CN107495020A - A kind of suitable polypeptide beverage water of diabetic population and its preparation technology - Google Patents
A kind of suitable polypeptide beverage water of diabetic population and its preparation technology Download PDFInfo
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- CN107495020A CN107495020A CN201710832625.8A CN201710832625A CN107495020A CN 107495020 A CN107495020 A CN 107495020A CN 201710832625 A CN201710832625 A CN 201710832625A CN 107495020 A CN107495020 A CN 107495020A
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- polypeptide
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- 210000001835 viscera Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/006—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from vegetable materials
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
A kind of suitable polypeptide beverage water of diabetic population and its preparation technology, are related to field of beverage, and the polypeptide beverage water raw materials by weight portion meter includes：100 200 portions of drinking water, 13 parts of bitter gourd polypeptide extract powder, 0.5 1 portions of vegetable juice concentrate powder, 12 parts of inulin and 0.5 2 portions of L arabinoses, 0.1 0.5 parts of vitamin B6s etc., hypoglycemic bitter gourd polypeptide albumen, water-soluble dietary fiber of the polypeptide beverage Shuifu County containing effective extraction purification, glycemic value is low after zoopery and test-meal show to drink, metabolism of blood glucose is can also adjust, nutrient and flavour is all good, meets the drink demand of diabetes patient.Preparation technology is in 20 35 DEG C of high-pressure homogeneous and vacuum outgas by the mixed liquor of above-mentioned raw materials, filtered after through the organic tube type filter membrance in two in parallel 0.01 0.2 μm, filtered fluid instantaneous sterilization under the conditions of 100 130 DEG C, be cooled to 30 35 DEG C it is filling, sealing after sterilize, cool down.
Description
Technical field
The present invention relates to field of beverage, and the suitable polypeptide beverage water of more particularly to a kind of diabetic population and its prepare work
Skill.
Background technology
Diabetes are due to defect of insulin secretion or the impaired caused metabolism characterized by hyperglycaemia of its biological agent
Property disease, seriously endanger to people health and daily life.China diabetic is up to 1.14 hundred million at present, and suffers from
Patient's number is also in cumulative year after year.The harm of diabetes is huge, and also patient is good for diabetic complication caused by diabetes
Health and life constitute a threat to.Diabetes Gu is referred to as quenching one's thirst, and is due to that yin deficiency is scorching, caused by deficient five internal organs to drink more, diuresis,
Eat and become thin, be tired more, the syndrome that urine sweet tea is principal character.Modern medicine study shows that the generation of diabetes is mainly
Because islet cells is impaired, hypoinsulinism or body function disorder cause body to decline insulin sensitivity, from
And the function of regulation blood glucose can not be played and cause diabetes.
Diabetic not only needs the long-term use of or hypoglycemic class medicine of injection, it is also necessary to it is controlled on diet,
Such as avoid taking in the food of high sugar content, this also serious diet selection for having influence on diabetic.Momordica calabash
Lu Ke balsam pear platymisciums, bitter is cold in nature, is a kind of medicine-food two-purpose vegetables.According to《Compendium of Materia Medica》And《The southern regions of the Yunnan Province book on Chinese herbal medicine》Record, balsam pear
There is clearing away heat and removing summer, nourishing blood and invigorating qi, kidney and spleen invigorating, nourishing liver for improving eyesight, hypoglycemic.Contain at present for diabetic
There are the different food products of balsam pear raw material.The drink that normal person can drink, sugar content is too high to be not suitable for diabetes patients, or not
With regulation blood glucose effect.Therefore, it is necessary to which a kind of nutrient and flavour mouthfeel is all good and to drink rear glycemic index low, drink for a long time
Safety simultaneously can reach the bitter gourd polypeptide drinking water of food therapy effect to diabetic.
The content of the invention
It is an object of the invention to provide a kind of suitable polypeptide beverage water of diabetic population, and it is rich in natural activity balsam pear
Polypeptide protein, and water soluble dietary fiber content is high, there is flavor taste and nutrition is all good, glycemic index after drink
It is low and can effectively adjust diabetes blood glucose's metabolism, the advantages of meeting the dietotherapy drink demand of diabetes patient.
Another object of the present invention is to provide a kind of preparation technology of the suitable polypeptide beverage water of diabetic population, technology
Method is stable, and quality controllability is strong.
The present invention is solved its technical problem and realized using following technical scheme.
