CN107456395A - A kind of Chinese medicinal toothpaste containing graphene oxide and its preparation method and application - Google Patents
A kind of Chinese medicinal toothpaste containing graphene oxide and its preparation method and application Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The present invention relates to a kind of Chinese medicinal toothpaste containing graphene oxide and its preparation method and application.It is made up of graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent.Chinese medicinal toothpaste provided by the invention containing graphene oxide creatively will add graphene oxide and Chinese medical extract in the raw material of toothpaste, cleaning and the anti-microbial property of toothpaste can not only be improved, the unique two-dimensional structure of graphene oxide can carry Chinese medical extract, make the drug effect of Chinese medical extract；The toothpaste stain removal effect being prepared is strong, stimulates mucous membrane of mouth and tooth low and its active constituents of medicine effectively to mitigate the morning sickness problem of pregnant woman, fresh breath；Safe to use, practicality is extensive.The material used of this Chinese medicinal toothpaste containing graphene oxide is routinely easy to get；Preparation technology is simple, is adapted to industrialized production.
Description
Technical field
The present invention relates to daily chemical products technical field, more particularly, to a kind of Chinese medicinal toothpaste containing graphene oxide and
Its preparation method and application.
Background technology
Toothpaste is conventional cleaning supplies.With the continuous development of scientific technology, technological equipment update and it is perfect,
Various types of toothpaste are come out one after another, and are improved constantly with the quality and class of product, present toothpaste variety is by single clear
Clean type toothpaste, develops into great variety of goods, meets the needs of the different levels level of consumption.
Graphene oxide is the important derivatives of graphene, and its structure is essentially identical with graphene, still remains stratiform
Structure, but many oxygen-containing functional groups are introduced on its lamella, such as carboxyl, hydroxyl, epoxy radicals and carbonyl, peeled off by solvent
Or hot soarfing is from obtained single layer structure.As the monolayer material stripped down from graphite oxide, due on surface and edge
The introducing of a large amount of oxy radicals, it can be stabilized in the aqueous solution and polar solvent.And make with stronger broad-spectrum antiseptic
With being especially better than bacterium to fungi inhibitory action, be natural antibiotics.It is existing that when pregnancy vomiting often occurs for pregnant woman
As having certain influence to pregnant woman and child body；The easy breed bacteria in oral cavity of puerpera, oral cavity is easily got angry；And in general toothpaste is only
It can play a part of temporarily cleaning down tooth, without the effect of other treatments.And disclosed Application No. in the prior art
CN201510783408.5 a kind of novel toothpaste containing graphene oxide and preparation method thereof, mainly by following weight content
Component forms：Graphene oxide 0.01~1.5%, ionic liquid 0.1~0.85%, surplus are auxiliary agent.And ionic liquid is selected
N- butyl-pyridiniums hexafluorophosphate, N- butyl-pyridiniums tetrafluoroborate, one or more of in 1- methylimidazole trifluoroacetates；
It is well known that such a ionic liquid is toxic, is not suitable for various people, especially pregnant woman and uses；Searching one kind can solve pregnant
The morning sickness problem of woman, cleaning is antibacterial, safely and effectively novel toothpaste, is an important directions of future development.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicinal toothpaste containing graphene oxide and preparation method thereof and
Using solving the problems, such as the oral cleaning of pregnant woman, while effectively clearing up and resist oral bacteria, traditional Chinese medicine ingredients can be alleviated pregnant
The problems such as morning sickness of woman, and toothpaste security performance provided by the invention is high, anti-inflammation, cleaning effect is good, practical.
The purpose of the present invention is achieved by the following technical programs：
A kind of Chinese medicinal toothpaste containing graphene oxide is provided, by graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent group
Into matching in parts by weight：
Further optimally, the graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent, are matched in parts by weight：
Another object of the present invention is to, there is provided a kind of preparation method of the Chinese medicinal toothpaste containing graphene oxide, and it is oxygen-containing
The application of the Chinese medicinal toothpaste of graphite alkene.
