CN107456542A - A kind of preparation method for treating hypertension ginkgo medicine - Google Patents
A kind of preparation method for treating hypertension ginkgo medicine Download PDFInfo
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Abstract
A kind of preparation method for treating hypertension ginkgo medicine, the invention belongs to pharmaceutical technology field.A kind of pharmaceutical composition is disclosed, by ginkgo nut and ginkgo biloba p.e, the pharmaceutical formulation being combined by coating technology and other drugs according to certain ratio, and the preparation method and purposes of medicine.The pharmaceutical preparation can be used for the common fault of ginkgo three for treating hypertension class.
Description
Technical field
The invention belongs to the field of Chinese medicines, is related to a kind of preparation method for treating hypertension ginkgo medicine.
Background technology
In recent years, what hypertension was serious endangers the health of the mankind, however, such a disease is a kind of Comprehensive Clinical
Disease, so it is difficult that thoroughly treatment is good to be, it can only be nursed one's health by medicine.Ginkgo is the widest problem of Recent study,
Wherein ginkgo biloba extract can be good at improving cardiovascular circulation, be had a significant effect to reducing blood pressure, and do not have pair
Effect, however, because the main component of ginkgo biloba extract is ginkgo lactones and flavonol glycosides, when this medicine is directly entered stomach
Reason, due to there is substantial amounts of hydrochloric acid in stomach, it can promote ginkgo lactones and flavonol glycosides that hydrolysis occurs and loses drug effect, so needing
Cladding processing is carried out to ginkgo biloba extract, medicine is entered in enteron aisle and just start to discharge medicine, thus ensure that well
Medicine effect.Therefore, we are prepared for a kind of ginkgo medicine for treating hypertension, provide one for the treatment of hypertension and more have
The more direct approach of effect.
The content of the invention
In order to solve technical problem present in background technology, an object of the present invention is to provide one kind and treats hypertension
Effect is good, the ginkgo class medicine of few side effects, and it is a further object of the present invention to provide a kind of hypertension and its derivative disease for the treatment of
Ginkgo medicine.
In order to achieve the above object, the present invention adopts the following technical scheme that:
The preparation method of hypertension ginkgo medicine is treated, by below by the bulk drug of weight meter number:Ginkgo biloba extract bag
Cover body 2-5 parts, cassia seed 10-12 parts, root of herbaceous peony 5-10 parts, return tail 6-10 parts, cordyceps sinensis 0.5-1 parts, Radix Astragali 8-12 parts, mother chrysanthemum
Spend 10-15 parts, Ramulus Taxilli 2-5 parts, Ligusticum wallichii 4-6 parts, sieve not sesame slices 4-8 parts, goldenseal 6-10 parts, Radix Codonopsis 1-5 parts, Poria cocos 2-5
Part, fruit of Chinese magnoliavine 3-6 parts, Radix Angelicae Sinensis 4-10 parts, bighead atractylodes rhizome 1-3 parts, radix rehmanniae recen 4-8 parts, radix glycyrrhizae 2-5 parts, root of Dahurain angelica 3-6 parts, pseudo-ginseng 4-8
Part, aspongopus 4-8 parts, fleece-flower root 1-2 parts, Semen Cuscutae 3-5 parts, wilsonii 3-8 parts, elecampane 2-5 parts, dandelion 8-12 parts,
Rheum officinale 4-10 parts, starch 30-50 parts are made.
The present invention a preferable technical scheme be:By below by the bulk drug of weight meter number:Ginkgo biloba extract bag
Cover 2 parts of body, 10 parts of cassia seed, 5 parts of the root of herbaceous peony, return 6 parts of tail, 0.5 part of cordyceps sinensis, 8 parts of the Radix Astragali, 10 parts of chrysanthemum indicum, Ramulus Taxilli 2
Not 4 parts of sesame slices, 6 parts of goldenseal, 1 part of Radix Codonopsis, 2 parts of Poria cocos, 3 parts of the fruit of Chinese magnoliavine, 4 parts of Radix Angelicae Sinensis, 1 part of the bighead atractylodes rhizome, the life of part, 4 parts of Ligusticum wallichii, sieve
4 parts of glutinous rehmannia, 2 parts of radix glycyrrhizae, 3 parts of the root of Dahurain angelica, 4 parts of pseudo-ginseng, 4 parts of aspongopus, 1 part of the fleece-flower root, 3 parts of Semen Cuscutae, 3 parts of wilsonii, building
Fragrant 2 parts, 8 parts of dandelion, 4 parts of rheum officinale, 30 parts of starch, 60 parts of sterile water for injection is then added, is pressed after well mixed
Piece, manufactured sheet medicine after drying.
The present invention a preferable technical scheme be:By below by the bulk drug of weight meter number:Ginkgo biloba extract bag
Cover 3 parts of body, 11 parts of cassia seed, 8 parts of the root of herbaceous peony, return 8 parts of tail, 1 part of cordyceps sinensis, 10 parts of the Radix Astragali, 12 parts of chrysanthemum indicum, 3 parts of Ramulus Taxilli,
4 parts of Ligusticum wallichii, sieve not 5 parts of sesame slices, 8 parts of goldenseal, 4 parts of Radix Codonopsis, 3 parts of Poria cocos, 4 parts of the fruit of Chinese magnoliavine, 7 parts of Radix Angelicae Sinensis, 2 parts of the bighead atractylodes rhizome, the dried rhizome of rehmannia
Yellow 6 parts, 3 parts of radix glycyrrhizae, 5 parts of the root of Dahurain angelica, 6 parts of pseudo-ginseng, 6 parts of aspongopus, 1 part of the fleece-flower root, 4 parts of Semen Cuscutae, 5 parts of wilsonii, elecampane 3
Part, 10 parts of dandelion, 7 parts of rheum officinale, 40 parts of starch, 60 parts of sterile water for injection is then added, tabletting is carried out after well mixed,
Manufactured sheet medicine after drying.
