CN107468752A - A kind of compound Danshen Root sticks micropill and its preparation technology - Google Patents
A kind of compound Danshen Root sticks micropill and its preparation technology Download PDFInfo
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- CN107468752A CN107468752A CN201710609695.7A CN201710609695A CN107468752A CN 107468752 A CN107468752 A CN 107468752A CN 201710609695 A CN201710609695 A CN 201710609695A CN 107468752 A CN107468752 A CN 107468752A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The present invention discloses a kind of compound Danshen Root and sticks micropill and preparation method thereof, it is primarily characterized in that and takes the red sage root, pseudo-ginseng, borneol, the extraction of 70% ethanol is respectively adopted with pseudo-ginseng in the red sage root, obtain extract, borneol is included using betadex, take its inclusion compound, micropill is prepared using extrusion spheronization machine, compound Danshen Root prepared by the present invention sticks micropill, medicine can be made to attach to human intestines and stomach's mucous membrane, extend residence time of the medicine in intestines and stomach, it is remarkably improved the bioavilability of compound red sage root formula, simultaneously, borneol is included using betadex, the stability of borneol in the formulation can be improved.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of compound Danshen Root sticks micropill and its preparation technology.
Background technology
Compound red sage root preparation is one of big kind of famous-brand and high-quality Chinese patent drug, and clinic is widely used in the hearts such as treatment coronary heart disease, angina pectoris
Vascular diseases, it is curative for effect.Compound red sage root formula is made up of three taste Chinese medicines, the red sage root, pseudo-ginseng and borneol.With Tanshinone II in the red sage root
A is that the liposoluble constituent diterpene quinone dissolution of representative is poor, and using tanshin polyphenolic acid B and Saponins from Panax notoginseng as representative
Less stable of the water soluble ingredient in gastric juice, borneol has the effect of inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, but borneol has volatilization
Property, long-term place may cause content of drug effect components in preparation to reduce.
Bio-adhesive technology can solve the problems, such as medicine residence time deficiency in intestines and stomach, its by increase medicine with
Active force between gastrointestinal tract mucosa, extend holdup time of the medicine in intestines and stomach, promote the close contact of medicine and mucous membrane,
So as to improve the bioavilability of medicine.Using betadex inclusion technique, can effectively prevent during producing and storing
The volatilization of borneol.
The content of the invention
Present invention aims at providing a kind of compound Danshen Root to stick micropill, the present invention seeks to real by following technical solution
Existing：
A kind of compound Danshen Root sticks micropill, weighs Salvia root P.E 6-10 parts by weight, Notogineng Extract 1-3 parts by weight, ice
Piece inclusion compound 1-4 parts by weight, hydroxypropyl methyl celluloseK100M1-3 parts by weight, chitosan 1-3 parts by weight, carbomer940 1-3
Parts by weight, microcrystalline cellulose 2-7 parts by weight, mix, add 20-40% sodium-chloride water solution 10-15 parts by volume, rolled using extrusion
Circule method prepares micropill, produces compound Danshen Root and sticks micropill；
Compound Danshen Root of the present invention sticks micropill and is preferably as follows method preparation：
Weigh the parts by weight of Salvia root P.E 8.09, the parts by weight of Notogineng Extract 1.57, the parts by weight of borneol inclusion compound 2.176,
Hydroxypropyl methyl celluloseK100M, chitosan, each 2.5 parts by weight of carbomer940, the parts by weight of microcrystalline cellulose 5.56, mix, add
Enter 20-40% sodium-chloride water solutions, preparing compound Danshen Root using extrusion spheronization method sticks micropill, is drying to obtain.