Chinese medicinal toothpaste disclosed by the invention containing graphene oxide creatively will add graphite oxide in the raw material of toothpaste
Alkene and Chinese medical extract, can not only improve cleaning and the anti-microbial property of toothpaste, and the unique two-dimensional structure of graphene oxide can be held
Chinese medical extract is carried, makes the drug effect of Chinese medical extract more preferably；The toothpaste stain removal effect being prepared is strong, to mucous membrane of mouth and tooth
Low and its active constituents of medicine of tooth stimulation can effectively mitigate the morning sickness problem of pregnant woman, fresh breath, strong applicability.
Further, the Chinese medical extract is radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon；Match in parts by weight：
It is further preferred that the Chinese medical extract is radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon；Match somebody with somebody in parts by weight
Than：
Radix scutellariae contains abundant active mineral matter, can stimulate, strong nerve, and not only can effectively alleviate pregnant woman can be effective
Alleviate the moods such as the nervous, nervousness often having in busy life, neurasthenia, depression, sense of crisis in ground.Also because it has
Heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of arresting bleeding and miscarriage prevention, it is especially suitable for pregnant woman and uses.
Armeniaca mume has liver of relaxing, and stomach, the effect of resolving sputum, can mitigate the symptoms such as poor appetite, dizziness.
Dried orange peel has a qi-regulating, in tune, eliminating dampness, and the effect of resolving sputum.Abdominal distension, the Nausea and vomiting of pregnant woman can effectively be alleviated；It is uncomfortable in chest
The symptoms such as abdominal distension.
Lotus stem has relieving summer-heat heat-clearing, qi-regulating dampness elimination；Ventilate wide chest, and the effect that stomach is antiabortive；Especially to the summer-heat and damp chest of pregnant woman
It is vexed not relax；Diarrhea；Dysentery；Gonorrhoea；Under band；The vomiting of pregnancy, fetal irritability have preferable mitigation.
Containing abundant citric acid in lemon, containing vitamin C, energy preventing phlegm from forming and stopping coughing, stomach invigorating of promoting the production of body fluid.For bronchitis, hundred
The symptoms such as day cough, poor appetite, hypovitaminosis, heatstroke polydipsia, and can effectively eliminate pregnant woman and generate heat morning sickness phenomenon.
Radix scutellariae is ministerial drug in the Chinese medical extract of the present invention, is aided with armeniaca mume, dried orange peel, lotus stem and lemon compatibility, each component
Effectively collaboration so that toothpaste of the invention has hot eliminating dampness simultaneously, purging intense heat and detonicating, the effect of arresting bleeding and miscarriage prevention, to the uncomfortable in chest of pregnant woman
Qi-regulating, and the antiabortive positive effect of stomach；In addition, by adding graphene oxide in proportion, not only make the anti-microbial property of toothpaste increase,
The synergy of the combination of Chinese medical extract and graphene oxide, Chinese medical extract and graphene oxide is more strengthened, leads to oxidation
The scientific matching of graphene, Chinese medical extract and auxiliary agent, the antibacterial and Chinese medicine effect for making toothpaste reach optimal, expand and adapt to people
Group, also improves effect.
Further, the dispersion liquid is any in ethanol or polyvinylpyrrolidone.Preferably ethanol.
Dispersion liquid is mainly used in scattered graphene oxide, the not hydrophilic also not oleophylic, and due to model moral of graphene oxide sheet
Hua Li is also easy to reunite, it is difficult to which long-time stable is scattered in the solution.The dispersant environment protection health that the present invention selects is nontoxic
Side effect；Graphene oxide dispersion of the present invention selects ethanol or polyvinylpyrrolidone；Ethanol not still graphene oxide
Good organic solvent, and most of organic principle in Chinese medical extract can be dissolved, contribute to the analysis of effective ingredient
Go out；The effect of qi-regulating promoting circulation of blood medicine is set preferably to be played；Graphene oxide and Chinese medical extract are effectively combined, played more
Good synergy.
The excellent physiological inertia of polyvinylpyrrolidone, is not involved in human metabolism, has excellent bio-compatible again
Property, graphene may be homogenously dispersed in wherein, and polyvinylpyrrolidone does not form any stimulation to skin and oral mucosa etc..It is applicable
Used in pregnant woman.
Further, the auxiliary agent is rubbing agent, NMF, thickener, foaming agent, aromatic and water.