The present invention proposes a kind of suitable polypeptide beverage water of diabetic population, and it uses following raw material configuration to form, by weight
Number meter is measured, raw material includes：
Drinking water 100-200 parts；And
Bitter gourd polypeptide extract powder 1-3 parts.
Further, in present pre-ferred embodiments, raw material also includes 0.5-1 parts Fresh Cucumber Juice concentration powder, Tomato juice
Concentrate powder or spinach juice concentration powder.
Further, in present pre-ferred embodiments, raw material also includes 1-2 part inulin.
Further, in present pre-ferred embodiments, raw material also includes 0.5-2 part L-arabinoses.
Further, in present pre-ferred embodiments, raw material also includes 0.1-0.5 part vitamin B6s.
Further, in present pre-ferred embodiments, raw material also includes 0.001-0.005 parts D-sorbite, 0.001-
At least one of 0.003 part of chlorophyll copper sodium.
Further, in present pre-ferred embodiments, raw material also include 0.01-0.02 parts sodium carboxymethylcellulose,
At least one of 0.01-0.05 part beta-schardinger dextrins.
A kind of preparation technology of the suitable polypeptide beverage water of diabetic population, it comprises the following steps：
Count in parts by weight, weigh 100-200 parts drinking water and the mixing of 1-3 part bitter melon proteins polypeptide extract, must mix
Liquid；
By mixed liquor under conditions of 20-35 DEG C, 27-30Mpa homogeneous；
Deaerated under conditions of being 0.07-0.09Mpa in 20-35 DEG C, vacuum by the mixed liquor after homogeneous.
Further, in present pre-ferred embodiments, the preparation method of bitter melon protein polypeptide extract is：
The cleaning of balsam pear raw material, mashing is broken, balsam pear raw material is extracted at 40 DEG C or so with purified water, then centrifuge and remove slag, obtain
Centrifugate；
Centrifugate was carried out by three organic tube type filter membrance systems in parallel that molecular cut off is 3 μm -0.1 μm
Filter, big molecular impurity is removed, obtains microfiltration membranes permeate；
Microfiltration membranes permeate is purified into system by two rolling ultrafiltration membranes in parallel that molecular cut off is 100-200kDa
System is filtered, and obtains milipore filter permeate；
Milipore filter permeate is purified into system through two rolling ultrafiltration membranes in parallel that molecular cut off is 500-1000Da again
System is filtered, and obtains milipore filter trapped fluid；
Rolling high pressure reverse osmosis membrane system of the trapped fluid by four series connection that molecular cut off is 100-150Da is carried out
Concentration, moisture and part residual inorganic salts and small molecular weight impurity are removed, obtain concentrate, the solid content of concentrate >=
30%；
Concentrate is dried, obtains the Bitter Melon P.E powder that bitter gourd polypeptide protein content is not less than 25%.
Further, in present pre-ferred embodiments, preparation technology is additionally included in the filtering carried out after degassing, sterilization fills
The steps such as envelope, the mixed liquor after degassing is specifically passed through to 0.01 μm -0.2 μm of two organic tube type filter membrance systems in parallel
Filtered, filtered fluid instantaneous sterilization under conditions of 100-130 DEG C, be cooled to 30-35 DEG C it is filling, sealing after, then at 77-87
DEG C sterilization, be cooled to room temperature.
The beneficial effect of the suitable polypeptide beverage water of the diabetic population of the embodiment of the present invention and its preparation technology is：This hair
The polypeptide beverage water that the diabetic population of bright embodiment is suitable is formed using the configuration of following raw material, raw materials by weight portion meter bag
Include：100-200 part drinking water, 1-3 part bitter gourd polypeptide extract powder etc., polypeptide beverage Shuifu County having containing effective extraction purification
The natural balsam pear polypeptide protein of hypoglycemic activity, water soluble dietary fiber content are high, have flavor taste and nutrition is all good, after drink
Glycemic index is low and can effectively adjust diabetes blood glucose's metabolism, meets the dietotherapy drink demand of diabetes patient
Advantage；The preparation technology of the suitable polypeptide beverage water of the diabetic population is through high-pressure homogeneous and true by the mixed liquor of above-mentioned raw materials
After sky degassing, filtered using the organic tube type filter membrance of two in parallel 0.01-0.2 μm, filtered fluid high-temperature instantaneous sterilization, after cooling
Sterilize, cool down after filling, sealing, the technology method is stable, and quality controllability is strong.
Brief description of the drawings
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below by embodiment it is required use it is attached
Figure is briefly described, it will be appreciated that the following drawings illustrate only certain embodiments of the present invention, therefore be not construed as pair
The restriction of scope, for those of ordinary skill in the art, on the premise of not paying creative work, can also be according to this
A little accompanying drawings obtain other related accompanying drawings.