The present invention a preferable technical scheme be:By below by the bulk drug of weight meter number:Ginkgo biloba extract bag
Cover 5 parts of body, 12 parts of cassia seed, 10 parts of the root of herbaceous peony, return 10 parts of tail, 1 part of cordyceps sinensis, 12 parts of the Radix Astragali, 15 parts of chrysanthemum indicum, Ramulus Taxilli 5
Part, 6 parts of Ligusticum wallichii, sieve not 8 parts of sesame slices, 10 parts of goldenseal, 5 parts of Radix Codonopsis, 5 parts of Poria cocos, 6 parts of the fruit of Chinese magnoliavine, 10 parts of Radix Angelicae Sinensis, 3 parts of the bighead atractylodes rhizome,
8 parts of radix rehmanniae recen, 5 parts of radix glycyrrhizae, 6 parts of the root of Dahurain angelica, 8 parts of pseudo-ginseng, 8 parts of aspongopus, 2 parts of the fleece-flower root, 5 parts of Semen Cuscutae, 8 parts of wilsonii, soil
5 parts of the banksia rose, 12 parts of dandelion, 10 parts of rheum officinale, 50 parts of starch, 60 parts of sterile water for injection is then added, is well mixed laggard
Row tabletting, manufactured sheet medicine after drying.
The weight of composition described above raw material is calculated with crude drug, can be proportionally in production using parts by weight as proportioning
Increase is reduced, as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also with gram or milli
Gram it is unit, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion before each composition.It is and heavy above
The ratio of amount proportioning screens to obtain by science, can accordingly adjust the proportioning of the amount of composition, increase or decrease and be no more than
100%, drug effect is constant.
As a further improvement on the present invention, described Ginkgo biloba leaves are the leaf of the ginkgo of at least more than 10 years,
And the acquisition time of leaf is 7-10 months of 1 year, the leaf not gone mouldy with worm hole;
Further, described cassia seed, the root of herbaceous peony, return tail, the Radix Astragali, Ramulus Taxilli, Ligusticum wallichii, goldenseal, Radix Codonopsis, pseudo-ginseng, nine
, its growth year is more than 2 years for this kind of medicine of fragrant worm, the fleece-flower root;
Further, described starch is medicinal soluble starch.
As a further improvement on the present invention, present invention also offers the preparation method for the treatment of hypertension ginkgo medicine, bag
Include following steps:
(1) preparation of ginkgo biloba extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven
Row drying, wherein oven temperature are 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and carry out powder
It is broken, the sieve of 80-100 mesh is used after crushing, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of silver
Apricot leaf powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator control rotating speed and is existed
200-300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, is cooled to room temperature, Ran Houjin
Row decompression filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, removes ethyl acetate
The powder obtained afterwards, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature exists
30-50 DEG C), the product after drying is ginkgo biloba extract.
(2) prepared by ginkgo biloba extract cladding:By ginkgo biloba extract and edible ethanol solution using mass ratio as 1:4-6 ratio
Example, which is mixed and (when having part insoluble in course of dissolution, suitably heated, its temperature control is at 40-60 DEG C), to be mixed
Solution, then by mixed solution and porous type resin using mass ratio as 10:1-2 ratio is mixed, by mixed liquor after mixing
It is put into ultrasonic machine and carries out ultrasonic 1-2h, rush allows medicament to fully enter porous type resin.After the completion of ultrasound, this medicine is entered
Row vacuum filtration, filtrate are recycled, and filter residue are taken out, by filter residue and PEG solution using mass ratio as 10:1-3 ratio is entered
Row mixing, it is 50-60 DEG C that temperature is placed on after well mixed, and 1-2h, question response are heated in rotating speed 200-300rpm water-bath
After completely, this medicament is just ginkgo biloba extract cladding, is taken out standby.
(3) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, mulberry is returned to post
Life, Ligusticum wallichii, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, nine fragrant
Worm, the fleece-flower root, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, dried (drying temperature is at 50-60 DEG C), Ran Houfen
It Jia Ru not be crushed in pulverizer, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes,
Then according to drug dose, cassia seed 10-12 parts, root of herbaceous peony 5-10 parts, tail 6-10 parts, cordyceps sinensis 0.5-1 parts, Radix Astragali 8-12 are returned
Part, chrysanthemum indicum 10-15 parts, Ramulus Taxilli 2-5 parts, Ligusticum wallichii 4-6 parts, sieve not sesame slices 4-8 parts, goldenseal 6-10 parts, Radix Codonopsis 1-5 parts,
Poria cocos 2-5 parts, fruit of Chinese magnoliavine 3-6 parts, Radix Angelicae Sinensis 4-10 parts, bighead atractylodes rhizome 1-3 parts, radix rehmanniae recen 4-8 parts, radix glycyrrhizae 2-5 parts, root of Dahurain angelica 3-6 parts, three
Seven 4-8 parts, aspongopus 4-8 parts, fleece-flower root 1-2 parts, Semen Cuscutae 3-5 parts, wilsonii 3-8 parts, elecampane 2-5 parts, dandelion 8-
12 parts, the proportioning of rheum officinale 4-10 parts, add in batch mixer and mixed (incorporation time 1-5min), taken out after mixing standby;
(4) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step are weighed
(2) medicine in weighs 120-180 parts and weighs the starch of 30-50 parts, adds in sterile barrel, is mixed with puddler.
Appropriate water (60-80 parts) is added, is then stirred after it is become the semisolid of imaging surface bulk, is taken out standby.
(5) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine
In 1-5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(6) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
Application the invention also provides treatment hypertension ginkgo medicine in hypertension symptom is treated in addition.
As can be seen here, the preparation method for the treatment of hypertension ginkgo medicine provided by the invention, the Chinese traditional medicine composition formula have been
Complete scientific and reasonable, individual component cooperates with compatibility, can be good at playing curative effect of medication, medicine has anticoagulation, reduced blood pressure
Effect, through experimental results demonstrate, the present invention has evident in efficacy, giving consideration to both the incidental and fundamental to hypertension symptom, it is safe and non-toxic it is good in
Into medicine.
