CN107440981A - A kind of matrimony vine facial mask and preparation method thereof - Google Patents
A kind of matrimony vine facial mask and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of matrimony vine facial mask and preparation method thereof, it is related to cosmetic technical field.The matrimony vine facial mask contains each component of following percetage by weight：Matrimony vine 5%~20%, NMF 5%~12%, thickener 0.5%~2%, solubilizer 0.05%~0.2%, nourishing additive agent 0.015%~0.2%, nertralizer 0.05%~0.1%, preservative 0.05%~0.2%, deionized water surplus.The matrimony vine added in the present invention is that a kind of nutriture value is planted and the very high integration of drinking and medicinal herbs Chinese medicine of medical value, with bioactivity such as anti-oxidant, removing free radical, anti-aging, radioresistances, arranged in pairs or groups NMF and nourishing additive agent, the facial mask is set to have pharmacology and nutrition double action concurrently, reach whitening moisten, replenishing water and preserving moisture, open and flat wrinkle of skin, delay skin aging and other effects.Preparation method provided by the invention is simple, and condition is controllable, is adapted to a large amount of productions.
Description
Technical field
The present invention relates to cosmetic field, in particular it relates to a kind of matrimony vine facial mask and preparation method thereof.
Background technology
With the continuous development of society, there occurs the change of matter, attention rate to exceed for concern of the people to life and health
Conventional any age, " back to nature ", " green " consumption turn into fashion, and natural function plant industry has welcome unprecedented
Opportunity to develop.According to the incomplete statistics of the World Health Organization, whole world functional plants market is with annual 10%~20% speed
Degree is incremented by, and U.S.'s functional plants output value is increased with the speed more than 20% every year, it can be seen that, functional plants product market
Potential of demand is huge.In face of the grand occasion of functional product, how comprehensive development and utilization functional plants, research and develop end of high added value
Product is held, is connected industry link, establishes industry chain (supply chain), pulls functional plants resource industries to continue healthy and rapid development and becomes
For the current important process for being badly in need of carrying out.
Matrimony vine (Lycium bararum L.) is China's tradition integration of drinking and medicinal herbs Chinese medicine, its fruit, flower, leaf, skin, root
It is used as medicine, there is very high nutritive value and medicinal health effect.Research in recent years is found, human immunity is adjusted possessed by matrimony vine
Power, the LBP-X in the pharmacological action and matrimony vine that suppress tumour growth, prevent and obstruct cancer cell mutation etc., beet
The compositions such as alkali, beta carotene are relevant.In addition, matrimony vine has the various nutritional ingredients of needed by human body, detection and analysis, per 100g Chinese hollys
There are protein 12g, carbohydrate 46.3g, dietary fiber 12.6g, also carrotene 19.6mg, VB10.2mg in Qi fresh fruit,
Niacin 4.5mg, ascorbic acid 13mg, calcium 37mg, iron 6.5mg, phosphorus 224mg, magnesium 41mg, zinc 15mg, manganese 0.79mg and selenium
1.67mg.In addition, clinical medicine confirms, the LBP-X in matrimony vine not only has reducing blood lipid, hypoglycemic, lipotropic
Effect, can be with antifatigue, anti-aging, removing free radical, suppression lipid oxide generation, and makes the glutathione in blood of human body
Peroxidase (GSP-Px) and the enhancing of the vigor of erythrocyte superoxide dismutase (SOD).Boxthorn Seed Oil can promote skin blood
Liquid circulates, and directly participates in skin metabolism, eliminates oxygen radical, delays the aging of epidermis and corium, strengthens skin hydration work(
Can, make skin emolliency and high resilience, have obvious whitening effect, have obvious fading to senile plaque expelling and chloasma pigment calmness
Effect；Therefore, LBP-X has very high Development volue as natural with Boxthorn Seed Oil.