The Salvia root P.E, Notogineng Extract are made up of conventional method；
The borneol inclusion compound is made by the following method：
Betadex 4-8 parts by weight are weighed, are placed in ball grinder, add 10-30 parts by volume distilled water；Weigh borneol
0.5-2 parts by weight, add absolute ethyl alcohol to dissolve, and the solution is added in ball grinder, grind, and take out, are stood overnight with 3-5 DEG C, filter
Cross, the borneol adsorbed on filter cake washed with absolute ethyl alcohol, put 40-60 DEG C and be dried under reduced pressure, the finely ground mesh sieve of mistake 80, produce borneol times he
Cyclodextrin inclusion compound.
The Salvia root P.E or Notogineng Extract are preferably as follows method preparation：
Salvia piece or notoginseng decoction piece, 6-10 times of weight 60-90% alcohol refluxs are added to extract 1-3 times, each 1-2h, filter
Cross, merge extract solution, be concentrated into thick paste, 40-70 DEG C is dried under reduced pressure, and obtains Salvia root P.E or Notogineng Extract.
The relation of parts by weight and parts by volume of the present invention is g/ml relation.
Brief description of the drawings：
R in Fig. 1 compound red sage root preparations1Blood concentration-time curve map
R in Fig. 2 compound red sage root preparationsg1Blood concentration-time curve map
R in Fig. 3 compound red sage root preparationseBlood concentration-time curve map
R in Fig. 4 compound red sage root preparationsb1Blood concentration-time curve map
R in Fig. 5 compound red sage root preparationsdBlood concentration-time curve map
The present invention is with hydroxypropyl methyl celluloseK100M, chitosan and carbomer940 be pasting material, rolled using extrusion
Circle pill method, is prepared into compound Danshen Root by compound red sage root formula and sticks micropill, so as to increase in compound red sage root formula each medicine in vivo
Holdup time, extend medicine inside discharge, improve the bioavilability of medicine.Borneol of the present invention uses betadex bag
Close, inclusion technique can effectively prevent the volatilization of borneol during producing and storing, the stability of enhancing borneol in the formulation.
Experimental example 1：The compound Danshen Root of embodiment 1 sticks the test of micropill Adhesion property
1 external adhesion assay
1.1 tissue residue methods
Fresh chitterlings are taken, the content in small intestine is washed out with pH6.8 phosphate buffers, are cut into 10cm intestinal segments, longitudinal direction
Cut off, be laid on glass plate, binder clip is fixed.Micropill 100 is taken, is uniformly sprinkling upon intestinal mucosa surface, in 37 DEG C of simulated intestinal fluids
Vibration, 100 times/min of frequency of oscillation count the micropill number for being stranded in intestinal mucosa surface after a certain time, and experimental result is shown in
Table 1.
The tissue residue method adhesion assay result (n=2) of table 1
1.2 minimum stripping force methods
Fresh chitterlings are taken, the content in small intestine is washed out with pH6.8 phosphate buffers, are cut into 10cm intestinal segments, longitudinal direction
Cut off, sticked with four wide adhesive tapes of 2cm on small intestine, each two of both ends, non-overlapping copies, centre reserves the wide spaces of 2cm, claimed
Take 0.5g to stick micropill, be uniformly sprinkling upon on small intestine, take pH6.8 phosphate buffer 0.5mL, drop on micropill, make micropill
Fully swelling, takes another fresh chitterlings, longitudinally cuts off, inner surface is affixed on small intestine, one an equal amount of glass of upper cover
Glass plate, 20min is pressed with 6N pressure, is put in after allowing on electronic stripping tester, clamps one section, started, record small intestine starts time shift
Dynamic numerical value is greatest measure, and this numerical value is minimum peeling force, and experimental result is shown in Table 2.
The minimum peeling force result of the test (n=2) of table 2
Adhesion assay in 2 bodies
SD rats, fasting 24h, free water.Every rat gives the micropill 100 of different prescriptions, with 1mL physiological saline
Gavage.Rat Fast prohibits water after administration.Rat is put to death after 4h, is dissected, stomach is taken out and small intestine, level is extended in white enamel tray
On, the length of small intestine is measured, is longitudinally splitted, small intestine is equally divided into upper, middle and lower segment, micropill is measured and is retained for each section in small intestine
Length.Stick length of the micropill in each section of small intestine is weighted, epimere (L1) weight larger, middle-end (L2) take second place, lower end
(L3) weighting minimum, stick index N=0.5L1+0.3L2+0.2L3, experimental result is shown in Table 3.
