CN107441017B - A kind of anti-apolexis composition and its preparation and use - Google Patents
A kind of anti-apolexis composition and its preparation and use Download PDFInfo
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- CN107441017B CN107441017B CN201710657130.6A CN201710657130A CN107441017B CN 107441017 B CN107441017 B CN 107441017B CN 201710657130 A CN201710657130 A CN 201710657130A CN 107441017 B CN107441017 B CN 107441017B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention belongs to cosmetic field, and in particular to a kind of anti-apolexis composition and its preparation and use, it is made of the component of following parts by weight：1 0.5~2 parts of 1~3 part of hydrolyzed pearl powder, long 1~3 part of pubescence Chinese yam root extract, 8 0.5~2 parts of acetyl group hexapeptide, 3 0.5~2 parts of acetyl group octapeptide and nonapeptide.Tests prove that, anti-apolexis composition of the present invention is respectively provided with to nature static wrinkle, dynamic wrinkle and posture Squeezing ground wrinkle and extremely significantly dispels effect, the propagation of human skin fibroblasts can be remarkably promoted at the same time, pole remarkably promotes the synthesis of I, III collagen type, and pole significantly inhibits the expression of MMP1 and MMP3.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of anti-apolexis composition and its preparation and use.
Background technology
Victory peptide is polymer that more than two amino acid are combined into mutually with carboxyl and amino, first amino acid
The amino of carboxyl and second amino acid sloughs a hydrone, forms covalent victory peptide bond；The carboxyl of second amino acid is again
Combined with the amino of the 3rd amino acid.And so on, two amino acid aggregate into dipeptides, and three amino acid aggregate into tripeptides,
Four amino acid aggregate into tetrapeptide, and five amino acid aggregates into pentapeptide etc..The biological action for winning peptide depends on amino acid
Composition and sequence.
Skin senescence is a part for body aging, shows as cutis laxa, and thinning, wrinkle is formed, and gradually increase and
Deepen, be body aging most intuitively one of external manifestation.Research shows, skin senescence and skin fibroblasts multiplication capacity
It is related with the decline of dermal collagen content.After skin fibroblasts aging in addition to stopping breeding, its corresponding function is also shown
The change of work.Fibroblast both synthesizes and secretes collagen, elastin laminin, generation collagenous fibres, reticular fibre and elasticity
Fiber, also synthesizes and secretes the matrix components such as glycosaminoglycan and glycoprotein；The wherein glue of human skin fibroblasts synthesis secretion
Former albumen is extremely important to the function and characteristic for maintaining skin, and research shows I, III Collagen Type VI of human skin fibroblasts secretion
Not only play a supportive role, but also play a significant role in terms of the propagation, migration and the expression of specific gene that adjust cell.In people
In skin dermis, the content of Type I collagen albumen accounts for 80%, and III collagen type accounts for 10%.
MMP is a zinc dependent enzyme family by MMP gene codes, the egg in the connective tissue that can specifically degrade
White matter, wherein MMP1, also known as clostridiopetidase A, degradable I, III type, VII, Ⅹ Collagen Type VI；MMP3, also known as stromlysin -1 or poly- egg
White polysaccharase, can degrade III, IV, V, Ⅹ Collagen Type VI, proteoglycan, fibronectin and denatured collagen etc..
Wrinkle is divided into three kinds of common types, nature static wrinkle, dynamic wrinkle and posture Squeezing ground wrinkle.Nature static wrinkle
Just visible wrinkle when referring to face's calmness without doing any expression, it is divided into hyperkeratosis wrinkle and gravity traction wrinkle again
Line；Dynamic wrinkle refers to the contraction traction because of expression muscle, can just cause the wrinkle of surface skin；Posture Squeezing ground wrinkle is
It is to repeat a certain posture for a long time, the fine wrinkle for extruding skin and being formed.
A kind of composition that can dispel above-mentioned three kinds of wrinkles at the same time is not yet found at present, therefore, it is necessary to provide one kind
The composition of comprehensive effectively anti-aging can be provided.
The content of the invention
The present invention is intended to provide a kind of anti-apolexis composition and its preparation and application, which can at the same time effectively
Dispel nature static wrinkle, dynamic wrinkle and posture Squeezing ground wrinkle, and can remarkably promote I, III collagen type synthesis and
Suppress the expression of MMP1, MMP3, there is comprehensively effectively anti-aging.
