
The basic function of soap is cleaning washing, and soil dirt, skin secretion, row are certainly removed above skin
Let out thing, chemical substance or bacterium etc..In the today for stressing cosmetic result, cosmetics, skin care products or the medicine of removing skin surface
Thing is also one of its main purposes.Therefore, feature soap continuously emerges, for example, the baby for adding advanced skin-protecting factor is fragrant
Soap;In order to sterilize and cure the boric acid of superficial part mould, the sulfur soap of parasite addition sulphur and addition boric acid for disinfection
Bath soap product;The perfumed soap of mosquito repellent is to use Chinese medicine mosquito repellent composition, is extracted through high concentration, is incorporated among soap base, can reach mosquito repellent effect
Fruit.Wherein, antimicrobial soap have received most concerns.Particularly, American-European disabling in 2016 contains triclosan and triclocarban etc.
Antibacterial soaps, the hand cleanser of composition, because it easily causes disease risks.In addition, as people are thin to the abuse of antibiotic, drug resistance
The quick generation of bacterium, have to common antibiotics natural resistance multidrug resistant pathogen continue to occur have become one and urgently solve
Certainly the problem of.Some lethal bacterias such as methicillin-resistant Staphylococcus aureus, to conventional antibiotic such as first
Oxygen benzopenicillin, aminoglycosides, macrolides, tetracycline, chloramphenicol, vancomycin and lincosamides produce
Drug resistance.The drawbacks of these all allow increasing people to recognize to utilize tradition antibacterial, people are also promoted to pay close attention to include
The development and utilization of green antibacterial agent including natural material, inorganic material.
The content of the invention
For deficiency of the prior art, present invention aims at:A kind of preparation method of antibiotic skin-care soap is provided, its
To there is the chitosan of broad spectrum antibacterial performance/metal ion nano-complex to be prepared as additive.
Another object of the present invention is:The product that above-mentioned preparation method obtains is provided.
The object of the invention is realized by following proposal:A kind of preparation method of antibiotic skin-care soap, including soap preparing process and
Following steps:
(1)The preparation of multi function shell glycan and its derivates nanometer grain
A, 8 ~ 10 parts of Chitosan-phospholipid complex are added in 4 ~ 5 parts of acetic acid solution dissolve it is standby;By 4 ~ 5 parts of tripolyphosphates
The deionized water dissolving that sodium is added to 4 ~ 5 parts is standby;1 ~ 2 part of sodium tripolyphosphate solution is slowly dropped to 4 ~ 5 parts of chitosan
In solution, stir at least 30 minutes and form Chitosan-phospholipid complex nano-particle, then rotating speed centrifuges more than 10000 turns,
Separate out thing again in freeze dryer freeze obtain Chitosan-phospholipid complex nanoparticle powder;
B, 8 ~ 10 parts of Chitosan-phospholipid complex nano-particles are dispersed in 4 ~ 5 parts of deionized waters, 1 ~ 2 part of crosslinking agent of addition,
0.5 ~ 1 part of Sodium Hyaluronate, after stirring at least 12 hours, rotating speed centrifuges more than 10000 turns, separates out thing and freezes again in freeze dryer
It is dry to obtain hyaluronic acid decorated Chitosan-phospholipid complex nanoparticle powder;
C, 8 ~ 10 parts of above-mentioned nanoparticle powders are dispersed in 10 parts of deionized waters, add 1 ~ 2 part of metal ion compound,
Stirring at least 10 hours after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain multi function shell glycan
And its derivates nanometer grain;
(2)The preparation of antibiotic skin-care soap
By 36 parts of soap fat heating, stir;Add 2 parts of organic bases, 5 parts of deionized waters, mass percent is 0.1~
3.5% multi function shell glycan and its derivates nanometer grain, is stirred continuously, to soap lye into thick;Deployed soap base material is squeezed into
Vacuum drying cabinet, through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
The present invention first prepares chitosan nano, then by surface modification hyaluronic acid, then with complexing of metal ion;By this
Soap is made as the additive of soap in kind multifunctional nano grain, so as to obtain antibiotic skin-care soap.The antibacterial shield of the present invention
Skin soap has antibacterial, the effect of whitening.
