CN107468797A - A kind of hemorrhoids hemostasia particle and preparation method thereof - Google Patents
A kind of hemorrhoids hemostasia particle and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of hemorrhoids hemostasia particle, it is made up of Chinese medicine and auxiliary material, the Chinese medicine includes the raw material of following parts by weight：150~200 parts of the Fructus Sophorae, 150~200 parts of golden cypress, 150~180 parts of Chinese gall, 130~160 parts of MAZHIXIAN, 130~160 parts of hairyvein agrimony, 130~160 parts of rhizome of cyrtomium, 150~180 parts of the Radix Astragali, 120~150 parts of rattletop, the auxiliary material include raw material in parts by weight：1.5~2 parts of beta cyclodextrin 0.5~0.8, honey；And provide its preparation method.The particle is worked using mode for oral administration to hemorrhoid, the medicinal material that there is yang invigorating to act on for the Radix Astragali and rattletop is also added into compared with existing acne cream, suppository, in particle, sufferings caused by hemorrhoid, bleeding are treated by nursing one's health human body viscera, haemorrhoids can be obviously reduced, it is uneasy to recur.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, in particular it relates to a kind of hemorrhoids hemostasia particle and preparation method thereof.
Background technology
Hemorrhoid (being commonly called as hemorrhoid) are a kind of common diseases positioned at anus area, and any age can all fall ill, but with the age
Increase, the incidence of disease gradually increases.In China, hemorrhoid are most common anorectal diseases.
The cause of disease on hemorrhoid mainly has two kinds of theories：First, varicose vein theory, it is believed that hemorrhoid are distal rectal mucous membranes
The venous group that veniplex extravasated blood, expansion and flexing under lower and anal canal skin are formed；Second, Thomson anus pad moves down
Say, it is believed that hemorrhoid are originally the normal anatomical structure in anal tube position, i.e. blood vessel pad, are dentate line and above 1.5cm ring-type sea
Mian Yang taeniae telarums.When only anus pad tissue occurs exception and is associated with symptom, hemorrhoid could be referred to as, just need to treat, treat mesh
Be to release symptom, and non-elimination hemorrhoid body.The risk factor of hemorrhoid is a lot, wherein constipation, long-term alcohol, a large amount of excitants of feed
It is main inducing that food and sitting are stood long.
Hemorrhoid are divided into internal piles, external piles, mixed hemorrhoid by the difference of happening part.In anal canal skin and the junction of rectal mucosa
There is a jagged visible line anal tube dentate line.More than dentate line for internal piles；It is external piles below dentate line, quilt
Anal tube mucous membrane is covered, connective tissue external piles, varicose external piles, thrombosed external hemorrhoid can be divided into；Have internal piles and external piles concurrently is
Mixed hemorrhoid, it is that internal piles is merged by veniplex with corresponding external piles, i.e., upper and lower veniplex coincide.
The treatment method of hemorrhoid is divided into drug therapy and operative treatment.Therapeutic method of surgery is by after hemorrhoid removal, if causing
Recurrence, will be unable to be performed the operation again.The medicine for treating hemorrhoid is mainly cream, suppository, directly acts on affected part, antalgesic-antipruritic stops
Blood effect is very fast, but is easily recurred after being discontinued.
The content of the invention
First purpose of the present invention is to overcome drawbacks described above, there is provided a kind of hemorrhoids hemostasia particle.
Second object of the present invention is to provide the preparation method of above-mentioned particle.
The purpose of the present invention implements by the following technical programs：
A kind of hemorrhoids hemostasia particle, is made up of Chinese medicine and auxiliary material, and the Chinese medicine includes the raw material of following parts by weight：
150~200 parts of the Fructus Sophorae, 150~200 parts of golden cypress, 150~180 parts of Chinese gall, 130~160 parts of MAZHIXIAN, red crowned crane
130~160 parts of grass, 130~160 parts of rhizome of cyrtomium, 150~180 parts of the Radix Astragali, 120~150 parts of rattletop,
The auxiliary material includes raw material in parts by weight：
1.5~2 parts of beta-schardinger dextrin 0.5~0.8, honey.
As preferable, the Chinese medicine is made up of the raw material of following parts by weight：
190 parts of the Fructus Sophorae, 180 parts of golden cypress, 160 parts of Chinese gall, 145 parts of MAZHIXIAN, 145 parts of hairyvein agrimony, 145 parts of rhizome of cyrtomium, Huang
160 parts of stilbene, 130 parts of rattletop.
