CN1596917A - Preparation method of compound red-rooted salvia micro pill - Google Patents
Preparation method of compound red-rooted salvia micro pill Download PDFInfo
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- CN1596917A CN1596917A CN 03135829 CN03135829A CN1596917A CN 1596917 A CN1596917 A CN 1596917A CN 03135829 CN03135829 CN 03135829 CN 03135829 A CN03135829 A CN 03135829A CN 1596917 A CN1596917 A CN 1596917A
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- micropill
- salviae miltiorrhizae
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- millimeters
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Abstract
A compound danshen micropill is based on the compound danshen dripping pill but contains additional microcrystaline cellulose and starch.
Description
The technical field pharmaceutical technology
The background technology FUFANG DANSHEN DIWAN record version in 2000 " one one of Chinese pharmacopoeia, the 519th page is the anginal common drug of treatment, is made up of Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum, former dosage form is the drop pill of every 25mg.The micropill technology is sophisticated gradually in recent years a kind of advanced dosage form, can improve the bioavailability of medicine with pellet preparations, and the micropill technology is applied to the prescription of FUFANG DANSHEN DIWAN, make a kind of efficiently, dosage form easily, the problem that the present invention that Here it is solves.
Summary of the invention was with version " one one of Chinese pharmacopoeia in 2000, the 519th page of crude drug that the FUFANG DANSHEN DIWAN of recording is identical and extraction process, add adjuvants such as microcrystalline Cellulose, methylcellulose, ethyl cellulose, Polyethylene Glycol, a kind of by following preparation technology: 1, with medicine and adjuvant powder mix homogeneously, add binding agent and make soft material, the granulation of sieving is rolled onto micropill in coating pan.2, medicine and adjuvant are placed fluid bed, blast air-flow, make the two mix homogeneously, spray into binding agent again, make it to become granule, stop spraying when granular size meets the demands, the gained granule is directly at the ebullated bed inner drying.3, medicine, adjuvant powder are added the binding agent mix homogeneously, it is extruded into the bar column, in spheronizator, cylindrical material is cut again, be rolled onto even, the regular sphere of size by extruder.Make and be not less than 0.5 millimeter, also be not more than 2.5 millimeters pill, and " appendix of Chinese pharmacopoeia is about the relevant requirements of " micropill " to meet version in 2000.
Compound Salviae Miltiorrhizae micropill and the comparative study of FUFANG DANSHEN PIAN dissolution: FUFANG DANSHEN PIAN is made by Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum, and danshensu is the main effective ingredient of said preparation.Investigated the dissolution and the compound Salviae Miltiorrhizae micropill dissolution of 6 producer's like product coated tablets, proved that the compound Salviae Miltiorrhizae micropill has high bioavailability.
1. instrument UV-3000 spectrophotometer (day the island proper Tianjin); 753WBI microcomputer type ultraviolet-uisible spectrophotometer (optical instrument factory, Shanghai); ZRS-4 intelligence dissolution test instrument (Radio Factory of Tianjin Univ.).
2. method and result
Measure wavelength determination and get 20 of test products, porphyrize, accurately take by weighing and be equivalent to average sheet weight, put in the 1L beaker, add the about 800ml of water, taking-up is put cold behind the heating in water bath and the 30min that vibrates, change standardize solution in the 1L measuring bottle over to, filter, get subsequent filtrate, and be that blank is made UV scanning with water, the result has an absworption peak at the 283nm place.Other gets 20 and removes coating, according to said method, remakes UV scanning, and the result shows that coating does not have influence to absorbing, and makes to measure wavelength so determine 283nm.
Dissolution determination gets 6 of each test samples and the accurate stator that claims weighs (Wi), and purified water 900ml is a dissolution medium, rotating speed 150r/min, 37.0 ℃ ± 0.5 ℃ of temperature; Change basket and enter release pond timing, 20,30,40,50,60, the 10ml that takes a sample behind the 70min (replenishing the dissolution medium of equal-volume uniform temp simultaneously) filters; Get subsequent filtrate and survey trap (Ai) value, calculate accumulation stripping percentage rate (%) relatively, the results are shown in Table 1.
