CN107501371A - A kind of complex compound of secondary complexing manganese and its production and use - Google Patents
A kind of complex compound of secondary complexing manganese and its production and use Download PDFInfo
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- CN107501371A CN107501371A CN201710723279.XA CN201710723279A CN107501371A CN 107501371 A CN107501371 A CN 107501371A CN 201710723279 A CN201710723279 A CN 201710723279A CN 107501371 A CN107501371 A CN 107501371A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Abstract
The present invention relates to a kind of complex compound, particularly a kind of complex compound, preparation method and its purposes in animal feed additive of secondary complexing manganese.A kind of complex compound of secondary complexing manganese, is complexed manganese by sucrose first, is then ensured that manganese ion reaction is complete with the manganese ion in amino-acid complex waste liquid and filter residue again, is finally again mixed sucrose manganese product with amino-acid complex manganese product.The complex compound of the secondary complexing manganese of the present invention had both possessed sucrose complexing manganese low cost, growth promoting function clear advantage, but also with the advantages of amino-acid complex manganese biological value is high, chemical property is stable, palatability is good, compared with the cost used in amino-acid complex (chelating) trace element merely, present invention reduces 30 40% use cost.
Description
Technical field
The present invention relates to a kind of complex compound, particularly a kind of complex compound of secondary complexing manganese, preparation method and its in animal
Purposes in feed addictive.
Background technology
Manganese is arginase in body, prolinase, RNA polymerase, superoxide dismutase, pyruvate carboxylase
Constituent.Manganese ion has the function of activating a variety of enzymes, such as to aldolase, phosphorylase, phosphoglucomutase, different lemon
Lemon acidohydrogenase and CHE have activation.Manganese is to participate in carbohydrate, fat by the effect of enzyme in animal body
The important substances such as fat, protein it is metabolic, and vitamin B, C, E synthesis can be strengthened, manganese is in choline metabolism mistake
There is lipotropic effect in journey.Glutamic-oxalacetic transaminease, glutamic-pyruvic transaminase, lactic dehydrogenase, cretinephosphokinase activity and diet
In manganese it is relevant.
Manganese is one of trace element closely related with livestock and poultry bone growth, and manganese element grows with weight to bone
Act on.Wilgus just studies confirmation before more than 60 years, and manganese deficiency can cause the generation of chick " sliding tendon disease ".Manganese element influences bone
Grow, participate in forming the formation of bone matrix chondroitin sulfate mainly due to manganese.Chondroitin sulfate is that organic matter is viscous more
The constituent of sugar.Manganese is the special activity factor of polysaccharide polymerase and galactosyl transferase.So in the synthesis of mucopolysaccharide,
Necessary to manganese is polysaccharide polymerase and galactosyl transferase.Galactolipin-galactolipin-wood is formed by UDP- galactolipins and xylose
Sugar.This trisaccharide connects with serine, then polymerize to form mucopolysaccharide with aminohexose.Manganese deficiency can cause polysaccharide polymerase and,
Both enzymatic activitys of benevolence galactosyltransferase reduce, and the synthesis of chondroitin sulfate substantially reduces, so as to influence normally forming for bone.
It is morphologic from ill domestic animal it has been observed that manganese deficiency influence bone development essentially consist in bone sacrum lesion, this is also manganese deficiency and other things
Matter (choline, biotin) lacks the difference for influenceing bone growth and development." sliding tendon disease " during chick manganese deficiency, occurs or " bone is short
Thick disease ".Typical symptom is in " 0 " shape or " x " shape when being and standing, and is shortened thicker.Chicken manganese deficiency also specifically influences chest muscle growth hair
Educate, it is smaller to show as chest muscle fibre diameter.Cardinal symptom during domestic animal manganese deficiency shows as forelimb arch, leg tubbiness and bend, it is attached
Arthrocele, walk lamely.
One of an important factor for manganese element and reproduction manganese are promotion animal gonad development and endocrine function.Manganese is dicarboxylic acids
The indispensable factor of enzymatic cholesterol biosynthesis, so Biosynthesis of cholesterol is reduced during manganese deficiency, cholesterol is before sex hormone
Body, therefore manganese deficiency can cause anhormonia.Degeneration change occurs for the convoluted seminiferous tubule of buck testis during manganese deficiency, and testis withers
Contracting, semen quality is bad or quantity is reduced, sexual hypoesthesia or loses breeding capacity；The sexual cycle of jenny is disorderly, out of heat
Or weak heat, ovarian atrophy, ovulation stagnate, conception rate reduce or be acyesis, fetus absorb, stillborn foetus.
