CN107446006A - A kind of complex compound of secondary complexing calcium and its production and use - Google Patents
A kind of complex compound of secondary complexing calcium and its production and use Download PDFInfo
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- CN107446006A CN107446006A CN201710723094.9A CN201710723094A CN107446006A CN 107446006 A CN107446006 A CN 107446006A CN 201710723094 A CN201710723094 A CN 201710723094A CN 107446006 A CN107446006 A CN 107446006A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
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- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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Abstract
The present invention relates to a kind of complex compound, the particularly a kind of complex compound of secondary complexing calcium, preparation method and its purposes in animal feed additive.A kind of complex compound of secondary complexing calcium, first by sucrose complexing calcium, then ensure that calcium reaction is complete, finally again by sucrose calcium product and Calcium Amino Acid chelate product mix with the calcium ion in amino-acid complex waste liquid and filter residue again.The complex compound of the secondary complexing calcium of the present invention had both possessed sucrose complexing calcium low cost, growth promoting function clear advantage, but also with the advantages of amino-acid complex inorganic calcium biological value is high, chemical property is stable, palatability is good, compared with the cost used in amino-acid complex (chelating) trace element merely, present invention reduces 30 40% use cost.
Description
Technical field
The present invention relates to a kind of complex compound, particularly a kind of complex compound of secondary complexing calcium, preparation method and its in animal
Purposes in feed addictive.
Background technology
Calcium is the first mineral element in animal body, and calcium accounts for the 1-2% of the weight of animals.Bone and tooth be present in the 99% of calcium
In, remaining calcium is present in soft tissue body fluid.Obviously, calcium in the development of bone and tooth with being played an important role in maintaining,
In addition, calcium also has many important biological functions.Calcium is to blood clotting, the transmission of nerve impulse, the contraction of muscle, enzyme
Secretion of activity and hormone etc., suffers from decisive role.Calcium can adjust the excitability of muscle and nerve, can activate or suppress more
The activity of kind enzyme, calcium also have idiotrophic regulatory function, when External Calcium supply is insufficient, deposition calcium (particularly in bone)
Can largely it decompose for metabolic cycles needs, this function is to laying eggs, giving milk, animal pregnancy is particularly significant.When young animal lacks calcium
Rickets can occur, osteomalacia occur in adults when lacking calcium, calcium, phosphorus ratio imbalance can also cause acalcicosis, calcium deficiency
In addition to bone disorders are caused, while also breeding performonce fo animals are caused to decline.
At present, on husbandry sector, mainly using the inorganic calcium such as pulverized limestone, calcium carbonate and calcium monohydrogen phosphate class as main calcium source,
Wherein calcium carbonate due to calcium content is high, safely, effectively, it is particularly inexpensive the advantages of, it is most widely used.Although calcium carbonate calcium contains
Amount is high, cheap, but because dissolution of calcium carbonate is extremely low, it, which dissolves, needs relatively low pH, it is necessary under one's belt with substantial amounts of acid
It could be absorbed after reaction generation ionized calcium.Calcium carbonate has acidophilia, after neutralizing hydrochloric acid in gastric juice, produces carbon dioxide and causes animal intestines and stomach
Flatulence.Calcium carbonate is largely drained with indissoluble salt form, or deposition is in animal body, causes the waste of raw material, calcium uptake
It is bad to cause calcium phosphorus ration to lack of proper care and cause aphosphorosis.Especially young animal, digestive system development imperfection, stomach secrete sour energy
Power is higher than Adult Pig not as good as adults, stomach inner pH value, directly affects its absorption to calcium.Especially early-weaned pigletses, wean
Stomach inner pH value stress be caused significantly to rise, be unfavorable for growing.And inorganic calcium easily causes the imbalance of electrolyte, causes piglet
Diarrhea；Calcium carbonate also disturbs the absorption of the inorganic ions such as iron, zinc simultaneously.