It is further preferred that the auxiliary material is made up of the raw material of following parts by weight：
1.8 parts of beta-schardinger dextrin 0.7, honey.
The preparation method of above-mentioned hemorrhoids hemostasia particle, weighs Chinese medicine by weight, and the Chinese medicine is crushed, using water plus
Hot extraction produces Chinese medicine extract solution, then obtained Chinese medicine extract solution is concentrated under reduced pressure, in obtaining first through pre-concentration
Medicinal material concentrate, obtained Chinese medicine concentrate are dried to solid, add auxiliary material, particle is made, produces.
Further, methods described specifically comprises the following steps：
(1) Chinese medicine crushes
The Fructus Sophorae, golden cypress, Chinese gall, MAZHIXIAN, hairyvein agrimony, rhizome of cyrtomium, the Radix Astragali, rattletop are weighed, above-mentioned Chinese medicine is entered respectively
Row is broken；
(2) preparation of Chinese medicine extract solution
The Fructus Sophorae, golden cypress, Chinese gall, MAZHIXIAN, hairyvein agrimony, rhizome of cyrtomium, the Radix Astragali, the rattletop that step (1) is crushed add water to carry out
Reheating is extracted, and extract solution merges, and obtains Chinese medicine extract solution；
(3) preparation of Chinese medicine concentrate
The Chinese medicine extract solution heating that step (2) is obtained carries out pre-concentration, and ethanol is added into obtained pre-concentration liquid,
Then stand, filter, be concentrated under reduced pressure and collect ethanol, obtain Chinese medicine concentrate；
(4) dry, crush
The Chinese medicine concentrate heating, drying that step (3) is obtained, obtained solids are crushed, and obtain Chinese medicine extraction
Thing powder；
(5) preparation of particle
The Chinese medicinal material extract powder and auxiliary material that step (4) is obtained are sufficiently mixed uniformly, through pelletizing, dispensing, are produced.
Further, in the step (2), when Chinese medicine carries out heating extraction, water and Chinese medicine when extracting for the first time
Weight ratio be 4~6:1, extraction time is 1.5~2h, and the weight ratio of water and Chinese medicine is 3~4 when extracting for the second time:1, carry
It is 1~1.5h to take the time.
Further, in the step (3), pre-concentration method is：Chinese medicine extract solution is heated at ambient pressure micro-
Boiling, is concentrated into relative density of fluid more than 1.16.
Further, in the step (3), the addition of ethanol ethanol content more than 55% into mixed liquor；
Time of repose is 30~36h.
Further, in the step (3), it is concentrated under reduced pressure and is carried out at -0.06~-0.07Mpa, 50~55 DEG C, extremely
Relative density of fluid more than 1.28.
Further, in the step (4), Chinese medicine concentrate is dried at 70~75 DEG C.
The effect of each raw material of hemorrhoids hemostasia particle of the present invention is as follows：
The Fructus Sophorae：Bitter, cold in nature, Return liver, large intestine channel, there is the effect of clearing heat-fire, cooling blood and hemostasis；
Golden cypress：Bitter, it is cold in nature, return kidney, bladder warp, there is the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment；
Chinese gall：It is sour, puckery, cold in nature, return lung, large intestine, kidney channel, there are astringe the lung fall fire, relieving diarrhea with astringents, arrest sweating, hemostasis, receipts
The effect of wet sore；
MAZHIXIAN：It is sour, cold in nature, Return liver, large intestine channel, there is the effect of clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery；
Hairyvein agrimony：Bitter, puckery, mild-natured, the thoughts of returning home, Liver Channel, there is the effect of astringing to arrest bleeding, preventing malaria, stop dysentery, removing toxic substances, qi-restoratives；
Rhizome of cyrtomium：It is bitter, puckery, it is cold in nature, Return liver, stomach, there is desinsection, heat-clearing, removing toxic substances, cooling blood and hemostasis；
The Radix Astragali：It is sweet, slightly warm in nature, return lung, spleen, liver and kidney channel, there is invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation
The effect of；
Rattletop：Acrid flavour, sweet, cold nature, return lung, spleen, large intestine, stomach, have and deliver promoting eruption, clearing heat and detoxicating, yang invigorating
The effect of.
