CN107440969A - A kind of sun-proof renovation agent and its application - Google Patents
A kind of sun-proof renovation agent and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention relates to a kind of sun-proof renovation agent, and it includes following component and its parts by weight：Hydrolyze 40~70 parts of 1~10 part of avenin, 1~10 part of cyclodextrin complexes, 0.5~6 part of Herba Euphrasiae Regelii extract, 0.5~6 part of pearl active peptide, 1~6 part of N acetylglucosamines, 0.01~1 part of phenyllactic acid and water.Described sun-proof renovation agent is in liquid, is tended to smear out, and homogeneous clear and bright shape is kept under high temperature, low temperature, centrifugal condition, good stability, overcome traditional chemical sun-screening agent to separate out micro mist in storage process, block pore, the defects of causing harsh feeling, extend the shelf-life of product.And usage comfort is good, without greasy feeling, and it is easy to absorb, moistness is good, not only has preferably sun-proof performance, and is respectively provided with good repair to damaging such as dry, decortication and redness after solarization, and property is gentle, safe and effective non-stimulated.
Description
Technical field
The present invention relates to cosmetic technical field, and in particular to a kind of sun-proof renovation agent and its application.
Background technology
Injury of the ultraviolet to human body has obtained the common recognition of people, and it, which is mainly shown as, may cause short-term and for a long time tight
Weight effect, short-term effect is mainly shown as sunburn, and long-term effect is often characteristic of concentration, show as erythema, photo-aging,
Disorganization and cutaneum carcinoma etc..Therefore, how to reduce what ultraviolet came to mankind's health care belt as far as possible by using sunscreen product
Adverse effect, is one of topic that cosmetic industry is most popular in recent years.
At present, the sunscreen product majority of in the market commercialization contains chemical sun, such as：The different monooctyl ester of methoxy cinnamic acid,
BP-3, salicylate etc.；A small number of sunscreen products comprise only the natural sun-prevention composition such as titanium dioxide, zinc oxide, but due to
This kind of powder may block pore, and the especially sunscreen product containing titanium dioxide makes consumer skin have unnatural sense of turning white
Feel, and not surface treated powder may fray skin, and the hair that may reunite is thick, cause it is aged after product
Spf value is remarkably decreased, make cosmetic Manufacture business it is difficult to ensure that product quality and in 3 years sun-proof function shelf-lifves it is stable, so as to limit
The extensive use of titanium dioxide, zinc oxide natural sun-prevention composition is made.
Plant sun agent is natural, safety, has whitening spot-removing, anti-aging and other effects concurrently, more and more welcomed by the people,
It is the focus of sun care preparations producer research and development.Compared with chemical sun, plant sun agent to the effect of ultraviolet radiation absorption compared with
It is weak, anti-sunlight function unobvious, and because containing active skull cap components, less stable, there are strict requirements to preparation technology, can be real
The product of existing industrialization production is relatively fewer.If the B of Publication No. CN 101972219 Chinese patent application is " to cosmetics
Spf value has the natural sun-prevention composition of building capability ", wherein the matrix formulations spf value of chemical sun is 14.2, is being added
After 2% radix scutellariae root extract solution, 2% Purslane extract and 1% hydrolyzed wheat protein/PVP cross-linked polymers, formula
SPF just lifted to 16.1, it is seen that the contribution of natural sun-screening agents in common document to being formulated spf value is very limited.
Therefore, it is necessary to provide, a kind of sun-proof result is notable, and property is stable, can realize the natural sun-prevention of industrialization production
Agent, to meet the needs of market.
The content of the invention
To solve the problems, such as that prior art is present, it is an object of the invention to provide a kind of sun-proof renovation agent, the renovation agent
Quality is slim and graceful, naturally comfortable after use not have greasy feeling, and each composition is mutually coordinated, and sun-proof result is notable, no skin irritation,
Safe, property is stable.