Growth maintenance and production activity of the trace element to animal play an important roll.Under the conditions of modern production, with
The horizontal continuous improvement of animal productiong, animal are also continuously increased to the requirement of trace element, at present the main compensation process of manganese
It is the content for ignoring manganese in feed, is added by animal requirement, and wherein with the bioavailability highest of Chelated Manganese, trace element
The bioavailability of the chelate of manganese is higher than the utilization rate of inorganic ions, using microelement chelate and solves to be excessively added
Inorganic salts cause the effective ways of this problem of environmental pollution, while also prevent harmful effect caused by inorganic salts and dimension is given birth to
The antagonism of element.It is reported that metal ion in chelate with amino acid or small peptide so that torpescence is presented after Covalent bonding together
Property, it intactly can enter blood plasma, and fully inhaled effectively using amino acid and the absorbing path of small peptide by small intestinal mucosa
Target organ is transported to after receipts.
However, amino-acid complex (chelating) trace element with synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also of a relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost increasingly highlights.
Therefore, inventor is complexed manganese with sucrose, the manganese then not reacted completely with amino-acid complex again, both reduces into
This, moreover it is possible to keep certain biological value.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
It has been the prior art well known to persons skilled in the art when being considered as recognizing or implying the information structure in any form.
The content of the invention
For deficiencies of the prior art, the present invention provides one kind and had both possessed sucrose complexing manganese low cost, growth-promoting
Long effect clear advantage, but also with the two of the advantages of amino-acid complex manganese biological value is high, chemical property is stable, palatability is good
Complex compound of secondary complexing manganese and preparation method thereof.
To achieve the above object, technical scheme provided by the invention is as follows：
A kind of complex compound of secondary complexing manganese, it includes sucrose manganese and manganese amino acid；
The sucrose manganese is made up of sucrose and manganese salt of complex reaction；
The manganese amino acid is made up of amino acid and manganese salt of complex reaction.
Preferably, the manganese salt is manganese sulfate.
Preferably, the amino acid is any of methionine, glutamic acid, glycine.
Present invention also offers the preparation method of the complex compound of described secondary complexing manganese, comprise the following steps：
Take the raw material of following parts by weight：Sucrose 30-35 parts, water 60-65 parts, manganese salt 20-25 parts, amino acid 5-10 parts, press
Following steps are prepared：
(1) after the sucrose in reactor is dissolved with water, manganese salt is added, adjusts pH value to 11-12；
(2) for heating response device to reactor temperature after 80 DEG C of device Nei Wenduda, is kept at 70-80 DEG C, lasting stirring is anti-
1-2h is answered, sucrose manganese solution is made；
(3) sucrose manganese solution is cooled down to normal temperature, is separated by filtration, is obtained the first separating liquid and the first sediment, the first separation
Liquid adds the sedimentation of 75% ethanol solution, obtains the second separating liquid and the second sediment, and the centrifugation of the second sediment filters, and dries, sieve
Divide, detection, sucrose manganese is made；
(4) the second separating liquid is evaporated, reclaims ethanol, while obtains the 3rd separating liquid, by the 3rd separating liquid and step (3) institute
After obtaining the mixing of the first sediment, the manganese ion concentration in mixture is detected, adds amino acid, tune pH value is 6-7；
(5) continue stirring reaction 60-70min, concentration, dry, crush, screening, amino-acid complex manganese is made；
(6) gained sucrose manganese is mixed with amino-acid complex manganese, that is, the complex compound of secondary complexing manganese is made.
Preferably, the mass ratio of first separating liquid and 75% ethanol solution is 1: 2.
Preferably, first separating liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
Preferably, in the step (3), dry as vacuum drying.
Preferably, in the step (4), the mol ratio of amino acid and manganese ion is 2:1.
Preferably, gained sucrose manganese and amino-acid complex manganese 2-5 in mass ratio:1-3 is mixed.
Present invention also offers purposes of the complex compound of described secondary complexing manganese as animal feed additive, itself and feeding
Feeding animals after material mixing.
Further, the addition of animal feed additive is 200g/ ton feeds.