The auxiliary agent selects the conventional use of rubbing agent of toothpaste, NMF, thickener, foaming agent, aromatic and water.Its
Middle rubbing agent is any one of calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate, silica and aluminium hydroxide；NMF be glycerine,
Any one of sorbierite, propane diols, polyethylene glycol and water；Thickener is carboxymethyl cellulose, deer horn pectin, hydroxy ethyl fiber
Any one of element, xanthans, guar gum and carrageenan；Foaming agent is laruyl alcohol sodium sulfovinate；Aromatic be zinc citrate and
Glycerine mixes.
Another object of the present invention is to provide a kind of preparation method of the Chinese medicinal toothpaste containing graphene oxide, its feature exists
In comprising the following steps：
S1. the preparation of graphene oxide：The graphene oxide and dispersion liquid are added in deionized water, ultrasonic disperse 10
~30min；
S2. the preparation of Chinese medical extract：
S21. component weighs radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon by weight, is baked to grind into powder；
S22. powder described in step S22 is added in deionized water, passes through 10~30min of ultrasonic disperse；
S3. step S1~S2 is mixed in proportion, is placed in the batch mixing pond equipped with auxiliary agent, at room temperature stir 20~
35min。
Further, the power of ultrasonic disperse described in step S1 is 20~40KHz；The power of ultrasonic disperse described in step S2
For 20~40KHz.
Further, the revolution stirred described in step S3 is 3000~4000 turns/min.
Chinese medicinal toothpaste disclosed by the invention containing graphene oxide is applied to cleaning of teeth and the nursing of pregnant woman.
Compared with prior art, the present invention has the advantages that：
Chinese medicinal toothpaste provided by the invention containing graphene oxide creatively will add graphite oxide in the raw material of toothpaste
Alkene and Chinese medical extract, can not only improve cleaning and the anti-microbial property of toothpaste, and the unique two-dimensional structure of graphene oxide can be held
Chinese medical extract is carried, makes the drug effect of Chinese medical extract；The toothpaste stain removal effect being prepared is strong, and mucous membrane of mouth and tooth are pierced
The morning sickness problem of pregnant woman, fresh breath can effectively be mitigated by swashing low and its active constituents of medicine.
Chinese medicinal toothpaste provided by the invention containing graphene oxide is crossed adds graphene oxide in proportion, leads to graphite oxide
The scientific matching of alkene, Chinese medical extract and auxiliary agent, the antibacterial and Chinese medicine effect for making toothpaste reach optimal, expand adaptation population,
Also improve effect.
The dispersion liquid of the present invention is any in ethanol or polyvinylpyrrolidone, environment protection health, is had no toxic side effect；Can be with
Most of organic principle in Chinese medical extract is dissolved, contributes to the precipitation of effective ingredient；Make the effect of qi-regulating promoting circulation of blood medicine
Preferably played；Graphene oxide and Chinese medical extract are effectively combined, play preferably synergy.
Chinese medicinal toothpaste provided by the invention containing graphene oxide, can effectively kill oral bacteria, give full play to Chinese medicine spy
Property, make toothpaste that not only there is superpower cleaning function, and a series of oral problems of pregnant woman can also be alleviated, and can effectively prevent
Morning sickness, safe to use, practicality is extensive.The material used of this Chinese medicinal toothpaste containing graphene oxide is routinely easy to get；Prepare work
Skill is simple, is adapted to industrialized production.
Embodiment
Further illustrate the present invention below in conjunction with specification specific embodiment, but embodiment the present invention is not done it is any
The restriction of form.Unless stated otherwise, the reagent of the invention used, method and apparatus is the art conventional reagent, methods
And equipment.Unless stated otherwise, the raw material used in the present embodiment and equipment are that the art routinely raw material purchased in market and is set
It is standby.
Chinese medicinal toothpaste disclosed by the invention containing graphene oxide, by graphene oxide, dispersion liquid, Chinese medical extract and is helped
Agent forms, wherein, it is any in ethanol or polyvinylpyrrolidone that dispersion liquid, which chooses liquid,.Preferably ethanol；Chinese medical extract
Mixed in proportion for radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon；The auxiliary agent is from the conventional use of rubbing agent of toothpaste, guarantor
Humectant, thickener, foaming agent, aromatic and water.Rubbing agent is calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate, silica and hydrogen-oxygen
Change any one in aluminium；NMF is any one in glycerine, sorbierite, propane diols, polyethylene glycol and water；Thickener is
Any one in carboxymethyl cellulose, deer horn pectin, hydroxyethyl cellulose, xanthans, guar gum and carrageenan；Foaming agent is
Laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
Rubbing agent in auxiliary agent, NMF, thickener, foaming agent, the ratio of weight and number of aromatic and water are：45:15:1.5:
1.5:0.02：37.