At present, matrimony vine exploitation correlative study is mainly based on health products, and there is not yet by matrimony vine in cosmetic field
Polysaccharide is with Boxthorn Seed Oil as report anti-oxidant in cosmetics, removing free radical, anti-aging and radiation-resistant sole active agent
Road.Therefore, researching and developing a kind of functional matrimony vine facial mask has market potential value.
The content of the invention
The present invention is in order to overcome the above-mentioned deficiency of prior art, there is provided a kind of matrimony vine facial mask, the matrimony vine added in the facial mask
As sole active agent that is anti-oxidant, removing free radical, anti-aging, radioresistance etc., NMF of being arranged in pairs or groups adds with nutrition
Agent, the facial mask is had pharmacology and nutrition double action concurrently, reach whitening moisten, replenishing water and preserving moisture, open and flat wrinkle of skin, delaying skin
Aging and other effects.
It is a further object to provide the preparation method of above-mentioned matrimony vine facial mask.
To achieve these goals, the present invention is achieved by following scheme：
A kind of matrimony vine facial mask, each component containing following percetage by weight：Matrimony vine 5%~20%, NMF 5%~
12%, thickener 0.5%~2%, solubilizer 0.05%~0.2%, nourishing additive agent 0.015%~0.2%, nertralizer
0.05%~0.1%, preservative 0.05%~0.2%, deionized water surplus.
Contain LBP-X and Boxthorn Seed Oil isoreactivity composition in facial mask provided by the present invention, skin blood can be promoted to follow
Ring, skin metabolism is directly participated in, eliminate oxygen radical, delay the aging of epidermis and corium, strengthened skin hydration function, make
Skin emolliency and high resilience, there is obvious whitening effect, have obvious fading to act on to senile plaque expelling and chloasma pigment calmness.
Meanwhile the other compositions added in facial mask of the invention are gently non-stimulated, side effect is not produced to skin.
Preferably, the matrimony vine facial mask contains each component of following percetage by weight：Matrimony vine 5.0%~10.0%, moisturizing
Agent 8%~10%, thickener 0.5%~1%, solubilizer 0.05%~0.1%, nourishing additive agent 0.05%~0.1%, neutralize
Agent 0.05%~0.1%, preservative 0.1%~0.15%, deionized water surplus.
Preferably, the matrimony vine is any of wolfberry fruit extract, wolfberry fruit powder, matrimony vine essential oil or several.
Preferably, the NMF is glycerine, propane diols, 1,3-BDO, polyethylene glycol, hyaluronic acid, lactic acid, lactic acid
Any of sodium, pyrrolidone sodium carboxylate are several.
Preferably, the thickener is carbomer, Sodium Hyaluronate, pectin, carboxymethyl cellulose gum or ethyl cellulose
Any of or it is several.
Preferably, the solubilizer is polyoxyethylene hardened castor oil, Emulsifier EL-60, rilanit special, fat
Alcohol APEO, aliphatic alcohol polyethenoxy, polyethenoxy ether, polyoxyethylene sorbitan fatty acid ester, polyglycereol fat
Any of acid esters is several.
Preferably, the nourishing additive agent is any of royal jelly, vitamin C, vitamin E, collagen, tartaric acid
It is or several.
Preferably, the nertralizer is triethanolamine.
Preferably, the preservative be parabens, benzoic acid, sodium benzoate, potassium sorbate, outstanding horse BP,
Any of methyl hydroxybenzoate, Nipasol, Phenoxyethanol are several.