Fig. 1 is the SDS-PAGE electrophoresis of polypeptide protein molecular weight distribution in bitter gourd polypeptide extract powder in the embodiment of the present invention
Figure.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
The polypeptide beverage water suitable to the diabetic population of the embodiment of the present invention and its preparation technology are carried out specifically below
It is bright.
The embodiments of the invention provide a kind of suitable polypeptide beverage water of diabetic population, its use following raw material configure and
Into counting in parts by weight, raw material includes：100-200 parts drinking water and 1-3 part bitter melon protein polypeptide extracts.The present embodiment institute
Bitter gourd polypeptide extract powder is the product for extracting to obtain from balsam pear.The bitter gourd polypeptide contained in balsam pear have it is hypoglycemic,
The effect of reducing blood lipid, lifting body immunity, blood glucose and glycosuria, prevention and auxiliary treatment diabetes can be effectively reduced.It is bitter
The molecular weight of the bitter gourd polypeptide contained in melon polypeptide extract powder between 5-60kDa based on, its middle-molecular-weihydroxyethyl 6kDa's or so
The content accounting example of bitter gourd polypeptide fragment is 20% or so.These bitter gourd polypeptide clip sizes close to insulin molecular weight, with
The binding ability of insulin receptor is strong, can effectively activate insulin receptor protein signal path, recovers insulin function, and then
Blood sugar recovery effectively can be adjusted and controlled to normal level.Therefore the polypeptide prepared using the bitter gourd polypeptide extract powder is drunk
Water has extraordinary regulation and control diabetes effect, and glycemic index is low after not only drinking, long-term drink can adjust diabetes
People's metabolism of blood glucose, meet the dietotherapy drink demand of diabetes patient.
Optionally, raw material also includes 0.5-1 parts Fresh Cucumber Juice concentration powder, Tomato juice's concentration powder or spinach juice concentration powder.Can
Increase cucumber flavor, tomato-flavor or spinach flavor for polypeptide beverage water, make diabetes patient acceptant, be adapted to drink for a long time
With.
Optionally, raw material also includes 1-2 part inulin, and inulin not only has the effect of reducing blood glucose value, treating diabetes, also
Function with sweetener, while ensureing diabetes patient's health, improve the mouthfeel of polypeptide beverage water.
Optionally, raw material also includes 0.5-2 part L-arabinoses.L-arabinose is a kind of new sweet taste low in calories
Agent, it is widely present in the cot of fruit and coarse food grain, because the activity of invertase in human body intestinal canal can be suppressed, so as to be provided with suppression
The effect of sucrose processed absorbs；In addition, L-arabinose can also suppress body fat accumulation, thus can be used for preventing and treating it is fat,
The diseases such as hypertension, high fat of blood.
Optionally, raw material also includes 0.1-0.5 part vitamin B6s.Vitamin B6 prevents and treats diabetes：Modern study reports table
Bright, vitamin B6 is less than the diabetic of normal value, supplies 100 milligrams of vitamin B6s, numb limb and pain after 6 weeks daily
It can mitigate or disappear etc. symptom.The foods eaten brown rice, flour, egg, Chinese cabbage, dry ferment etc. and be rich in vitamin B6 usually more, equally
It is effective to preventing and treating diabetes.
Optionally, raw material is also included in 0.001-0.005 parts D-sorbite, 0.001-0.003 part chlorophyll copper sodiums extremely
Few one kind.D-sorbite is widely distributed in pears, peach, apple, and content is about 1%-2%.Its sugariness is suitable with glucose, but energy
Give dense sense.It is slowly absorbed in vivo, and blood glucose value does not increase.Chlorophyll copper sodium is with chlorophyll copper sodium
Salt is that raw material passes through the natural pigment that finishing forms.Sodium copper chlorophyllin is by the chlorophyll of extraction, by serial reaction simultaneously
Formed by refining.Chlorophyll copper sodium is easily absorbed by the body, and the effect of being enhanced metabolism to body cell, can also promote
Enter the healing in gastroenteritic ulcer face, promote the recovery of liver function.
Optionally, raw material is also included in 0.01-0.02 parts sodium carboxymethylcellulose, 0.01-0.05 part beta-schardinger dextrins extremely
Few one kind.Sodium carboxymethylcellulose can have hypoglycemic as other of bitter gourd polypeptide albumen in bitter gourd polypeptide extract and addition
The carrier of functional component, is easy to active ingredient to disperse, and reduces precipitation.Beta-schardinger dextrin can be used as embedding stabilizer, ensure polypeptide drink
Expect shelf-life and the quality stability of water, suitable commercialization.