Radix scutellariae is ministerial drug in the Chinese medical extract of the present invention, is aided with armeniaca mume, dried orange peel, lotus stem and lemon compatibility, each component
Effectively collaboration so that toothpaste of the invention has hot eliminating dampness simultaneously, purging intense heat and detonicating, the effect of arresting bleeding and miscarriage prevention, to the uncomfortable in chest of pregnant woman
Qi-regulating, and the antiabortive positive effect of stomach；In addition, by adding graphene oxide in proportion, not only make the anti-microbial property of toothpaste increase,
The synergy of the combination of Chinese medical extract and graphene oxide, Chinese medical extract and graphene oxide is more strengthened, leads to oxidation
The scientific matching of graphene, Chinese medical extract and auxiliary agent, the antibacterial and Chinese medicine effect for making toothpaste reach optimal, expand and adapt to people
Group, also improves effect.
Embodiment 1
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is ethanol, in
Medicament extract is radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；Auxiliary agent be rubbing agent, NMF, thickener,
Foaming agent, aromatic and water.Rubbing agent be calcium carbonate,；NMF is glycerine；Thickener is carboxymethyl cellulose；Foaming agent is
Laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide, comprises the following steps：
S1. the preparation of graphene oxide：The graphene oxide and dispersion liquid are added in deionized water, ultrasonic disperse
Under conditions of power is 20KHz, ultrasonic disperse 30min；
S2. the preparation of Chinese medical extract：
S21. component weighs radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon by weight, is baked to grind into powder；
S22. powder described in step S22 is added in deionized water, under conditions of the power of ultrasonic disperse is 30KHz, led to
Cross ultrasonic disperse 10min；
S3. step S1~S2 is mixed in proportion, be placed in the batch mixing pond equipped with auxiliary agent, at room temperature, revolution 3000
Turn/min, stir 20min.
Embodiment 2
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is polyethylene
Pyrrolidones, Chinese medical extract are radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；Auxiliary agent is rubbing agent, protected
Humectant, thickener, foaming agent, aromatic and water.Rubbing agent is calcium monohydrogen phosphate；NMF is sorbierite；Thickener is deer horn fruit
Glue；Foaming agent is laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide, comprises the following steps：
S1. the preparation of graphene oxide：The graphene oxide and dispersion liquid are added in deionized water, ultrasonic disperse
Under conditions of power is 40KHz, ultrasonic disperse 10min；
S2. the preparation of Chinese medical extract：
S21. component weighs radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon by weight, is baked to grind into powder；
S22. powder described in step S22 is added in deionized water, under conditions of the power of ultrasonic disperse is 20KHz, led to
Cross ultrasonic disperse 30min；
S3. step S1~S2 is mixed in proportion, be placed in the batch mixing pond equipped with auxiliary agent, at room temperature, revolution 4000
Turn/min, stir 35min.
Embodiment 3
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is ethanol, in
Medicament extract is radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；Auxiliary agent be rubbing agent, NMF, thickener,
Foaming agent, aromatic and water.Rubbing agent is calcium pyrophosphate；NMF is propane diols；Thickener is hydroxyethyl cellulose；Foaming agent
For laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide is same as Example 1, and its difference is, ultrasound point in step S2
Under conditions of scattered power is 25KHz, pass through ultrasonic disperse 20min；
Embodiment 4
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is ethanol, in
Medicament extract is radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；Auxiliary agent be rubbing agent, NMF, thickener,
Foaming agent, aromatic and water.Rubbing agent is silica；NMF is polyethylene glycol；Thickener is xanthans；Foaming agent is the moon
Cinnamic alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide is same as Example 1.
Embodiment 5
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is polyethylene
Pyrrolidones, Chinese medical extract are radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；Auxiliary agent is rubbing agent, protected
Humectant, thickener, foaming agent, aromatic and water.Any one in rubbing agent aluminium hydroxide；NMF is water；Thickener is
Guar gum；Foaming agent is laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide is same as Example 1.
