CN107496927A - A kind of pharmaceutical composition - Google Patents
A kind of pharmaceutical composition Download PDFInfo
- Publication number
- CN107496927A CN107496927A CN201710941277.8A CN201710941277A CN107496927A CN 107496927 A CN107496927 A CN 107496927A CN 201710941277 A CN201710941277 A CN 201710941277A CN 107496927 A CN107496927 A CN 107496927A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- acid
- weight
- parts
- source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 36
- 241000206575 Chondrus crispus Species 0.000 claims abstract description 41
- 229930091371 Fructose Natural products 0.000 claims abstract description 35
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 35
- 239000005715 Fructose Substances 0.000 claims abstract description 34
- 229920000881 Modified starch Polymers 0.000 claims abstract description 33
- 239000002253 acid Substances 0.000 claims abstract description 22
- 239000003513 alkali Substances 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 29
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 27
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 26
- 235000015165 citric acid Nutrition 0.000 claims description 25
- 150000002500 ions Chemical class 0.000 claims description 18
- 239000001103 potassium chloride Substances 0.000 claims description 13
- 235000011164 potassium chloride Nutrition 0.000 claims description 13
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 10
- 239000001527 calcium lactate Substances 0.000 claims description 10
- 235000011086 calcium lactate Nutrition 0.000 claims description 10
- 229960002401 calcium lactate Drugs 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 235000013402 health food Nutrition 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract 1
- 229960002737 fructose Drugs 0.000 description 29
- 239000000843 powder Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 241000894007 species Species 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001879 gelation Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 229920002752 Konjac Polymers 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- SMHNUIFHMAGAFL-UHFFFAOYSA-N calcium;2-hydroxypropanoic acid Chemical compound [Ca].CC(O)C(O)=O SMHNUIFHMAGAFL-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FYHXNYLLNIKZMR-UHFFFAOYSA-N calcium;carbonic acid Chemical compound [Ca].OC(O)=O FYHXNYLLNIKZMR-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/86—Addition of bitterness inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical fields such as medical science or health food, and in particular to a kind of pharmaceutical composition, the pharmaceutical composition include：Pregelatinized starch, carragheen, fructose, alkali source, acid source, ion gun.Pharmaceutical composition of the present invention is prepared into preparation, may be advantageously employed in children's medication, and its compliance further improves.
Description
Technical field
The invention belongs to the technical fields such as medical science or health food, and in particular to a kind of pharmaceutical composition, the medicine
Composition is prepared into preparation, aids in using for medicine feed, is more specifically used for children's medicine feed.
Background technology
Children have psychology and dual resistance physiologically to medicine, and therefore, more than 90% children are that refusal takes medicine
Thing, although children currently on the market is substantially also paid close attention to pulvis, capsule-type, oral type, many pharmacy corporations
This problem has been arrived, special-purpose medicaments have been supplied exclusively for children, it is contemplated that the characteristics of in mouthfeel, some sweet teas are generally added in medicine
Taste agent, acid etc. cover the bitter taste of medicine in itself, but still can produce resistance in children, and this just brings to children's medicine feed
Difficulty.
There are many medicine feed apparatuses in the prior art, directly medicine is sent in children's throat by apparatus, avoids medicine from connecing
The sense of taste is contacted, so as to reach the purpose for raising medicine, but apparatus is for innocent children, and with fear, therefore,
Research and develop it is a kind of it is new be used for raise the product that medicine uses, there are wide market prospects.
The content of the invention
For these reasons, applicant passes through test of many times, obtains a kind of new pharmaceutical composition, and the pharmaceutical composition is pre-
Gelling starch, carragheen, fructose, alkali source, acid source, ion gun；Research shows that pharmaceutical composition of the present invention is prepared into preparation, can
Taken medicine with being used for children well, its compliance further improves.
What the present invention was achieved through the following technical solutions.
A kind of pharmaceutical composition, the pharmaceutical composition include：Pregelatinized starch, carragheen, fructose, alkali source, acid source, ion
Source.