The traditional Chinese medical science always emphasizes " medication is not so good as dietotherapy ", has the advantages of following several big prominent by medicine of diet：
First, long-term use of medicine therapy often produces various side effects and dependence, but also human body may be good for
Health impacts；And dietotherapy is relatively safe and effective, toxic side effect is small.
What the 2nd, dietotherapy used is all food common in our daily lifes, and cheap, let us is in daily dining
The purpose of conditioning can be reached, this is that expensive medical fee is incomparable；
3rd, diet is that medicine also has the advantages of no pain, allows people to dispel slight illness during cuisines are enjoyed, avoids
Have an injection, take medicine, or even pain of surgery.
The embodiment of the present invention additionally provides a kind of preparation technology of the suitable polypeptide beverage water of diabetic population, it include with
Lower step：
S1,100-200 parts drinking water and 1-3 part bitter gourd polypeptide extract powder are weighed, uniformly mixing, obtains mixed liquor.
S2, by mixed liquor under conditions of 20-35 DEG C, 27-30Mpa homogeneous.
S3, by the mixed liquor after homogeneous 20-35 DEG C, vacuum be 0.07-0.09Mpa under conditions of deaerate.
S4, the mixed liquor after degassing carried out by the organic tube type filter membrance systems in parallel of two of 0.01 μm -0.2 μm
Filtering, filtered fluid instantaneous sterilization under conditions of 100-130 DEG C, be cooled to 30-35 DEG C it is filling, sealing after, killed then at 77-87 DEG C
Bacterium, room temperature is cooled to, produces the suitable polypeptide beverage water of diabetic population.
Wherein, the preparation method of bitter melon protein extract powder is：
By the cleaning of balsam pear raw material, crush, add purification flooding, then centrifuge and remove slag, obtain centrifugate；
Centrifugate was carried out by three organic tube type filter membrance systems in parallel that molecular cut off is 3 μm -0.1 μm
Filter, big molecular impurity is removed, obtains microfiltration membranes permeate；
Microfiltration membranes permeate is purified into system by two rolling ultrafiltration membranes in parallel that molecular cut off is 100k-200kDa
System is filtered, and obtains milipore filter permeate；
Milipore filter permeate is purified into system through two rolling ultrafiltration membranes in parallel that molecular cut off is 500-1000Da again
System is filtered, and obtains milipore filter trapped fluid；
Milipore filter trapped fluid is concentrated by the rolling high pressure reverse osmosis membrane that molecular cut off is 100-150Da, removed
Moisture and part residual inorganic salts and small molecular weight impurity are removed, obtains concentrate, solid content >=30% of concentrate；
Concentrate is dried, obtains the Bitter Melon P.E powder that bitter gourd polypeptide protein content is not less than 25%.
The preparation technology of the suitable polypeptide beverage water of the diabetic population of the embodiment of the present invention uses membrane separation and purification technology
Obtain bitter gourd polypeptide extract powder, exempt enzymolysis and high temperature enzyme deactivation step, with short production cycle, it is low to isolate and purify thickening temperature, has
Effect ensure that the natural activity and its high content of the bitter melon protein polypeptide of preparation, bitter gourd polypeptide albumen in bitter gourd polypeptide extract powder
The content of (molecular weight 4.5k-68kDa) is at least above 25%, the content of its middle-molecular-weihydroxyethyl 5.5-7kDa bitter gourd polypeptide fragment
Accounting example is 20% or so.These bitter gourd polypeptide clip sizes have close to the molecular weight of insulin and adjust and control blood glucose work(
Energy.
The molecular weight of bitter melon protein polypeptide in bitter gourd polypeptide extract powder is detected：
Examined using bitter gourd polypeptide extract powder polypeptide molecular weight of albumen distribution of the SDS-PAGE analytic approach to embodiment 1
Survey, Fig. 1 is the PAGE electrophoretograms detected.
By Fig. 1 it can be found that：The bitter gourd polypeptide albumen of the bitter gourd polypeptide extract powder obtained according to preparation method of the present invention,
Molecular weight be 5.5-7kDa bitter gourd polypeptide content accounting more than 20%, the Peptide of Protein is Effective Regulation blood glucose generation
The key function composition thanked, close to insulin molecule amount.Therefore, the balsam pear obtained according to the technical matters of the embodiment of the present invention is more
Contain a large amount of natural activity bitter gourd polypeptide albumen with regulation blood glucose function in peptide extract powder.
