CN107496628A - Treat traumatic injury, Traditional Chinese medicine gel emplastrum that extravasated blood swells and ache and preparation method thereof - Google Patents
Treat traumatic injury, Traditional Chinese medicine gel emplastrum that extravasated blood swells and ache and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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Abstract
Traditional Chinese medicine gel emplastrum to be swollen and ache the present invention relates to treatment traumatic injury, extravasated blood and preparation method thereof, can effectively solve the problems, such as traumatic injury, the medication of extravasated blood swelling and pain, its technical scheme solved is that the Traditional Chinese medicine gel emplastrum is made up of the raw material of following weight meter：The 15g of Radix Angelicae Sinensis 5, the 10g of the root of Dahurain angelica 2, the 15g of cape jasmine 5, the 10g of Rhizoma Arisaematis (processed) 5, windproof 5 15g, the 15g of safflower 5 and the 78g of matrix 25, described matrix is Sodium Polyacrylate, PVP, Dihydroxyaluminium Aminoacetate, tartaric acid, ethylenediamine tetra-acetic acid, kaolin, glycerine, 1,2 propane diols in proportion 2.38：2.25：1.0：0.15：0.025：1.88：16：8 are formulated, and using modern pharmaceutical technology Traditional Chinese medicine gel emplastrum is made in the present invention, there is the effect of promoting blood circulation, dispersing blood stasis, anti-inflammatory, analgesic, suitable for symptoms such as traumatic injury, blood stasis and swelling pains, be treat traumatic injury, the innovation that extravasated blood swells and ache on medicine.
Description
Technical field
The present invention relates to field of medicaments, particularly it is a kind of treat traumatic injury, extravasated blood swelling and pain Traditional Chinese medicine gel emplastrum and
Its preparation method.
Background technology
In daily life, traumatic injury occurs often, swelling and pain relieving, and the patch market demand of promoting blood circulation to remove blood stasis class is very
Greatly.The emplastrum of domestic promoting blood circulation to remove blood stasis is using quite varied, and rubber paste is all using rubber or high poly- chemical material as matrix, to skin
Skin excitant is stronger.It can not be tackled the problem at its root from PUR of the fusing point more than 135 DEG C, and medicine exists for a long time
At a high temperature of 135 DEG C, medicine can be caused effectively to be reduced into content, affected the treatment.Gel ointment is by traditional poultice hair
Exhibition, is a kind of Novel external patch, its framework material is high molecular weight water soluble polymer, can well absorb and carry water
Dissolubility and liposoluble constituent, component content can be greatly improved in this for the Chinese medical extract of complicated component, be have it is good
The external application Chinese medicine novel form of good development prospect.Therefore, invention is a kind of treats traumatic injury, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain
It is imperative.
The content of the invention
For the above situation, to solve the defect of prior art, the purpose of the present invention is just to provide one kind and treats bruise damage
Traditional Chinese medicine gel emplastrum that wound, extravasated blood swell and ache and preparation method thereof, can effectively solve traumatic injury, the medication of extravasated blood swelling and pain is asked
Topic.
The technical scheme that the present invention solves is that the Traditional Chinese medicine gel emplastrum is made up of the raw material of following weight meter：Radix Angelicae Sinensis
5-15g, root of Dahurain angelica 2-10g, cape jasmine 5-15g, Rhizoma Arisaematis (processed) 5-10g, windproof 5-15g, safflower 5-15g and matrix 25-78g, it is described
Matrix for Sodium Polyacrylate (NP-700), PVP (PVP-K90), Dihydroxyaluminium Aminoacetate, tartaric acid, ethylenediamine tetrem
Sour (EDTA), kaolin, glycerine, 1,2- propane diols in proportion 2.38：2.25：1.0：0.15：0.025：1.88：16：8 prepare and
Into.