Embodiment
Embodiment 1
Present embodiments provide a kind of preparation method for treating hypertension ginkgo medicine, the Chinese medicine composition includes, by with
Under by weight meter number bulk drug:2 parts of ginkgo biloba extract cladding, 10 parts of cassia seed, 5 parts of the root of herbaceous peony, return 6 parts of tail, worm summer in winter
0.5 part of grass, 8 parts of the Radix Astragali, 10 parts of chrysanthemum indicum, 2 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 4 parts of sesame slices, 6 parts of goldenseal, 1 part of Radix Codonopsis, Fu
2 parts of Siberian cocklebur, 3 parts of the fruit of Chinese magnoliavine, 4 parts of Radix Angelicae Sinensis, 1 part of the bighead atractylodes rhizome, 4 parts of radix rehmanniae recen, 2 parts of radix glycyrrhizae, 3 parts of the root of Dahurain angelica, 4 parts of pseudo-ginseng, 4 parts of aspongopus,
1 part of the fleece-flower root, 3 parts of Semen Cuscutae, 3 parts of wilsonii, 2 parts of elecampane, 8 parts of dandelion, 4 parts of rheum officinale, 30 parts of starch, then add 60
The sterile water for injection of part, tabletting is carried out after well mixed, manufactured sheet medicine after drying.
Wherein, present invention also offers the preparation method for the treatment of hypertension ginkgo medicine, comprise the following steps:
(1) preparation of ginkgo biloba extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven
Row drying, wherein oven temperature are 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and carry out powder
It is broken, the sieve of 80-100 mesh is used after crushing, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of silver
Apricot leaf powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator control rotating speed and is existed
200-300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, is cooled to room temperature, Ran Houjin
Row decompression filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, removes ethyl acetate
The powder obtained afterwards, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature exists
30-50 DEG C), the product after drying is ginkgo biloba extract.
(3) prepared by ginkgo biloba extract cladding:By ginkgo biloba extract and edible ethanol solution using mass ratio as 1:4-6 ratio
Example, which is mixed and (when having part insoluble in course of dissolution, suitably heated, its temperature control is at 40-60 DEG C), to be mixed
Solution, then by mixed solution and porous type resin using mass ratio as 10:1-2 ratio is mixed, by mixed liquor after mixing
It is put into ultrasonic machine and carries out ultrasonic 1-2h, rush allows medicament to fully enter porous type resin.After the completion of ultrasound, this medicine is entered
Row vacuum filtration, filtrate are recycled, and filter residue are taken out, by filter residue and PEG solution using mass ratio as 10:1-3 ratio is entered
Row mixing, it is 50-60 DEG C that temperature is placed on after well mixed, and 1-2h, question response are heated in rotating speed 200-300rpm water-bath
After completely, this medicament is just ginkgo biloba extract cladding, is taken out standby.
(3) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, mulberry is returned to post
Life, Ligusticum wallichii, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, nine fragrant
Worm, the fleece-flower root, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, dried (drying temperature is at 50-60 DEG C), Ran Houfen
It Jia Ru not be crushed in pulverizer, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes,
Then according to drug dose, 10 parts of cassia seed, 5 parts of the root of herbaceous peony, return 6 parts of tail, 0.5 part of cordyceps sinensis, 8 parts of the Radix Astragali, 10 parts of chrysanthemum indicum,
2 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 4 parts of sesame slices, 6 parts of goldenseal, 1 part of Radix Codonopsis, 2 parts of Poria cocos, 3 parts of the fruit of Chinese magnoliavine, 4 parts of Radix Angelicae Sinensis, white
1 part of art, 4 parts of radix rehmanniae recen, 2 parts of radix glycyrrhizae, 3 parts of the root of Dahurain angelica, 4 parts of pseudo-ginseng, 4 parts of aspongopus, 1 part of the fleece-flower root, 3 parts of Semen Cuscutae, wilsonii 3
Part, 2 parts of elecampane, 8 parts of dandelion, the proportioning of 4 parts of rheum officinale, add in batch mixer and mixed (incorporation time 1-5min), mix
Taken out after conjunction standby;
(4) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step are weighed
(2) medicine in weighs 120-180 parts and weighs the starch of 30-50 parts, adds in sterile barrel, is mixed with puddler.
Appropriate water (60-80 parts) is added, is then stirred after it is become the semisolid of imaging surface bulk, is taken out standby.
(5) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine
In 1-5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(6) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
Embodiment 2
Present embodiments provide a kind of preparation method for treating hypertension ginkgo medicine, the Chinese medicine composition includes, by with
Under by weight meter number bulk drug:3 parts of ginkgo biloba extract cladding, 11 parts of cassia seed, 8 parts of the root of herbaceous peony, return 8 parts of tail, worm summer in winter
1 part of grass, 10 parts of the Radix Astragali, 12 parts of chrysanthemum indicum, 3 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 5 parts of sesame slices, 8 parts of goldenseal, 4 parts of Radix Codonopsis, Fu
3 parts of Siberian cocklebur, 4 parts of the fruit of Chinese magnoliavine, 7 parts of Radix Angelicae Sinensis, 2 parts of the bighead atractylodes rhizome, 6 parts of radix rehmanniae recen, 3 parts of radix glycyrrhizae, 5 parts of the root of Dahurain angelica, 6 parts of pseudo-ginseng, 6 parts of aspongopus,
1 part of the fleece-flower root, 4 parts of Semen Cuscutae, 5 parts of wilsonii, 3 parts of elecampane, 10 parts of dandelion, 7 parts of rheum officinale, 40 parts of starch, are then added
60 parts of sterile water for injection, tabletting is carried out after well mixed, manufactured sheet medicine after drying.
Wherein, present invention also offers the preparation method for the treatment of hypertension ginkgo medicine, comprise the following steps:(1) ginkgo
The preparation of extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven
Row drying, wherein oven temperature are 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and carry out powder
It is broken, the sieve of 80-100 mesh is used after crushing, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of silver
Apricot leaf powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator control rotating speed and is existed
200-300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, is cooled to room temperature, Ran Houjin
Row decompression filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, removes ethyl acetate
The powder obtained afterwards, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature exists
30-50 DEG C), the product after drying is ginkgo biloba extract.