The preparation method of the matrimony vine facial mask is also claimed in the present invention, comprises the following steps：
S1. the preparation of matrimony vine：
(1) wolfberry fruit extract：Appropriate fructus lycii is taken, is concentrated by ultrafiltration after adding pigment broken, adds absolute ethyl alcohol standing, precipitation
Thing adds water to be filtered after being completely dissolved, and 3 times repeatedly, obtained sediment is completely dissolved with water again after drying, then carries out ultrafiltration, molten
After liquid concentration wolfberry fruit extract is obtained after elution, freeze-drying；
(2) wolfberry fruit powder：3h will be dried in vacuo under dried fruit of lycium barbarum low temperature, be then crushed with pulverizer and obtained after 200 mesh sieves point
Wolfberry fruit powder；
(3) matrimony vine essential oil：Appropriate matrimony vine is weighed, after obtaining wolfberry fruit powder by matrimony vine powder, preparation method thereof, is placed in smart heat extraction
In device, distilled water is added, heats 6h, collects essential oil；
S2. portions of de-ionized water is mixed with NMF in proportion, then adds thickener, stirred to complete
Dissolving, if too thick, adds appropriate phosphoric acid, and slowly stirring cools after being heated up to 80 DEG C of maintenance 20min, obtains thickening fluid；
S3. first deionized water, NMF, solubilizer and preservative are mixed in proportion, are heated up to 90 DEG C and are completely dissolved,
20min is incubated, S2 gained thickening fluids is added and stirs, be then proportionally added into nertralizer, stir, be cooled to 45 DEG C
Afterwards, matrimony vine, nourishing additive agent and essence are added to stir, deaerated；
Sampled at S4.40 DEG C, send initial survey, discharged after initial survey is qualified with 300~500 mesh filter-cloth filterings, produce matrimony vine facial mask
Liquid.
Compared with prior art, the invention has the advantages that：
(1) collocation such as the matrimony vine added in facial mask of the present invention and NMF, nourishing additive agent uses, and the facial mask is had medicine concurrently
Reason and nutrition double action, reach whitening moisten, replenishing water and preserving moisture, open and flat wrinkle of skin, delay skin aging and other effects.
(2) preparation method of matrimony vine facial mask of the present invention is simple, and condition is controllable, is adapted to a large amount of productions.
Brief description of the drawings
Fig. 1 is the preparation technology flow chart of matrimony vine facial mask.
Embodiment
The present invention is made with reference to Figure of description and specific embodiment and further being elaborated, the embodiment
It is served only for explaining the present invention, is not intended to limit the scope of the present invention.Preparation method used in following embodiments is such as without spy
Different explanation, is conventional method；Used material, reagent etc., unless otherwise specified, for the reagent commercially obtained
And material；Involved percentage is calculated in weight percent except being otherwise noted.
Embodiment 1~5
A kind of matrimony vine facial mask and preparation method thereof：
The weight percent content of matrimony vine face pack prescription is as shown in table 1 below in embodiment 1~5：
The matrimony vine face pack prescription of the embodiment 1~5 of table 1
The preparation method of matrimony vine facial mask comprises the following steps in embodiment 1~5：
S1. the extraction of matrimony vine：
(1) wolfberry fruit extract：Appropriate fructus lycii is taken, is concentrated after adding pigment broken with ultrafilter, adds absolute ethyl alcohol
Stand, sediment adds water to be filtered after being completely dissolved, and 3 times repeatedly, obtained sediment is completely dissolved with water again after drying, then is entered
Row ultrafiltration, wolfberry fruit extract is obtained after elution, freeze-drying after solution concentration；
(2) wolfberry fruit powder：3h will be dried in vacuo under dried fruit of lycium barbarum low temperature, be then crushed with pulverizer and obtained after 200 mesh sieves point
Wolfberry fruit powder；
(3) matrimony vine essential oil：Appropriate matrimony vine is weighed, after obtaining wolfberry fruit powder by matrimony vine powder, preparation method thereof, is placed in smart heat extraction
In device, distilled water is added, heats 6h, collects essential oil；
S2. first carry out disinfection each container standby, the appearance in proportion disinfecting portions of de-ionized water and NMF addition
In device A, slowly thickener is added in container A, homogenizer is started and slowly stirs to dissolving completely, if too thick, add appropriate phosphorus
Acid, slowly stirring cool after being heated up to 80 DEG C of maintenance 20min, obtain thickening fluid, standby；
S3. first deionized water, NMF, solubilizer and preservative are added in the container B disinfected in proportion, heating
It is complete to 90 DEG C or so dissolvings, 20min is incubated, standby good thickening fluid is added and stirs, be then proportionally added into neutralization
Agent triethanolamine, stirs, and after being cooled to 45 DEG C, adds matrimony vine, nourishing additive agent and essence and stirs, deaerate；
Sampled at S4.40 DEG C, send initial survey, discharged after initial survey is qualified with 300~500 mesh filter-cloth filterings, produce matrimony vine facial mask
Liquid.