Adhesion assay result (n=2) in the body of table 3
Inside and outside adhesion assay result shows that compound Danshen Root of the invention, which sticks micropill, has good Adhesion property.
Experimental example 2：The compound Danshen Root of embodiment 2 sticks micropill and index components R in common compound Danshen Root micropill1、Rb1、Re、
Rd1、Rg1Blood concentration contrast is investigated
240~260g of body weight male SD rat 12, adaptability fed for 1 week, are randomly divided into two groups：Group one is compound
The red sage root sticks micropill group；Group two is common compound Danshen Root micropill group.It is administered by 2.4g/kg, blood is taken in stipulated time point eye socket
0.5mL, it is placed in calparine pipe, 5000r/min refrigerated centrifuge 15min, takes the μ L of supernatant 200, precision adds 10 μ L (500ng/
ML) saikoside A and 600 μ L acetonitriles, vortex 3min, 14000r/min centrifugation 10min, take supernatant in 40 DEG C of vacuum concentration instrument
In volatilize.The redissolution of the acetonitrile solutions of 100 μ L 20% is added, vortex 2min, puts 100w power ultrasonics 10min in Ultrasound Instrument,
14000r/min centrifuges 10min, is centrifuged repeatedly three times, takes supernatant as need testing solution.
Compound Danshen Root sticks the average blood of index components R1, Rg1, Re, Rb1, Rd in micropill and compound Danshen Root ordinary preparation
Concentration-time graph is shown in Fig. 1-Fig. 5, and corresponding medicine moves fitting parameter and is shown in Table 4- tables 8
The R of table 41Medicine moves fitting parameter (n=6, mean ± SD)
Note：* represent that compound Danshen Root sticks micropill and has significant difference, P ＜ 0.05 compared with compound Danshen Root ordinary preparation.
The Rg of table 51Medicine moves fitting parameter (n=6, mean ± SD)
Note：* represent that compound Danshen Root sticks micropill and has significant difference, P ＜ 0.05 compared with compound Danshen Root ordinary preparation.
The Re medicines of table 6 move fitting parameter (n=6, mean ± SD)
Note：* represent that compound Danshen Root sticks micropill and has significant difference, P ＜ 0.05 compared with compound Danshen Root ordinary preparation.
The Rb of table 71Medicine moves fitting parameter (n=6, mean ± SD)
Note：* represent that compound Danshen Root sticks micropill and has significant difference, P ＜ 0.05 compared with compound Danshen Root ordinary preparation.
The Rd medicines of table 8 move fitting parameter (n=6, mean ± SD)
Note：* represent that compound Danshen Root sticks micropill and has significant difference, P ＜ 0.05 compared with compound Danshen Root ordinary preparation.
From result above, compound Danshen Root sticks five kinds of saponin constituent bioavilabilities in micropill and is all higher than commonly making
Agent.For five kinds of composition entirety, CLz/F is to stick preparation to be significantly lower than ordinary preparation, and stick preparation AUC and
CmaxOrdinary preparation is all remarkably higher than, illustrates that stick preparation serves adhesion effect in vivo, is attached on mucous membrane and shows medicine and its
Contact is closer, absorption it is more efficient, while extend effective soak time of medicine, bigger blood medicine provided to body
Concentration, so that bioavilability is significantly improved, there is provided it is more preferable the effect of.