(4) prepared by ginkgo biloba extract cladding:By ginkgo biloba extract and edible ethanol solution using mass ratio as 1:4-6 ratio
Example, which is mixed and (when having part insoluble in course of dissolution, suitably heated, its temperature control is at 40-60 DEG C), to be mixed
Solution, then by mixed solution and porous type resin using mass ratio as 10:1-2 ratio is mixed, by mixed liquor after mixing
It is put into ultrasonic machine and carries out ultrasonic 1-2h, rush allows medicament to fully enter porous type resin.After the completion of ultrasound, this medicine is entered
Row vacuum filtration, filtrate are recycled, and filter residue are taken out, by filter residue and PEG solution using mass ratio as 10:1-3 ratio is entered
Row mixing, it is 50-60 DEG C that temperature is placed on after well mixed, and 1-2h, question response are heated in rotating speed 200-300rpm water-bath
After completely, this medicament is just ginkgo biloba extract cladding, is taken out standby.
(3) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, mulberry is returned to post
Life, Ligusticum wallichii, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, nine fragrant
Worm, the fleece-flower root, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, dried (drying temperature is at 50-60 DEG C), Ran Houfen
It Jia Ru not be crushed in pulverizer, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes,
Then according to drug dose, 11 parts of cassia seed, 8 parts of the root of herbaceous peony, return 8 parts of tail, 1 part of cordyceps sinensis, 10 parts of the Radix Astragali, 12 parts of chrysanthemum indicum,
3 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 5 parts of sesame slices, 8 parts of goldenseal, 4 parts of Radix Codonopsis, 3 parts of Poria cocos, 4 parts of the fruit of Chinese magnoliavine, 7 parts of Radix Angelicae Sinensis, white
2 parts of art, 6 parts of radix rehmanniae recen, 3 parts of radix glycyrrhizae, 5 parts of the root of Dahurain angelica, 6 parts of pseudo-ginseng, 6 parts of aspongopus, 1 part of the fleece-flower root, 4 parts of Semen Cuscutae, wilsonii 5
Part, 3 parts of elecampane, 10 parts of dandelion, the proportioning of 7 parts of rheum officinale, add in batch mixer and mixed (incorporation time 1-5min), mix
Taken out after conjunction standby;
(4) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step are weighed
(2) medicine in weighs 120-180 parts and weighs the starch of 30-50 parts, adds in sterile barrel, is mixed with puddler.
Appropriate water (60-80 parts) is added, is then stirred after it is become the semisolid of imaging surface bulk, is taken out standby.
(5) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine
In 1-5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(6) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
Embodiment 3
A kind of preparation method for treating hypertension ginkgo medicine is present embodiments provided, the Chinese medicine composition includes, this hair
The preferable technical scheme of bright one is:By below by the bulk drug of weight meter number:5 parts of ginkgo biloba extract cladding, Cassia
12 parts of son, 10 parts of the root of herbaceous peony, return 10 parts of tail, 1 part of cordyceps sinensis, 12 parts of the Radix Astragali, 15 parts of chrysanthemum indicum, 5 parts of Ramulus Taxilli, 6 parts of Ligusticum wallichii, sieve
Not 8 parts of sesame slices, 10 parts of goldenseal, 5 parts of Radix Codonopsis, 5 parts of Poria cocos, 6 parts of the fruit of Chinese magnoliavine, 10 parts of Radix Angelicae Sinensis, 3 parts of the bighead atractylodes rhizome, 8 parts of radix rehmanniae recen, sweet
5 parts of grass, 6 parts of the root of Dahurain angelica, 8 parts of pseudo-ginseng, 8 parts of aspongopus, 2 parts of the fleece-flower root, 5 parts of Semen Cuscutae, 8 parts of wilsonii, 5 parts of elecampane, Pu Gong
12 parts of English, 10 parts of rheum officinale, 50 parts of starch, 60 parts of sterile water for injection is then added, tabletting is carried out after well mixed, after drying
And manufactured sheet medicine.
Wherein, present invention also offers the preparation method for the treatment of hypertension ginkgo medicine, comprise the following steps:
(1) preparation of ginkgo biloba extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven
Row drying, wherein oven temperature are 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and carry out powder
It is broken, the sieve of 80-100 mesh is used after crushing, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of silver
Apricot leaf powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator control rotating speed and is existed
200-300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, is cooled to room temperature, Ran Houjin
Row decompression filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, removes ethyl acetate
The powder obtained afterwards, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature exists
30-50 DEG C), the product after drying is ginkgo biloba extract.
(5) prepared by ginkgo biloba extract cladding:By ginkgo biloba extract and edible ethanol solution using mass ratio as 1:4-6 ratio
Example, which is mixed and (when having part insoluble in course of dissolution, suitably heated, its temperature control is at 40-60 DEG C), to be mixed
Solution, then by mixed solution and porous type resin using mass ratio as 10:1-2 ratio is mixed, by mixed liquor after mixing
It is put into ultrasonic machine and carries out ultrasonic 1-2h, rush allows medicament to fully enter porous type resin.After the completion of ultrasound, this medicine is entered
Row vacuum filtration, filtrate are recycled, and filter residue are taken out, by filter residue and PEG solution using mass ratio as 10:1-3 ratio is entered
Row mixing, it is 50-60 DEG C that temperature is placed on after well mixed, and 1-2h, question response are heated in rotating speed 200-300rpm water-bath
After completely, this medicament is just ginkgo biloba extract cladding, is taken out standby.
(3) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, mulberry is returned to post
Life, Ligusticum wallichii, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, nine fragrant
Worm, the fleece-flower root, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, dried (drying temperature is at 50-60 DEG C), Ran Houfen
It Jia Ru not be crushed in pulverizer, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes,
Then according to drug dose, 10 parts of cassia seed, 5 parts of the root of herbaceous peony, return 6 parts of tail, 0.5 part of cordyceps sinensis, 8 parts of the Radix Astragali, 10 parts of chrysanthemum indicum,
2 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 4 parts of sesame slices, 6 parts of goldenseal, 1 part of Radix Codonopsis, 2 parts of Poria cocos, 3 parts of the fruit of Chinese magnoliavine, 4 parts of Radix Angelicae Sinensis, white
1 part of art, 4 parts of radix rehmanniae recen, 2 parts of radix glycyrrhizae, 3 parts of the root of Dahurain angelica, 4 parts of pseudo-ginseng, 4 parts of aspongopus, 1 part of the fleece-flower root, 3 parts of Semen Cuscutae, wilsonii 3
Part, 2 parts of elecampane, 8 parts of dandelion, the proportioning of 4 parts of rheum officinale, add in batch mixer and mixed (incorporation time 1-5min), mix
Taken out after conjunction standby;
(4) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step are weighed
(2) medicine in weighs 120-180 parts and weighs the starch of 30-50 parts, adds in sterile barrel, is mixed with puddler.