The preparation method of Traditional Chinese medicine gel emplastrum, comprises the following steps：
(1) preparation of medicine：
Take the Radix Angelicae Sinensis, root of Dahurain angelica, cape jasmine, Rhizoma Arisaematis (processed), windproof, sovolin is returned, the root of Dahurain angelica, cape jasmine, Rhizoma Arisaematis (processed), windproof 5 times of weight
Mass concentration be 50% ethanol solution, refluxing extraction twice, each 2h, merges alcohol extract twice, is condensed at 50 DEG C
Relative density is 1.2 drug extract, standby；
Safflower adds the water of 20 times of its weight to soak, and successively soaks 12h, 4h, filtering, merges soak twice, use rotation
Evaporimeter concentrates, and is concentrated into 1/3rd of original volume, is heated to 45 DEG C, safflower water concentration extract is obtained, by carboxymethyl cellulose
Sodium (CMC-Na) and safflower water concentration extract in proportion 1:5.5 swellings, it is standby；
(2) preparation of gel emplastrum：
By Sodium Polyacrylate (NP-700), PVP (PVP-K90), Dihydroxyaluminium Aminoacetate, ethylenediamine tetra-acetic acid
(EDTA), kaolin, glycerine, 1,2-PD, drug extract mix, and are well mixed, obtain A phases；
Tartaric acid, safflower water concentration extract are mixed, is well mixed, obtains B phases；
A phases, B phases are placed in heating water bath in 60 DEG C of water-baths, B is added in A phases, and is at the uniform velocity stirred in one direction
5min is mixed, is coated on after bubble removing on non-woven fabrics, put and 2h is dried in 60 DEG C of baking ovens, epiphragma, be placed into 25 DEG C, relative humidity 30%
Continue refining in climatic chamber and close 24h, produce.
Traditional Chinese medicine gel emplastrum is made using modern pharmaceutical technology in the present invention, there is the effect of promoting blood circulation, dispersing blood stasis, anti-inflammatory, analgesic,
It is to treat traumatic injury, the innovation on extravasated blood swelling and pain medicine suitable for symptoms such as traumatic injury, blood stasis and swelling pains.
Embodiment
The embodiment of the present invention is described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, can be made up of the raw material of following weight meter：Radix Angelicae Sinensis 10g, root of Dahurain angelica 6g, cape jasmine 9g, system
Rhizoma arisaematis 9g, windproof 12g, safflower 10g and matrix 50g.
Embodiment 2
The present invention in the specific implementation, can also be made up of the material medicine of following weight meter：Radix Angelicae Sinensis 5g, root of Dahurain angelica 2g, cape jasmine
5g, Rhizoma Arisaematis (processed) 5g, windproof 5g, safflower 5g and matrix 26g.
Embodiment 3
The present invention in the specific implementation, can also be made up of the material medicine of following weight meter：Radix Angelicae Sinensis 15g, root of Dahurain angelica 10g, Cape jasmine
Sub- 15g, Rhizoma Arisaematis (processed) 10g, windproof 15g, safflower 15g and matrix 78g.
Embodiment 4
The present invention in the specific implementation, can also be made up of the material medicine of following weight meter：Radix Angelicae Sinensis 6-9g, root of Dahurain angelica 3-5g,
Cape jasmine 6-8g, Rhizoma Arisaematis (processed) 6-8g, windproof 6-11g, safflower 6-9 and matrix 27-49g.
Embodiment 5
The present invention in the specific implementation, can also be made up of the material medicine of following weight meter：Radix Angelicae Sinensis 10-14g, root of Dahurain angelica 7-
9g, cape jasmine 10-14g, Rhizoma Arisaematis (processed) 10g, windproof 12-14g, safflower 11-14 and matrix 51-77g.
Above-mentioned component is supported mutually, effective for treatment traumatic injury, extravasated blood swelling and pain, curative effect through science, reasonable compatibility
It is good, drug safety, and obtained fully proving through clinical data, relevant clinical data is as follows：
1 experiment material
Healthy kunming mice 120, male and female half and half, 20 ± 2g of body weight, purchased from experimental animal center of henan province, licensing
Number：SCXK (Henan) 2015-0004；
Yunnan Baiyao cream, purchased from the Yue Xin National People's Congress of Henan Province pharmacy；
Traditional Chinese medicine gel emplastrum, laboratory self-control；
After pulverizing medicinal materials, adjusted according to prescription ratio wine standby；
Blank gel cream base matter is standby；The graceful veet depilatory creams of common vetch (are purchased from supermarket)；
Acetic acid (Jinan century sensible Chemical Co., Ltd., lot number：145713)；
Carragheen Carrageenan, Shanghai Yuan Ye bio tech ltd, lot number：D03A6H3；
Dimethylbenzene (AR, Shantou Xi Long chemical plant, lot number:140621)；
RB-200 Intelligent medical adhesive tapes (hundred million letter Medical Treatment Equipment Co., Ltd)；
Medicated plaster cloth (Zhengzhou Ci Antang Pharmaceutical Technology Co., Ltd)；Hot-plate instrument (Chengdu TME Technology Co., Ltd.)；
BSA224S-CW type a ten thousandths balance (Sai Duolisi scientific instrument Co., Ltd)；
No. 8 card punch；Rubber hammer；Toes device for volume measurement；
Micro syringe (Town in Shanghai booth microsyringe factory).