In the present embodiment, 0.5-1 parts Fresh Cucumber Juice concentration powder, Tomato juice's concentration powder or spinach juice concentration powder can be also weighed again
And mixing is added, obtain mixed liquor.
Or can also weigh 1-2 parts inulin again and add mixing, obtain mixed liquor.
Or can also weigh 0.5-2 parts L-arabinose again and add mixing, obtain mixed liquor.
Or can also weigh 0.1-0.5 parts vitamin B6 again and add mixing, obtain mixed liquor.
Or it can also weigh again in 0.001-0.005 parts D-sorbite, 0.001-0.003 part chlorophyll copper sodiums at least
One kind simultaneously adds mixing, obtains mixed liquor.
Or it can also weigh again in 0.01-0.02 parts sodium carboxymethylcellulose, 0.01-0.05 part beta-schardinger dextrins at least
One kind simultaneously adds mixing, obtains mixed liquor.
Or also it can weigh both the above or plurality of raw materials simultaneously again and add and be mixed.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides a kind of diabetic population suitable polypeptide beverage water, and it uses following preparation method to be made：
S101, count in parts by weight, weigh 150kg drinking water, 2kg bitter gourd polypeptide extracts powder, the concentration of 0.2kg Fresh Cucumber Juices
Powder, 1kg inulin and the mixing of 0.3kgL- arabinoses, obtain mixed liquor.
S102, by mixed liquor under conditions of 30 DEG C, 28Mpa homogeneous.
S103, by the mixed liquor after homogeneous 25 DEG C, vacuum be 0.08Mpa under conditions of deaerate.
S104, the mixed liquor after degassing filtered by the organic tube type filter membrance system in two in parallel 0.05 μm,
Filtered fluid instantaneous sterilization under conditions of 125 DEG C, be cooled to 32 DEG C it is filling, sealing after, then at 80 DEG C sterilization, be cooled to room temperature,
Produce the suitable polypeptide beverage water of diabetic population.
Wherein, bitter gourd polypeptide extract powder is made using following methods：
Longer from growth period, the fresh bitter that green is partially yellow, balsam pear seed is fuller is first by balsam pear raw material as raw material
Clean through running water, then cleaned through electrolytic high-concentration ozone water.
Balsam pear raw material pulping after cleaning was broken into the liquid material of 20 eye mesh screens.
The balsam pear raw material being beaten after crushing is poured into Ultrasonic Wave-Assisted Extraction tank, and adds 8 mass times, 50 DEG C of purification
Water, using buffer salt regulation system pH ≈ 7, the adverse current for carrying out ultrasonic wave added is extracted 3 times, every time 30 minutes.
Centrifuged, and removed slag using disc centrifuge or tube centrifuge, obtain centrifugate.
Centrifugate is filtered by the hollow fiber microfiltration membrane system that molecular cut off is 1 μm, operation temperature 30
DEG C, operating pressure 0.3MPa, obtain microfiltration membranes permeate.
First microfiltration membranes permeate is filtered by the roll-to-roll ultrafiltration membranous system that molecular cut off is 200kDa respectively, grasped
Make temperature as 30 DEG C, operating pressure 0.8MPa, obtain milipore filter permeate；It is 800Da that liquid be will transmit through again by molecular cut off
Rolling ultrafiltration membrane purification system filtered, operation temperature be 30 DEG C, pressure 0.8MPa, obtain milipore filter trapped fluid.
Milipore filter trapped fluid is concentrated by the rolling high pressure reverse osmosis membrane system that molecular cut off is 150Da, grasped
Make temperature as 30 DEG C, operating pressure 4MPa, obtain the concentrate of solid content >=30%.
Concentrate is dried by the way of vacuum freeze drying or low temperature spray drying, obtains bitter gourd polypeptide extraction
Thing powder, the content of its polypeptide protein is up to 25.5%.
Embodiment 2
The present embodiment provides a kind of diabetic population suitable polypeptide beverage water, and it uses following preparation method to be made：
S201, count in parts by weight, weigh 180kg drinking water, 1kg bitter gourd polypeptides extract, the concentration of 0.5kg spinach juices
Powder, 1kg inulin, 0.5kgL- arabinoses, 0.01kg part vitamin B6s, 0.01kg D-sorbites and 0.01kg carboxymethyl celluloses
Plain sodium mixing, obtains mixed liquor.