The invention has the advantages that：
Hemorrhoids hemostasia particle provided by the invention, hemorrhoid are worked using mode for oral administration, with existing acne cream, suppository phase
Than the medicinal material that there is yang invigorating to act on for the Radix Astragali and rattletop being also added into particle, by nursing one's health human body viscera to treat hemorrhoid
Sufferings, bleeding caused by sore, can be obviously reduced haemorrhoids, uneasy to recur.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Raw material in the embodiment of the present invention is that market can obtain product.
Embodiment 1
A kind of hemorrhoid treating particle, preparation method are as follows：
(1) Chinese medicine crushes
By weight, weigh 190 parts of the Fructus Sophorae, 180 parts of golden cypress, 160 parts of Chinese gall, 145 parts of MAZHIXIAN, 145 parts of hairyvein agrimony,
145 parts of rhizome of cyrtomium, 160 parts of the Radix Astragali, 130 parts of rattletop, above-mentioned Chinese medicine is crushed respectively.
(2) preparation of Chinese medicine extract solution
Add water to carry out second extraction above-mentioned broken Chinese medicine, the pure of 5 times of medicinal material weight is added when extracting for the first time
Water, micro-boiling extraction 1.8h is heated to, an extract solution is filtered to obtain, adds the pure water of 4 times of medicinal material weight, be heated to micro-boiling and carry
1.5h is taken, filters to obtain secondary raffinate, extract solution merges, and obtains Chinese medicine extract solution.
(3) preparation of Chinese medicine concentrate
Chinese medicine extract solution is heated to micro-boiling pre-concentration at ambient pressure, to relative density of fluid more than 1.16.To obtaining
Pre-concentration liquid in add ethanol ethanol content more than 55% into mixed liquor, then stand 35h, filtrate be collected by filtration ,-
0.06~-0.07Mpa, be concentrated under reduced pressure at 50~55 DEG C and collect ethanol, to relative density of fluid more than 1.28, obtain Chinese medicine
Concentrate.
(4) dry, crush
Chinese medicine concentrate is heated to 70~75 DEG C, drying, obtained solids is crushed, and obtains Chinese medicinal material extract
Powder.
(5) preparation of particle
Beta-schardinger dextrin 0.7,1.8 parts of honey are added into Chinese medicinal material extract powder, is sufficiently mixed uniformly, through pelletizing, is divided
Dress, is produced.
Male patient, 28 years old, mixed hemorrhoid, the course of disease 6 years.Treated, be taken twice daily with the particle of the present embodiment, often
Secondary 10g, symptom of being had blood in stool after taking 5 days disappear, and sufferings symptom disappears substantially after 8 days, and defecation is smooth, continues to take, day of always taking medicine
Number 20 days, haemorrhoids reduce 74%.
Embodiment 2
A kind of hemorrhoid treating particle, preparation method are as follows：
(1) Chinese medicine crushes
By weight, weigh 200 parts of the Fructus Sophorae, 180 parts of golden cypress, 150 parts of Chinese gall, 130 parts of MAZHIXIAN, 130 parts of hairyvein agrimony,
160 parts of rhizome of cyrtomium, 180 parts of the Radix Astragali, 120 parts of rattletop, above-mentioned Chinese medicine is crushed respectively.
(2) preparation of Chinese medicine extract solution
Add water to carry out second extraction above-mentioned broken Chinese medicine, the pure of 4 times of medicinal material weight is added when extracting for the first time
Water, micro-boiling extraction 1.5h is heated to, an extract solution is filtered to obtain, adds the pure water of 4 times of medicinal material weight, be heated to micro-boiling and carry
1.5h is taken, filters to obtain secondary raffinate, extract solution merges, and obtains Chinese medicine extract solution.
(3) preparation of Chinese medicine concentrate
Chinese medicine extract solution is heated to micro-boiling pre-concentration at ambient pressure, to relative density of fluid more than 1.16.To obtaining
Pre-concentration liquid in add ethanol ethanol content more than 55% into mixed liquor, then stand 36h, filtrate be collected by filtration ,-
0.06~-0.07Mpa, be concentrated under reduced pressure at 50~55 DEG C and collect ethanol, to relative density of fluid more than 1.28, obtain Chinese medicine
Concentrate.