Match somebody with somebody as the development of feed industry and the feed addictive such as the progress of aquaculture, trace element, amino acid turn into
Close the indispensable raw material of feed.People add the micro of various dose according to different animals nutritional need in mixed feed
The feed addictives such as element, amino acid carry out balanced nutrients composition, promote animal productiong, improvement product quality to reach, improve and raise
Expect conversion ratio, reduce feeding cost, the purpose increased economic efficiency.
However, amino-acid complex (chelating) trace element with synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also of a relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost increasingly highlights.
Therefore, inventor the calcium then not reacted completely with amino-acid complex again, is both reduced into sucrose complexing calcium
This, moreover it is possible to keep certain biological value.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
It has been the prior art well known to persons skilled in the art when being considered as recognizing or implying the information structure in any form.
The content of the invention
For deficiencies of the prior art, the present invention provides one kind and had both possessed sucrose complexing calcium low cost, growth-promoting
Long effect clear advantage, but also with the two of the advantages of Calcium Amino Acid chelate biological value is high, chemical property is stable, palatability is good
Complex compound of secondary complexing calcium and preparation method thereof.
To achieve the above object, technical scheme provided by the invention is as follows：
A kind of complex compound of secondary complexing calcium, it includes lime saccharate and amino acid calcium；
The lime saccharate is made up of sucrose and calcium salt of complex reaction；
The amino acid calcium is made up of amino acid and calcium salt of complex reaction.
Preferably, the calcium salt is any of calcium chloride, calcium sulfate and calcium oxide.
Preferably, the amino acid is any of methionine, glutamic acid, glycine.
Present invention also offers the preparation method of the complex compound of described secondary complexing calcium, comprise the following steps：
Take the raw material of following parts by weight：Sucrose 30-40 parts, water 60-65 parts, calcium salt 8-11 parts, amino acid 4-15 parts, by with
Lower step is prepared：
(1) after the sucrose in reactor is dissolved with water, calcium salt is added, adjusts pH value to 11-12；
(2) heating response device continues stirring reaction 1-2h, sucrose calcium solution is made to 80 DEG C of device Nei Wenduda；
(3) sucrose calcium solution is cooled down to normal temperature, is separated by filtration, is obtained the first separating liquid and the first sediment, the first separation
Liquid adds the sedimentation of 75% ethanol solution, obtains the second separating liquid and the second sediment, and the centrifugation of the second sediment filters, and dries, sieve
Divide, detection, lime saccharate is made；
(4) the second separating liquid is evaporated, reclaims ethanol, while obtains the 3rd separating liquid, by the 3rd separating liquid and step (3) institute
After obtaining the mixing of the first sediment, the calcium ion concentration in mixture is detected, adds amino acid, tune pH value is 6-7；
(5) continue stirring reaction 60-70min, concentration, dry, crush, screening, Calcium Amino Acid chelate is made；
(6) gained lime saccharate is mixed with Calcium Amino Acid chelate, that is, the complex compound of secondary complexing calcium is made.
Preferably, the mass ratio of first separating liquid and 75% ethanol solution is 1: 2.
Preferably, in the step (2), reactor temperature is kept at 70-80 DEG C.
Preferably, first separating liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
Preferably, in the step (3), dry as vacuum drying.
Preferably, in the step (4), the mol ratio of amino acid and calcium ion is 2:1.
Preferably, in the step (6), lime saccharate and Calcium Amino Acid chelate are 2-5 in mass ratio:1-3.
Present invention also offers purposes of the complex compound of described secondary complexing calcium as animal feed additive, itself and feeding
Feeding animals after material mixing.
Further, the accounting of animal feed additive and feed is 0.3-0.5%.
There are a pair of lone pair electrons, while transition metal ions (M=Cu on the glycosidic bond of sucrose (few disaccharides)2+、 Zn2+、Mn2 +、Fe2+、Ca2+) there is suitable unoccupied orbital, " coordination effect " can be formed with sucrose under suitable temperature environment, after chemical reaction
Complexing forms complex state metal, is absorbed beneficial to animal body.It is as follows that it forms molecular structural formula：
Above-mentioned is sucrose trace element molecular structural formula, wherein M=Cu2+、Zn2+、Mn2+、Fe2+、 Ca2+。
Because the reaction of sucrose trace-element complex is complicated, product is different from general amino-acid chelate, more category
In macromolecular structure, the molecular weight not determined.