There are a pair of lone pair electrons, while transition metal ions (M=Cu on the glycosidic bond of sucrose (few disaccharides)2+、Zn2+、Mn2 +、Fe2+、Ca2+) there is suitable unoccupied orbital, " coordination effect " can be formed with sucrose under suitable temperature environment, after chemical reaction
Complexing forms complex state metal, is absorbed beneficial to animal body.It is as follows that it forms molecular structural formula：
Above-mentioned formula is sucrose trace element molecular structural formula, wherein M=Cu2+、Zn2+、Mn2+、Fe2+、Ca2+。
Because the reaction of sucrose trace-element complex is complicated, product is different from general amino-acid chelate, more category
In macromolecular structure, the molecular weight not determined.
Inventor remaining waste liquid and is separated by filtration the obtained mixing of filter residue after making full use of waste water evaporation recovery ethanol
Thing, the manganese ion in the mixture is subjected to secondary complex reaction, the moderate complex compound of generation stability constant, complexing with amino acid
Metal ion in thing with amino acid or small peptide so that inertness is presented after Covalent bonding together, it can effectively using amino acid and
The absorbing path of small peptide, blood plasma is intactly entered by small intestinal mucosa, and target organ is transported to after being fully absorbed, avoid with
The competition of other mineral elements operated by mineral element Ions Absorption passage and antagonism.The biochemical property of other complex compound is more
Add stabilization, effectively resist other nutrients in daily ration and adverse effect occurs therewith.Complex compound solubility property in body is good, easy suction
Receive, utilization rate height.
At present, the complex products of most of amino acid and trace element are all by 1 with amino acid with trace element both at home and abroad:
For 1 mol ratio come the product that is complexed, what is obtained is the not neutral complex compound of electricity.The not neutral complex ion of electricity is absorbed into by animal
, can be by other anion, such as PO in substrate in animal body before entering cell4 3-、SO4 2-、CO3 2-Etc. the suction of many negatively charged ions
Draw, interception is combined into ionic bond, so as to stop that complex ion smoothly absorbs and utilized.Because 1:The complex compound of 1 mol ratio only has
One complexing ring, so bioactivity is also than 2:1 mol ratio it is low, the amount that causes complex compound to be absorbed by animal is not uncertain, not yet
It is stable.And the amino-acid complex manganese described in step 2) of the present invention, amino acid and the manganese ion mol ratio of complex reaction are 2：1,
The product that step 2) obtains is organic complex, complete electroneutral.
The application method of complex compound of the secondary complexing manganese of the present invention is：After being well mixed with feed, for pig, chicken, duck,
Ox and the feeding of sheep, addition are 200g/ ton feeds.
Compared with prior art, the present invention has the advantages that：
(1) complex compound of secondary complexing manganese of the invention, manganese is complexed by sucrose first, then given up again with amino-acid complex
Manganese ion in liquid and filter residue, ensure that manganese reaction is complete, finally again mix sucrose manganese product with amino-acid complex manganese product.Should
Mixture had both possessed sucrose complexing manganese low cost, growth promoting function clear advantage, but also with amino-acid complex manganese biological value
The advantages of height, chemical property are stable, palatability is good, with the cost phase used in amino-acid complex (chelating) trace element merely
Than present invention reduces 30-40% use cost.
(2) complex compound of secondary complexing manganese of the invention, sucrose manganese dissolubility therein is good, it is easy absorb, stability it is good, make
For feed addictive, the excrement excretion of feed source trace element can be substantially reduced, reduces pollution of the aquaculture to environment, moreover it is possible to
Improve meat yellowish pink, strengthen the anti-oxidation function of body, significantly improve the vigor of the GSH-Px in liver, muscle, improve serum
T-AOC and T-SOD, UN is reduced, the Nutrient Apparent Digestibilities such as feed CP, EE, manganese, phosphorus is significantly improved, increases the deposition of nitrogen, moreover it is possible to
Significantly improve serum levels of iron and liver iron content.After sucrose manganese enters in animal stomach, it is readily absorbed by with the generation of hydrochloric acid in gastric juice slow reaction
Organic Manganese.