(4) dry, crush
Chinese medicine concentrate is heated to 70~75 DEG C, drying, obtained solids is crushed, and obtains Chinese medicinal material extract
Powder.
(5) preparation of particle
Beta-schardinger dextrin 0.5,2 parts of honey are added into Chinese medicinal material extract powder, is sufficiently mixed uniformly, through pelletizing, dispensing,
Produce.
Male patient, 21 years old, mixed hemorrhoid, the course of disease 2 years.Treated, be taken twice daily with the particle of the present embodiment, often
Secondary 10g, symptom of being had blood in stool after taking 3 days disappear, and sufferings symptom disappears substantially after 5 days, and defecation is smooth, continues to take, day of always taking medicine
Number 14 days, haemorrhoids reduce 75%.
Embodiment 3
A kind of hemorrhoid treating particle, preparation method are as follows：
(1) Chinese medicine crushes
By weight, weigh 150 parts of the Fructus Sophorae, 200 parts of golden cypress, 180 parts of Chinese gall, 160 parts of MAZHIXIAN, 160 parts of hairyvein agrimony,
130 parts of rhizome of cyrtomium, 150 parts of the Radix Astragali, 150 parts of rattletop, above-mentioned Chinese medicine is crushed respectively.
(2) preparation of Chinese medicine extract solution
Add water to carry out second extraction above-mentioned broken Chinese medicine, the pure of 6 times of medicinal material weight is added when extracting for the first time
Water, micro-boiling extraction 2h is heated to, an extract solution is filtered to obtain, adds the pure water of 3 times of medicinal material weight, is heated to micro-boiling extraction
1h, secondary raffinate is filtered to obtain, extract solution merges, and obtains Chinese medicine extract solution.
(3) preparation of Chinese medicine concentrate
Chinese medicine extract solution is heated to micro-boiling pre-concentration at ambient pressure, to relative density of fluid more than 1.16.To obtaining
Pre-concentration liquid in add ethanol ethanol content more than 55% into mixed liquor, then stand 30h, filtrate be collected by filtration ,-
0.06~-0.07Mpa, be concentrated under reduced pressure at 50~55 DEG C and collect ethanol, to relative density of fluid more than 1.28, obtain Chinese medicine
Concentrate.
(4) dry, crush
Chinese medicine concentrate is heated to 70~75 DEG C, drying, obtained solids is crushed, and obtains Chinese medicinal material extract
Powder.
(5) preparation of particle
Beta-schardinger dextrin 0.8,1.5 parts of honey are added into Chinese medicinal material extract powder, is sufficiently mixed uniformly, through pelletizing, is divided
Dress, is produced.
Male patient, 45 years old, external piles, the course of disease 15 years.Treated, be taken twice daily with the particle of the present embodiment, often
Secondary 10g, symptom of being had blood in stool after taking 6 days disappear, and sufferings symptom disappears substantially after 11 days, and defecation is smooth, continues to take, day of always taking medicine
Number 21 days, haemorrhoids reduce 68%.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, although with reference to foregoing reality
Apply example the present invention is described in detail, for those skilled in the art, it still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic.All essences in the present invention
God any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.
Claims (10)
1. a kind of hemorrhoids hemostasia particle, is made up of Chinese medicine and auxiliary material, it is characterised in that the Chinese medicine includes following parts by weight
Raw material：
150~200 parts of the Fructus Sophorae, 150~200 parts of golden cypress, 150~180 parts of Chinese gall, 130~160 parts of MAZHIXIAN, hairyvein agrimony 130
~160 parts, 130~160 parts of rhizome of cyrtomium, 150~180 parts of the Radix Astragali, 120~150 parts of rattletop,
The auxiliary material includes raw material in parts by weight：
1.5~2 parts of beta-schardinger dextrin 0.5~0.8, honey.
2. hemorrhoids hemostasia particle according to claim 1, it is characterised in that the Chinese medicine by following parts by weight raw material
Composition：
190 parts of the Fructus Sophorae, 180 parts of golden cypress, 160 parts of Chinese gall, 145 parts of MAZHIXIAN, 145 parts of hairyvein agrimony, 145 parts of rhizome of cyrtomium, the Radix Astragali 160
Part, 130 parts of rattletop.
3. hemorrhoids hemostasia particle according to claim 2, it is characterised in that the auxiliary material by following parts by weight raw material group
Into：
1.8 parts of beta-schardinger dextrin 0.7, honey.