A kind of described pharmaceutical composition, wherein pregelatinized starch 0.4-0.6 parts by weight, carragheen 0.05-0.2 weight
Part, fructose 2.5-2.8 parts by weight, alkali source 0.03-0.09 parts by weight, acid source 0.01-0.03 parts by weight, ion gun 0.03-0.08
Parts by weight.
A kind of described pharmaceutical composition, the wherein parts by weight of pregelatinized starch 0.5, the parts by weight of carragheen 0.12, fructose 2.6
Parts by weight, the parts by weight of alkali source 0.15, the parts by weight of acid source 0.05, the parts by weight of ion gun 0.05.
A kind of described pharmaceutical composition, wherein alkali source are sodium carbonate, sodium acid carbonate, potassium carbonate, saleratus, carbonic acid
Calcium.
A kind of described pharmaceutical composition, wherein alkali source are sodium acid carbonate.
A kind of described pharmaceutical composition, wherein acid source are citric acid, tartaric acid, fumaric acid, adipic acid, malic acid.
A kind of described pharmaceutical composition, wherein acid source are citric acid.
A kind of described pharmaceutical composition, wherein ion gun are calcium lactate or potassium chloride.
A kind of described pharmaceutical composition, it is characterised in that application of the pharmaceutical composition in assisting child raises medicine.
A kind of described pharmaceutical composition, it is characterised in that pharmaceutical composition is that raw material is prepared into auxiliary medicine feed food, its
Preparation method is：
Sieving：Pregelatinized starch, carragheen, fructose, alkali source, acid source, ion gun are sieved respectively；
Mixing：Acid source and alkali source are well mixed stand-by；Ion gun and essence are well mixed simultaneously stand-by；By first latter two
After mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Specific embodiment
Technical scheme, but protection scope of the present invention not limited to this are illustrated with specific embodiment below.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology
Personnel according to present inventive concept it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
State, but the invention is not limited in above-mentioned specific embodiments and applications field, following specific embodiments are only to show
It is meaning property, guiding rather than restricted.One of ordinary skill in the art is under the enlightenment of this specification and is not taking off
In the case of the scope protected from the claims in the present invention, the form of many kinds can also be made, these belong to the present invention
The row of protection.
The following experiments of the present invention, it is on the basis of multiple creative experiment, with the claimed technical scheme of the present invention
Based on, the conclusive experiment of the research staff of summary.
Preparation method：Sieving：Pregelatinized starch, carragheen, fructose, alkali source, acid source, ion gun are sieved respectively；Mixing：
Acid source and alkali source are well mixed stand-by；Ion gun and essence are well mixed simultaneously stand-by；By first latter two mixture and OK a karaoke club
After glue, pre-gelatinized starch are well mixed, add fructose and mix to uniform, you can.
Experiment 1
By pre-gelatinized starch 5g, carragheen 1g, fructose 26g, sodium acid carbonate 0.6g, citric acid 0.2g, calcium lactate 0.5g, press
Prepare, obtained in powder composition according to preparation method.Take 3g to add 8ml water and mix, 0.1g Zitromax is added in gelation
Element, further mixing.Organoleptic examination is carried out with 10 subjects.Respectively with 1g sodium alginates, xanthans, agar, konjaku flour generation
For carragheen, as comparative group.Carragheen is not added with as blank group.
Result of the test：It is shown in Table 1.
The sensory experience result of table 1
Experiment 2
Foaming ingredient is on deliquescent influence
Carragheen 0.1g, fructose 2.6g, sodium acid carbonate 0.06g, citric acid 0.02g, prepared according to preparation method, obtain powder
In powder composition.Determine dissolubility.Change anionic polymer species, respectively with 0.1g sodium alginates, xanthans, agar,
Konjaku flour replaces carragheen, obtains powder composition measure dissolubility.In addition, the powder group of sodium acid carbonate and citric acid is not added
Compound, as comparative example.