In order to achieve the above object, the present invention uses following technical scheme：A kind of anti-apolexis composition, by following parts by weight
Several component compositions：1~3 part of hydrolyzed pearl powder, long 1~3 part of pubescence Chinese yam root extract, 0.5~2 part of Argireline,
Acetyl group octapeptide -30.5~2 part and nonapeptide -10.5~2 part.
Further, the anti-apolexis composition is made of the component of following parts by weight：2 parts of hydrolyzed pearl powder, length are soft
- 11 parts of 2 parts of hair Chinese yam root extract, 1 part of Argireline, -31 parts of acetyl group octapeptide and nonapeptide.
Further, the anti-apolexis composition is made of the component of following parts by weight：1 part of hydrolyzed pearl powder, length are soft
- 10.5 parts of 1 part of hair Chinese yam root extract, 0.5 part of Argireline, -30.5 parts of acetyl group octapeptide and nonapeptide.
Further, the anti-apolexis composition is made of the component of following parts by weight：3 parts of hydrolyzed pearl powder, length are soft
- 12 parts of 3 parts of hair Chinese yam root extract, 2 parts of Argireline, -32 parts of acetyl group octapeptide and nonapeptide.
Another object of the present invention is in the purposes in the above-mentioned anti-apolexis composition of offer in cosmetics, skin care item are prepared.
Further, the anti-apolexis composition promotes the secretion of I type and III collagen type.
Further, the anti-apolexis composition suppresses the expression of MMP1 and MMP3.
Another object of the present invention is to provide a kind of anti-aging creme, includes the component of following parts by weight：It is above-mentioned anti-ageing
Old 5~20 parts of composition, 3~6 parts of moisturizer, 1~3 part of emulsifying agent, 3~6 parts of emollient, 1~2 part of sea salt, thickener 0.1~
0.3 part, 0.1~0.2 part of preservative, 0.1~0.3 part of composite essential oil, 0.1~0.3 part of neutralizer, EDETATE SODIUM 0.1~0.2
Part, 0.1~0.3 part of allantoin, 0.05~0.2 part of tocopherol acetate and 40~60 parts of water.
Further, the composite essential oil includes 0.05~0.15 part of rosewood oil, 0.01~0.1 part of frankincense oil and jasmine
0.01~0.03 part of flower essential oil.
Further, the moisturizer is selected from 1,3-PD, glycerine, ethoxy urea, pungent glycol, glucan and ethyl hexyl
One or more in base glycerol.
Further, the emulsifying agent be selected from cetanol, stearine, PEG-75 stearates, ceteth-
20th, stereth -20, stearic acid, stearine, PEG-100 stearates, the smooth stearate of sorb and sucrose cocounut oil
One or more in acid esters.
Further, the emollient is selected from octyl dodecanol myristinate, cetanol ethylhexoate, Queensland nut
One kind in seed oil, ethylhexyl palmitate, dimethyl silicone polymer, Cholesteryl hydroxystearate and dimethyl silicone polymer
It is or a variety of.
Further, the thickener is acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers.
Further, the preservative is selected from the one or two of Phenoxyethanol and peach girder phenol.
Correspondingly, present invention also offers a kind of method for preparing above-mentioned creme, it comprises the following steps：
D emulsifying agent, emollient mixing) are taken, is heated to 70~90 DEG C, dissolving is complete, obtains oil phase；
E) toward purified water is added in main bucket, allantoin and EDETATE SODIUM are put into, 2~4min is stirred, thickener is sprayed on
Surface, after wet-laid to be absorbed, stirring to no transparent grain, adds moisturizer, 1~3min of stirring, obtains water phase；
F) water phase and oil phase are moved in emulsifying tank, homogeneous stirs 3~10min, is cooled to 40 DEG C；Anti-aging is put into successively
Composition, composite essential oil, preservative, sea salt and tocopherol acetate, homogeneous stir 1~3min；Add neutralizer, homogeneous stirring
1~3min, vacuumizes 5~15min of stirring, discharging, to obtain the final product.