Application examples 1
The quality of the gained matrimony vine facial mask of embodiment 1 is evaluated：
With reference to international standard method and cosmetic standard, the matrimony vine facial mask of the gained of example 1 is subjected to sense organ, physicochemical property, micro-
The many indexs such as biology detect, as a result as shown in table 2 below：
The quality measurements of the gained matrimony vine facial mask of 2 embodiment of table 1
Application examples 2
Eye irritant test detection is carried out to the gained matrimony vine facial mask of embodiment 1~5：
Select healthy adult white rabbit 5, male and female half and half, facial mask liquid prepared by the formula according to embodiment 1~5
0.1mL is respectively dropped on the left of 5 rabbit in eyes conjunctival sac, eye is passively closed 5~10s after dropping liquid, and right side eye is control.Note
Record dropping liquid after 1,24,48, the local reaction of 72h eyes, 4d and 7d observation recovery situation.
Clinical examination and scoring：After instillation 1,24,48,72h and 4d and 7d checked rabbit eyes.
Observed in 72h and do not occur stimulate the reaction, you can off-test.If the situation of Eye irritation occurs, and not recuperator in 7d,
Observing time need to be extended to determine the invertibity or irreversibility of this infringement, observation number of days is no more than 21d, interim to record the
7d, 14d, 21d observation situation.Integration note is carried out to the Eye irritation reaction checked every time by the standards of grading (table 3) of eye infringement
Record.Stimulus intensity (table 4) of the sample to eye is determined according to accumulative integration.
The standards of grading of 3 infringements of table
The reaction classification of the Eye irritation of table 4
After instilling the matrimony vine facial mask liquid of embodiment 1~5, in the eye conditions that 5 rabbit are observed in 72h, as a result animal horn
Film, conjunctiva and iris are normal, the stimulate the reactions such as no hyperemia, oedema, ulcer are formed.Table 5 is that matrimony vine facial mask pierces to rabbit eyes
Swash property result of the test.
The matrimony vine facial mask of table 5 is to rabbit the irritating experiment with eyes result
As seen from the results in Table 5, matrimony vine facial mask is 0 to rabbit eyes irritative response integration, belongs to nonirritant rank.
Application examples 3
Human body patch test is carried out to the gained matrimony vine facial mask of embodiment 1~5：
Healthy volunteer 30 is selected, is divided into 5 groups, every group 6.0.020g matrimony vine film sample is put into spot examination respectively
In device, control wells do not put any material as blank control, by added with matrimony vine facial mask spot try device with medical adhesive tape be pasted on by
On the forearm song side skin of examination person, continue 24h.Remove tested material spot and try 30min after device, it is anti-to observe skin after impression disappearance
Should.Negative findings person, 24h and 48h is observed once again respectively after experiment.Dermoreaction result is recorded by table 6.
The skin adverse reaction grade scale of table 6
If occur more than 51 grade of skin adverse reactions in 30 subjects, or more than 22 grades of skin adverse reactions, or
When there is any 13 grades or more than 3 grades skin adverse reactions, then judge that tested material causes skin adverse reaction to human body.
As a result show, 30 subjects are negative reaction, do not occur the skin irritations such as erythema, oedema, papule, shouting pain
Reaction, shows matrimony vine facial mask made from embodiment 1~5 to the non-stimulated adverse reaction of human body skin.
Application examples 4
Antioxidation activity evaluation is carried out to the gained matrimony vine facial mask of embodiment 1~5：
2mL DPPH storing solutions are drawn, are shaken up with absolute ethyl alcohol constant volume in 100mL volumetric flasks to be measured.Utilize DPPH solution
Feature aubergine group absorption, with UV-VIS spectrophotometry measure plus antioxidant extract solution after wavelength 517nm at suction
The decline of receipts represents that it eliminates ability to organic free radical, by table 7 plus reaction solution.