Inventor remaining waste liquid and is separated by filtration the obtained mixing of filter residue after making full use of waste water evaporation recovery ethanol
Thing, the calcium ion in the mixture is subjected to secondary complex reaction with amino acid, generates the moderate complex compound of stability constant, these
Complex compound utilizes Amino Acid Absorption passage in small intestine, avoids other ore deposits with being operated by mineral element Ions Absorption passage
The competition of matter-element element and antagonism.The biochemical property of other complex compound is more stable, effectively resists other nutrients in daily ration and sends out therewith
Raw adverse effect.Complex compound solubility property in body is good, it is easy absorb, utilization rate it is high.
At present, the complex products of most of amino acid and trace element are all by 1 with amino acid with trace element both at home and abroad:
For 1 mol ratio come the product that is complexed, what is obtained is the not neutral complex compound of electricity.The not neutral complex ion of electricity is absorbed into by animal
, can be by other anion, such as PO in substrate in animal body before entering cell4 3-、SO4 2-、CO3 2-Etc. the suction of many negatively charged ions
Draw, interception is combined into ionic bond, so as to stop that complex ion smoothly absorbs and utilized.Because 1:The complex compound of 1 mol ratio only has
One complexing ring, so bioactivity is also than 2:1 mol ratio it is low, the amount that causes complex compound to be absorbed by animal is not uncertain, not yet
It is stable.And the Calcium Amino Acid chelate described in step 2) of the present invention, amino acid and the calcium ion mol ratio of complex reaction are 2：1,
The product that step 2) obtains is organic complex, complete electroneutral.
The application method of the complex compound of the secondary complexing calcium of the present invention is：After being well mixed with feed, for pig, chicken, duck, ox
With the feeding of sheep, addition is 3-5 kgs/tonne of feed.
Compared with prior art, the present invention has the advantages that：
(1) complex compound of secondary complexing calcium of the invention, first by sucrose complexing calcium, is then given up with amino-acid complex again
Calcium ion in liquid and filter residue, ensure that calcium reaction is complete, finally again by sucrose calcium product and Calcium Amino Acid chelate product mix.Should
Mixture had both possessed sucrose complexing calcium low cost, growth promoting function clear advantage, but also with Calcium Amino Acid chelate biological value
The advantages of height, chemical property are stable, palatability is good, with the cost phase used in amino-acid complex (chelating) trace element merely
Than present invention reduces 30-40% use cost.
(2) complex compound of secondary complexing calcium of the invention, sucrose the solubility of calcium therein is good, it is easy absorb, stability it is good, make
For feed addictive, the excrement excretion of feed source trace element can be substantially reduced, reduces pollution of the aquaculture to environment, moreover it is possible to change
Kind meat is yellowish pink, strengthens the anti-oxidation function of body, significantly improves the vigor of the GSH-Px in liver, muscle, improve serum T-
AOC and T-SOD, UN is reduced, the Nutrient Apparent Digestibilities such as feed CP, EE, calcium, phosphorus is significantly improved, increases the deposition of nitrogen, moreover it is possible to be aobvious
Write and improve serum levels of iron and liver iron content.After lime saccharate enters in animal stomach, generated with hydrochloric acid in gastric juice slow reaction absorbable
Organic calcium.
(3) complex compound of secondary complexing calcium of the invention, Calcium Amino Acid chelate therein can effectively be alleviated between mineral element
Antagonism, only body does not provide microelements of calcium, and also provides essential amino acid, and palatability is good, and it is unnecessary to avoid
Waste.Calcium Amino Acid chelate utilizes Amino Acid Absorption passage in small intestine, avoids with being led to by mineral element Ions Absorption
The competition of other mineral elements of road operating and antagonism.The biochemical property of the other complex compound is more stable, effectively resists daily ration
In other nutrients adverse effect occurs therewith.Complex compound solubility property in body is good, it is easy absorb, utilization rate it is high.