S202, by mixed liquor under conditions of 25 DEG C, 30Mpa homogeneous.
S203, by the mixed liquor after homogeneous 25 DEG C, vacuum be 0.09Mpa under conditions of deaerate.
S204, the mixed liquor after degassing filtered by the organic tube type filter membrance system in two in parallel 0.02 μm,
Filtered fluid instantaneous sterilization under conditions of 125 DEG C, be cooled to 35 DEG C it is filling, sealing after, then at 70 DEG C sterilization, be cooled to room temperature,
Produce the suitable polypeptide beverage water of diabetic population.
Wherein, bitter gourd polypeptide extract powder is made using following methods：
Longer from growth period, the fresh bitter that green is partially yellow, balsam pear seed is fuller is first by balsam pear raw material as raw material
Clean, then cleaned through electrolytic high-concentration ozone water, Measuring Ozone Concentration in Water 20mg/L, water-carrying capacity 450L/h through running water, with drop
Low agriculture residual pesticide and microorganism residual.
Balsam pear raw material pulping after cleaning was broken into the liquid material of 20 eye mesh screens.
The balsam pear raw material being beaten after crushing is poured into Ultrasonic Wave-Assisted Extraction tank, and adds 5 mass times, 38 DEG C of purification
Water, using buffer salt regulation system pH ≈ 6.7, the adverse current for carrying out ultrasonic wave added is extracted 4 times, every time 60 minutes.
Centrifuged, and removed slag using high speed tube centrifuge, obtain centrifugate.
Centrifugate is filtered by organic tube type filter membrance system that molecular cut off is 0.1 μm, operation temperature is
25 DEG C, pressure 0.5MPa, obtain microfiltration membranes permeate.
First microfiltration membranes permeate was carried out by the rolling ultrafiltration membrane purification system that molecular cut off is 100kDa respectively
Filter, operation temperature are 35 DEG C, pressure 0.6MPa, obtain milipore filter permeate；Will transmit through liquid again is by molecular cut off
1000Da rolling ultrafiltration membrane purification system is filtered, and operation temperature is 25 DEG C, pressure 0.8MPa, obtains milipore filter retention
Liquid.Milipore filter trapped fluid is concentrated by the rolling high pressure reverse osmosis membrane system that molecular cut off is 100Da, operation temperature
For 25 DEG C, operating pressure 5.0MPa, the concentrate of solid content >=30% is obtained.
Concentrate is dried by the way of vacuum freeze drying or low temperature spray drying, obtains bitter gourd polypeptide extraction
Thing powder, the content of its polypeptide protein is 26.5%.
Embodiment 3
The present embodiment provides a kind of diabetic population suitable polypeptide beverage water, and it uses following preparation method to be made：
S301, count in parts by weight, weigh 200kg drinking water, 3kg bitter melon proteins polypeptide extract, 0.8kg Tomato juice
Powder, 1.2kg inulin, 0.2kg vitamin B6s, 0.003kg chlorophyll copper sodiums and the mixing of 0.04kg beta-schardinger dextrins are concentrated, must be mixed
Liquid.
S302, by mixed liquor under conditions of 25 DEG C, 27Mpa homogeneous.
S303, by the mixed liquor after homogeneous 28 DEG C, vacuum be 0.07Mpa under conditions of deaerate.
S304, it will be filtered after degassing, sterilize the steps such as embedding, the mixed liquor after degassing is specifically passed through 0.1 μm
Two organic tube type filter membrance systems in parallel filtered, filtered fluid instantaneous sterilization under conditions of 120 DEG C, be cooled to 30
After DEG C filling, sealing, then at 85 DEG C of sterilizations, room temperature is cooled to, produces the suitable polypeptide beverage water of diabetic population.
Wherein, bitter gourd polypeptide extract powder is made using following methods：
Raw material is used as from the drying balsam pear or balsam pear section that green is partially yellow, meat is full, balsam pear raw material was ground into
The coarse powder of 20 mesh sieves.
Balsam pear raw material after crushing is poured into Ultrasonic Wave-Assisted Extraction tank, and adds 10 mass times, 52 DEG C of purified water, profit
With buffer salt regulation system pH ≈ 6.8, the adverse current for carrying out ultrasonic assistant is extracted 2 times, every time 45 minutes.
Centrifuged, and removed slag using disc centrifuge or tube centrifuge, obtain centrifugate.