Argireline and acetyl group octapeptide -3 nature static that can releive caused by hyperkeratosis, gravity traction are wrinkled
Line, as nodded wrinkle under decree line, corners of the mouth line and bilateral, but through experiment, both are to dynamic wrinkle and because of extruding generation
Wrinkle is without obvious effect of releiving.By a series of investigation and experiment, inventor obtains a kind of active ingredient combinations finally, its
It is made of 6 kinds of functional components, tests prove that, it is respectively provided with nature static wrinkle, dynamic wrinkle and posture Squeezing ground wrinkle
Effect is extremely significantly dispelled, and it can remarkably promote the propagation of human skin fibroblasts, pole remarkably promotes I, III Collagen Type VI egg
White synthesis, pole significantly inhibits the expression of MMP1 and MMP3, and compared with 6 kinds of functional components are used alone, has conspicuousness
Difference, achieves unexpected technique effect.
The present invention has the following advantages：
1) claimed a kind of anti-apolexis composition, it is formed by 6 kinds of functional component collocation, is had significant anti-
The effect of aging.
2) tests prove that, anti-apolexis composition of the present invention wrinkles nature static wrinkle, dynamic wrinkle and posture Squeezing ground
Line, which is respectively provided with, extremely significantly dispels effect, remarkably promotes the propagation of human skin fibroblasts, and pole remarkably promotes I, III Collagen Type VI
The secretion of albumen, pole significantly inhibit the expression of MMP1 and MMP3 and compared with 6 kinds of functional components are used alone, and have conspicuousness
Difference, achieves unexpected technique effect.
Embodiment
The embodiment of form by the following examples, makees further specifically the above of the present invention
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiments.
Hydrolyzed pearl powder of the present invention is purchased from CRODAROM, article No. Pearl Extract；Long pubescence Chinese yam root extract is purchased from
ACTIVE ORGANICS, INC, article No.YAM PH；
Embodiment 1, anti-apolexis composition of the present invention
Composition 1：2 parts of hydrolyzed pearl powder, long 2 parts of pubescence Chinese yam root extract, 1 part of Argireline, acetyl group eight
- 11 parts of -31 parts of peptide and nonapeptide.
Composition 2：1 part of hydrolyzed pearl powder, long 1 part of pubescence Chinese yam root extract, 0.5 part of Argireline, acetyl group
- 10.5 parts of -30.5 parts of octapeptide and nonapeptide.
Composition 3：3 parts of hydrolyzed pearl powder, long 3 parts of pubescence Chinese yam root extract, 2 parts of Argireline, acetyl group eight
- 12 parts of -32 parts of peptide and nonapeptide.
Composition 4：3 parts of pearl powder, long 3 parts of pubescence Chinese yam root extract, 2 parts of Argireline, acetyl group octapeptide -32
- 12 parts of part and nonapeptide.
Embodiment 2, a kind of anti-aging creme
Creme described in the embodiment of the present invention 2 is made of the component of following parts by weight：Composition 115 described in embodiment 1
Part, 5 parts of moisturizer, 2 parts of emulsifying agent, 4 parts of emollient, 1 part of sea salt, 0.2 part of thickener, 0.1 part of preservative, composite essential oil 0.1
Part, 0.1 part of neutralizer and 55 parts of 0.2 part of EDETATE SODIUM, 0.2 part of allantoin, 0.1 part of tocopherol acetate and water, wherein,
The moisturizer includes 1 part of 1 part of glycerine, 1 part of 1,3- propane diols and ethoxy urea；The emulsifying agent includes 0.5 part of cetanol, sweet
1 part of oleostearin acid esters；The emollient includes 0.5 part of octyl dodecanol myristinate, 1 part of cetanol ethylhexoate, Australia
0.5 part of continent nut seed oil；The thickener is acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers；It is described multiple
Close 0.1 part of essential oil rosewood oil, 0.05 part of frankincense oil, 0.02 part of jasmine essential oil；The neutralizer is sodium hydroxide, described anti-
Rotten agent is peach girder phenol.
Preparation method：
A emulsifying agent, emollient mixing) are taken, is heated to 80 DEG C, dissolving is complete, obtains oil phase；
B) toward purified water is added in main bucket, allantoin and EDETATE SODIUM are put into, 3min is stirred, thickener is sprayed on table
Face, after wet-laid to be absorbed, stirring to no transparent grain, adds moisturizer, stirring 3min, obtains water phase；
C) water phase and oil phase are moved in emulsifying tank, homogeneous stirring 8min, is cooled to 40 DEG C；Anti-aging combination is put into successively
Thing, composite essential oil, preservative, sea salt and tocopherol acetate, homogeneous stirring 3min；Neutralizer is added, homogeneous stirring 3min, takes out
Be stirred under vacuum 10min, discharge, to obtain the final product.