Embodiment 6
(1) Chinese medicinal toothpaste containing graphene oxide
Graphene oxide, dispersion liquid, Chinese medical extract and auxiliary agent are weighed by the proportioning of table 1, wherein dispersion liquid is polyethylene
Pyrrolidones, Chinese medical extract are radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon, and its content is shown in Table 2；The auxiliary agent is friction
Agent, NMF, thickener, foaming agent, aromatic and water.Rubbing agent is calcium carbonate；NMF is glycerine；Thickener is carrageenan
In any one；Foaming agent is laruyl alcohol sodium sulfovinate；Aromatic is zinc citrate and glycerine in mass ratio 1:1 mixing.
(2) preparation method of the Chinese medicinal toothpaste containing graphene oxide
The preparation method of the toothpaste of graphene oxide is same as Example 1.
Comparative example 1
This comparative example discloses a kind of Chinese medicinal toothpaste containing graphene oxide, identical with the raw material proportioning of embodiment 3, and it is different
Part is, Chinese medical extract is free of in raw material, and its preparation method is：
Y1. the preparation of graphene oxide：The graphene oxide and dispersion liquid are added in deionized water, ultrasonic disperse
Under conditions of power is 40KHz, ultrasonic disperse 10min；
Y2. by the scattered rear solution of step Y1 graphene oxide, it is placed in the batch mixing pond equipped with auxiliary agent, at room temperature, turns
Number is 4000 turns/min, stirs 20min.The Chinese medicinal toothpaste containing graphene oxide is prepared.
Comparative example 2
This comparative example discloses a kind of Chinese medicinal toothpaste, identical with the raw material proportioning of embodiment 3, and its difference is, raw material
In be free of graphene oxide, its preparation method is：
P1. the preparation of Chinese medical extract：
P11. component weighs radix scutellariae, armeniaca mume, dried orange peel, lotus stem and lemon by weight, is baked to grind into powder；
P12. powder described in step P22 is added in deionized water, under conditions of the power of ultrasonic disperse is 30KHz, led to
Cross ultrasonic disperse 30min；
P2. by Chinese medical extract solution obtained by step P1, it is placed in the batch mixing pond equipped with auxiliary agent, at room temperature, revolution is
4000 turns/min, stir 20min.Chinese medicinal toothpaste is made.
Comparative example 3
This comparative example discloses a kind of Chinese medicinal toothpaste, is chosen with the raw material of embodiment 3 and preparation method is identical, difference exists
Ratio between raw material is different, and specific proportioning is shown in Table 1.
Table 1
| Graphene oxide (part) | Dispersion liquid (part) | Chinese medical extract (part) | Auxiliary agent (part) | |
| Embodiment 1 | 0.1 | 0.2 | 0.7 | 98.0 |
| Embodiment 2 | 0.8 | 0.6 | 2.0 | 99.0 |
| Embodiment 3 | 0.6 | 0.6 | 2.0 | 98.5 |
| Embodiment 4 | 0.5 | 0.3 | 1.5 | 99.0 |
| Embodiment 5 | 0.7 | 0.4 | 0.8 | 99.0 |
| Embodiment 6 | 0.2 | 0.5 | 1.0 | 98.5 |
| Comparative example 1 | 0.6 | 0.6 | —— | 98.5 |
| Comparative example 2 | —— | 0.6 | 2.0 | 98.5 |
| Comparative example 3 | 0.05 | 0.1 | 0.5 | 97 |
Table 2
The Chinese medicinal toothpaste containing graphene oxide of embodiment 1~6 be particularly suitable for use in pregnant woman tooth cleaning and nursing.For
Effect and the effect of embodiment 1~6 and comparative example 1~3 are further verified, carries out antibacterial experiment, specific experiment scheme is as follows：Will
90 subjects are randomly divided into 9 groups, every group 10；Subject is aspirated to collect bacterium, so before experiment in tongue back side
The sample of collection is cultivated under 37 DEG C of anaerobic condition with blood agar culture-medium afterwards, after 72 hours, calculates average bacteriological
CFU (baseline), then subject respectively use the present embodiment 1~6 dentifrice composition, brush teeth daily sooner or later each 1
It is secondary, 2 grams of toothpaste is used every time, continues 3 months, is brushed teeth using horizontal vibration method；After 3 months, subject is another at tongue back
Side is aspirated to collect bacterium, is then cultivated under 37 DEG C of anaerobic condition the sample of collection with blood agar culture-medium, 72
After hour, average bacteriological CFU is calculated, compares the dentifrice composition using the present embodiment 1~6 and comparative example 1~3
The average colony of front and rear subject forms the change of unit results.Its experiment the results are shown in Table 3.