The present invention utilizes the broad spectrum antibacterial performance of chitosan/metal ion complex, and hyaluronic acid and nano material
Skin care principle, effectively increase absorption of the active component in human body.This organic/inorganic complex antimicrobials possess excellent wide
Antibiotic property is composed, the bacteriostatic activity of various pathogens is greatly improved;Preparation method of the present invention is simple, the properties of product of gained
Apparently higher than the product of existing market.
On the basis of such scheme, described Chitosan-phospholipid complex is chitosan, carboxyl chitosan, sulfonation shell gather
One kind in sugar, hydroxylating chitosan, chitosan quaternary amine, carboxymethyl chitosan, carboxyetbyl chitosan and carboxylic propyl group chitosan
And combinations thereof.
On the basis of such scheme, described crosslinking agent is tetraisocyanate, propane diamine, polyethylene glycol, polypropylene glycol, three
Hydroxymethyl-propane, polypropylene glycol glycidol ether, a- methyl styrenes, acrylonitrile, acrylic acid, methacrylic acid, glyoxal, just
Silester, methyl silicate, trimethoxy silane, p-methyl benzenesulfonic acid, paratoluensulfonyl chloride, diacrylate-BDO
Ester, GDMA, butyl acrylate, cumyl peroxide, peroxidating double 2,4 one dichloro-benzoyls, third
Olefin(e) acid, hydroxy-ethyl acrylate, hydroxypropyl acrylate, methacrylic acid, hydroxyethyl methacrylate, hydroxy propyl methacrylate,
One kind in divinylbenzene, N hydroxymethyl acrylamide, DAAM and combinations thereof.
On the basis of such scheme, described metal ion compound is copper sulphate, zinc sulfate, zinc chloride, copper chloride, nitre
One kind in sour zinc, silver nitrate and combinations thereof.
Described soap fat is at least two kinds in sesame oil, palmolive oil, olive oil and fractional oil of haw kernel.
Described organic base is triethylamine, N, N dimethyl aniline, disodium ethylene diamine tetraacetate, monoethanolamine, diethanol amine,
One kind in caustic alcohol and combinations thereof.
The present invention provides a kind of antibiotic skin-care soap obtained according to any of the above-described preparation method.Not only to a variety of causes
The bacteriostatic activity of germ greatly improves, and utilizes hyaluronic acid and nano effect, and increase active component is in human body
Absorb.
Compared with prior art, the present invention has following beneficial effect:
The advantage of the invention is that:(1)The antibiotic skin-care soap of the present invention, not only can be to the bacteriostatic activities of various pathogens all
Greatly improve, and hyaluronic acid and nano effect can be utilized, absorption of the increase active component in human body.(2)This hair
Bright preparation method is simple, the product of the properties of product of gained apparently higher than existing market.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
Embodiment 1
(1)The preparation of multi-functional chitosan nano
A, 8 parts of chitosans are added in 5 parts of acetic acid solutions, stir 1 hour;5 parts of sodium tripolyphosphates are added to 4 parts
In ionized water, stir 45 minutes.2 parts of sodium tripolyphosphate solutions are slowly dropped in 4 parts of chitosan solution, stirred 30 minutes
Form chitin nanometer.Then more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain chitosan
Nanoparticle powder.
B, 10 parts of chitin nanometers are dispersed in 4 parts of deionized waters, 2 parts of polypropylene glycol glycidol ethers of addition,
0.5 part of Sodium Hyaluronate, after stirring at least 12 hours, rotating speed centrifuges more than 10000 turns, separates out thing and is freezed again in freeze dryer
Obtain hyaluronic acid decorated chitosan nano powder.