Technical scheme is as follows：
A kind of sun-proof renovation agent, it includes following component and its parts by weight：Hydrolyze 1~10 part of avenin, cyclodextrin
1~10 part of compound, 0.5~6 part of Herba Euphrasiae Regelii extract, 0.5~6 part of pearl active peptide, 1~6 part of N-Acetyl-D-glucosamine, benzene
40~70 parts of 0.01~1 part of lactic acid and water.
Preferably, described sun-proof renovation agent includes following component and its parts by weight：Hydrolyze 4~6 parts of avenin, ring
4~8 parts of dextrin compound, 1~2 part of Herba Euphrasiae Regelii extract, 2~4 parts of pearl active peptide, 2~4 parts of N-Acetyl-D-glucosamine, benzene
60~70 parts of 0.2~0.6 part of lactic acid and water.
Further, described cyclodextrin complexes by cyclodextrine derivatives and active components of plants with 1:0.01~0.4
Mass ratio composition；Described active components of plants is by chlorophyll and lycopene with 1:0.1~1 mass ratio composition.
Preferably, described cyclodextrin complexes by cyclodextrine derivatives and active components of plants with 1:0.2 mass ratio
Composition；Described active components of plants is by chlorophyll and lycopene with 1:0.6 mass ratio composition.
Further, described cyclodextrine derivatives are cyclodextrin grafting fiber konjak portuguese gansu polyose sugar derivatives.
Specifically, the preparation of above-mentioned cyclodextrin complexes comprises the following steps：
(1) prepared by cyclodextrine derivatives：Weigh cyclodextrin and be dissolved in water, the solution that concentration is 2% (m/v) is made, is stirring
Under the conditions of konjaku glucomannan is added in a manner of equal increments, stir to solution clarify after, be added dropwise sodium tripolyphosphate solution, institute
Final concentration of 1~2% (m/v) of the sodium tripolyphosphate stated in the solution, continue 30~60min of stirring, be vortexed 5~10min, will
Liquid centrifuges 15min under 20000rpm rotating speed, takes precipitation, vacuum freeze drying 12h, produces cyclodextrin grafting fiber Amorphophallus rivieri glucomannan
Polysaccharid derivative；
(2) prepared by cyclodextrin complexes：Weigh active components of plants to be dissolved with ethanol, be slowly added dropwise into advance dissolving ring paste
Smart derivative saturated aqueous solution, magnetic therapy stirring 30~60min of hydration reaction, is stored at room temperature 1~2h, is dried under reduced pressure, cross 80~150
Mesh sieve, produce cyclodextrin complexes.
Further, the addition of konjaku glucomannan is the 10~30% of cyclodextrin weight in above-mentioned steps (1).
In the sun-proof renovation agent of the present invention, chlorophyll and lycopene are natural fat-soluble pigment, have light absorbs
Performance, there is preferable synergistic function.Cyclodextrin is creatively performed the derivatization processing by the present invention, is prepared cyclodextrin and is connect
Branch konjak portuguese gansu polyose sugar derivatives, using the cavity structure of cyclodextrin, chlorophyll and lycopene are coated in, greatly improve
Both solubility properties and stability, avoid degradation of the extraneous factor to chlorophyll and lycopene, so as to fully send out
The absorption of chlorophyll and lycopene to visible ray and ultraviolet is waved, so as to obtain preferable sun-proof result.Meanwhile side chain
The konjaku glucomannan of grafting, cyclodextrin inclusion compound can be made to form very thin one layer in the position of smearing in use thin
Film, make sun-proof renovation agent more pro-skin docile, avoid sweat etc. from promoting sun-screening agent to be lost in too early, effect is more lasting.
In the sun-proof renovation agent of the present invention, pearl active peptide is pearl fine powder by high-frequency high-voltage stream process by shell angle egg
The small active peptides that white degraded obtains, with Herba Euphrasiae Regelii extract compounding use, there is the effect of preferable after-sun, mitigate thin
Born of the same parents' oxidative damage and the apoptosis of ultraviolet mediation, accelerate cell metabolism, promote the synthesis such as hyaluronic acid, suppress tyrosine
Enzymatic activity, so as to reach elimination color spot, promote to repair, the effect of skin-active tender skin, to UV-induced erythema, photic old
The inhibition of phenomena such as change is good.