Appropriate water (60-80 parts) is added, is then stirred after it is become the semisolid of imaging surface bulk, is taken out standby.
(5) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine
In 1-5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(6) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
Embodiment 4
A kind of preparation method for treating hypertension ginkgo medicine is present embodiments provided, the Chinese medicine composition includes, this hair
The preferable technical scheme of bright one is:By below by the bulk drug of weight meter number:5 parts of ginkgo biloba extract cladding, Cassia
10 parts of son, 10 parts of the root of herbaceous peony, return 10 parts of tail, 1 part of cordyceps sinensis, 10 parts of the Radix Astragali, 12 parts of chrysanthemum indicum, 5 parts of Ramulus Taxilli, 6 parts of Ligusticum wallichii, sieve
Not 8 parts of sesame slices, 10 parts of goldenseal, 3 parts of Radix Codonopsis, 5 parts of Poria cocos, 6 parts of the fruit of Chinese magnoliavine, 10 parts of Radix Angelicae Sinensis, 3 parts of the bighead atractylodes rhizome, 8 parts of radix rehmanniae recen, sweet
5 parts of grass, 6 parts of the root of Dahurain angelica, 8 parts of pseudo-ginseng, 8 parts of aspongopus, 2 parts of the fleece-flower root, 5 parts of Semen Cuscutae, 8 parts of wilsonii, 5 parts of elecampane, Pu Gong
12 parts of English, 10 parts of rheum officinale, 50 parts of starch, 60 parts of sterile water for injection is then added, tabletting is carried out after well mixed, after drying
And manufactured sheet medicine.
Wherein, present invention also offers the preparation method for the treatment of hypertension ginkgo medicine, comprise the following steps:
(1) preparation of ginkgo biloba extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven
Row drying, wherein oven temperature are 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and carry out powder
It is broken, the sieve of 80-100 mesh is used after crushing, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of silver
Apricot leaf powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator control rotating speed and is existed
200-300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, is cooled to room temperature, Ran Houjin
Row decompression filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, removes ethyl acetate
The powder obtained afterwards, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature exists
30-50 DEG C), the product after drying is ginkgo biloba extract.
(2) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, mulberry is returned to post
Life, Ligusticum wallichii, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, nine fragrant
Worm, the fleece-flower root, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, dried (drying temperature is at 50-60 DEG C), Ran Houfen
It Jia Ru not be crushed in pulverizer, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes,
Then according to drug dose, 10 parts of cassia seed, 10 parts of the root of herbaceous peony, 10 parts of tail, 1 part of cordyceps sinensis, 10 parts of the Radix Astragali, chrysanthemum indicum 12 are returned
Part, 5 parts of Ramulus Taxilli, 6 parts of Ligusticum wallichii, sieve not 8 parts of sesame slices, 10 parts of goldenseal, 3 parts of Radix Codonopsis, 5 parts of Poria cocos, 6 parts of the fruit of Chinese magnoliavine, Radix Angelicae Sinensis 10
Part, 3 parts of the bighead atractylodes rhizome, 8 parts of radix rehmanniae recen, 5 parts of radix glycyrrhizae, 6 parts of the root of Dahurain angelica, 8 parts of pseudo-ginseng, 8 parts of aspongopus, 2 parts of the fleece-flower root, 5 parts of Semen Cuscutae, thorn
8 parts of slender acanthopanax, 5 parts of elecampane, 12 parts of dandelion, the proportioning of 10 parts of rheum officinale, add in batch mixer and mixed (incorporation time 1-
5min), taken out after mixing standby;
(3) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step are weighed
(2) medicine in weighs 120-180 parts and weighs the starch of 30-50 parts, adds in sterile barrel, is mixed with puddler.
Appropriate water (60-80 parts) is added, is then stirred after it is become the semisolid of imaging surface bulk, is taken out standby.
(4) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine
In 1-5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(5) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
Drug effect performance detects
Test a stability experiment
Tested 1. illumination is stable
The sample that embodiment 1-4 is obtained in the present invention is taken, is placed in the closed container of water white transparency, is placed on intensity
(equivalent to general indoor illumination intensity) under 2000Lx illumination conditions, formulation aesthetics are observed respectively at 0,2,4,6,8,10d, and had
Close measure.After 10d, acid-base value, viscosity does not change.By detection, wherein the content of 1-3 effective component of chinese medicine is not also sent out
Changing, but the effective component of embodiment 4 has partial loss.By above-mentioned experiment, it may indicate that product of the present invention has well
Stability, but drug effect has partial loss if being handled without ginkgo biloba extract cladding.
The vitro release testing experiment of the tablet provided by the invention including Chinese medicine composition of test example two
The release detection of pharmaceutical composition:With reference to 2010 editions《Chinese Pharmacopoeia》Annex XIXD vitro drug releases degree is examined
Look into.
The licorice tablet for taking above example 1-4, market to sell respectively, tablet is respectively implanted in digestion instrument, in 1h, 2h,
4h, 8h, 12h, 18h, 24h are separately sampled, and the sample of taking-up is detected into dissolution percentage with high performance liquid chromatography, and calculate
The accumulation release percentage of medicine.Its result such as following table:
Note:Dissolution rate is represented with percentage concentration
The pharmaceutical composition for the licorice tablet that embodiment 4 and market are sold all discharges in 12h as can be seen from the table, real
The pharmaceutical composition for applying a 1-3 only released 83%, 85% and 90% respectively within 24 hours.Therefore, it is provided by the invention
Pharmaceutical composition to ginkgo biloba extract, after being coated after, the stability of drug regimen raw material can be significantly improved, played
Slow release effect, promote the absorption of active component in Chinese medicine major ingredient.
The toxicity test of test example three
Acute toxicity test
Subjects:Healthy SD rat
Test group 50, male mouse, the week old of age 5;
Control group 50, male mouse, the week old of age 5.