Table 3
Dental plaque index reduced rate=[(the preceding dental plaque index of use-uses 3 months Dental Plaque indexes)/use labial teeth
Plaque index] × 100%.
From upper table 3, after the toothpaste using the graphene oxide of the present invention, dental plaque index reduced rate up to 71.73~
82.95%, amount of bacteria removal effect is notable.
In order to which the bacterial plaque of the dentifrice composition of the present invention removes effect, following experimental verification, specific experiment side have been carried out
Case is as follows：
90 subjects are randomly divided into 9 groups, every group 10；Subject uses the present embodiment 1~6 and comparative example 1 respectively
~3 dentifrice composition, brush teeth daily each 1 time sooner or later, use 2 grams of toothpaste every time, continue 3 months, using horizontal vibration method brush
Tooth；Investigate using the dental plaque index (PLI) of subject before and after the present embodiment 1~6 and the dentifrice composition of comparative example 1~3
Change.Dental plaque index (PLI) calculates average value.Its experiment the results are shown in Table 4.
Table 4
From upper table 4, using the toothpaste of the graphene oxide of the present invention, dental plaque index reduced rate up to 59.8~
70.0%, anti-plaque positive effect.
The Chinese medicinal toothpaste containing graphene oxide prepared from above-mentioned experiment, the present invention, can there is killing oral bacteria, good
Good anti-microbial property；The mutual gain of energy on toothpaste of graphene oxide and Chinese medical extract, the proportioning of embodiment 3 are selected, made
It is most obvious to obtain bactericidal effect；Cleaning and the anti-microbial property of toothpaste can be improved, the unique two-dimensional structure of graphene oxide can carry
Chinese medical extract, make the drug effect of Chinese medical extract；The toothpaste stain removal effect being prepared is strong, and mucous membrane of mouth and tooth are stimulated
It is low, fresh breath.
In order to further verify the effect of the present invention, Consumer's Experience tracking test is carried out, this is containing in graphene oxide
The using effect of medicine toothpaste：
Pregnant woman 50, to adhere to daily using the Chinese medicinal toothpaste containing graphene oxide once, its dosage is identical with ordinary toothpaste,
Continuous use 10 days, morning sickness phenomenon mitigate 42 of significant effect, account for 84%.
Chinese medicinal toothpaste provided by the invention containing graphene oxide, not only can effectively kill oral bacteria, in giving full play to
Medicine characteristic, make toothpaste that not only there is superpower cleaning function, and a series of oral problems of pregnant woman can also be alleviated, and can be effective
Prevent from vomiting during pregnancy, safe to use, practicality is extensive.The material used of this Chinese medicinal toothpaste containing graphene oxide is routinely easy to get；System
Standby technique is simple, is adapted to industrialized production.
The general principle and the advantage of principal character and the present invention of the present invention has been shown and described above.The technology of this area
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, and this is to this
It is it will be apparent that these changes and improvements all fall within the protetion scope of the claimed invention for art personnel.This hair
Bright claimed scope is by appended claims and its equivalent thereof.
Claims (10)
- A kind of 1. Chinese medicinal toothpaste containing graphene oxide, it is characterised in that by graphene oxide, dispersion liquid, Chinese medical extract and Auxiliary agent forms, and proportioning is in parts by weight：Graphene oxide：0.1 ~ 0..8 partsDispersion liquid：0.2 ~ 0.6 partChinese medical extract：0.7 ~ 2.0 partAuxiliary agent：98 ~ 99.0 parts.
- 2. the Chinese medicinal toothpaste containing graphene oxide according to claim 1, it is characterised in that the graphene oxide, disperse Liquid, Chinese medical extract and auxiliary agent, in parts by weight proportioning are：Graphene oxide：0.5 ~ 0.7 partDispersion liquid：0.3 ~ 0.5 partChinese medical extract：1.0 ~ 2.0 partsAuxiliary agent：98.5 ~ 99.0 parts.