Table 1 compound Salviae Miltiorrhizae micropill is relative with FUFANG DANSHEN PIAN accumulate the stripping percentage comparisons (%, n=6)
Sample 10 20 30 40 50 60 70min
Tablet A 8.3 30.9 52.4 70.2 86.3 95.3
Tablet B 2.3 15.1 40.8 63.7 77.0 81.8
Tablet C 6.7 34.0 58.2 81.2 89.7 92.0
Tablet D 51.7 79.3 93.8 98.0 98.4 99.3
Tablet E 3.2 35.4 69.8 89.5 97.8 100.0
Tablet F 4.8 10.3 33.9 60.8 82.5 90.5
Micropill 85.6 92.3 100.0
The specific embodiment
1, be crude drug with Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum, add microcrystalline cellulose excipients, methylcellulose, Polyethylene Glycol etc., by following preparation technology: with medicine and adjuvant powder mix homogeneously, add binding agent and make soft material, the granulation of sieving, in coating pan, be rolled onto and be not less than 0.5 millimeter, also be not more than 2.5 millimeters pill, and " appendix of Chinese pharmacopoeia is about the relevant requirements of " micropill " to meet version in 2000.
2, be crude drug with Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum, add adjuvants such as microcrystalline Cellulose, methylcellulose, mix homogeneously is extruded into the bar column by extruder with it, in spheronizator cylindrical material is cut again, is rolled onto even, the regular micropill of size.Make and be not less than 0.5 millimeter, also be not more than 2.5 millimeters pill, and " appendix of Chinese pharmacopoeia is about the relevant requirements of " micropill " to meet version in 2000.
Claims (3)
1, a kind of compound Salviae Miltiorrhizae micropill, the adjuvant (microcrystalline Cellulose, Polyethylene Glycol etc.) that it contains the active ingredient identical with FUFANG DANSHEN DIWAN and screens is in addition made and is not less than 0.5 millimeter, also is not more than 2.5 millimeters pill.
2, according to the preparation technology of the described compound Salviae Miltiorrhizae micropill of claim 1, it is with medicine and adjuvant powder mix homogeneously, adds binding agent and makes soft material, and the granulation of sieving is rolled onto in coating pan and is not less than 0.5 millimeter, also is not more than 2.5 millimeters micropill.
3, according to the preparation technology of the described compound Salviae Miltiorrhizae micropill of claim 1, it is with medicine and adjuvant powder mix homogeneously, by extruder it is extruded into the bar column, in spheronizator, cylindrical material is cut again, be rolled onto that size is even, regular to be not less than 0.5 millimeter, also be not more than 2.5 millimeters pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135829 CN1596917A (en) | 2003-09-16 | 2003-09-16 | Preparation method of compound red-rooted salvia micro pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135829 CN1596917A (en) | 2003-09-16 | 2003-09-16 | Preparation method of compound red-rooted salvia micro pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1596917A true CN1596917A (en) | 2005-03-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03135829 Pending CN1596917A (en) | 2003-09-16 | 2003-09-16 | Preparation method of compound red-rooted salvia micro pill |
Country Status (1)
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| CN (1) | CN1596917A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214275B (en) * | 2005-10-27 | 2011-07-27 | 广东药学院 | Compound red sage root extended release formulation and preparation thereof |
| CN103913520A (en) * | 2013-01-05 | 2014-07-09 | 天士力制药集团股份有限公司 | Determination method for compound salvia miltiorrhiza bunge dripping pill dissolution |
| CN104224727A (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicine pellet |
| CN107468752A (en) * | 2017-07-25 | 2017-12-15 | 北京中医药大学 | A kind of compound Danshen Root sticks micropill and its preparation technology |
-
2003
- 2003-09-16 CN CN 03135829 patent/CN1596917A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214275B (en) * | 2005-10-27 | 2011-07-27 | 广东药学院 | Compound red sage root extended release formulation and preparation thereof |
| CN103913520A (en) * | 2013-01-05 | 2014-07-09 | 天士力制药集团股份有限公司 | Determination method for compound salvia miltiorrhiza bunge dripping pill dissolution |
| CN104224727A (en) * | 2013-06-17 | 2014-12-24 | 天士力制药集团股份有限公司 | Preparation method of traditional Chinese medicine pellet |
| CN104224727B (en) * | 2013-06-17 | 2018-04-03 | 天士力医药集团股份有限公司 | A kind of preparation method of traditional Chinese medicine pellet |
| CN107468752A (en) * | 2017-07-25 | 2017-12-15 | 北京中医药大学 | A kind of compound Danshen Root sticks micropill and its preparation technology |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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