Embodiment 1：
Salvia piece 450g adds 8 times of 70% alcohol refluxs of amount to extract 2 times, each 1.5h, filtration, merges extract solution, concentration
To thick paste, 60 DEG C are dried under reduced pressure, and obtain Salvia root P.E, and paste-forming rate 42.8%, Salvia root P.E is finely ground, cross 80 mesh sieves, standby
With；Notoginseng decoction piece 141g adds 8 times of 70% alcohol refluxs of amount to extract 2 times, each 1.5h, filtration, merges extract solution, is concentrated into thick
Cream, 60 DEG C are dried under reduced pressure, and obtain Notogineng Extract, and paste-forming rate 26.43%, Notogineng Extract is finely ground, cross 80 mesh sieves, standby；
Betadex 6g is weighed, is placed in ball grinder, adds 20mL distilled water；Borneol 1g (crossing 80 mesh sieves) is weighed, adds the anhydrous second of 2mL
Alcohol dissolves, and the solution is added in ball grinder, rotating speed 300rmin-1, 30min is ground, takes out, was placed in 4 DEG C of refrigerators
At night, filtration, the borneol adsorbed on filter cake is washed with 5mL absolute ethyl alcohols, 50 DEG C is put and is dried under reduced pressure 6h, produce borneol betadex
Inclusion compound, the finely ground mesh sieve of mistake 80, standby, paste-forming rate 680%.
Weigh Salvia root P.E 8.09g (red sage root paste-forming rate is 42.5%), Notogineng Extract 1.57g (pseudo-ginseng paste-forming rates
26.43%), borneol inclusion compound 2.176g (paste-forming rate 680%), hydroxypropyl methyl celluloseK100M, chitosan, carbomer
934P each 2.5g, microcrystalline cellulose 5.56g, mix, add 30% sodium-chloride water solution 12mL, prepared using extrusion spheronization method multiple
Fang Dancan sticks micropill, extruded velocity 25r/min, and round as a ball speed is 1600r/min, and the round as a ball time is 4min, drying time
For 2h.
Embodiment 2：Salvia piece 450g adds 8 times of 70% alcohol refluxs of amount to extract 2 times, each 1.5h, filtration, merges extraction
Liquid, concentration, 60 DEG C are dried under reduced pressure, and obtain Salvia root P.E, and paste-forming rate 44.92%, Salvia root P.E is finely ground, cross 80 mesh sieves,
It is standby；Notoginseng decoction piece 141g adds 8 times of 70% alcohol refluxs of amount to extract 2 times, each 1.5h, filtration, merges extract solution, concentrates, 60
DEG C it is dried under reduced pressure, obtains Notogineng Extract, paste-forming rate 29.88%, Notogineng Extract is finely ground, crosses 80 mesh sieves, standby；Weigh again
He is cyclodextrin 6g, is placed in ball grinder, adds 20mL distilled water；Borneol 1g (crossing 80 mesh sieves) is weighed, adds 2mL absolute ethyl alcohols molten
Solution, the solution is added in ball grinder, 300rmin-1, 30min is ground, is taken out, with being stood overnight in 4 DEG C of refrigerators, filters, uses
The borneol that adsorbs on 5mL absolute ethyl alcohols washing filter cake, put 50 DEG C and be dried under reduced pressure 6h, the finely ground mesh sieve of mistake 80, produce borneol times his ring
Cyclodextrin inclusion compound, standby, paste-forming rate 680%.
Salvia root P.E 8.02g (paste-forming rate 44.92%), Notogineng Extract 1.67g (paste-forming rate 29.88%), borneol bag
Compound 2.176g, hydroxypropyl methyl celluloseK100M, chitosan, carbomer940, each 2.5g, microcrystalline cellulose 5.634g, mix
It is even, 30% sodium-chloride water solution 12mL is added, extruded velocity 25r/min, round as a ball speed is 1600r/min, and the round as a ball time is
4min, drying time 2h, is produced.