(3) complex compound of secondary complexing manganese of the invention, amino-acid complex manganese therein can effectively be alleviated between mineral element
Antagonism, only body does not provide trace element manganese, and also provides essential amino acid, and palatability is good, and it is unnecessary to avoid
Waste.Amino-acid complex manganese utilizes Amino Acid Absorption passage in small intestine, avoids with being led to by mineral element Ions Absorption
The competition of other mineral elements of road operating and antagonism.The biochemical property of the other complex compound is more stable, effectively resists daily ration
In other nutrients adverse effect occurs therewith.Complex compound solubility property in body is good, it is easy absorb, utilization rate it is high.Manganese amino acid
Ewe heat unobvious, miscarriage, ram sperm generation exception etc. can be prevented and treated.
(4) complex compound of secondary complexing manganese of the invention, organic trace element amount ratio inorganic ions is few, and absorbs profit
3-4 times is higher by with rate, will not cause to waste, while problem of environmental pollution is improved, and the security of people is improved.
(5) for the complex compound of secondary complexing manganese of the invention compared with inorganic manganese, trap is high, with high content of technology, and effect is high,
Growth promoting gaining effect is good, and use cost is low compared with manganese amino acid, significantly improves the core competitiveness of product.
Embodiment
With reference to specific embodiment, the embodiment of the present invention is described in detail, it is to be understood that this hair
Bright protection domain is not limited by embodiment.
Embodiment 1：
A kind of complex compound of secondary complexing manganese, it is made up of sucrose, manganese salt and amino acid.
The preparation method of the complex compound of described secondary complexing manganese, comprises the following steps：
(1) toward in reactor plus 30 parts by weight sucrose, after the water dissolving saccharose for adding 60 parts by weight, add 20 parts by weight sulphur
Sour manganese, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 11, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 1h is carried out, course of reaction is stirred continuously, and is generated sucrose manganese solution, is separated by filtration, obtains filter residue A and filtrate a,
75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, centrifuges and filters after precipitating completely, obtain filter residue B and filter
Liquid b, filter residue B vacuum drying drying, screening, detection, that is, obtain sucrose manganese product；Described filtrate can return to as dissolving saccharose
Mother liquor, the reaction of above-mentioned generation sucrose manganese is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect manganese ion concentration in mixture, be then 2 by amino acid and manganese ion:1 mol ratio adds
Methionine, it is 6 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 70 DEG C, carries out complex reaction, during reaction
Between control in 60min, after reaction terminates, concentration, dry, then crushed with pulverizer, then sieved, detection obtains
Amino-acid complex manganese；
(3) by sucrose manganese product and amino-acid complex manganese product in mass ratio 1:1 mixing, that is, obtain the network of secondary complexing manganese
Compound.
Embodiment 2：
A kind of complex compound of secondary complexing manganese, it is made up of sucrose, manganese salt and amino acid.
The preparation method of the complex compound of described secondary complexing manganese, comprises the following steps：
(1) toward in reactor plus 35 parts by weight sucrose, after the water dissolving saccharose for adding 65 parts by weight, add 25 parts by weight sulphur
Sour manganese, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 12, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 2h is carried out, course of reaction is stirred continuously, and is generated sucrose manganese solution, is separated by filtration, obtains filter residue A and filtrate a,
75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, centrifuges and filters after precipitating completely, obtain filter residue B and filter
Liquid b, filter residue B vacuum drying drying, screening, detection, that is, obtain sucrose manganese product；Described filtrate can return to as dissolving saccharose
Mother liquor, the reaction of above-mentioned generation sucrose manganese is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect manganese ion concentration in mixture, be then 2 by amino acid and manganese ion:1 mol ratio adds
Glutamic acid, it is 7 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 80 DEG C, carries out complex reaction, during reaction
Between control in 70min, after reaction terminates, concentration, dry, then crushed with pulverizer, then sieved, detection obtains
Amino-acid complex manganese；
(3) by sucrose manganese product and amino-acid complex manganese product in mass ratio 2:1 mixing, that is, obtain the network of secondary complexing manganese
Compound.
Embodiment 3：
A kind of complex compound of secondary complexing manganese, it is made up of sucrose, manganese salt and amino acid.