The DPPH of table 7 experiment sample-adding tables
Firmly shake up, by AiAfter represented sample stands 30min at room temperature, add and absorbance is carried out in cuvette
Measure, measures A0、Ai、AjThe absorbance of represented sample, each sample replication 3 times, averages.Clearance rate press with
Lower formula calculates：
SA(%)=1- (Ai-Aj)/A0×100
In formula：A0：Not plus the DPPH solution of sample solution absorbance；
Ai：The absorbance of the DPPH solution added after sample solution；
Aj：Absolute ethyl alcohol and the mixed absorbance of sample solution.
The test result of the DPPH clearance rates of the gained matrimony vine facial mask of 8 embodiment of table 1~5
By table 8 it can be seen that the matrimony vine facial mask of the present invention all has certain DPPH Scavenging activities, its strong and weak order is real
Apply 5 ＞ and implement 2 ＞ implementation 3 ＞, 4 ＞ of implementation implementations 1.
Application examples 5
The performance of keeping humidity of the gained matrimony vine facial mask of embodiment 1~5 is tested：
5 kinds of different matrimony vine face pack prescription number consecutivelies by the gained of embodiment 1~5 are 1,2,3,4,5.
25 qualified volunteers take one's test, and sex is random, 18~25 years old age, 5 one group of people, during test with
Machine selects volunteer, and test test zone in morning on the same day can not smear any cosmetics, and volunteer makes in the case where staff instructs
Recipient site is cleaned with clear water, and 4cm × 4cm test block is marked in inner side of cranking arm, then in test environment
(25 ± 2 DEG C of temperature, relative humidity 50 ± 5%) is quiet to wait 20~30min, and 2mg/cm is pressed in tested area2Smear embodiment 1~5
Facial mask liquid, hyaluronic acid do not smear any product as blank control, the tested area of volunteer during test as positive control
Without using other any cosmetics.Test period is 4h, and in test period Inner, subject, which forbids feeding, drinks water, quarrels and fights noisily, etc. causes
The activity of moisture of skin strong variations.
After product uses preceding and product to use 1h, 2h and 4h, respectively using skinanalysis apparatus Comeometer
CM825 is tested moisture of skin.Test zone is left and right inner forearm, and each test section is tested 5 times and averaged.
Within test period, evaluation and test person does not occur the skin such as obvious systemic adverse reactions or more than 3 grades of skin irritatin
Malaise symptoms.
Found out by table 9, in test period 4h, after the sample using matrimony vine facial mask liquid, skin moisture content MMV values are relative
Significantly (P ＜ 0.01) is raised in having using preceding and blank group.Since 1h, and skin moisture content MMV values, embodiment 4
The ＞ blank groups of 51 ＞ embodiments of ＞ positive controls ＞ 2 ＞ embodiments of embodiment of ＞ embodiments 3, i.e. embodiment 4 and the skin of embodiment 5
The a little higher than positive control hyaluronic acid of skin moisture, and the moisture content of skin of embodiment 2,1,3 is also all higher than blank group, it is seen that
Matrimony vine facial mask has preferable performance of keeping humidity, and the performance of keeping humidity of embodiment 4 and embodiment 5 is more excellent.
