CN103380900A - Preparation method for novel corrective flavor type oral rehydration salt powders and novel corrective flavor type oral rehydration salt powders - Google Patents
Preparation method for novel corrective flavor type oral rehydration salt powders and novel corrective flavor type oral rehydration salt powders Download PDFInfo
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- CN103380900A CN103380900A CN2013102436665A CN201310243666A CN103380900A CN 103380900 A CN103380900 A CN 103380900A CN 2013102436665 A CN2013102436665 A CN 2013102436665A CN 201310243666 A CN201310243666 A CN 201310243666A CN 103380900 A CN103380900 A CN 103380900A
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Abstract
The invention discloses a preparation method for novel corrective flavor type oral rehydration salt powders. Active ingredients comprise potassium chloride, sodium chloride, sodium citrate and dextrose anhydrous, and essence is added as an auxiliary material. The essence is added by using a spraying method, a method of adsorbing the essence by a superfine silica powder, a method of microencapsulating the essence to obtain an essence powder with beta-cyclodextrin as a wall material, or a polyvinylpyrrolidone (PVP-K30) copolymer method, and the essence is evenly mixed with the active ingredients for subpackage to obtain the oral rehydration salt powders. Based on a conventional oral rehydration salt, the essences with different flavors are added by different ways, and the oral rehydration salt powders with the different flavors are prepared; the oral rehydration salt powders improve conventional poor taste, are easy to take and especially easy to take for children, and improve the medical compliance.
Description
Technical field
The present invention relates to a kind of ORS loose, relate in particular to the loose preparation method of a kind of novel flavoring type ORS.
Background technology
ORS (ORS) is the medicine that the treatment acute diarrhea dehydration of world health organisation recommendations has excellent curative effect, and prescription forms rationally, and raw material is cheap and easy to get, convenience and high-efficiency, and the speed of its correct dehydration is better than drip-feed.But the ORS of listing is owing to being sugared salt mixture at present, and mouthfeel is very poor, is difficult to take, and especially children, cure very poor from property.
The present invention is on the basis of former ORS, add essence (fruity flavor, chocolate essence, plant essence etc.) by different modes, make flavoring type ORS loose, make ORS loose for having more taste, improve its original bad mouthfeel, be easy to take, especially be easy to children taking.
Summary of the invention
The object of the present invention is to provide the loose preparation method of a kind of novel flavoring type ORS.
The technical solution used in the present invention is as follows:
The preparation method that a kind of novel flavoring type ORS is loose is characterized in that comprising the following steps:
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65, potassium chloride 0.375, sodium citrate 0.725 and DEXTROSE ANHYDROUS 3.375;
(2) after being pulverized the 80-120 mesh sieve, sodium chloride, potassium chloride, sodium citrate and DEXTROSE ANHYDROUS mix;
(3) add essence or essence powder to mix by the mass ratio of 100:0.1-3 in the powder of gained, packing and get final product.
The preparation method of the essence powder in step (3):
The superfine silica gel powder that takes essence 3-10 times quality gets the essence powder as carrier adsorption essence.
The preparation method of the essence powder in step (3):
Take 3-10 times of quality beta-schardinger dextrin-of essence, add 4-10 times of quality water of beta-schardinger dextrin-, put in colloid mill, add essence, fully stir, decompress filter is also used absolute ethanol washing 2-4 time, low temperature drying, and getting white powder is the essence powder.
The preparation method of the essence powder in step (3):
Take the 3-10 times of weight polyethylene pyrrolidones (PVP-K30) of essence, add the 4-10 times of ethanol of PVP-K30, add essence, abundant stirring and dissolving, low temperature drying is pulverized, and gets powder, i.e. the essence powder.
Described essence is selected from one or more mixing in fruity flavor, chocolate essence and plant essence.
Described fruity flavor is selected from one or more mixing in lemon flavor essence, strawberry flavor essence, apple fragrance type essence, banana-aroma-type essence, vine odor type essence, "Hami" melon flavor essence, mango flavor essence, honey peach flavor essence.