Test method:
Test group:By the Chinese medicine composition normal saline of present invention treatment hypertension ginkgo medicine into 65% concentration
Solution, press a 40ml/kg gavage to rat, in one day twice in succession, be then discontinued, continue after drug withdrawal observation 7 days.
Control group:A 40ml/kg gavage is pressed to rat with physiological saline, in one day twice in succession, is then discontinued, is discontinued
After continue observation 7 days.
Statistical method:Respectively in experiment 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, record two groups of rats the death rate and
Rat behavior has Non Apparent Abnormality;After the observation period terminates, rat was put to death in the 8th day, carries out cut open inspection, records the dirty of two groups of rats
Device abnormal change situation.
Result of the test:As a result show that death condition did not occur in 7 days in the rat of experimental group and control group, at the 8th day
Dead rat, cut open inspection is carried out, finding the internal organs of rat does not have abnormal conditions.From the comparison of test group and control group, the present invention
The Chinese traditional medicine composition medicine for the treatment of hypertension ginkgo medicine does not have acute toxicity to rat.
Conclusion:The Chinese medicine composition of present invention treatment hypertension ginkgo medicine, degree of safety is high, no acute toxicity.
Long term toxicity test
1. subjects:Healthy SD rat
Test group 50, male mouse, the week old of age 5;
Control group 50, male mouse, the week old of age 5.
2. test method:
Test group:The Chinese medicine composition of this hair treatment hypertension ginkgo medicine is dissolved in water gavage, dosage with
White mouse batheroom scale, daily 0.5g/kg, continuous 180 days, continue observation 30 days after drug withdrawal.
Control group:Feeding as test group and without Chinese medicine composition of the present invention food, quantity of food also with test group
Equally, and gavage normal saline, continuous 180 days, during 30 day subsequent observation period, rat was treated as test group.
Statistical method:Respectively experiment 0 day, 30 days, 60 days, 90 days, 120 days, 150 days, 180 days and the observation period terminate
When, the death rate and rat behavior of two groups of rats of record have Non Apparent Abnormality;After observation period result, rat is put to death, is cutd open
Inspection, record diet, drinking-water, body weight increase and the internal organs abnormal change situation of two groups of rats.
3. result of the test:As a result show that the rat of experimental group and control group death condition did not occur in 180 days, locating
After dead rat, cut open inspection is carried out, finding the internal organs of rat does not have abnormal conditions.From the comparison of test group and control group, this hair
The Chinese traditional medicine composition medicine that Mingzhi treats hypertension ginkgo medicine does not have acute toxicity to rat.
4. conclusion:The Chinese medicine composition of present invention treatment hypertension ginkgo medicine, degree of safety is high, no acute toxicity
Influence of the present composition of experimental example four to rat platelet agglutination
Animal subject male rat, 250, body weight 200-220g, it is randomly divided into 4 groups, every group 50.
Test sample 1-4 of the embodiment of the present invention, the tablet saline control group of preparation:Sodium chloride injection 250ml:
2.25g Shangdong Changfu Jiejing Pharmaceutical Industry Co., Ltd.;
Test method each group animal fills administration by daily 0.5g/kg dosages stomach, 2 times a day, successive administration 7 days,
After last time administration in 7th day 1 hour, with 30% yellow Jackets 30mg/kg intraperitoneal injection of anesthesia, from abdominal aortic blood,
With 3.28% Chinese holly edge acid sodium anti-freezing (with whole blood with 1:9 mixing).By anticoagulated whole blood, 1500rpm centrifugations 5min is obtained under the conditions of 20 DEG C
Platelet rich plasma (PPR), after take quantitative PPR after, by remaining PPR again with 3000rpm centrifuge 10min, it is right to obtain itself
According to platelet poor plasma (PPR), PPR concentration is adjusted with PPP, makes each PPR concentration identical.By PPR in 37 DEG C of constant temperature hole it is pre-
After heat, adenosine diphosphate (ADP) (ADP, final concentration of 3 μm of olL-1) induced platelet aggregation is added, records maximum aggregation rate, and count
Calculate L-Arginine=(control group PAR-medicine group PAR)/control group PAR x100%.Result of the test is such as
Under:
As can be seen from the above table compared with saline control group, embodiment 1-4 groups can significantly inhibit blood platelet and coagulate
Collection, but embodiment 4 is relatively poor with respect to platelet aggregation effect is suppressed for embodiment 1-3, therefore the bag of ginkgo biloba extract
Coating technique has preferable effect to suppressing platelet aggregation.On the other hand, hypertension ginkgo medicine is treated as can be seen from the table
The Chinese medicine composition of thing, there is significant curative effect in face in terms of suppressing platelet aggregation, hypertension is formed and treat hypertension.
The clinical trial of experimental example five
Case 1
Lee XX, man, 43 years old, with mild hypertension, its blood pressure was between 120-160.Treatment method, use the present invention's
Tablet, early, middle and late once a dose, and 3 tablets once, using course for the treatment of 15 days, coordinates normal blood pressure detecting daily, after a course for the treatment of
Blood pressure is returned to 90-140.
Case 2
XX is opened, female, 30 years old, with mild hypertension, its blood pressure was between 120-170.Treatment method, use the present invention's
Tablet, early, middle and late once a dose, and 3 tablets once, using course for the treatment of 15 days, coordinates normal blood pressure detecting daily, after a course for the treatment of
Blood pressure is returned to 90-140.
Case 3
King XX, female, 62 years old, with severe hypertension, its blood pressure was between 130-260.Treatment method, use the present invention's
Tablet, early, middle and late once a dose, and 3 tablets once, using course for the treatment of 15 days, coordinates normal blood pressure detecting daily, after a course for the treatment of
Blood pressure is returned to 110-170.
Case 4
Cai XX, man, 60 years old, with severe hypertension, its blood pressure was between 130-260.Treatment method, use the present invention's
Tablet, early, middle and late once a dose, and 3 tablets once, using course for the treatment of 15 days, coordinates normal blood pressure detecting daily, after a course for the treatment of
Blood pressure is returned to 110-170.