Compared with conventional Nano pearl powder, pearl active peptide dissolubility of the invention is good, and bioavilability is high, with this hair
The Miscibility of bright sun-proof renovation agent is high, long-term storage, is not in that crystallite separates out, will not more occur with cyclodextrin complexes
Aggregation.Also, small-molecular peptides of the pearl active peptide as solubility, can promote Herba Euphrasiae Regelii extract to permeate skin, may be used also
Significantly mitigate the wrinkling of skin, be advantageous to the surface that sun-proof renovation agent is fully pasted on skin, play a role.
Specifically, the preparation of above-mentioned pearl active peptide comprises the following steps：
(1) pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios, 60% (m/v) sodium lactate aqueous solution is added, surpassed
Sound mixes, and adds malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.2~0.5%,
At room temperature, toward normal pressure forward current is first passed through in solution, handle after being passed through the reverse 5~10s of current processing of normal pressure after 10~15s
High-frequency high-voltage current is passed through, is cut off the electricity supply after handling 60~90min, obtains treatment fluid；
(2) appropriate glycine buffer, modulation pH to neutrality, Ran Houli are added dropwise in the treatment fluid obtained toward step (1)
The heart, supernatant is collected, supernatant is dried under reduced pressure, produced.
Further, being passed through normal pressure forward current processing time in the preparation process (1) of described pearl active peptide is
12s, it is 6s to be passed through the normal pressure reverse current processing time.
Further, the frequency of preparation process (1) medium-high frequency high-tension current of described pearl active peptide be 6000~
9000 hertz, voltage is 4000~8000 volts.
In above-mentioned pearl active peptide preparation technology, the present inventor creatively utilizes high-frequency high-voltage stream process pearl
Fine powder, in the presence of electric field force, the organic molecule such as Chitosan-alginate microcapsules is polarized, and shows electric polarity, and intermolecular gravitation is destroyed,
Intermolecular distance increases, and malic acid is fully acted on inside pearl fine powder, then be passed through high-frequency high-voltage current and pass through caused by it
Vibration, makes protein molecular degrade to form small-molecular peptides, compared with the enzymatic isolation method of routine, the pearl active peptide content of the invention harvested
Height, solubility property are good.
In addition, the present invention also provides a kind of above-mentioned sun-proof renovation agent has sun-proof repair function cosmetics in preparation
In application.
Compared with prior art, advantage of the invention is that：
(1) sun-proof renovation agent usage comfort provided by the invention is good, without greasy feeling, and is easy to absorb, moistness
It is good, not only there is preferably sun-proof performance, and damage after solarization such as dry, decortication and redness are respectively provided with good reparation and made
With property is gentle, safely and effectively non-stimulated.
(2) sun-proof renovation agent provided by the invention is in liquid and tends to smear out, protected under high temperature, low temperature, centrifugal condition
Homogeneous clear and bright shape is held, good stability, overcomes traditional chemical sun-screening agent to separate out micro mist in storage process, blocks pore, is caused thick
The defects of rough sense, extend the shelf-life of product.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.
The preparation of the cyclodextrine derivatives of embodiment 1
Weigh 100g cyclodextrin and be dissolved in water, the solution that concentration is 2% (m/v) is made, under agitation with equal increments
Mode add 20g konjaku glucomannans, stir to solution clarify after, be added dropwise sodium tripolyphosphate solution, described tripolyphosphate
Final concentration of 1% (m/v) of sodium in the solution, continue to stir 40min, vortex 8min, by liquid under 20000rpm rotating speed
15min is centrifuged, precipitation is taken, vacuum freeze drying 12h, produces cyclodextrin grafting fiber konjak portuguese gansu polyose sugar derivatives.