Test example one, anti-wrinkle experiment
1. pair nature static wrinkle dispelling is tested
Take nature static wrinkle volunteer 210, after face cleaning, sterilized to skin at wrinkle with medicinal alcohol, by above-mentioned 180
Name volunteer is randomly divided into 7 groups, and every group of 30 people, each group smears 1 composition of embodiment, 1 aqueous solution, 1 composition 4 of embodiment respectively
Aqueous solution, hydrolyzed pearl amidin, long pubescence Chinese yam root extract aqueous solution, Argireline aqueous solution, acetyl group eight
The aqueous solution of peptide -3 and the aqueous solution of nonapeptide -1, massage are scored up to fully absorbing after respectively using 1 time, 30 days daily morning and evening by table 1
Standard scores, and appraisal result is as shown in table 2.
1 standards of grading of table
Table 2 is to nature static wrinkle dispelling result of the test
Note：Compared with 1 group of composition,**P ＜ 0.01,*P ＜ 0.05.
As shown in Table 2, the composition of above-mentioned 6 kinds of functional components dispels nature static wrinkle significant effect and is better than each functional component
Group, wherein, long pubescence Chinese yam root extract aqueous solution group, nonapeptide -1 and hydrolyzed pearl powder dispel effect to nature static wrinkle
Unobvious, Argireline and the group of acetyl group octapeptide -3 have to nature static wrinkle it is obvious dispels effect, but with above-mentioned 6 kinds
Functional component is applied in combination compared to the difference still with conspicuousness.
2. pair dynamic wrinkle dispels experiment
Dynamic wrinkle volunteer/210 are chosen, are tested by 1 test method of experiment, result of the test is as shown in table 3.
Table 3 is to dynamic wrinkle dispelling result of the test
Note：Compared with 1 group of composition,**P ＜ 0.01,*P ＜ 0.05.
As shown in Table 3, above-mentioned 6 kinds of functional components are undesirable to dynamic wrinkle dispelling effect, and the combination with them makes
With compared to, have pole significant difference (**P ＜ 0.01), compared with composition 1, hydrolyzed pearl powder, composition 4 are replaced with pearl powder
Dynamic wrinkle dispelling effect is decreased significantly.
3. pair Squeezing ground wrinkle dispelling is tested
Squeezing ground wrinkle volunteer 210 is chosen, is tested by 1 test method of experiment, result of the test is as shown in table 4.
Table 4 is to Squeezing ground wrinkle dispelling result of the test
Note：Compared with 1 group of composition,**P ＜ 0.01,*P ＜ 0.05.
As shown in Table 4, above-mentioned 6 kinds of functional components are undesirable to Squeezing ground wrinkle dispelling effect, and the combination with them makes
With compared to, have pole significant difference (**P ＜ 0.01).
In conclusion the exclusive use of above-mentioned 6 kinds of functional components has preferable effect to dispelling nature static wrinkle, still
Pair compared with dynamic wrinkle and Squeezing ground wrinkle dispelling effect unobvious, use in combination, there is pole significant difference.This
Illustrate, being applied in combination of 6 kinds of functional components has haveed the function that mutual synergistic, achieves significant effect.
Test example two, test proliferation of human dermal fibroblasts
Take human skin fibroblasts that culture medium exists in the MEM culture mediums for being inoculated in 5% hyclone containing volume fraction
5%CO2, 37 DEG C of CO2Cultivated in incubator, liquid is changed 1 time per 3d, culture carries out cell passage after 7 days, suctions out original fluid, uses
PBS buffer washing cell 3 times, adds the 4Na solution 0.5mL of ˙ containing 0.25%Trypsin-1mMEDTA, adds 10mLMEM trainings
Base is supported, soft pressure-vaccum, makes cell suspend, move in centrifuge tube, and 2000rpm centrifugation 5min, absorb supernatant, addition contains body in right amount
The MEM culture mediums of 5% hyclone of fraction, soft pressure-vaccum, is resuspended cell.96 orifice plates are taken, cell suspension 100 is added in every hole
μ L (contain 1000, cell), after cell attachment, are separately added into 1 aqueous solution of composition, 15 μ L, 4 aqueous solution of composition, 15 μ L, water
Solve 15 μ L of pearl amidin, long 15 μ L of pubescence Chinese yam root extract aqueous solution, 15 μ L of Argireline aqueous solution, acetyl group
15 μ L of 15 μ L of the aqueous solution of octapeptide -3 and the aqueous solution of nonapeptide -1, and using isometric PBS buffer as blank control, in incubator
It is middle culture 72 it is small when, take out 96 orifice plates, 15 μ LWST-8 solution are added into each hole, place into incubator be incubated 4 it is small when show
Color, takes out 96 orifice plates, OD values is measured under 450nm, statistical result, carries out statistical procedures, as a result with SPSS softwares to result
As shown in table 5.