Claims (10)
1. a kind of preparation method for treating hypertension ginkgo medicine, it is characterised in that by below by the bulk drug of weight meter number:
Ginkgo biloba extract cladding 2-5 parts, cassia seed 10-12 parts, root of herbaceous peony 5-10 parts, return tail 6-10 parts, cordyceps sinensis 0.5-1 parts, Huang
Stilbene 8-12 parts, chrysanthemum indicum 10-15 parts, Ramulus Taxilli 2-5 parts, Ligusticum wallichii 4-6 parts, sieve not sesame slices 4-8 parts, goldenseal 6-10 parts, Radix Codonopsis
1-5 parts, Poria cocos 2-5 parts, fruit of Chinese magnoliavine 3-6 parts, Radix Angelicae Sinensis 4-10 parts, bighead atractylodes rhizome 1-3 parts, radix rehmanniae recen 4-8 parts, radix glycyrrhizae 2-5 parts, root of Dahurain angelica 3-
6 parts, pseudo-ginseng 4-8 parts, aspongopus 4-8 parts, fleece-flower root 1-2 parts, Semen Cuscutae 3-5 parts, wilsonii 3-8 parts, elecampane 2-5 parts, Pu
Public English 8-12 parts, rheum officinale 4-10 parts, starch 30-50 parts are made.
2. the preparation method for the treatment of hypertension ginkgo medicine according to claim 1, it is characterised in that by below by weight
Count the bulk drug of number:2 parts of ginkgo biloba extract cladding, 10 parts of cassia seed, 5 parts of the root of herbaceous peony, return 6 parts of tail, 0.5 part of cordyceps sinensis,
8 parts of the Radix Astragali, 10 parts of chrysanthemum indicum, 2 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 4 parts of sesame slices, 6 parts of goldenseal, 1 part of Radix Codonopsis, 2 parts of Poria cocos, five
3 parts of taste, 4 parts of Radix Angelicae Sinensis, 1 part of the bighead atractylodes rhizome, 4 parts of radix rehmanniae recen, 2 parts of radix glycyrrhizae, 3 parts of the root of Dahurain angelica, 4 parts of pseudo-ginseng, 4 parts of aspongopus, the fleece-flower root 1
Part, 3 parts of Semen Cuscutae, 3 parts of wilsonii, 2 parts of elecampane, 8 parts of dandelion, 4 parts of rheum officinale, 30 parts of starch, then add 60 parts of nothing
Bacterium water for injection, tabletting is carried out after well mixed, manufactured sheet medicine after drying.
3. the preparation method for the treatment of hypertension ginkgo medicine according to claim 1, it is characterised in that characterized in that,
By below by the bulk drug of weight meter number:3 parts of ginkgo biloba extract cladding, 11 parts of cassia seed, 8 parts of the root of herbaceous peony, return 8 parts of tail, winter
1 part of worm summer grass, 10 parts of the Radix Astragali, 12 parts of chrysanthemum indicum, 3 parts of Ramulus Taxilli, 4 parts of Ligusticum wallichii, sieve not 5 parts of sesame slices, 8 parts of goldenseal, Radix Codonopsis 4
Part, 3 parts of Poria cocos, 4 parts of the fruit of Chinese magnoliavine, 7 parts of Radix Angelicae Sinensis, 2 parts of the bighead atractylodes rhizome, 6 parts of radix rehmanniae recen, 3 parts of radix glycyrrhizae, 5 parts of the root of Dahurain angelica, 6 parts of pseudo-ginseng, aspongopus
6 parts, 1 part of the fleece-flower root, 4 parts of Semen Cuscutae, 5 parts of wilsonii, 3 parts of elecampane, 10 parts of dandelion, 7 parts of rheum officinale, 40 parts of starch, then
60 parts of sterile water for injection is added, carries out tabletting after well mixed, manufactured sheet medicine after drying.
4. the preparation method for the treatment of hypertension ginkgo medicine according to claim 1, it is characterised in that characterized in that,
By below by the bulk drug of weight meter number:5 parts of ginkgo biloba extract cladding, 12 parts of cassia seed, 10 parts of the root of herbaceous peony, return 10 parts of tail,
1 part of cordyceps sinensis, 12 parts of the Radix Astragali, 15 parts of chrysanthemum indicum, 5 parts of Ramulus Taxilli, 6 parts of Ligusticum wallichii, sieve not 8 parts of sesame slices, 10 parts of goldenseal, Radix Codonopsis
5 parts, it is 5 parts of Poria cocos, 6 parts of the fruit of Chinese magnoliavine, 10 parts of Radix Angelicae Sinensis, 3 parts of the bighead atractylodes rhizome, 8 parts of radix rehmanniae recen, 5 parts of radix glycyrrhizae, 6 parts of the root of Dahurain angelica, 8 parts of pseudo-ginseng, nine fragrant
8 parts of worm, 2 parts of the fleece-flower root, 5 parts of Semen Cuscutae, 8 parts of wilsonii, 5 parts of elecampane, 12 parts of dandelion, 10 parts of rheum officinale, 50 parts of starch, so
60 parts of sterile water for injection is added afterwards, carries out tabletting after well mixed, manufactured sheet medicine after drying.
5. the preparation method of the treatment hypertension ginkgo medicine according to claim 1-4 any one, it is characterised in that institute
The medicine stated is separately made or combined by multi-medicament and formed with pharmaceutically acceptable carrier by Chinese medicine composition.
6. the preparation method of the treatment hypertension ginkgo medicine according to claim 1-4 any one, it is characterised in that institute
The preparation method for the treatment hypertension ginkgo medicine stated comprises the following steps:
(1) preparation of ginkgo biloba extract
In desinfection chamber, the Ginkgo biloba leaves for collecting are screened, the leaf not gone mouldy is chosen and is put into baking oven and is dried
Dry, wherein oven temperature is 60-70 DEG C, and the Ginkgo biloba leaves after drying are added in high-speed multifunctional pulverizer and crushed, powder
The sieve of 80-100 mesh is used after broken, is screened, chooses Ginkgo biloba leaves powder of the mesh number in 80 mesh.Weigh 100 parts of ginkgo leaf
Sub- powder is added in three-necked flask, then adds the ethyl acetate of 200-300 parts, is opened agitator and is controlled rotating speed in 200-
300rpm, between temperature is 80-100 DEG C, condensing reflux 1-2h is carried out, after question response is complete, room temperature is cooled to, is then subtracted
Pressure filters, and removes filter residue, obtains filtrate.Filtrate is added in Rotary Evaporators, is evaporated under reduced pressure, is obtained after removing ethyl acetate
The powder arrived, add sterile water for injection and cleaned, remove water-solubility impurity, then dried that (drying temperature is in 30-50
DEG C), the product after drying is ginkgo biloba extract.