Skin moisture content (%) after the different disposal of table 9
| Time (h) | 0 | 1 | 2 | 4 |
| Embodiment 1 | 27.28±3.94 | 41.54±3.81 | 37.92±3.94 | 35.27±5.36 |
| Embodiment 2 | 26.32±4.70 | 42.17±7.03 | 38.37±6.91 | 34.59±4.72 |
| Embodiment 3 | 26.81±2.49 | 39.77±4.56 | 36.78±7.09 | 33.94±3.96 |
| Embodiment 4 | 27.39±5.06 | 48.20±6.21 | 41.66±5.11 | 38.72±6.63 |
| Embodiment 5 | 27.07±4.42 | 47.62±5.37 | 40.28±4.13 | 37.81±7.03 |
| Positive controls | 26.47±4.83 | 45.82±4.13 | 39.83±5.53 | 37.09±4.75 |
| Blank group | 26.39±3.81 | 29.76±4.37 | 30.20±3.11 | 28.81±3.94 |
Application examples 6
The measure of tyrosinase inhibition rate is carried out to the gained matrimony vine facial mask of embodiment 1~5：
It is positive control to select ursin.The facial mask liquid of embodiment 1~5 is made into 1000.00mgL-1Test sample
Solution (contains 50% dimethyl sulfoxide (DMSO)).Tyrosinase 25KU is dissolved in 0.05molL-1PH6.8 phosphate buffers (PBS)
In, 100mL is settled to, obtains 250UmL-1Tyrosinase solution.Appropriate tyrosine is accurately weighed, is dissolved in 0.05molL- 1In PBS, 100.00mgL is made into-1Tyrosine solution.Point sample is carried out by table 10, reactant cumulative volume in each reacting hole
200μL.After point sample, 30min is incubated in 37 DEG C, A (n=3) is determined at 475nm, is calculated as follows：
Inhibiting rate %=[(A1- A2)/(A3- A4)] × 100%
Wherein A1、A2、A3、A4Indicate respectively sample thing but without tester, both n.s thing and also without tester, have sample
Thing and tester, absorbance when having tester but a n.s thing.Investigate various forms of matrimony vines and ursin mass concentration is equal
For 1000mgL-1When to the inhibition of tyrosinase, the results are shown in Table 11.
The tyrosinase Inhibition test prepare liquid of table 10 and composition (μ L)
The matrimony vine facial mask of table 11 is to tyrosinase inhibitory activity result
The inhibitory activity result of tyrosinase is shown by the matrimony vine facial mask of table 11, the matrimony vine facial mask pair that embodiment 1~5 obtains
Tyrosinase has certain rejection ability, though it is poorer than the inhibitory activity of simple ursin, skin-whitening is can be used for, especially
The inhibitory activity highest of embodiment 5, embodiment 3 are taken second place.Illustrate the facial mask pair of matrimony vine content high (i.e. LBP-X content is high)
Tyrosinase inhibitory action is strong, and the composition containing matrimony vine of comparative example 1 is few, and wolfberry fruit extract and matrimony vine essential oil content are few, and its is right
Tyrosinase suppresses poor.Show that matrimony vine has certain tyrosinase rejection ability, there is whitening function available for preparing
Facial mask.
Embodiment 6~10
A kind of matrimony vine facial mask and preparation method thereof：
The weight percent content of the face pack prescription of embodiment 6~10 is as shown in table 12 below：
The matrimony vine face pack prescription of the embodiment 6~10 of table 12
Antioxidation activity evaluation is carried out to the gained matrimony vine facial mask of embodiment 6~10 using the method for application examples 4, as a result such as table
Shown in 13：
The test result of the DPPH clearance rates of the gained matrimony vine facial mask of 13 embodiment of table 6~10
From the result of table 13, the oxidation resistance of the gained matrimony vine facial mask of embodiment 6~10 is below the matrimony vine of embodiment 5
Facial mask.
The performance of keeping humidity of the gained matrimony vine facial mask of embodiment 6~10 is tested using the method for application examples 5, as a result such as table
Shown in 14：
Skin moisture content (%) after the different disposal of table 14
| Time (h) | 0 | 1 | 2 | 4 |
| Embodiment 6 | 27.41±3.76 | 41.26±3.23 | 35.12±3.14 | 32.47±3.07 |
| Embodiment 7 | 26.83±1.85 | 43.14±2.69 | 36.43±4.02 | 33.68±2.87 |
| Embodiment 8 | 27.14±2.48 | 39.31±4.01 | 33.68±2.51 | 31.24±1.99 |
| Embodiment 9 | 26.50±3.31 | 46.55±2.33 | 39.77±3.81 | 37.43±3.05 |
| Embodiment 10 | 26.73±2.24 | 45.11±3.05 | 38.64±2.90 | 35.77±4.17 |
| Positive controls | 26.47±4.83 | 45.82±4.13 | 39.83±5.53 | 37.09±4.75 |
| Blank group | 26.39±3.81 | 29.76±4.37 | 30.20±3.11 | 28.81±3.94 |
From the result of table 14, the performance of keeping humidity of the gained matrimony vine facial mask of embodiment 6~10 is below the matrimony vine face of embodiment 5
Film.