The preparation method of the complex compound of described secondary complexing manganese, comprises the following steps：
(1) toward in reactor plus 32 parts by weight sucrose, after the water dissolving saccharose for adding 60 parts by weight, add 23 parts by weight sulphur
Sour manganese, hydrogenation aqueous solution of sodium oxide alkalization, adjust solution pH be 12, heating response kettle, keep temperature in the kettle 70-80 DEG C it
Between, complex reaction 1.5h is carried out, course of reaction is stirred continuously, and is generated sucrose manganese solution, is separated by filtration, obtains filter residue A and filtrate
A, by filtrate a add 2 times of parts by weight 75% ethanol solution precipitated, precipitate completely after centrifugation filter, obtain filter residue B and
Filtrate b, filter residue B vacuum drying drying, screening, detection, that is, obtain sucrose manganese product；Described filtrate can return to as dissolving sugarcane
The mother liquor of sugar, the reaction of above-mentioned generation sucrose manganese is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations recovery ethanol, and obtains extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, mixture is obtained, detect manganese ion concentration in mixture, be then 2 by amino acid and manganese ion:1 mol ratio adds
Glycine, it is 6.5 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 75 DEG C, carries out complex reaction, reaction
Time control is in 65min, after reaction terminates, concentration, dries, then is crushed with pulverizer, is then sieved, detects and produce
To amino-acid complex manganese；
(3) by sucrose manganese product and amino-acid complex manganese product in mass ratio 5:3 mixing, that is, obtain the network of secondary complexing manganese
Compound.
Embodiment 4：The application effect of the complex compound of the secondary complexing manganese of the present invention
4.1 experimental animals and experimental design
The average weight of 108 ages in days is randomly assigned into 2 processing in 49.21g male Broiler chicks, each handles 9
Individual repetition, each repeat 6 chickens.Control group is the nothing of addition manganese 60mg/kg on the basis of feeding corn-soybean meal basal diet
Machine manganese sulfate, test group add the manganese 60mg/ that method is prepared in 1-3 of the embodiment of the present invention respectively on same basal diet
The complex compound of kg secondary complexing manganese；Test as early stage (0-21 ages in days) and (22-42 ages in days).
The source of 4.2 test materials
Inorganic manganese sulfate is commercial diet level manganese sulfate；The complex compound of secondary complexing manganese is in 1-3 of the embodiment of the present invention
What method was prepared.
4.3 feeding management
Broiler chicks feed in 69cm*65cm*38cm 3 layers of chicken coop, each stage illumination all referring to《AA Broiler chicks raising pipe
Manage handbook》, temperature is temperature automatically controlled, and at 35 DEG C, second week control was controlled at 29 DEG C in 32 DEG C, the 3rd week for control in first week, after
Temperature control is at 24 DEG C；Free water；Indoor humidity is maintained at 60%-65%, records temperature, humidity daily in the process.
4.4 method of testings and index
Production performance：Test the 21st, 42d 8 hours on an empty stomach in units of repetition respectively, claim weight and residual mass,
And the quality that increases day by day, daily ingestion amount and the feed conversion rate of Broiler chicks are calculated accordingly.
4.5 test results and analysis
Influence of the complex compound of manganese sulfate and secondary complexing manganese to Broiler chicks production performance is added in the diet of table 1 respectively
As can be seen from Table 1, on the basis of the identical of daily ration basis, method is prepared in 1-3 of the embodiment of the present invention two
The adding weight (0-6 weeks) of the complex compound of secondary complexing manganese is substantially higher than control group, and feed intake (0-6 weeks) is basically identical, material
Then test group is then significantly lower than control group to meat ratio (0-6 weeks).It can be seen that the complex compound that secondary complexing manganese is added in broiler diet can
To improve efficiency of feed utilization, the adding weight of Broiler chicks is improved.
In summary, the complex compound of secondary complexing manganese of the invention had both possessed sucrose complexing manganese low cost, growth promoting function
Clear advantage, but also with the advantages of amino-acid complex manganese biological value is high, chemical property is stable, palatability is good, used with simple
Cost used in amino-acid complex (chelating) trace element is compared, and present invention reduces 30-40% use cost.
The description of the foregoing specific illustrative embodiment to the present invention is to illustrate and the purpose of illustration.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explain that the certain principles of the present invention and its reality should
With so that those skilled in the art can realize and utilize the present invention a variety of exemplaries and
Various chooses and changes.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (10)
1. a kind of complex compound of secondary complexing manganese, it is characterised in that including sucrose manganese and manganese amino acid；
The sucrose manganese is made up of sucrose and manganese salt of complex reaction；
The manganese amino acid is made up of amino acid and manganese salt of complex reaction.
2. the complex compound of secondary manganese according to claim 1, it is characterised in that the manganese salt is manganese sulfate.