Adopt the flavoring type ORS of the inventive method preparation loose.
Beneficial effect of the present invention:
The present invention is on the basis of former ORS, adds the different essence of taste by different modes, and the flavoring type ORS of making different taste is loose, improves its original bad mouthfeel, is easy to take, and especially is easy to children taking, has improved the doctor from property.
The present invention adds essence by three kinds of methods, and a kind of is to adopt conventional spraying that essence is dissolved in ethanol, evenly be sprayed in particle, and this method technology maturation, easy to operate; A kind ofly make superfine silica gel powder make carrier adsorption essence to make and be uniformly dispersed and greatly improve mobility of particle, improve bulk density, thereby improve the product appearance uniformity that makes and improve content uniformity; A kind of microencapsulation of essence that carries out as the wall material with beta-schardinger dextrin-, easy to operate, easily mix, do not increase the temperature that adds incense products, product keeps original pulverulence, can variable color in white sugar-containing product, and greatly extended shelf-life of product.
The specific embodiment
The present invention is described further in conjunction with the embodiments; to further understand method of the present invention and advantage; but embodiment is only for understanding the present invention; be not restriction the present invention, those skilled in the art falls into protection scope of the present invention according to inventive concept to any improvement that the present invention makes.
Embodiment 1
The preparation method that a kind of novel flavoring type ORS is loose,
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65, potassium chloride 0.375, sodium citrate 0.725 and DEXTROSE ANHYDROUS 3.375;
(2) mix after sodium chloride, potassium chloride, sodium citrate and DEXTROSE ANHYDROUS were pulverized the 80-120 mesh sieve, obtain mixed-powder;
(3) essence is dissolved in ethanol, evenly is sprayed in particle, after airtight 24h, dry, packing, the mass ratio of mixed-powder and essence is 100:0.1.
Embodiment 2
The preparation method that novel lemon ORS is loose:
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65g, potassium chloride 0.375g, sodium citrate 0.725g and DEXTROSE ANHYDROUS 3.375g;
(2) after being pulverized respectively 120 mesh sieves, potassium chloride, sodium chloride, sodium citrate and DEXTROSE ANHYDROUS mix;
(3) superfine silica gel powder that takes 6 times of quality of lemon flavor essence gets lemon flavor essence powder as carrier adsorption essence.
Add lemon flavor essence powder to mix by the mass ratio of 100:0.5 in the powder of gained, namely obtain novel lemon ORS by every bag of packing of 5.5g loose.
Embodiment 3
The preparation method that novel chocolate flavoured ORS is loose:
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65g, potassium chloride 0.375g, sodium citrate 0.725g and DEXTROSE ANHYDROUS 3.375g;
(2) after being pulverized respectively 120 mesh sieves, potassium chloride, sodium chloride, sodium citrate and DEXTROSE ANHYDROUS mix;
(3) take the beta-schardinger dextrin-of 5 times of quality of chocolate flavoured essence, add 6 times of quality water of beta-schardinger dextrin-, put in colloid mill, add chocolate flavoured essence, fully stir, decompress filter is also used absolute ethanol washing 2 times, low temperature drying, getting white powder is chocolate flavoured essence powder.
Add chocolate flavoured essence powder to mix by the mass ratio of 100:1 in the powder of gained, namely get novel chocolate flavoured ORS by every bag of packing of 5.5g loose.
Embodiment 4
The loose preparation method of novel strawberry flavor ORS
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65g, potassium chloride 0.375g, sodium citrate 0.725g and DEXTROSE ANHYDROUS 3.375g;
(2) after being pulverized respectively 120 mesh sieves, potassium chloride, sodium chloride, sodium citrate and DEXTROSE ANHYDROUS mix;
(3) take the polyvinylpyrrolidone (PVP-K30) of 5 times of quality of strawberry flavor essence, add the 4-10 times of ethanol of PVP-K30, add the strawberry flavor essence, abundant stirring and dissolving, low temperature drying is pulverized, and getting powder is strawberry flavor essence powder.