The measure of tyrosinase inhibition rate, knot are carried out to the gained matrimony vine facial mask of embodiment 6~10 using the method for application examples 6
Fruit is as shown in Table 15：
The matrimony vine facial mask of table 15 is to tyrosinase inhibitory activity result
| Sample | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Ursin |
| Inhibiting rate (%) | 43.21 | 44.87 | 40.63 | 49.31 | 45.69 | 77.73 |
From the result of table 15, the tyrosinase inhibition rate of the gained matrimony vine facial mask of embodiment 6~10 is below embodiment 5
Matrimony vine facial mask, therefore whitening effect is also not so good as the matrimony vine facial mask of embodiment 5.
Comparative example 1~5
A kind of matrimony vine facial mask and preparation method thereof：
The weight percent content of the face pack prescription of comparative example 1~5 is as shown in table 16 below：
The matrimony vine face pack prescription of the comparative example 1~5 of table 16
Antioxidation activity evaluation is carried out to the gained matrimony vine facial mask of comparative example 1~5 using the method for application examples 4, as a result such as table
Shown in 17：
The test result of the DPPH clearance rates of the gained matrimony vine facial mask of 17 comparative example of table 1~5
From the result of table 17, the oxidation resistance of the gained matrimony vine facial mask of comparative example 1~5 is below the matrimony vine of embodiment 5
Facial mask.
The performance of keeping humidity of the gained matrimony vine facial mask of comparative example 1~5 is tested using the method for application examples 5, as a result such as table
Shown in 18：
Skin moisture content (%) after the different disposal of table 18
| Time (h) | 0 | 1 | 2 | 4 |
| Comparative example 1 | 27.24±1.89 | 39.93±4.31 | 36.37±2.49 | 33.81±2.51 |
| Comparative example 2 | 26.51±3.44 | 37.22±3.45 | 34.21±4.47 | 32.13±3.36 |
| Comparative example 3 | 26.72±2.33 | 41.26±3.09 | 38.36±2.68 | 35.37±2.78 |
| Comparative example 4 | 27.06±3.31 | 43.07±2.88 | 40.69±3.67 | 37.17±3.16 |
| Comparative example 5 | 26.29±2.74 | 45.98±3.53 | 42.57±4.22 | 39.20±4.48 |
| Positive controls | 26.47±4.83 | 45.82±4.13 | 39.83±5.53 | 37.09±4.75 |
| Blank group | 26.39±3.81 | 29.76±4.37 | 30.20±3.11 | 28.81±3.94 |
From the result of table 18, the performance of keeping humidity of the gained matrimony vine facial mask of comparative example 1~5 is below the matrimony vine face of embodiment 5
Film.
The measure of tyrosinase inhibition rate, knot are carried out to the gained matrimony vine facial mask of comparative example 1~5 using the method for application examples 6
Fruit is as shown in table 19：
The matrimony vine facial mask of table 19 is to tyrosinase inhibitory activity result
From the result of table 19, the tyrosinase inhibition rate of the gained matrimony vine facial mask of comparative example 1~5 is below embodiment 5
Matrimony vine facial mask, therefore whitening effect is also not so good as the matrimony vine facial mask of embodiment 5.
Claims (10)
1. a kind of matrimony vine facial mask, it is characterised in that the matrimony vine facial mask contains each component of following percetage by weight：Matrimony vine 5%~
20%, NMF 5%~12%, thickener 0.5%~2%, solubilizer 0.05%~0.2%, nourishing additive agent 0.015%~0.2%, in
With agent 0.05%~0.1%, preservative 0.05%~0.2%, deionized water surplus.