Table 5 is to proliferation of human dermal fibroblasts result of the test
Note：Compared with blank control group,**P ＜ 0.01,*P ＜ 0.05；Compared with 1 group of composition,##P ＜ 0.01,#P ＜
0.05。
As shown in Table 5, compared with blank control group, above-mentioned 6 kinds of functional components are applied in combination with remarkably promoting fell
The effect of skin fibroblastic growth, and compared with each component is independent there is pole to remarkably promote human skin fibroblasts growth
Effect.
Test example three, the influence to the secretion of I, III collagen type and MMP1, MMP3 expression are tested
96 orifice plates are taken, add 1000 individual's skin fibroblasts per hole, liquid is changed once per 3d, after cell attachment, each group
In be separately added into 1 aqueous solution of composition, 15 μ L, 15 μ L of hydrolyzed pearl amidin, long 15 μ of pubescence Chinese yam root extract aqueous solution
L, 15 μ L of 15 μ L of Argireline aqueous solution, 15 μ L of the aqueous solution of acetyl group octapeptide -3 and the aqueous solution of nonapeptide -1, and sky is set
White control group (isometric PBS buffer).After cultivating 7d, ELASA methods measure I types, III collagen type, MMP1 and MMP3
Content, carries out statistical procedures, as a result as shown in table 6,7 using SPSS statistical softwares to result.
The influence (n=10) that table 6 secretes I types and III collagen type
Note：Compared with blank control group,**P ＜ 0.01,*P ＜ 0.05；Compared with 1 group of composition,##P ＜ 0.01,#P ＜
0.05。
As shown in Table 6, compared with blank control group, in addition to hydrolyzed pearl powder, long pubescence Chinese yam root extract, remaining each group
Can pole be obviously promoted I-type collagen secretion (**P ＜ 0.01)；But above-mentioned 6 kinds of functional components are used alone, III type
Collagen content compared with blank control group without significant difference, without statistical significance, but surprisingly, on
State 6 kinds of functional components be applied in combination have the function that pole be obviously promoted the secretion of III collagen type (**P ＜ 0.01).
Influence (n=10) of the table 7 to MMP1 and MMP3 contents
Note：Compared with blank control group,**P ＜ 0.01,*P ＜ 0.05；Compared with 1 group of composition,##P ＜ 0.01,#P ＜
0.05。
As shown in Table 7, compared with blank control group, except hydrolyzed pearl powder, long pubescence Chinese yam root extract group and nonapeptide-
Outside 1, remaining each group can significantly inhibit the expression of MMP1 and MMP3, what deserves to be explained is, the combination of above-mentioned 6 kinds of functional components
Using either pole obvious action is respectively provided with terms of MMP1 or MMP3 expression is suppressed, the effect of synergy is achieved.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (7)
1. a kind of anti-apolexis composition, it is characterised in that be made of the component of following parts by weight：1~3 part of hydrolyzed pearl powder,
Long 1~3 part of pubescence Chinese yam root extract, 0.5~2 part of Argireline, acetyl group octapeptide -30.5~2 part and nonapeptide -10.5
~2 parts；The anti-apolexis composition can be used for preparing the synthesis for promoting I type and III collagen type and suppress MMP1 and MMP3
Expression cosmetics, skin care item.
2. anti-apolexis composition as claimed in claim 1, it is characterised in that be made of the component of following parts by weight：Hydrolysis
- 11 parts of 2 parts of pearl powder, long 2 parts of pubescence Chinese yam root extract, 1 part of Argireline, -31 parts of acetyl group octapeptide and nonapeptide.