The preparation of the cyclodextrin complexes of embodiment 2
| Group | Cyclodextrine derivatives | Active components of plants |
| A groups | Cyclodextrine derivatives 100g made from embodiment 1 | 20g (contains chlorophyll：12.5g, lycopene 7.5g) |
| B groups | Cyclodextrine derivatives 100g made from embodiment 1 | 20g (contains chlorophyll：5g, lycopene 5g) |
| C groups | Cyclodextrine derivatives 100g made from embodiment 1 | 20g (only containing chlorophyll) |
| D groups | Replace with cyclodextrin 100g | 20g (contains chlorophyll：12.5g, lycopene 7.5g) |
It is prepared by A groups cyclodextrin complexes：
Chlorophyll and lycopene are weighed, is mixed, is dissolved, be slowly added dropwise into the cyclodextrine derivatives dissolved in advance with ethanol
Saturated aqueous solution, magnetic therapy stirring hydration reaction 40min, is stored at room temperature 1h, is dried under reduced pressure, cross 80 mesh sieves, it is compound to produce cyclodextrin
Thing.
The preparation of B-D group cyclodextrin complexes refers to above-mentioned A groups.
The preparation of the pearl active peptide of embodiment 3
(1) pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios, 60% (m/v) sodium lactate aqueous solution is added, surpassed
Sound mixes, and adds malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.4%, in room temperature
Under, normal pressure forward current is first passed through into solution, high-frequency high-voltage is passed through after being passed through the reverse current processing 6s of normal pressure after processing 12s
Stream, the frequency of electric current is 7000 hertz, and voltage is 5000 volts, is cut off the electricity supply after handling 60min, obtains treatment fluid；
(2) appropriate glycine buffer, modulation pH to neutrality, Ran Houli are added dropwise in the treatment fluid obtained toward step (1)
The heart, supernatant is collected, supernatant is dried under reduced pressure, produces pearl active peptide.
With reference to Chinese patent CN 103333222B " a kind of Pearl natural active peptide and its extraction side with whitening function
Liquid phase chromatogram condition in method and application " detects to pearl active peptide obtained above, obtained pearl active peptide molecule
For amount in 100~500Da contents up to more than 60%, small molecule active peptide content is high.
Embodiment 4-5 and the sun-proof renovation agents of comparative example 1-5 preparation
The composition of 4-5 of the embodiment of the present invention and the sun-proof renovation agents of comparative example 1-5 see the table below shown (counting in parts by weight), its
Middle pearl active peptide is prepared by embodiment 3.
The preparation of 4 sun-proof renovation agent of embodiment：
Take cyclodextrin complexes to be dissolved in water, sequentially add hydrolysis avenin, Herba Euphrasiae Regelii extract, pearl active peptide, N-
Acetylglucosamine, phenyllactic acid, it is well mixed, it is filling while hot, room temperature is cooled to, is produced.
The preparation of embodiment 5 and the sun-proof renovation agents of comparative example 1-5 refers to above-mentioned method.
Test example one, human skin patch
With reference to 2015 editions of Ministry of Public Health's issue《Cosmetics health specification》In " human skin patch " related request
4-5 of the embodiment of the present invention, comparative example 1-5 sun-proof renovation agent are tested with assay method, respectively 0h, 6h, 12h,
24h, 48h observe dermoreaction, and the experimental result of all trial volunteers is negative findings, does not occur skin adverse reaction.
Show that sun-proof renovation agent provided by the invention is nonirritant, it is safe.
Test example two, stability test
Take 4-5 of the embodiment of the present invention, comparative example 1-5 sun-proof renovation agent, carry out high and low temperature storage stability test and
Dewatering ability experiment investigation, experimental condition：1) thimble test：Placed 30 days in 40 DEG C of electro-heating standing-temperature cultivators,
Observed after recovering room temperature；2) low-temperature stability is tested：Deposited 1 week at -15 DEG C, observe its stability；3) dewatering ability tries
Test：4000r/min × 30min, it is as a result as shown in table 1 below.