(2) prepared by ginkgo biloba extract cladding:By ginkgo biloba extract and edible ethanol solution using mass ratio as 1:4-6 ratio is entered
Row mixing (when having part insoluble in course of dissolution, suitably being heated, its temperature control is at 40-60 DEG C) obtains mixing molten
Liquid, then by mixed solution and porous type resin using mass ratio as 10:1-2 ratio is mixed, and puts mixed liquor after mixing
Enter and ultrasonic 1-2h is carried out in ultrasonic machine, rush allows medicament to fully enter porous type resin.After the completion of ultrasound, this medicine is carried out
Vacuum filtration, filtrate are recycled, and filter residue are taken out, by filter residue and PEG solution using mass ratio as 10:1-3 ratio is carried out
Mixing, it is 50-60 DEG C that temperature is placed on after well mixed, heats 1-2h in rotating speed 200-300rpm water-bath, question response is complete
Quan Hou, this medicament are just ginkgo biloba extract cladding, are taken out standby.
(3) prepared by powder:In desinfection chamber, by cassia seed, the root of herbaceous peony, return tail, cordyceps sinensis, the Radix Astragali, chrysanthemum indicum, Ramulus Taxilli, river
Rhizome of chuanxiong, sieve not sesame slices, goldenseal, Radix Codonopsis, Poria cocos, the fruit of Chinese magnoliavine, Radix Angelicae Sinensis, the bighead atractylodes rhizome, radix rehmanniae recen, radix glycyrrhizae, the root of Dahurain angelica, pseudo-ginseng, aspongopus, what
The tuber of multiflower knotweed, Semen Cuscutae, wilsonii, elecampane, dandelion, rheum officinale, (drying temperature is at 50-60 DEG C) is dried, then added respectively
Enter in pulverizer and crushed, the sieve of 80-100 mesh is used after crushing, is screened, selection mesh number is standby in 80 purposes, then
According to drug dose, cassia seed 10-12 parts, root of herbaceous peony 5-10 parts, return tail 6-10 parts, cordyceps sinensis 0.5-1 parts, Radix Astragali 8-12 parts,
Chrysanthemum indicum 10-15 parts, Ramulus Taxilli 2-5 parts, Ligusticum wallichii 4-6 parts, sieve not sesame slices 4-8 parts, goldenseal 6-10 parts, Radix Codonopsis 1-5 parts, Poria cocos
2-5 parts, fruit of Chinese magnoliavine 3-6 parts, Radix Angelicae Sinensis 4-10 parts, bighead atractylodes rhizome 1-3 parts, radix rehmanniae recen 4-8 parts, radix glycyrrhizae 2-5 parts, root of Dahurain angelica 3-6 parts, pseudo-ginseng 4-
8 parts, aspongopus 4-8 parts, fleece-flower root 1-2 parts, Semen Cuscutae 3-5 parts, wilsonii 3-8 parts, elecampane 2-5 parts, dandelion 8-12 parts,
The proportioning of rheum officinale 4-10 parts, add in batch mixer and mixed (incorporation time 1-5min), taken out after mixing standby;
(4) medicine mixes:In desinfection chamber, by the ginkgo biloba extract cladding of step (1) preparation, 2-5 parts, step (2) are weighed
In medicine weigh 120-180 parts and weigh the starch of 30-50 parts, add in sterile barrel, mixed with puddler.Add
Appropriate water (60-80 parts), then it is stirred after it is become the semisolid of imaging surface bulk, takes out standby.
(5) synthetic drug:Raw material in step (3) is added in pelleter and carries out film-making, the Weight control of every tablet of medicine is in 1-
5g.Then medicine is dried (drying temperature is at 40-50 DEG C);
(6) pack:The medicine obtained in step (4) is subjected to quality inspection, certified products are packed, and obtain finished medicines.
7. the preparation method for the treatment of hypertension ginkgo medicine according to claim 5, it is characterised in that described step
(1) in, Ginkgo biloba leaves are the leaf of the ginkgo of at least more than 10 years, and the acquisition time of leaf is the 7-10 months of 1 year
Part, the leaf not gone mouldy with worm hole.
8. the preparation method for the treatment of hypertension ginkgo medicine according to claim 5, it is characterised in that described step
(2) in, porous type resin is that inside is that resin, its compression strength such as hollow acetate fiber, PEPA, edible PVC exist
20-40MP。
9. the preparation method for the treatment of hypertension ginkgo medicine according to claim 5, it is characterised in that described step
(2) in, PEG solution be concentration in 10-40%, and the PEG degree of polymerization is in 1000-5000.
10. the preparation method for the treatment of hypertension ginkgo medicine according to claim 5, it is characterised in that institute in step (4)
The starch stated is medicinal soluble starch.
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CN1387903A (en) * | 2002-07-08 | 2003-01-01 | 王汝明 | Cardiac and cerebral blood vessel nourishing tea |
CN102362881A (en) * | 2011-10-31 | 2012-02-29 | 广西亿康药业股份有限公司 | Method for preparing ginkgo and American ginseng preparation |
CN106361727A (en) * | 2016-11-25 | 2017-02-01 | 遵义医学院 | Bilobalide-PVA nanoparticle and preparation method thereof |
-
2017
- 2017-09-12 CN CN201710819130.1A patent/CN107456542A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1387903A (en) * | 2002-07-08 | 2003-01-01 | 王汝明 | Cardiac and cerebral blood vessel nourishing tea |
CN102362881A (en) * | 2011-10-31 | 2012-02-29 | 广西亿康药业股份有限公司 | Method for preparing ginkgo and American ginseng preparation |
CN106361727A (en) * | 2016-11-25 | 2017-02-01 | 遵义医学院 | Bilobalide-PVA nanoparticle and preparation method thereof |
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