3. the complex compound of secondary manganese according to claim 1, it is characterised in that the amino acid be methionine, glutamic acid,
Any of glycine.
4. the preparation method of the complex compound of secondary complexing manganese according to claim 1, it is characterised in that take following parts by weight
Raw material：Sucrose 30-35 parts, water 60-65 parts, manganese salt 20-25 parts, amino acid 5-10 parts, it is prepared according to the following steps：
(1) after the sucrose in reactor is dissolved with water, manganese salt is added, adjusts pH value to 11-12；
(2) heating response device is to after 80 DEG C of device Nei Wenduda, keeping reactor temperature to continue stirring reaction 1- at 70-80 DEG C
2h, sucrose manganese solution is made；
(3) sucrose manganese solution is cooled down to normal temperature, is separated by filtration, is obtained the first separating liquid and the first sediment, the first separating liquid adds
Enter the sedimentation of 75% ethanol solution, obtain the second separating liquid and the second sediment, the centrifugation of the second sediment filters, and dries, sieves, inspection
Survey, sucrose manganese is made；
(4) the second separating liquid is evaporated, ethanol is reclaimed, while obtains the 3rd separating liquid, by obtained by the 3rd separating liquid and step (3) the
After the mixing of one sediment, the manganese ion concentration in mixture is detected, adds amino acid, tune pH value is 6-7；
(5) continue stirring reaction 60-70min, concentration, dry, crush, screening, amino-acid complex manganese is made；
(6) gained sucrose manganese is mixed with amino-acid complex manganese, that is, the complex compound of secondary complexing manganese is made.
5. the preparation method of the complex compound of secondary complexing manganese according to claim 4, it is characterised in that first separation
The mass ratio of liquid and 75% ethanol solution is 1: 2.
6. the preparation method of the complex compound of secondary complexing manganese according to claim 4, it is characterised in that first separation
Liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
7. the preparation method of the complex compound of secondary complexing manganese according to claim 4, it is characterised in that the step (4)
In, the mol ratio of amino acid and manganese ion is 2:1.
8. it is according to claim 4 it is secondary complexing manganese complex compound preparation method, it is characterised in that gained sucrose manganese with
Amino-acid complex manganese 2-5 in mass ratio:1-3 is mixed.
9. the complex compound purposes of secondary complexing manganese according to claim 1, it is characterised in that added as animal feed
Agent, feeding animals after being mixed with feed.
10. the complex compound purposes of secondary complexing manganese according to claim 9, it is characterised in that animal feed additive
Addition is 200g/ ton feeds.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113845435A (en) * | 2021-10-14 | 2021-12-28 | 四川吉隆达生物科技集团有限公司 | Production process of feed-grade manganese glutamate |
| CN114163342A (en) * | 2021-12-28 | 2022-03-11 | 山东亚太海华生物科技有限公司 | Preparation method of manganese glycinate for feed with high manganese content |
| CN116003650A (en) * | 2023-01-18 | 2023-04-25 | 中鲨动物保健品（厦门）有限公司 | Dry process for preparing amino acid polysaccharide complex (chelate) compound |
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| CN106220691A (en) * | 2016-08-01 | 2016-12-14 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose manganese complex |
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| CN102626180A (en) * | 2012-04-10 | 2012-08-08 | 南宁市泽威尔饲料有限责任公司 | Amino acid chelating compound organic feed additive and production method thereof |
| CN106220691A (en) * | 2016-08-01 | 2016-12-14 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose manganese complex |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113845435A (en) * | 2021-10-14 | 2021-12-28 | 四川吉隆达生物科技集团有限公司 | Production process of feed-grade manganese glutamate |
| CN114163342A (en) * | 2021-12-28 | 2022-03-11 | 山东亚太海华生物科技有限公司 | Preparation method of manganese glycinate for feed with high manganese content |
| CN114163342B (en) * | 2021-12-28 | 2023-11-24 | 山东亚太海华生物科技有限公司 | Preparation method of manganese glycinate for feed with high manganese content |
| CN116003650A (en) * | 2023-01-18 | 2023-04-25 | 中鲨动物保健品（厦门）有限公司 | Dry process for preparing amino acid polysaccharide complex (chelate) compound |
| CN116003650B (en) * | 2023-01-18 | 2024-03-22 | 中鲨动物保健品（厦门）有限公司 | Dry process for preparing amino acid polysaccharide complex (chelate) compound |
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