Centrifugate is filtered by the ceramic micro filter membranous system that molecular cut off is 0.2 μm, operation temperature is 35 DEG C,
Pressure is 0.5MPa, obtains microfiltration membranes permeate.
First microfiltration membranes permeate was carried out by the rolling ultrafiltration membrane purification system that molecular cut off is 150kDa respectively
Filter, operation temperature are 35 DEG C, pressure 0.5MPa, obtain milipore filter permeate；It is 500Da that liquid be will transmit through again by molecular cut off
Rolling ultrafiltration membrane purification system filtered, operation temperature be 35 DEG C, pressure 0.5MPa, obtain milipore filter trapped fluid.
Milipore filter trapped fluid is concentrated by the rolling high pressure reverse osmosis membrane system that molecular cut off is 100Da, grasped
Make temperature as 35 DEG C, pressure 4.5MPa, obtain the concentrate of solid content >=30%.
Concentrate is dried by the way of vacuum freeze drying or low temperature spray drying, obtains bitter gourd polypeptide extraction
Thing powder, the content of its polypeptide protein is up to 27.0%.
The polypeptide beverage water suitable to the diabetic population of embodiment 1, embodiment 2 and embodiment 3 offer is carried out real below
Test evaluation：
From the rat (150g ± 2g) of health, rat is randomly assigned into 4 groups, used by 60mg/kg/day dosage
Streptozotocin injection rat is diabetic model rats twice.Respectively to three groups of rats after tail vein measuring blood sugar of blood extracting value
Polypeptide beverage water in gavage embodiment 1, embodiment 2 and embodiment 3, gavage amount are 6g/kg body weight, and the rat of control group fills
The common drinking water of stomach equivalent, gavage amount are 6g/kg body weight, every 30min tail vein measuring blood sugar of blood extracting values after gavage, as a result
It is as shown in table 1 below.
Influence of the polypeptide beverage water of table 1 to rat blood sugar
From table 1, the blood sugar test value of each group rat there was no significant difference (P before experiment>0.05).Compared with control group
Each group rat blood sugar value rise is relatively low and blood glucose reduces speed, shows the suitable polypeptide beverage water of the diabetic population
Have the function that glycemic value is low and adjust blood glucose.
In summary, the suitable polypeptide beverage Shuifu County of the diabetic population of the embodiment of the present invention contains with hypoglycemic activity
Natural balsam pear polypeptide protein, water soluble dietary fiber content are high, have flavor taste and nutrition is all good, glycemic index after drink
It is worth the advantages of low, can effectively adjusts diabetes blood glucose's metabolism, meets the dietotherapy drink demand of diabetes patient.Diabetic population
The preparation technology of suitable polypeptide beverage water, technical method is stable, and quality controllability is strong.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. the suitable polypeptide beverage water of a kind of diabetic population, it is characterised in that it uses following raw material configuration to form, by weight
Number meter, the raw material include：
Drinking water 100-200 parts；And
Bitter gourd polypeptide extract powder 1-3 parts.
2. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
0.5-1 parts Fresh Cucumber Juice concentration powder, Tomato juice's concentration powder or spinach juice concentration powder.
3. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
1-2 part inulin.
4. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
0.5-2 part L-arabinoses.
5. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
0.1-0.5 part vitamin B6s.
6. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
At least one of 0.001-0.005 parts D-sorbite, 0.001-0.003 part chlorophyll copper sodiums.
7. the suitable polypeptide beverage water of diabetic population according to claim 1, it is characterised in that the raw material also includes
At least one of 0.01-0.02 parts sodium carboxymethylcellulose, 0.01-0.05 part beta-schardinger dextrins.
8. the preparation technology of the suitable polypeptide beverage water of a kind of diabetic population, it is characterised in that it comprises the following steps：
Count in parts by weight, weigh 100-200 parts drinking water and 1-3 part bitter gourd polypeptide extract powder, uniformly mixing, must be mixed
Liquid；
By mixed liquor under conditions of 20-35 DEG C, 27-30Mpa homogeneous；
Deaerated under conditions of being 0.07-0.09Mpa in 20-35 DEG C, vacuum by the mixed liquor after homogeneous.