The sun-proof renovation agent Detection of Stability result of each group of table 1
| Group | Outward appearance | High-temperature stability | Low-temperature stability | Dewatering ability |
| Embodiment 4 | Homogeneous clear liquid | Normally | Normally | Normally |
| Embodiment 5 | Homogeneous clear liquid | Normally | Normally | Normally |
| Comparative example 1 | Homogeneous clear liquid | Normally | Normally | Normally |
| Comparative example 2 | Homogeneous clear liquid | Normally | Layering | Layering |
| Comparative example 3 | Homogeneous clear liquid | Normally | Normally | Normally |
| Comparative example 4 | Homogeneous clear liquid | Normally | Normally | Normally |
| Comparative example 5 | Homogeneous clear liquid | Layering | Layering | Layering |
As seen from the above table, sun-proof renovation agent stability made from the embodiment of the present invention 4 and 5 is good, under high temperature, cryogenic conditions
Storage carries out centrifugal test, keeps homogeneous clear and bright liquid condition.From comparative example 2, plant is lived using cyclodextrin
Property composition carry out inclusion compound preparation, further stability is good under the high temperature conditions for obtained sun-proof renovation agent, but in cryogenic conditions
And occur lamination under centrifugal test, show to carry out cyclodextrin konjac glucomannan grafted, to be prepared ring paste
Smart derivative can improve stability of the cyclodextrin complexes in system.From comparative example 5, this is replaced using Nano pearl powder
The pearl active peptide of invention carries out sun-proof renovation agent preparation, homogeneous clear liquid is obtained, under high temperature, low temperature and centrifugal condition
It is unstable, there is lamination.
Test example three, sun-proof performance test
Sun-proof renovation agent made from 4-5 of the embodiment of the present invention, comparative example 1-5 is carried out respectively SPF (spf value) and
Long wave ultraviolet protection index (PFA values) determines, and concrete scheme is：1) SPF is determined：With reference to the Ministry of Public Health《Cosmetics health specification》
The related request of " sun care preparations SPF (spf value) assay method " and assay method are carried out in (version in 2007).2)PFA
Value measure：With reference to the Ministry of Public Health《Cosmetics health specification》" sun care preparations long wave ultraviolet protection index in (version in 2007)
The related request and assay method of (PFA values) assay method " are carried out, and result of the test see the table below shown in 2.
The sun-proof result testing result of the sun-proof renovation agent of each group of table 2
| Group | Embodiment 4 | Embodiment 5 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Spf value | 27 | 25 | 10 | 22 | 18 | 14 | 18 |
| PFA values | 9 | 8 | 2 | 6 | 5 | 4 | 6 |
| PA grades | PA+++ | PA+++ | PA+ | PA++ | PA++ | PA+ | PA++ |
As seen from the above table, more than 25, PA grades reach the spf value of sun-proof renovation agent made from 4-5 of the embodiment of the present invention
To PA+++, illustrate that sun-proof renovation agent provided by the invention is respectively provided with good absorption and barrier property, sun-proof effect to UVB and UVA
Fruit is notable.From comparative example 1, lycopene can effectively improve the sun-proof performance of sun-proof renovation agent with chlorophyll compounding use；
From comparative example 2, compared with cyclodextrin, cyclodextrin grafting fiber konjaku glucomannan has one to the sun-proof result of sun-proof renovation agent
Fixed facilitation；From comparative example 3,4,5, lack Semen setariae extract or pearl active peptide, or replace with Nano pearl powder
Pearl active peptide, the sun-proof result that sun-proof renovation agent is made weaken, and show that Semen setariae extract and pearl active peptide have necessarily
Sun-proof result.