Claims (8)
1. a kind of compound Danshen Root sticks micropill, it is characterised in that the micropill is made by the following method：
Weigh Salvia root P.E 6-10 parts by weight, Notogineng Extract 1-3 parts by weight, borneol inclusion compound 1-4 parts by weight, hydroxypropyl first
Base celluloseK100M1-3 parts by weight, chitosan 1-3 parts by weight, carbomer940 1-3 parts by weight, microcrystalline cellulose 2-7 weight
Part, mix, add 20-40% sodium-chloride water solution 10-15 parts by volume, micropill is prepared using extrusion spheronization method, produce compound pellet
Ginseng sticks micropill；
The Salvia root P.E, Notogineng Extract have conventional method to be made；
The borneol inclusion compound is made by the following method：
Betadex 4-8 parts by weight are weighed, are placed in ball grinder, add 10-30 parts by volume distilled water；Weigh borneol 0.5-2
Parts by weight, add absolute ethyl alcohol to dissolve, the solution is added in ball grinder, grind, take out, stood overnight with 3-5 DEG C, filter, use
The borneol that adsorbs on absolute ethyl alcohol washing filter cake, puts 40-60 DEG C and is dried under reduced pressure, the finely ground mesh sieve of mistake 80, produces borneol times his ring paste
Inclusion compounds.
2. compound Danshen Root as claimed in claim 1 sticks micropill, it is characterised in that the micropill is made by the following method：
Weigh the parts by weight of Salvia root P.E 8.09, the parts by weight of Notogineng Extract 1.57, the parts by weight of borneol inclusion compound 2.176, hydroxypropyl
Ylmethyl celluloseK100M, chitosan, each 2.5 parts by weight of carbomer940, the parts by weight of microcrystalline cellulose 5.56, mix, add
The parts by volume of 30% sodium-chloride water solution 12, compound Danshen Root is prepared using extrusion spheronization method and sticks micropill.
3. compound Danshen Root as claimed in claim 1 or 2 sticks micropill, it is characterised in that the Salvia root P.E or pseudo-ginseng extraction
Thing is prepared by the following method：
Salvia piece or notoginseng decoction piece, add 6-10 times of weight 60-90% alcohol refluxs to extract 1-3 times, each 1-2h, filter, close
And extract solution, thick paste is concentrated into, 40-70 DEG C is dried under reduced pressure, and obtains Salvia root P.E or Notogineng Extract.
4. compound Danshen Root as claimed in claim 1 or 2 sticks micropill, it is characterised in that the borneol inclusion compound is by the following method
Prepare：
The parts by weight of betadex 6 are weighed, are placed in ball grinder, add 20 parts by volume distilled water；The parts by weight of borneol 1 are weighed, add 2
Parts by volume absolute ethyl alcohol dissolves, and the solution is added in ball grinder, 300rmin-1, 30min is ground, is taken out, and in 4 DEG C of refrigerators
Stand overnight, filter, the borneol adsorbed on filter cake is washed with 5 parts by volume absolute ethyl alcohols, 50 DEG C is put and is dried under reduced pressure 6h, finely ground mistake 80
Mesh sieve, produce borneol betadex inclusion compound.
5. a kind of compound Danshen Root sticks the preparation method of micropill, it is characterised in that this method is：
Weigh Salvia root P.E 6-10 parts by weight, Notogineng Extract 1-3 parts by weight, borneol inclusion compound 1-4 parts by weight, hydroxypropyl first
Base celluloseK100M1-3 parts by weight, chitosan 1-3 parts by weight, carbomer940 1-3 parts by weight, microcrystalline cellulose 2-7 weight
Part, mix, add 20-40% sodium-chloride water solution 10-15 parts by volume, micropill is prepared using extrusion spheronization method, produce compound pellet
Ginseng sticks micropill；
The Salvia root P.E, Notogineng Extract have conventional method to be made；
The borneol inclusion compound is made by the following method：
Betadex 4-8 parts by weight are weighed, are placed in ball grinder, add 10-30 parts by volume distilled water；Weigh borneol 0.5-2
Parts by weight, add absolute ethyl alcohol to dissolve, the solution is added in ball grinder, grind, take out, stood overnight with 3-5 DEG C, filter, use
The borneol that adsorbs on absolute ethyl alcohol washing filter cake, puts 40-60 DEG C and is dried under reduced pressure, the finely ground mesh sieve of mistake 80, produces borneol times his ring paste
Inclusion compounds.