2 analgesic activities test (one) hot plate method
2.1 experimental method：
(1) screening test mouse：
Kunming mice is adapted into raising three days, during which notices that control body weight increases, takes female mice to carry out pain threshold screening.
Intelligent hot-plate instrument is opened, plate face temperature is risen to 55 ± 0.5 DEG C, mouse licks metapedes from hot plate is set foot on to occurring takeofing or licking
Time is the pain threshold of the mouse, parallel 3 surveys pain threshold (the adjacent measurement twice of same female mice should be spaced at least 5min), is calculated every
Female mice threshold of pain average value, female mice of the average pain threshold less than 5s or higher than 30s is excluded.
(2) experiment packet：
The female mice filtered out is divided into 4 groups, every group 10, respectively blank group, experimental group, positive controls and wine apply
Control group.Lost hair or feathers in the previous day on-test in mouse back same area, depilation area about 2 × 2cm2。
(3) medication：
After Fundamentals of Measurement pain threshold, equal area (1.5 × 2.0cm is given respectively2) bare substrate, Chinese medicine of the present invention coagulates
Sticker paste, Yunnan Baiyao paste and wine mediate prescription powder (being administered by medicated plaster cloth), and reinforcing prevents from dropping, continue three days to
Medicine.
(4) pain threshold measures
Last time administration terminates rear 20min, 1h, 2h and distinguishes the parallel pain threshold for measuring every female mice three times.
(5) the calculating of percentage is improved in the threshold of pain：
Improve percentage={ pain threshold before (pain threshold before pain threshold-administration after administration)/administration } × 100% in the threshold of pain
1.2.2 hot plate method experimental result:
The change of each group test mice pain threshold is as shown in table 1：
The comparison of each group mouse pain threshold of table 1
Table 1Comparison of pain thresholdin mice
During 20min, 1h, 2h when group between have pole significant difference (P<0.01), experimental group, positive group, deposited three groups of the group of wine
Compared with blank group, equal P<0.01, there is pole significant difference, and data illustrate experimental group, positive group, wine applies group has to mouse
Analgesic activity；Experimental group contrasts P with positive group>0.05, without significant difference, the two applies the more equal P of group with wine<0.01, say
Bright experimental group is suitable with the positive group of analgesic activity to mouse.Find out that wine applies group and has certain analgesic effect according to data, but test
Group is significantly stronger than wine with the positive group of analgesic effect to mouse and applies group.
3 analgesic activities test (two) acetic acid writhing test
3.1 experimental method：
(1) experiment packet：
Take mouse 40, male and female half and half are randomly divided into 4 groups, every group 10, respectively blank group, experimental group, positive control
Group and wine apply control group.Lost hair or feathers in the previous day on-test in mouse back same area, depilation area about 2 × 2cm2。
(2) medication：
Before administration, the writhing number of every mouse is measured.Medication is the same as 2.1 lower medications.
(3) writhing number determines
After last time administration terminates, to every mouse peritoneal injection 0.2mL 0.6% acetum, with i.e. will be small
Mouse is put into transparent vessel, and the number of writhing occurs for mouse in 30min after being recorded in.There is the exceptionally straight body of hind leg and drawn in mouse
Stretch, abdominal retraction or reduce creeped close to container bottom or buttocks chimb over the water torsion be counted as a writhing.
1.3.2 writhing method experimental result:
Each group test mice writhing number average value is calculated, the change of each group writhing number is as shown in table 2：
The comparison of each group mouse writhing number of table 2
Table 2Comparison of writhing times of mice
There is pole significant difference (P between group<0.01), experimental group, positive group are compared with blank group, equal P<0.01, have
Pole significant difference, wine apply group P compared with blank group>0.05, no significant difference；Experimental group contrasts P with positive group>0.05, do not have
There is significant difference, the two applies the more equal P of group with wine<0.05, there is significant difference.Find out that wine applies group analgesic effect according to data
Unobvious, experimental group, positive group it is obvious to mouse analgesic activity, be better than wine apply group.
4 antiinflammatory actions test (one) auricle edema method
4.1 experimental method：
(1) experiment packet：
With 3.1 lower group technologies.
(2) medication：
Medication is the same as 2.1 lower medications.
(3) auricle causes scorching and swelling inhibiting rate to calculate：
After last time administration terminates, every mouse right ear ear edge point 0.02mL caused by dimethylbenzene xylene is scorching, by mouse after 15min
Extremely, ears are cut, takes same area with 8mm card punch, weigh.