Add strawberry flavor essence powder to mix by the mass ratio of 100:1 in the powder of gained, can obtain novel strawberry flavor ORS loose, press every bag of packing of 5.5g and get final product.
Claims (7)
1. the loose preparation method of a novel flavoring type ORS is characterized in that comprising the following steps:
(1) take the raw material that the component by following weight ratio forms: sodium chloride 0.65, potassium chloride 0.375, sodium citrate 0.725 and DEXTROSE ANHYDROUS 3.375;
(2) after being pulverized the 80-120 mesh sieve, sodium chloride, potassium chloride, sodium citrate and DEXTROSE ANHYDROUS mix;
(3) add essence or essence powder to mix by the mass ratio of 100:0.1-3 in the powder of gained, packing and get final product.
2. the loose preparation method of a novel flavoring type ORS as claimed in claim 1 is characterized in that the preparation method of the essence powder in step (3):
The superfine silica gel powder that takes essence 3-10 times quality gets the essence powder as carrier adsorption essence.
3. the loose preparation method of a novel flavoring type ORS as claimed in claim 1 is characterized in that the preparation method of the essence powder in step (3):
Take 3-10 times of quality beta-schardinger dextrin-of essence, add 4-10 times of quality water of beta-schardinger dextrin-, put in colloid mill, add essence, fully stir, decompress filter is also used absolute ethanol washing 2-4 time, low temperature drying, and getting white powder is the essence powder.
4. the loose preparation method of a novel flavoring type ORS as claimed in claim 1 is characterized in that the preparation method of the essence powder in step (3):
Take the 3-10 times of weight polyethylene pyrrolidones (PVP-K30) of essence, add the 4-10 times of ethanol of PVP-K30, add essence, abundant stirring and dissolving, low temperature drying is pulverized, and gets powder, i.e. the essence powder.
5. according to the loose preparation method of the described novel flavoring type ORS of claim power 1-4 any one, it is characterized in that, described essence is selected from one or more mixing in fruity flavor, chocolate essence and plant essence.
6. the loose preparation method of novel flavoring type ORS according to claim 5, it is characterized in that, described fruity flavor is selected from one or more mixing in lemon flavor essence, strawberry flavor essence, apple fragrance type essence, banana-aroma-type essence, vine odor type essence, "Hami" melon flavor essence, mango flavor essence, honey peach flavor essence.
7. one kind is adopted the flavoring type ORS of the loose preparation method's preparation of novel flavoring type ORS claimed in claim 1 loose.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013102436665A CN103380900A (en) | 2013-06-19 | 2013-06-19 | Preparation method for novel corrective flavor type oral rehydration salt powders and novel corrective flavor type oral rehydration salt powders |
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| CN2013102436665A CN103380900A (en) | 2013-06-19 | 2013-06-19 | Preparation method for novel corrective flavor type oral rehydration salt powders and novel corrective flavor type oral rehydration salt powders |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610692A (en) * | 2013-12-05 | 2014-03-05 | 厦门恩成制药有限公司 | Preparation method of low-permeability oral rehydration salt |
| WO2018178406A1 (en) * | 2017-03-28 | 2018-10-04 | Adventia Pharma S.L. | Pack of flavour additives for oral enteral nutrition |
| CN109043470A (en) * | 2018-07-25 | 2018-12-21 | 长春雷允上药业有限公司 | A kind of fruit powder salt solid composite and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103610692A (en) * | 2013-12-05 | 2014-03-05 | 厦门恩成制药有限公司 | Preparation method of low-permeability oral rehydration salt |
| CN103610692B (en) * | 2013-12-05 | 2015-11-18 | 厦门恩成制药有限公司 | A kind of preparation method of low-permeability oral rehydration salt |
| WO2018178406A1 (en) * | 2017-03-28 | 2018-10-04 | Adventia Pharma S.L. | Pack of flavour additives for oral enteral nutrition |
| CN109043470A (en) * | 2018-07-25 | 2018-12-21 | 长春雷允上药业有限公司 | A kind of fruit powder salt solid composite and preparation method thereof |
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Application publication date: 20131106 |