3. a kind of anti-aging creme, it is characterised in that include the component of following parts by weight：It is as claimed in claim 1 or 2 anti-
5~20 parts of anti-aging composition, 3~6 parts of moisturizer, 1~3 part of emulsifying agent, 3~6 parts of emollient, 1~2 part of sea salt, thickener 0.1
~0.3 part, 0.1~0.2 part of preservative, 0.1~0.3 part of composite essential oil, 0.1~0.3 part of neutralizer, EDETATE SODIUM 0.1~0.2
Part, 0.1~0.3 part of allantoin, 0.05~0.2 part of tocopherol acetate and 40~60 parts of water.
4. creme as claimed in claim 3, it is characterised in that the composite essential oil include 0.05~0.15 part of rosewood oil,
0.01~0.03 part of 0.01~0.1 part of frankincense oil and jasmine essential oil.
5. creme as claimed in claim 3, it is characterised in that the moisturizer is selected from 1,3-PD, glycerine, ethoxy
One or more in urea, pungent glycol, glucan and Sensiva SC50；The emulsifying agent is selected from cetanol, glycerol stearate
Ester, PEG-75 stearates, ceteth -20, stereth -20, stearic acid, stearine, PEG-100 are stearic
One or more in the smooth stearate of acid esters, sorb and sucrose cocounut oil acid esters.
6. creme as claimed in claim 3, it is characterised in that the emollient is selected from octyl dodecanol myristinate, whale
Ceryl alcohol ethylhexoate, Queensland nut seed oil, ethylhexyl palmitate, dimethyl silicone polymer, Cholesteryl hydroxystearate
With the one or more in dimethyl silicone polymer；The thickener is handed over for acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters
Linked polymer；The preservative is selected from the one or two of Phenoxyethanol and peach girder phenol.
A kind of 7. method for preparing the creme as described in claim 3~6 is any, it is characterised in that comprise the following steps：
A emulsifying agent, emollient mixing) are taken, is heated to 70~90 DEG C, dissolving is complete, obtains oil phase；
B) toward purified water is added in main bucket, allantoin and EDETATE SODIUM are put into, 2~4min is stirred, thickener is sprayed on surface,
After wet-laid to be absorbed, stirring to no transparent grain, adds moisturizer, stirs 1~3min, obtains water phase；
C) water phase and oil phase are moved in emulsifying tank, homogeneous stirs 3~10min, is cooled to 40 DEG C；Anti-aging combination is put into successively
Thing, composite essential oil, preservative, sea salt and tocopherol acetate, homogeneous stir 1~3min；Addition neutralizer, homogeneous stirring 1~
3min, vacuumizes 5~15min of stirring, discharging, to obtain the final product.
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| CN109939016A (en) * | 2017-12-20 | 2019-06-28 | 隐纱化妆品有限公司 | The composition for preventing and treating skin aging |
| CN108096113B (en) * | 2018-01-17 | 2020-12-15 | 广东肽世家生物科技有限公司 | Sheep placenta peptide composition and facial mask liquid containing same |
| CN108379110B (en) * | 2018-05-16 | 2021-03-16 | 广州莎利曼尔生物科技有限公司 | Skin care composition, skin care cream and preparation method thereof |
| CN113616774B (en) * | 2021-09-10 | 2024-02-02 | 山东丽达生物科技集团有限公司 | Antibacterial composition containing plant stem cells, maintenance antibacterial liquid and preparation method thereof |
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|---|---|---|---|---|
| CN106265330A (en) * | 2016-08-29 | 2017-01-04 | 杭州千岛湖蓝色天使实业有限公司 | The cream that a kind of wrinkle removing is anti-ageing |
| CN106265439A (en) * | 2016-08-24 | 2017-01-04 | 登封市科创商务咨询有限公司 | Nidus collocaliae white beauty mask only |
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| CN103876991A (en) * | 2012-12-23 | 2014-06-25 | 吕子玉 | Pearl powder cosmetic and its preparation method |
| CN105411974A (en) * | 2015-12-06 | 2016-03-23 | 重庆维可健康咨询有限公司 | Facial mask having anti-wrinkle effect |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106265439A (en) * | 2016-08-24 | 2017-01-04 | 登封市科创商务咨询有限公司 | Nidus collocaliae white beauty mask only |
| CN106265330A (en) * | 2016-08-29 | 2017-01-04 | 杭州千岛湖蓝色天使实业有限公司 | The cream that a kind of wrinkle removing is anti-ageing |
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