C, 10 parts of above-mentioned nanoparticle powders are dispersed in 10 parts of deionized waters, add 2 parts of zinc sulfate, stirring at least 10
Hour after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain multi-functional chitosan nano.
(2)The preparation of antibiotic skin-care soap
By 8 parts of sesame oil, 10 parts of palmolive oil, 12 parts of olive oil, 6 parts of fractional oil of haw kernel, heating, stir.Add 2 part of three second
Amine, 5 parts of deionized waters, 1% multi-functional chitosan nano, it is stirred continuously, to soap lye into thick;Deployed soap base material is beaten
Enter vacuum drying cabinet, through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
Testing result:Antibiotic rate 96%.
Embodiment 2
(1)The preparation of polyfunctional hydroxy chitosan nano
A, 9 parts of hydroxylating chitosans are added in 5 parts of acetic acid solutions, stir 1 hour;5 parts of sodium tripolyphosphates are added to 5
In the deionized water of part, stir 45 minutes.2 parts of sodium tripolyphosphate solutions are slowly dropped to 5 parts of hydroxylating chitosan solution
In, stir 30 minutes and form hydroxylating chitin nanometer.Then rotating speed centrifuges more than 10000 turns, separates out thing and is freezing again
Freezed in dry machine and obtain hydroxylating chitosan nano powder.
B, 10 parts of hydroxylating chitin nanometers are dispersed in 5 parts of deionized waters, add 2 parts of glyoxals, 1 part it is transparent
Matter acid sodium, stirring at least 12 hours after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain it is transparent
The hydroxylating chitosan nano powder of matter acid modification.
C, 10 parts of above-mentioned nanoparticle powders are dispersed in 5 parts of deionized waters, add 2 parts of copper chlorides, stirring at least 10
Hour after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain polyfunctional hydroxy chitosan nano
Grain.
(2)The preparation of antibiotic skin-care soap
By 10 parts of sesame oil, 14 parts of palmolive oil, 12 parts of olive oil, heating, stir.2 parts of disodium ethylene diamine tetraacetates are added,
5 parts of deionized waters, 3% polyfunctional hydroxy chitosan nano, are stirred continuously, to soap lye into thick;Deployed soap base material
Vacuum drying cabinet is squeezed into, through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
Testing result:Antibiotic rate 90%.
Embodiment 3
(1)The preparation of multi-functional nanometer carboxymethyl chitosan particle
A, 10 parts of hydroxylating chitosans are added in 4 parts of acetic acid solutions, stir 1 hour;5 parts of sodium tripolyphosphates are added to
In 4 parts of deionized water, stir 45 minutes.It is molten that 1.5 parts of sodium tripolyphosphate solutions are slowly dropped to 5 parts of carboxymethyl chitosan
In liquid, stir 30 minutes and form carboxymethyl chitosan nanoparticles.Then rotating speed centrifuges more than 10000 turns, separates out thing and exists again
Freezed in freeze dryer and obtain nanometer carboxymethyl chitosan particle powder.
B, 10 parts of carboxymethyl chitosan nanoparticles are dispersed in 5 parts of deionized waters, add 2 parts of acrylic acid, 1 part it is transparent
Matter acid sodium, stirring at least 12 hours after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain it is transparent
The nanometer carboxymethyl chitosan particle powder of matter acid modification.
C, 10 parts of above-mentioned nanoparticle powders are dispersed in 5 parts of deionized waters, add 2 parts of silver nitrates, stirring at least 10
Hour after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain multi-functional carboxymethyl chitosan nanometer
Grain.