(4) complex compound of secondary complexing calcium of the invention, organic trace element amount ratio inorganic ions is few, and absorbs profit
3-4 times is higher by with rate, will not cause to waste, while problem of environmental pollution is improved, and the security of people is improved.
(5) for the complex compound of secondary complexing calcium of the invention compared with inorganic calcium, trap is high, with high content of technology, and effect is high,
Growth promoting gaining effect is good, and use cost is low compared with amino acid calcium, significantly improves the core competitiveness of product.
Embodiment
With reference to specific embodiment, the embodiment of the present invention is described in detail, it is to be understood that this hair
Bright protection domain is not limited by embodiment.
Embodiment 1：
A kind of complex compound of secondary complexing calcium, it is made up of sucrose, calcium salt and amino acid.
The preparation method of the complex compound of described secondary complexing calcium, comprises the following steps：
(1) toward in reactor plus 30 parts by weight sucrose, after the water dissolving saccharose for adding 60 parts by weight, add 8 parts by weight chlorine
Change calcium, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 11, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 1h is carried out, course of reaction is stirred continuously, and is generated sucrose calcium solution, is separated by filtration, obtains filter residue A and filtrate a,
75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, centrifuges and filters after precipitating completely, obtain filter residue B and filter
Liquid b, filter residue B vacuum drying drying, screening, detection, that is, obtain lime saccharate product；Described filtrate can return to as dissolving saccharose
Mother liquor, the reaction of above-mentioned generation lime saccharate is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect calcium ion concentration in mixture, be then 2 by amino acid and calcium ion:1 mol ratio adds
Methionine, it is 6 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 70 DEG C, carries out complex reaction, during reaction
Between control in 60min, after reaction terminates, concentration, dry, then crushed with pulverizer, then sieved, detection obtains
Calcium Amino Acid chelate；
(3) by sucrose calcium product and amino-acid complex calcium product in mass ratio 2:1 mixing, that is, obtain the network of secondary complexing calcium
Compound.
Embodiment 2：
A kind of complex compound of secondary complexing calcium, it is made up of sucrose, calcium salt and amino acid.
The preparation method of the complex compound of described secondary complexing calcium, comprises the following steps：
(1) toward in reactor plus 40 parts by weight sucrose, after the water dissolving saccharose for adding 65 parts by weight, add 11 parts by weight sulphur
Sour calcium, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 12, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 2h is carried out, course of reaction is stirred continuously, and is generated sucrose calcium solution, is separated by filtration, obtains filter residue A and filtrate a,
75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, centrifuges and filters after precipitating completely, obtain filter residue B and filter
Liquid b, filter residue B vacuum drying drying, screening, detection, that is, obtain lime saccharate product；Described filtrate can return to as dissolving saccharose
Mother liquor, the reaction of above-mentioned generation lime saccharate is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect calcium ion concentration in mixture, be then 2 by amino acid and calcium ion:1 mol ratio adds
Glutamic acid, it is 7 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 80 DEG C, carries out complex reaction, reaction
Time control is in 70min, after reaction terminates, concentration, dries, then is crushed with pulverizer, is then sieved, detects and produce
To Calcium Amino Acid chelate；
(3) by sucrose calcium product and amino-acid complex calcium product in mass ratio 1:1 mixing, that is, obtain the network of secondary complexing calcium
Compound.
Embodiment 3：
A kind of complex compound of secondary complexing calcium, it is made up of sucrose, calcium salt and amino acid.