1.4.2 auricle edema method experimental result:
Mouse right ear auricle and left ear auricle weight difference are ear edema degree, compare each group ear edema degree and swelling suppression
Rate processed, swelling inhibiting rate=(control group swelling-blank group swelling)/blank group swelling × 100%, experimental result such as table
Shown in 3：
The ear edema degree of table 3 and swelling inhibiting rate
Table 3Ear swelling and inhibition rate
There is pole significant difference (P between group<0.01), experimental group, positive group, wine apply group with blank group compared with, distinguish P<
0.01、P<0.05、P>0.05, experimental group has pole significant difference with blank group, and positive group has conspicuousness poor with blank group
Different, wine applies group and blank group no significant difference；Experimental group contrasts P with positive group>0.05, without significant difference, the two and wine
Deposited group is compared P respectively<0.05、P>0.05, experimental group and wine, which apply group, a significant difference, and positive group and wine apply group without conspicuousness,
Found out according to data, wine applies a group antiphlogistic effects unobvious, experimental group, positive group mouse corrosion disease is acted on obvious, be better than wine and apply group.
5 antiinflammatory actions test (two) toes swelling method
5.1 experimental method：
(1) experiment packet：
With 3.1 lower group technologies.
(2) medication：
Medication is the same as 2.1 lower medications.
(3) toes swelling and swelling inhibiting rate calculate：
After last time administration terminates, the carrageenan solutions of mouse 1% are given, every mouse gives 20 microlitres, injection side
Method micro syringe is injected to mouse sole center.Mouse toes volume is determined after 20min, 1h.
5.2 toes swelling method experimental results:
Mouse toes volume difference is toes swelling, compares each group toes swelling and swelling inhibiting rate, swelling suppression
Rate processed=(control group swelling-blank group swelling)/blank group swelling × 100%, experimental result are as shown in table 4：
The toes swelling of table 4 and swelling inhibiting rate
Table 4Toe swelling and inhibition rate
There is pole significant difference (P between group<0.01) after 20min, is administered, experimental group, positive group, the deposited group of wine and blank group
Compare, be P<0.01, three groups have pole significant difference with blank group；Experimental group contrasts P with positive group>0.05, do not show
Write sex differernce, the two apply group with wine compared be P<0.05, have significant difference, according to data find out experimental group, positive group and
Wine, which applies group, antiinflammatory action to mouse, and experimental group is suitable with the positive group of analgesic activity to mouse, is better than wine and applies group.1h is administered
Afterwards, experimental group, positive group, wine apply group compared with blank group, be P<0.01, three groups have pole significant difference with blank group；
Experimental group contrasts P with positive group>0.05, without significant difference, the two apply group with wine compared be P<0.05, there is conspicuousness poor
Different, applying group according to data wine has certain antiphlogistic effects, but experimental group is significantly stronger than wine with the positive group of antiphlogistic effects to mouse and applied
Group.
6. conclusion
To sum up, it can be deduced that, Traditional Chinese medicine gel emplastrum convenient drug administration of the present invention, there are promoting blood circulation, dispersing blood stasis, anti-inflammatory, the work(of analgesic
Effect, analgesic activity, anti-inflammatory effects are notable, and suitable for symptoms such as traumatic injury, blood stasis and swelling pains, and the present invention uses water-soluble high score
Sub- material is matrix, with Modern preparations technology, prepares novel percutaneous preparation, Traditional Chinese medicine gel emplastrum and skin of the present invention
Affinity is strong, has that excitant is small, long action time, easy to use, dosage is easily controllable, the compliance of increase patient etc. is excellent
Point, it is to treat traumatic injury, the innovation on extravasated blood swelling and pain medicine, there is actual clinical meaning and good popularization and application valency
Value.
Claims (7)
1. a kind of treat traumatic injury, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that the Traditional Chinese medicine gel emplastrum is
It is made up of the raw material of following weight meter：Radix Angelicae Sinensis 5-15g, root of Dahurain angelica 2-10g, cape jasmine 5-15g, Rhizoma Arisaematis (processed) 5-10g, windproof 5-15g,
Safflower 5-15g and matrix 25-78g, described matrix be Sodium Polyacrylate, PVP, Dihydroxyaluminium Aminoacetate, tartaric acid,
Ethylenediamine tetra-acetic acid, kaolin, glycerine, 1,2- propane diols in proportion 2.38：2.25：1.0：0.15：0.025：1.88：16：8 match somebody with somebody
System forms.