9. the preparation technology of the suitable polypeptide beverage water of diabetic population according to claim 8, it is characterised in that described
The preparation method of bitter gourd polypeptide extract powder is：
The cleaning of balsam pear raw material, mashing is broken, balsam pear raw material is extracted at 40 DEG C or so with purified water, then centrifuge and remove slag, it must centrifuge
Liquid；
The centrifugate was carried out by three organic tube type filter membrance systems in parallel that molecular cut off is 3 μm -0.1 μm
Filter, big molecular impurity is removed, obtains microfiltration membranes permeate；
The microfiltration membranes permeate is purified into system by two rolling ultrafiltration membranes in parallel that molecular cut off is 100-200kDa
System is filtered, and obtains milipore filter permeate；
The milipore filter permeate is purified into system through two rolling ultrafiltration membranes in parallel that molecular cut off is 500-1000Da again
System is filtered, and obtains milipore filter trapped fluid；
Rolling high pressure reverse osmosis membrane system of the trapped fluid by four series connection that molecular cut off is 100-150Da is carried out
Concentration, moisture and part residual inorganic salts and small molecular weight impurity are removed, obtain concentrate, the solid content of the concentrate >=
30%；
The concentrate is dried, obtains the bitter gourd polypeptide extract powder that bitter gourd polypeptide protein content is not less than 25%.
10. the preparation technology of the suitable polypeptide beverage water of diabetic population according to claim 8, it is characterised in that institute
State preparation technology and be additionally included in the steps such as the filtering carried out after degassing, sterilization embedding, specifically pass through the mixed liquor after degassing
0.01 μm -0.2 μm of two organic tube type filter membrance systems in parallel are filtered, and filtered fluid is under conditions of 100-130 DEG C
Instantaneous sterilization, be cooled to 30-35 DEG C it is filling, sealing after, then at 77-87 DEG C sterilization, be cooled to room temperature.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259248A (en) * | 2018-11-12 | 2019-01-25 | 深圳市鸿美达生物科技有限公司 | A kind of drop body fat, hypoglycemic food formula |
| CN109757642A (en) * | 2019-03-21 | 2019-05-17 | 安徽农业大学 | A kind of preparation method of balsam pear solid beverage |
| CN110801024A (en) * | 2019-10-25 | 2020-02-18 | 运鸿集团股份有限公司 | Polysaccharide composite polypeptide for reducing blood sugar, blood fat and glycosylated hemoglobin and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102246986A (en) * | 2011-08-09 | 2011-11-23 | 韩金光 | Bitter melon juice drink and preparation method thereof |
| CN102273684A (en) * | 2011-06-27 | 2011-12-14 | 天津市恒安食品有限公司 | Tomato and bitter melon juice beverage and preparation method thereof |
| CN106421741A (en) * | 2016-09-26 | 2017-02-22 | 南京中生生物科技有限公司 | Water-soluble olive leaf extract health-care product and preparation method thereof |
| CN106606529A (en) * | 2016-12-27 | 2017-05-03 | 南京圣诺生物科技实业有限公司 | Composition with auxiliary blood sugar reduction efficacy, and preparation method and application thereof |
-
2017
- 2017-09-15 CN CN201710832625.8A patent/CN107495020A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102273684A (en) * | 2011-06-27 | 2011-12-14 | 天津市恒安食品有限公司 | Tomato and bitter melon juice beverage and preparation method thereof |
| CN102246986A (en) * | 2011-08-09 | 2011-11-23 | 韩金光 | Bitter melon juice drink and preparation method thereof |
| CN106421741A (en) * | 2016-09-26 | 2017-02-22 | 南京中生生物科技有限公司 | Water-soluble olive leaf extract health-care product and preparation method thereof |
| CN106606529A (en) * | 2016-12-27 | 2017-05-03 | 南京圣诺生物科技实业有限公司 | Composition with auxiliary blood sugar reduction efficacy, and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 盛清凯: "苦瓜降糖多肽-P的分离纯化及降糖机理研究", 《中国博士学位论文全文数据库（电子期刊），工程科技I辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109259248A (en) * | 2018-11-12 | 2019-01-25 | 深圳市鸿美达生物科技有限公司 | A kind of drop body fat, hypoglycemic food formula |
| CN109757642A (en) * | 2019-03-21 | 2019-05-17 | 安徽农业大学 | A kind of preparation method of balsam pear solid beverage |
| CN110801024A (en) * | 2019-10-25 | 2020-02-18 | 运鸿集团股份有限公司 | Polysaccharide composite polypeptide for reducing blood sugar, blood fat and glycosylated hemoglobin and preparation method thereof |
| GB2608697B (en) * | 2019-10-25 | 2023-11-15 | China Yunhong Holdings Co Ltd | Polysaccharide-peptide complex for lowering blood sugar, blood lipid and glycosylated hemoglobin levels, and preparation method |
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Application publication date: 20171222 |