Result of the test is shown in Table 2.
The different group dissolubilities of table 2 compare
Experiment 3
Ionic species are on deliquescent influence
Carragheen 0.1g, fructose 2.6g, pre-gelatinized starch 0.5g, calcium lactate 0.05g, prepare, obtain according to preparation method
In powder composition.Determine dissolubility.Change the species of ionic species, replace lactic acid with 0.05g potassium chloride, sodium citrate respectively
Calcium, obtain powder composition measure dissolubility.In addition the powder composition of ionic species is not added, as comparative example.
Result of the test is shown in Table 3.
Influence of the different ions material of table 3 to solubility
Test the bitter taste screening effect of 4 carragheens and ionic substance
By pre-gelatinized starch 5g, carragheen 1g, fructose 26g, calcium lactate 0.5g, prepared according to preparation method, obtain powder
In composition.Take 3g to add 8ml water and mix, 0.1g azithromycins are added in gelation, further mixing.It is tested with 10
Person carries out organoleptic examination.The powder composition of carragheen and calcium lactate is not added as comparative example.
Result of the test is shown in Table 4.
Influence of the 4 different groups of table to taste
Test the bitter taste screening effect of 5 carragheens and foaming ingredient
By pre-gelatinized starch 5g, carragheen 1g, fructose 26g, sodium acid carbonate 0.6g, citric acid 0.2g, according to preparation method
Prepare, obtain in powder composition.Take 3g to add 8ml water and mix, 0.1g azithromycins are added in gelation, are further mixed
Close.Organoleptic examination is carried out with 10 subjects.Carragheen, sodium acid carbonate, the powder composition of citric acid is not added to be used as and compare
Example.
Influence of the 5 different groups of table to taste
Conclusion (of pressure testing)：By above-mentioned experiment, finally determine that pharmaceutical composition of the present invention is：Pregelatinized starch, carragheen, fruit
Sugar, alkali source, acid source, ion gun, wherein preferable alkali source is sodium acid carbonate, acid source is citric acid, and ion gun is calcium lactate or chlorine
Change potassium..
Prepare embodiment
Embodiment 1
Raw material is：Pre-gelatinized starch 5g, carragheen 1g, fructose 26g, sodium acid carbonate 0.6g, citric acid 0.2g, calcium lactate
0.5g
Preparation method：Sieving：By pregelatinized starch, carragheen, fructose, sodium acid carbonate, citric acid, potassium chloride mistake respectively
Sieve；
Mixing：Sodium acid carbonate and citric acid are well mixed stand-by；Potassium chloride and essence are well mixed simultaneously stand-by；Will be first
After latter two mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Embodiment 2
Raw material is：Pre-gelatinized starch 50g, carragheen 10g, fructose 260g, sodium acid carbonate 6g, citric acid 2g, calcium lactate 5g
Preparation method：Sieving：By pregelatinized starch, carragheen, fructose, sodium acid carbonate, citric acid, potassium chloride mistake respectively
Sieve；
Mixing：Sodium acid carbonate and citric acid are well mixed stand-by；Potassium chloride and essence are well mixed simultaneously stand-by；Will be first
After latter two mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Embodiment 3
Raw material is：Pre-gelatinized starch 500g, carragheen 100g, fructose 2600g, sodium acid carbonate 60g, citric acid 20g, lactic acid
Calcium 50g
Preparation method：Sieving：By pregelatinized starch, carragheen, fructose, sodium acid carbonate, citric acid, potassium chloride mistake respectively
Sieve；
Mixing：Sodium acid carbonate and citric acid are well mixed stand-by；Potassium chloride and essence are well mixed simultaneously stand-by；Will be first
After latter two mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Embodiment 4
Raw material is：Pre-gelatinized starch 250g, carragheen 50g, fructose 1300g, sodium acid carbonate 30g, citric acid 10g, lactic acid
Calcium 25g
Preparation method：Sieving：By pregelatinized starch, carragheen, fructose, sodium acid carbonate, citric acid, potassium chloride mistake respectively
Sieve；
Mixing：Sodium acid carbonate and citric acid are well mixed stand-by；Potassium chloride and essence are well mixed simultaneously stand-by；Will be first
After latter two mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Embodiment 5
Raw material is：Pre-gelatinized starch 100g, carragheen 20g, fructose 520g, sodium acid carbonate 12g, citric acid 4g, calcium lactate
10g
Preparation method：Sieving：By pregelatinized starch, carragheen, fructose, sodium acid carbonate, citric acid, potassium chloride mistake respectively
Sieve；
Mixing：Sodium acid carbonate and citric acid are well mixed stand-by；Potassium chloride and essence are well mixed simultaneously stand-by；Will be first
After latter two mixture is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
The embodiment is including but not limited to above-mentioned.