2. matrimony vine facial mask according to claim 1, it is characterised in that the matrimony vine facial mask contains following percetage by weight
Each component：Matrimony vine 5.0%~10.0%, NMF 8%~10%, thickener 0.5%~1%, solubilizer 0.05%~0.1%, nutrition adds
Add agent 0.05%~0.1%, nertralizer 0.05%~0.1%, preservative 0.1%~0.15%, deionized water surplus.
3. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the matrimony vine be wolfberry fruit extract, wolfberry fruit powder,
Any of matrimony vine essential oil is several.
4. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the NMF is glycerine, propane diols, 1,3-
Any of butanediol, polyethylene glycol, hyaluronic acid, lactic acid, sodium lactate, pyrrolidone sodium carboxylate are several.
5. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the thickener is carbomer, hyaluronic acid
Any of sodium, pectin, carboxymethyl cellulose gum or ethyl cellulose are several.
6. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the solubilizer is polyoxyethylene hardened castor-oil plant
Oil, Emulsifier EL-60, rilanit special, AEO, aliphatic alcohol polyethenoxy, polyethenoxy ether, polyoxy
Any of ethene sorbitan fatty acid ester, polyglyceryl fatty acid ester are several.
7. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the nourishing additive agent is royal jelly, vitamin
C, any of vitamin E, collagen, tartaric acid or several.
8. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the nertralizer is triethanolamine.
9. matrimony vine facial mask according to claim 1 or 2, it is characterised in that the preservative be parabens,
Any of benzoic acid, sodium benzoate, potassium sorbate, outstanding horse BP, methyl hydroxybenzoate, Nipasol, Phenoxyethanol are several.
10. the preparation method of the matrimony vine facial mask described in claim 1 or 2, it is characterised in that comprise the following steps：
S1. the preparation of matrimony vine：
（1）Wolfberry fruit extract：Appropriate fructus lycii is taken, is concentrated by ultrafiltration after adding pigment broken, adds absolute ethyl alcohol standing, sediment adds
Water is filtered after being completely dissolved, and 3 times repeatedly, obtained sediment is completely dissolved with water again after drying, then carries out ultrafiltration, and solution is dense
Eluted after contracting, wolfberry fruit extract is obtained after freeze-drying；
（2）Wolfberry fruit powder：3h will be dried in vacuo under dried fruit of lycium barbarum low temperature, be then crushed with pulverizer and matrimony vine is obtained after 200 mesh sieves point
Powder；
（3）Matrimony vine essential oil：Appropriate matrimony vine is weighed, after obtaining wolfberry fruit powder by matrimony vine powder, preparation method thereof, is placed in the hot extractor of essence,
Distilled water is added, heats 6h, collects essential oil；
S2. portions of de-ionized water is mixed with NMF in proportion, then adds thickener, stirred to completely molten
Solution, if too thick, adds appropriate phosphoric acid, and slowly stirring cools after being heated up to 80 DEG C of maintenance 20min, obtains thickening fluid；
S3. first deionized water, NMF, solubilizer and preservative are mixed in proportion, is heated up to 90 DEG C and is completely dissolved, be incubated
20min, add S2 gained thickening fluids and stir, be then proportionally added into nertralizer, stir, after being cooled to 45 DEG C,
Add matrimony vine, nourishing additive agent and essence to stir, deaerate；
Sampled at S4.40 DEG C, send initial survey, discharged after initial survey is qualified with 300~500 mesh filter-cloth filterings, produce matrimony vine facial mask liquid.
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| CN111759771A (en) * | 2020-08-06 | 2020-10-13 | 山西火品生物科技有限公司 | Lycium ruthenicum mask and preparation method thereof |
| CN111920722A (en) * | 2020-09-08 | 2020-11-13 | 邓守毅 | Production process of wolfberry facial mask |
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