(2)The preparation of antibiotic skin-care soap
By 8 parts of sesame oil, 10 parts of palmolive oil, 12 parts of olive oil, 6 parts of fractional oil of haw kernel, heating, stir.Add 2 parts of N, N
Dimethylaniline, 5 parts of deionized waters, 3% multi-functional nanometer carboxymethyl chitosan particle, it is stirred continuously, to soap lye into thick;Adjust
The soap base material prepared squeezes into vacuum drying cabinet, and through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
Testing result:Antibiotic rate 99%.
Embodiment 4
(1)The preparation of multi-functional sulfated chitosan nanoparticle
A, 8 parts of sulfated chitosans are added in 5 parts of acetic acid solutions, stir 1 hour;4 parts of sodium tripolyphosphates are added to 5 parts
Deionized water in, stir 45 minutes.2 parts of sodium tripolyphosphate solutions are slowly dropped in 4 parts of sulfated chitosan solution, stirred
Mix 30 minutes and form sulfated chitosan nano-particle.Then rotating speed centrifuges more than 10000 turns, separates out thing and freezes again in freeze dryer
It is dry to obtain sulfated chitosan nanoparticle powder.
B, 9 parts of sulfated chitosan nano-particles are dispersed in 5 parts of deionized waters, add 2 parts of glyoxals, 1 part of hyalomitome
Sour sodium, stirring at least 12 hours after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain hyalomitome
The sulfated chitosan nanoparticle powder of acid modification.
C, 10 parts of above-mentioned nanoparticle powders are dispersed in 10 parts of deionized waters, add 2 parts of zinc chloride, stirring at least 10
Hour after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain multi-functional sulfated chitosan nanometer
Grain.
(2)The preparation of antibiotic skin-care soap
By 8 parts of sesame oil, 10 parts of palmolive oil, 12 parts of olive oil, 6 parts of fractional oil of haw kernel, heating, stir.Add 2 parts of ethanol
Sodium, 5 parts of deionized waters, 1.5% multi-functional sulfated chitosan nanoparticle, it is stirred continuously, to soap lye into thick;Deployed soap
Base-material squeezes into vacuum drying cabinet, and through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
Testing result:Antibiotic rate 99%.
Claims (8)
1. a kind of preparation method of antibiotic skin-care soap, including soap preparing process, are characterised by:Also comprise the following steps:
(1)The preparation of multi function shell glycan and its derivates nanometer grain
A, 8 ~ 10 parts of Chitosan-phospholipid complex are added in 4 ~ 5 parts of acetic acid solution dissolve it is standby;By 4 ~ 5 parts of tripolyphosphates
The deionized water dissolving that sodium is added to 4 ~ 5 parts is standby, and 1 ~ 2 part of sodium tripolyphosphate solution is slowly dropped to 4 ~ 5 parts of chitosan
In solution, stir at least 30 minutes and form Chitosan-phospholipid complex nano-particle, then rotating speed centrifuges more than 10000 turns,
Separate out thing again in freeze dryer freeze obtain Chitosan-phospholipid complex nanoparticle powder;
B, 8 ~ 10 parts of Chitosan-phospholipid complex nano-particles are dispersed in 4 ~ 5 parts of deionized waters, 1 ~ 2 part of crosslinking agent of addition,
0.5 ~ 1 part of Sodium Hyaluronate, after stirring at least 12 hours, rotating speed centrifuges more than 10000 turns, and the product of centrifugation is freezing again
Freezed in dry machine and obtain hyaluronic acid decorated Chitosan-phospholipid complex nanoparticle powder;
C, 8 ~ 10 parts of above-mentioned nanoparticle powders are dispersed in 10 parts of deionized waters, add 1 ~ 2 part of metal ion compound,
Stirring at least 10 hours after, more than 10000 turns rotating speed centrifuge, separate out thing again in freeze dryer freeze obtain multi function shell glycan
And its derivates nanometer grain;
(2)The preparation of antibiotic skin-care soap
36 parts of soap fat is heated, stirring;2 parts of organic bases, 5 parts of deionized waters are added, soap mass percent is 0.1~3.5%
Multi function shell glycan and its derivates nanometer grain, be stirred continuously, to soap lye into thick;Deployed soap base material squeezes into vacuum
Hothouse, through extruding, cutting into neat soap, shaping, stripping and slicing are into soap.
2. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described chitosan and its spread out
Biology is chitosan, carboxyl chitosan, sulfated chitosan, hydroxylating chitosan, chitosan quaternary amine, carboxymethyl chitosan, carboxylic
Ethyl chitosan and one kind in carboxylic propyl group chitosan or its combination.
3. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described crosslinking agent is four different
Cyanate, propane diamine, polyethylene glycol, polypropylene glycol, trimethylolpropane, polypropylene glycol glycidol ether, a- methyl styrenes,
Acrylonitrile, acrylic acid, methacrylic acid, glyoxal, tetraethyl orthosilicate, methyl silicate, trimethoxy silane, to toluene sulphur
Acid, paratoluensulfonyl chloride, diacrylate-BDO ester, GDMA, butyl acrylate, peroxidating
Diisopropylbenzene (DIPB), double 2,4 one dichloro-benzoyls of peroxidating, acrylic acid, hydroxy-ethyl acrylate, hydroxypropyl acrylate, methacrylic acid,
Hydroxyethyl methacrylate, hydroxy propyl methacrylate, divinylbenzene, N hydroxymethyl acrylamide, DAAM
In one or more kinds of compositions.
4. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described metal ion chemical combination
Thing is one or more than one kinds of combinations in copper sulphate, zinc sulfate, zinc chloride, copper chloride, zinc nitrate, silver nitrate.
5. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described multi function shell glycan
And its derivates nanometer grain.
6. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described soap fat is sesame oil, palm fibre
Two or more mixture in olive oil, olive oil and fractional oil of haw kernel.
7. the preparation method of antibiotic skin-care soap according to claim 1, it is characterised in that described organic base is three second
Amine, N, N dimethyl aniline, disodium ethylene diamine tetraacetate, one kind in monoethanolamine, diethanol amine, caustic alcohol and combinations thereof.
A kind of 8. antibiotic skin-care soap being prepared according to any methods describeds of claim 1-7.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108531318A (en) * | 2018-07-21 | 2018-09-14 | 安溪县凤城建金产品外观设计服务中心 | A kind of preparation process of the soap containing paris polyphylla extract |
CN108559669A (en) * | 2018-03-28 | 2018-09-21 | 中华全国供销合作总社昆明食用菌研究所 | A kind of bacteria inhibiting composition and the preparation method and application thereof |
CN109463952A (en) * | 2018-08-31 | 2019-03-15 | 陈小初 | A kind of preparation method of health care straw mat |
CN114028301A (en) * | 2021-12-28 | 2022-02-11 | 山东中大药业有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
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CN102423291A (en) * | 2011-12-30 | 2012-04-25 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof |
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CN1559433A (en) * | 2004-02-17 | 2005-01-05 | 浙江大学 | Polyhexose type nanometer antimicrobial matter, prepn. method and use thereof |
CN1644669A (en) * | 2004-12-20 | 2005-07-27 | 林荣业 | Chitin soap |
CN102423291A (en) * | 2011-12-30 | 2012-04-25 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibiotic skincare hand cleanser and preparation method thereof |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108559669A (en) * | 2018-03-28 | 2018-09-21 | 中华全国供销合作总社昆明食用菌研究所 | A kind of bacteria inhibiting composition and the preparation method and application thereof |
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CN109463952A (en) * | 2018-08-31 | 2019-03-15 | 陈小初 | A kind of preparation method of health care straw mat |
CN114028301A (en) * | 2021-12-28 | 2022-02-11 | 山东中大药业有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
CN114028301B (en) * | 2021-12-28 | 2023-08-22 | 山东中大药业有限公司 | No-wash antibacterial hand sanitizer and preparation method thereof |
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