4. the preparation method of the hemorrhoids hemostasia particle described in claim any one of 1-3, it is characterised in that weigh Chinese medicine by weight
Material, the Chinese medicine is crushed, Chinese medicine extract solution is taken using water heating extracting legal system, obtained Chinese medicine extract solution passes through first
Pre-concentration, then it is concentrated under reduced pressure, obtains Chinese medicine concentrate, obtained Chinese medicine concentrate is dried to solid, adds auxiliary material,
Particle is made, produces.
5. the preparation method of hemorrhoids hemostasia particle according to claim 4, it is characterised in that methods described specifically include as
Lower step：
(1) Chinese medicine crushes
The Fructus Sophorae, golden cypress, Chinese gall, MAZHIXIAN, hairyvein agrimony, rhizome of cyrtomium, the Radix Astragali, rattletop are weighed, above-mentioned Chinese medicine is broken respectively
It is broken；
(2) preparation of Chinese medicine extract solution
It is secondary that the Fructus Sophorae, golden cypress, Chinese gall, MAZHIXIAN, hairyvein agrimony, rhizome of cyrtomium, the Radix Astragali, the rattletop that step (1) is crushed add water to carry out
Heating extraction, extract solution merge, and obtain Chinese medicine extract solution；
(3) preparation of Chinese medicine concentrate
The Chinese medicine extract solution heating that step (2) is obtained carries out pre-concentration, adds ethanol into obtained pre-concentration liquid, then
Stand, filtering, be concentrated under reduced pressure and collect ethanol, obtain Chinese medicine concentrate；
(4) dry, crush
The Chinese medicine concentrate heating, drying that step (3) is obtained, obtained solids are crushed, and obtain Chinese medicinal material extract powder
End；
(5) preparation of particle
The Chinese medicinal material extract powder and auxiliary material that step (4) is obtained are sufficiently mixed uniformly, through pelletizing, dispensing, are produced.
6. the preparation method of hemorrhoids hemostasia particle according to claim 5, it is characterised in that in the step (2), Chinese medicine
When material carries out heating extraction, the weight ratio of water and Chinese medicine is 4~6 when extracting for the first time:1, extraction time is 1.5~2h, the
The weight of water and Chinese medicine ratio is 3~4 during second extraction:1, extraction time is 1~1.5h.
7. the preparation method of hemorrhoids hemostasia particle according to claim 5, it is characterised in that pre- dense in the step (3)
Compression method is：Chinese medicine extract solution is heated to micro-boiling at ambient pressure, is concentrated into relative density of fluid more than 1.16.
8. the preparation method of hemorrhoids hemostasia particle according to claim 5, it is characterised in that in the step (3), ethanol
Addition into mixed liquor ethanol content more than 55%；
Time of repose is 30~36h.
9. the preparation method of hemorrhoids hemostasia particle according to claim 5, it is characterised in that in the step (3), decompression
It is concentrated in -0.06~-0.07Mpa, carries out at 50~55 DEG C, to relative density of fluid more than 1.28.
10. the preparation method of hemorrhoids hemostasia particle according to claim 5, it is characterised in that in the step (4), in
Medicinal material concentrate is dried at 70~75 DEG C.
Priority Applications (1)
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Cited By (2)
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| CN110841017A (en) * | 2019-12-30 | 2020-02-28 | 武汉自然萃创新科技有限公司 | Hemorrhoid powder, hemorrhoid medicine and preparation method |
| CN110974882A (en) * | 2019-12-30 | 2020-04-10 | 武汉自然萃创新科技有限公司 | Medicinal powder and lotion for treating hemorrhoid and preparation method thereof |
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| CN103417614A (en) * | 2012-05-21 | 2013-12-04 | 孙玉洁 | Traditional Chinese medicine for treating hemorrhoid |
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| CN103417614A (en) * | 2012-05-21 | 2013-12-04 | 孙玉洁 | Traditional Chinese medicine for treating hemorrhoid |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110841017A (en) * | 2019-12-30 | 2020-02-28 | 武汉自然萃创新科技有限公司 | Hemorrhoid powder, hemorrhoid medicine and preparation method |
| CN110974882A (en) * | 2019-12-30 | 2020-04-10 | 武汉自然萃创新科技有限公司 | Medicinal powder and lotion for treating hemorrhoid and preparation method thereof |
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