The preparation method of the complex compound of described secondary complexing calcium, comprises the following steps：
(1) toward in reactor plus 35 parts by weight sucrose, after the water dissolving saccharose for adding 63 parts by weight, add 10 parts by weight oxygen
Change calcium, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 11, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 1.5h is carried out, course of reaction is stirred continuously, and is generated sucrose calcium solution, is separated by filtration, obtains filter residue A and filtrate
A, by filtrate a add 2 times of parts by weight 75% ethanol solution precipitated, precipitate completely after centrifugation filter, obtain filter residue B and
Filtrate b, filter residue B vacuum drying drying, screening, detection, that is, obtain lime saccharate product；Described filtrate can return to as dissolving sugarcane
The mother liquor of sugar, the reaction of above-mentioned generation lime saccharate is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect calcium ion concentration in mixture, be then 2 by amino acid and calcium ion:1 mol ratio adds
Glycine, it is 6.5 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 75 DEG C, carries out complex reaction, instead
Time control is answered in 65min, after reaction terminates, concentration, is dried, then is crushed with pulverizer, is then sieved, detection is
Obtain Calcium Amino Acid chelate；
(3) by sucrose calcium product and amino-acid complex calcium product in mass ratio 5:3 mixing, that is, obtain the network of secondary complexing calcium
Compound.
Embodiment 4：The experiment effect checking of the complex compound of the secondary complexing calcium of the present invention
4.1 test material
Commercially available precipitated calcium carbonate；Secondary complexing calcium complex is that method is prepared in 1-3 of the embodiment of the present invention.
4.2 experimental animals and packet
Weanling pig 90 (body weight 7.0kg or so) is selected, wherein 84 are randomly divided into 14 processing, each processing three
Repeat, each to repeat 2, remaining 6 are assigned randomly to calcium level and respectively repeat each one for 2 treatment groups of NRC standards.
4.3 experimental design
The basal diet composition and trophic level of experiment piglet are consistent, and the addition of calcium is 100mg/kg, and experiment is divided into
14 processing, control group provide calcium source for precipitated calcium carbonate, and test group is then the secondary of method preparation in 1-3 of the embodiment of the present invention
The complex compound of complexing calcium provides calcium source.
4.4 feeding management
Nursery house uses slatted floor child care equipment, and at 22-25 DEG C, relative humidity controls in 65-75% house temperature control system.
Experiment the last week to pig house and it is various feeding utensil thoroughly cleaned, washed away and sterilized, with caustic soda sprinkling ground, fence,
The facilities such as trough.Daily hog house disinfection Peracetic acid.Colony house ventilation, cleaning are kept during experiment, is dried.It is pre- to raise 3 days, it is positive to raise
Phase 35d.Try pig day to feed 4 times, feed amount and showed a small surplus with hopper after eating and be limited, free water.
4.5 experimental designs and testing index
4.5.1 the production performance of piglet, the daily gain of piglet is determined, feed intake also has feedstuff-meat ratio.Positive examination phase 28d claims
Weight, feed addition is recorded daily.Calculate average daily gain, average daily gain and calculate feedstuff-meat ratio.
4.5.2 blood sample, off-test, after 8 points of morning weighs on an empty stomach to examination pig, all pigs are taken a blood sample, point
From serum.Determine Determination of Calcium in Serum, phosphorus, alkaline phosphatase activities.
4.6 result of the test
The influence of calcium carbonate and secondary complexing calcium complex to weaned piglets is added in the diet of table 1 respectively
As shown in Table 1, between 0-14d and 15-28d, method is prepared in embodiments of the invention 1-3 secondary complexing calcium
The average daily gain of piglet of complex compound (test group), feed intake will be higher than calcium carbonate (control group), and be calculated with this
The feedstuff-meat ratio come, the feedstuff-meat ratio of secondary complexing calcium complex test group are significantly lower than calcium carbonate group, it follows that the present invention
Secondary complexing calcium complex calcium source as piglet more preferably than calcium carbonate, secondary complexing calcium complex can improve the growth of piglet
Performance.
The influence of calcium carbonate and secondary complexing calcium complex to piglet blood biochemical indicator is added in the diet of table 2 respectively
As shown in Table 1, by blood parameters it can be found that method is prepared in embodiments of the invention 1-3 two
The utilization rate group of the complex compound calcium phosphorus of secondary complexing calcium is significantly higher than control group, the complex compound of secondary complexing calcium in embodiment 1-3
Serum alkaline phosphatase activity is also significantly greater than control group, and secondary complexing calcium complex can improve the productivity of piglet
Energy.