Claims (10)
1. a kind of pharmaceutical composition, it is characterised in that the pharmaceutical composition includes：Pregelatinized starch, carragheen, fructose, alkali source,
Acid source, ion gun.
2. a kind of pharmaceutical composition according to claim 1, wherein pregelatinized starch 0.4-0.6 parts by weight, carragheen
0.05-0.2 parts by weight, fructose 2.5-2.8 parts by weight, alkali source 0.03-0.09 parts by weight, acid source 0.01-0.03 parts by weight, ion
Source 0.03-0.08 parts by weight.
3. a kind of pharmaceutical composition according to claim 1, the wherein parts by weight of pregelatinized starch 0.5, the weight of carragheen 0.10
Measure part, the parts by weight of fructose 2.6, the parts by weight of alkali source 0.06, the parts by weight of acid source 0.02, the parts by weight of ion gun 0.05.
4. according to a kind of pharmaceutical composition described in claim any one of 1-3, wherein alkali source is sodium carbonate, sodium acid carbonate, carbon
Sour potassium, saleratus, calcium carbonate.
5. according to a kind of pharmaceutical composition described in claim any one of 1-3, wherein alkali source is sodium acid carbonate.
6. according to a kind of pharmaceutical composition described in claim any one of 1-3, wherein acid source is citric acid, tartaric acid, rich horse
Acid, adipic acid, malic acid.
7. according to a kind of pharmaceutical composition described in claim any one of 1-3, wherein acid source is citric acid.
8. according to a kind of pharmaceutical composition described in claim any one of 1-3, wherein ion gun is calcium lactate or potassium chloride.
9. according to a kind of pharmaceutical composition described in claim any one of 1-3, it is characterised in that pharmaceutical composition is in auxiliary youngster
Child raises the application in medicine.
10. according to a kind of pharmaceutical composition described in claim any one of 1-3, it is characterised in that pharmaceutical composition is raw material system
It is standby to be into auxiliary medicine feed food, its preparation method：
Sieving：Pregelatinized starch, carragheen, fructose, alkali source, acid source, ion gun are sieved respectively；
Mixing：Acid source and alkali source are well mixed stand-by；Ion gun and essence are well mixed simultaneously stand-by；First latter two is mixed
After thing is well mixed with carragheen, pre-gelatinized starch, adds fructose and mix to uniform, you can.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710941277.8A CN107496927A (en) | 2017-10-11 | 2017-10-11 | A kind of pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710941277.8A CN107496927A (en) | 2017-10-11 | 2017-10-11 | A kind of pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107496927A true CN107496927A (en) | 2017-12-22 |
Family
ID=60700746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710941277.8A Pending CN107496927A (en) | 2017-10-11 | 2017-10-11 | A kind of pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107496927A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02269180A (en) * | 1989-04-07 | 1990-11-02 | Takasugi Seiyaku Kk | Gel-like instantaneously cooling and low-temperature flexible cold storage agent |
| US20050074489A1 (en) * | 2003-10-01 | 2005-04-07 | Pediamed Pharmaceuticals, Inc. | Effervescent and effervescent-dispersion compositions for medicaments and methods of use thereof |
| CN103768008A (en) * | 2014-02-28 | 2014-05-07 | 哈尔滨坤盟医药科技有限公司 | Modified gel matrix-based gel unit for oral nucleoside antiviral agent for children and preparation method thereof |