2. treatment traumatic injury according to claim 1, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that can
It is made up of the raw material of following weight meter：Radix Angelicae Sinensis 10g, root of Dahurain angelica 6g, cape jasmine 9g, Rhizoma Arisaematis (processed) 9g, windproof 12g, safflower 10g and matrix
50g。
3. treatment traumatic injury according to claim 1, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that by
The material medicine of following weight meter is made：Radix Angelicae Sinensis 5g, root of Dahurain angelica 2g, cape jasmine 5g, Rhizoma Arisaematis (processed) 5g, windproof 5g, safflower 5g and matrix
26g。
4. treatment traumatic injury according to claim 1, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that by
The material medicine of following weight meter is made：Radix Angelicae Sinensis 15g, root of Dahurain angelica 10g, cape jasmine 15g, Rhizoma Arisaematis (processed) 10g, windproof 15g, safflower 15g
With matrix 78g.
5. treatment traumatic injury according to claim 1, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that by
The material medicine of following weight meter is made：It is Radix Angelicae Sinensis 6-9g, root of Dahurain angelica 3-5g, cape jasmine 6-8g, Rhizoma Arisaematis (processed) 6-8g, windproof 6-11g, red
Flower 6-9 and matrix 27-49g.
6. treatment traumatic injury according to claim 1, the Traditional Chinese medicine gel emplastrum of extravasated blood swelling and pain, it is characterised in that by
The material medicine of following weight meter is made：Radix Angelicae Sinensis 10-14g, root of Dahurain angelica 7-9g, cape jasmine 10-14g, Rhizoma Arisaematis (processed) 10g, windproof 12-
14g, safflower 11-14 and matrix 51-77g.
7. the preparation side of the Traditional Chinese medicine gel emplastrum for the treatment of traumatic injury, extravasated blood swelling and pain described in claim 1 or any one of 2-6
Method, it is characterised in that comprise the following steps：
（1）The preparation of medicine：
Take the Radix Angelicae Sinensis, root of Dahurain angelica, cape jasmine, Rhizoma Arisaematis (processed), windproof, sovolin is returned, the root of Dahurain angelica, cape jasmine, Rhizoma Arisaematis (processed), the matter of windproof 5 times of weight
The ethanol solution that concentration is 50% is measured, refluxing extraction twice, each 2h, merges alcohol extract twice, is condensed into relatively close at 50 DEG C
The drug extract for 1.2 is spent, it is standby；
Safflower adds the water of 20 times of its weight to soak, and successively soaks 12h, 4h, filtering, merges soak twice, use rotary evaporation
Instrument concentrate, be concentrated into 1/3rd of original volume, be heated to 45 DEG C, obtain safflower water concentration extract, by sodium carboxymethylcellulose with
Safflower water concentration extract in proportion 1:5.5 swellings, it is standby；
（2）The preparation of gel emplastrum：
By Sodium Polyacrylate, PVP, Dihydroxyaluminium Aminoacetate, ethylenediamine tetra-acetic acid, kaolin, glycerine, 1,2- propane diols,
Drug extract mixes, and is well mixed, obtains A phases；
Tartaric acid, safflower water concentration extract are mixed, is well mixed, obtains B phases；
A phases, B phases are placed in heating water bath in 60 DEG C of water-baths, B is added in A phases, and is at the uniform velocity stirred in one direction
5min, it is coated on non-woven fabrics after bubble removing, puts and 2h is dried in 60 DEG C of baking ovens, epiphragma, be placed into 25 DEG C, the perseverance of relative humidity 30%
Continue refining in constant temperature and humidity case and close 24h, produce.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710707829.9A CN107496628A (en) | 2017-08-17 | 2017-08-17 | Treat traumatic injury, Traditional Chinese medicine gel emplastrum that extravasated blood swells and ache and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710707829.9A CN107496628A (en) | 2017-08-17 | 2017-08-17 | Treat traumatic injury, Traditional Chinese medicine gel emplastrum that extravasated blood swells and ache and preparation method thereof |
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| CN107496628A true CN107496628A (en) | 2017-12-22 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387915A (en) * | 2002-07-11 | 2003-01-01 | 中国人民解放军第二军医大学 | Plaster matrix and its prepn |
| CN1403139A (en) * | 2002-10-08 | 2003-03-19 | 李德邦 | Externally applied Chinese medicine for treating osteoarthropathy and its prepn process |
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Application publication date: 20171222 |