- 3. the Chinese medicinal toothpaste containing graphene oxide according to claim 1, it is characterised in that the Chinese medical extract is Huang Siberian cocklebur, armeniaca mume, dried orange peel, lotus stem and lemon；Match in parts by weight：Radix scutellariae：0.5 ~ 2.0 partArmeniaca mume：0.5 ~ 1.0 partDried orange peel：0.5 ~ 1.0 partLotus stem：0.5 ~ 2.0 partLemon：3.0 ~ 5.0 parts.
- 4. the Chinese medicinal toothpaste containing graphene oxide according to claim 3, it is characterised in that the Chinese medical extract is Huang Siberian cocklebur, armeniaca mume, dried orange peel, lotus stem and lemon；Match in parts by weight：Radix scutellariae：1.5 partArmeniaca mume：0.8 partDried orange peel：0.5 partLotus stem：1 partLemon：3 parts.
- 5. the Chinese medicinal toothpaste containing graphene oxide according to claim 1, it is characterised in that the dispersion liquid is ethanol or gathered It is any in vinylpyrrolidone.
- 6. the Chinese medicinal toothpaste containing graphene oxide according to claim 1, it is characterised in that the auxiliary agent is rubbing agent, protected Humectant, thickener, foaming agent, aromatic and water.
- 7. a kind of preparation method of the Chinese medicinal toothpaste containing graphene oxide according to claim 1 ~ 6 any one, its feature It is, comprises the following steps：S1. the preparation of graphene oxide：The graphene oxide and dispersion liquid are added in deionized water, ultrasonic disperse 10 ~ 30min；S2. the preparation of Chinese medical extract：S21. component weighs radix scutellariae, armeniaca mume, dried orange peel lotus stem and lemon by weight, is baked to grind into powder；S22. powder described in step S22 is added in deionized water, passes through 10 ~ 30min of ultrasonic disperse；S3. step S1 ~ S2 is mixed in proportion, be placed in the batch mixing pond equipped with auxiliary agent, stir 20 ~ 35min at room temperature.
- 8. the preparation method of the Chinese medicinal toothpaste containing graphene oxide according to claim 7, it is characterised in that described in step S1 The power of ultrasonic disperse is 20 ~ 40KHz；The power of ultrasonic disperse described in step S2 is 20 ~ 30KHz.
- 9. the preparation method of the Chinese medicinal toothpaste containing graphene oxide according to claim 7, it is characterised in that described in step S3 The revolution of stirring is 3000 ~ 4000 turns/min.
- 10. a kind of Chinese medicinal toothpaste containing graphene oxide according to claim 1 ~ 6 or 8 ~ 9 any one is applied to pregnant woman's Cleaning of teeth and nursing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381911A (en) * | 2022-06-13 | 2022-11-25 | 深圳市华壹健康投资有限公司 | Traditional Chinese medicine patch containing graphene and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105395372A (en) * | 2015-11-17 | 2016-03-16 | 张建刚 | Novel toothpaste with graphene oxide and preparation method thereof |
| CN105534792A (en) * | 2015-12-16 | 2016-05-04 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Chinese herbal medicine toothpaste containing nano diamond olefine |
| JP2016074636A (en) * | 2014-10-08 | 2016-05-12 | 国立大学法人北海道大学 | Antibacterial coating composition for dentistry |
-
2017
- 2017-08-04 CN CN201710661008.6A patent/CN107456395A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016074636A (en) * | 2014-10-08 | 2016-05-12 | 国立大学法人北海道大学 | Antibacterial coating composition for dentistry |
| CN105395372A (en) * | 2015-11-17 | 2016-03-16 | 张建刚 | Novel toothpaste with graphene oxide and preparation method thereof |
| CN105534792A (en) * | 2015-12-16 | 2016-05-04 | 郑州人造金刚石及制品工程技术研究中心有限公司 | Chinese herbal medicine toothpaste containing nano diamond olefine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381911A (en) * | 2022-06-13 | 2022-11-25 | 深圳市华壹健康投资有限公司 | Traditional Chinese medicine patch containing graphene and preparation method thereof |
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Application publication date: 20171212 |