6. compound Danshen Root as claimed in claim 1 sticks the preparation method of micropill, it is characterised in that this method is：
Weigh the parts by weight of Salvia root P.E 8.09, the parts by weight of Notogineng Extract 1.57, the parts by weight of borneol inclusion compound 2.176, hydroxypropyl
Ylmethyl celluloseK100M, chitosan, each 2.5 parts by weight of carbomer940, the parts by weight of microcrystalline cellulose 5.56, mix, add
The parts by volume of 30% sodium-chloride water solution 12, compound Danshen Root is prepared using extrusion spheronization method and sticks micropill.
7. compound Danshen Root as claimed in claim 1 or 2 sticks the preparation method of micropill, it is characterised in that red described in this method
Conopsea extraction or Notogineng Extract are prepared by the following method：
Salvia piece or notoginseng decoction piece, add 6-10 times of weight 60-90% alcohol refluxs to extract 1-3 times, each 1-2h, filter, close
And extract solution, thick paste is concentrated into, 40-70 DEG C is dried under reduced pressure, and obtains Salvia root P.E or Notogineng Extract.
8. compound Danshen Root as claimed in claim 1 or 2 sticks the preparation method of micropill, it is characterised in that ice described in this method
Piece inclusion compound is prepared by the following method：
The parts by weight of betadex 6 are weighed, are placed in ball grinder, 20 parts by volume distilled water is added, weighs the parts by weight of borneol 1, add 2
Parts by volume absolute ethyl alcohol dissolves, and the solution is added in ball grinder, 300rmin-1, 30min is ground, is taken out, and in 4 DEG C of refrigerators
Stand overnight, filter, the borneol adsorbed on filter cake is washed with 5 parts by volume absolute ethyl alcohols, 50 DEG C is put and is dried under reduced pressure 6h, finely ground mistake 80
Mesh sieve, produce borneol betadex inclusion compound.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349818A (en) * | 2001-10-24 | 2002-05-22 | 沈阳药科大学 | Effective part group in red sage mixture and its delayed release prepn. medicinal use and prepn process |
| CN1596917A (en) * | 2003-09-16 | 2005-03-23 | 成都尚科药业有限公司 | Preparation method of compound red-rooted salvia micro pill |
| CN101229225A (en) * | 2007-11-23 | 2008-07-30 | 复旦大学 | Salvia miltiorrhiza total phenolic acid gastric stasis preparation |
| WO2015115512A1 (en) * | 2014-01-29 | 2015-08-06 | 独立行政法人産業技術総合研究所 | Method for preparing water extract of ashwagandha leaves which has enhanced anti-cancer activity utilizing cyclodextrin, and pharmaceutical composition containing ashwagandha leaves |
-
2017
- 2017-07-25 CN CN201710609695.7A patent/CN107468752A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1349818A (en) * | 2001-10-24 | 2002-05-22 | 沈阳药科大学 | Effective part group in red sage mixture and its delayed release prepn. medicinal use and prepn process |
| CN1596917A (en) * | 2003-09-16 | 2005-03-23 | 成都尚科药业有限公司 | Preparation method of compound red-rooted salvia micro pill |
| CN101229225A (en) * | 2007-11-23 | 2008-07-30 | 复旦大学 | Salvia miltiorrhiza total phenolic acid gastric stasis preparation |
| WO2015115512A1 (en) * | 2014-01-29 | 2015-08-06 | 独立行政法人産業技術総合研究所 | Method for preparing water extract of ashwagandha leaves which has enhanced anti-cancer activity utilizing cyclodextrin, and pharmaceutical composition containing ashwagandha leaves |
Non-Patent Citations (1)
| Title |
|---|
| 傅超美等主编: "《药用辅料学》", 31 October 2008, 中国中医药出版社 * |
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