| CN103784396A (en) * | 2014-03-10 | 2014-05-14 | 哈尔滨坤盟医药科技有限公司 | Oral ibuprofen pellet xerogel and preparation method thereof |
| CN106170282A (en) * | 2013-04-02 | 2016-11-30 | 贝克斯棰公司 | Compositions as the aid for oral drugs |
-
2017
- 2017-10-11 CN CN201710941277.8A patent/CN107496927A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02269180A (en) * | 1989-04-07 | 1990-11-02 | Takasugi Seiyaku Kk | Gel-like instantaneously cooling and low-temperature flexible cold storage agent |
| US20050074489A1 (en) * | 2003-10-01 | 2005-04-07 | Pediamed Pharmaceuticals, Inc. | Effervescent and effervescent-dispersion compositions for medicaments and methods of use thereof |
| CN106170282A (en) * | 2013-04-02 | 2016-11-30 | 贝克斯棰公司 | Compositions as the aid for oral drugs |
| CN103768008A (en) * | 2014-02-28 | 2014-05-07 | 哈尔滨坤盟医药科技有限公司 | Modified gel matrix-based gel unit for oral nucleoside antiviral agent for children and preparation method thereof |
| CN103784396A (en) * | 2014-03-10 | 2014-05-14 | 哈尔滨坤盟医药科技有限公司 | Oral ibuprofen pellet xerogel and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102389116B (en) | Effervescent tablet for alleviating physical fatigue and preparation technology thereof | |
| CN106420655A (en) | Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet | |
| CN109123630A (en) | Has effects that nutraceutical of assisting deglutition and preparation method thereof | |
| CN107206098B (en) | Jelly for assisting administration of drug and method for producing the same | |
| JP4657893B2 (en) | Thickener for liquid composition | |
| CN106387585A (en) | Taurine electrolyte sports solid beverage and production technology thereof | |
| CN104664026A (en) | Nutritional and health mulberry leaf chewing gum and preparation method thereof | |
| CN104686660B (en) | A kind of milk tablet and preparation method thereof containing jumping candy | |
| CN103918960A (en) | Jelly and preparation method thereof | |
| CN103784482A (en) | Antrodia cinnamomea effervescent tablet and preparation method thereof | |
| CN109588694A (en) | The thickener composition and its preparation process of liquid viscosity can be quicklyd increase | |
| WO2017041742A1 (en) | Solid beverage containing honeysuckle and preparation method thereof | |
| CN104544058A (en) | Inulin composition and preparation method thereof | |
| CN102326815A (en) | Worm grass oral liquid and preparation method thereof | |
| CN111838500A (en) | Ginseng pine needle effervescent tablet and preparation method thereof | |
| CN104304599A (en) | Method for making konjaku and tartary buckwheat milk tea | |
| CN107496927A (en) | A kind of pharmaceutical composition | |
| CN103431465A (en) | Beverage capable of invigorating stomach and prompting digestion, and preparation method thereof | |
| CN106387596A (en) | Effervescent tablets capable of refreshing mind and restoring consciousness and preparation method of effervescent tablets | |
| CN112546183A (en) | Health-care plaster containing Chinese mugwort, navel and red bean | |
| JP2007006834A (en) | Method for preparation of miso and miso food | |
| CN109043279A (en) | Ginseng effervescent tablet and preparation method thereof | |
| CN1660134A (en) | Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique | |
| CN103380900A (en) | Preparation method for novel corrective flavor type oral rehydration salt powders and novel corrective flavor type oral rehydration salt powders | |
| RU2550603C1 (en) | Chewing sweets with biologically active substances |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171222 |
|
| WD01 | Invention patent application deemed withdrawn after publication |