In summary, the complex compound of secondary complexing calcium of the invention had both possessed sucrose complexing calcium low cost, growth promoting function
Clear advantage, but also with the advantages of amino-acid complex inorganic calcium biological value is high, chemical property is stable, palatability is good, with list
The pure cost used in amino-acid complex (chelating) trace element is compared, present invention reduces 30-40% use cost, two
The complex compound of secondary complexing calcium is the calcium source more high-quality than calcium carbonate in piglet produces.
The description of the foregoing specific illustrative embodiment to the present invention is to illustrate and the purpose of illustration.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explain that the certain principles of the present invention and its reality should
With so that those skilled in the art can realize and utilize the present invention a variety of exemplaries and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (10)
1. a kind of complex compound of secondary complexing calcium, it is characterised in that including lime saccharate and amino acid calcium；
The lime saccharate is made up of sucrose and calcium salt of complex reaction；
The amino acid calcium is made up of amino acid and calcium salt of complex reaction.
2. the complex compound of secondary calcium according to claim 1, it is characterised in that the calcium salt be calcium chloride, calcium sulfate and
Any of calcium oxide.
3. the complex compound of secondary calcium according to claim 1, it is characterised in that the amino acid be methionine, glutamic acid,
Any of glycine.
4. the preparation method of the complex compound of secondary complexing calcium according to claim 1, it is characterised in that take following parts by weight
Raw material：Sucrose 30-40 parts, water 60-65 parts, calcium salt 8-11 parts, amino acid 4-15 parts, it is prepared according to the following steps：
(1) after the sucrose in reactor is dissolved with water, calcium salt is added, adjusts pH value to 11-12；
(2) heating response device is to after 80 DEG C of device Nei Wenduda, keeping reactor temperature to continue stirring reaction 1- at 70-80 DEG C
2h, sucrose calcium solution is made；
(3) sucrose calcium solution is cooled down to normal temperature, is separated by filtration, is obtained the first separating liquid and the first sediment, the first separating liquid adds
Enter the sedimentation of 75% ethanol solution, obtain the second separating liquid and the second sediment, the centrifugation of the second sediment filters, and dries, sieves, inspection
Survey, lime saccharate is made；
(4) the second separating liquid is evaporated, ethanol is reclaimed, while obtains the 3rd separating liquid, by obtained by the 3rd separating liquid and step (3) the
After the mixing of one sediment, the calcium ion concentration in mixture is detected, adds amino acid, tune pH value is 6-7；
(5) continue stirring reaction 60-70min, concentration, dry, crush, screening, Calcium Amino Acid chelate is made；
(6) gained lime saccharate is mixed with Calcium Amino Acid chelate, that is, the complex compound of secondary complexing calcium is made.
5. the preparation method of the complex compound of secondary complexing calcium according to claim 4, it is characterised in that first separation
The mass ratio of liquid and 75% ethanol solution is 1: 2.
6. the preparation method of the complex compound of secondary complexing calcium according to claim 4, it is characterised in that first separation
Liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
7. the preparation method of the complex compound of secondary complexing calcium according to claim 4, it is characterised in that the step (4)
In, the mol ratio of amino acid and calcium ion is 2:1.
8. the preparation method of the complex compound of secondary complexing calcium according to claim 4, it is characterised in that the step (6)
In, lime saccharate and Calcium Amino Acid chelate are 2-5 in mass ratio:1-3 is mixed.
9. the purposes of secondary complexing calcium according to claim 1, it is characterised in that as animal feed additive, with feeding
Feeding animals after material mixing.
10. the purposes of secondary complexing calcium according to claim 9, it is characterised in that animal feed additive and feed
Accounting is 0.3-0.5%.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626180A (en) * | 2012-04-10 | 2012-08-08 | 南宁市泽威尔饲料有限责任公司 | Amino acid chelating compound organic feed additive and production method thereof |
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