Test example four, after-sun performance test
Screening face has the volunteer patients 120 damaged after solarization in various degree, and injury symptoms are respectively red and swollen, de- after solarization
Skin and drying, are randomly divided into 6 groups, every group of 20 people, respectively embodiment 4, comparative example 1-5 groups, each group respectively using embodiment 4,
Sun-proof renovation agent made from comparative example 1-5, respectively use 1 time, be used continuously 2 weeks sooner or later, evaluation and use feeling, according to use
Effect 0~10/marking, 9~10 points be it is fine, 7~8 points be it is preferable, 5~6 points be it is general, 3~4 points be it is poor, 1
~2 points are very poor, are averaged, and evaluate the situation of skin injury reparation after each group volunteer patients shine, and as a result see the table below 3 and 4
It is shown.
The sun-proof renovation agent of each group of table 3 uses Analyses Methods for Sensory Evaluation Results
| Index | Embodiment 4 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Assimilation effect | 9.4 | 8.6 | 8.0 | 7.2 | 6.8 | 7.9 |
| Stretchability | 9.0 | 9.0 | 8.5 | 8.3 | 8.2 | 8.0 |
| Salubrious degree | 8.8 | 8.2 | 8.2 | 7.9 | 7.8 | 8.2 |
| Moistness | 9.2 | 8.5 | 8.4 | 7.0 | 6.7 | 7.7 |
| Common sensation | 9.2 | 8.4 | 8.2 | 7.5 | 7.2 | 7.8 |
The after-sun effect of the sun-proof renovation agent of each group of table 4
From upper table 3, there is no greasy feeling using sun-proof adsorbent made from the embodiment of the present invention 4, salubrious degree is good, and
It is easy to absorb, there is preferable moistness, hence it is evident that better than renovation agent made from comparative example 1-4.
From upper table 4, sun-proof renovation agent made from the embodiment of the present invention 4 not only has preferable sun-proof performance, and
To caused malaise symptoms after solarization as dried, decortication and it is red and swollen be respectively provided with certain therapeutic effect, repairing for wound after shining can be promoted
It is multiple.From comparative example 1-5, in formula the change of composition there is different degrees of influence to the repair function of sun-proof renovation agent,
The injury symptoms especially after Herba Euphrasiae Regelii extract, pearl active peptide is lacked to solarization in prescription：Dry, decortication and the influence of redness
It is maximum.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of sun-proof renovation agent, it is characterised in that described sun-proof renovation agent includes following component and its parts by weight：Hydrolysis
1~10 part of avenin, 1~10 part of cyclodextrin complexes, 0.5~6 part of Herba Euphrasiae Regelii extract, 0.5~6 part of pearl active peptide,
40~70 parts of 1~6 part of N-Acetyl-D-glucosamine, 0.01~1 part of phenyllactic acid and water.
2. sun-proof renovation agent according to claim 1, it is characterised in that described sun-proof renovation agent include following component and
Its parts by weight：Hydrolyze 4~6 parts of avenin, 4~8 parts of cyclodextrin complexes, 1~2 part of Herba Euphrasiae Regelii extract, pearl active
60~70 parts of 2~4 parts of peptide, 2~4 parts of N-Acetyl-D-glucosamine, 0.2~0.6 part of phenyllactic acid and water.
3. sun-proof renovation agent according to claim 1 or 2, it is characterised in that described cyclodextrin complexes are by cyclodextrin
Derivative and active components of plants are with 1:0.01~0.4 mass ratio composition；Described active components of plants by chlorophyll and kind
Lycopene is with 1:0.1~1 mass ratio composition, described cyclodextrine derivatives derive for cyclodextrin grafting fiber konjaku glucomannan
Thing.
4. sun-proof renovation agent according to claim 3, it is characterised in that described cyclodextrin complexes are derived by cyclodextrin
Thing and active components of plants are with 1:0.2 mass ratio composition；Described active components of plants is by chlorophyll and lycopene with 1:
0.6 mass ratio composition.
5. sun-proof renovation agent according to claim 3, it is characterised in that the preparation of described cyclodextrin complexes include with
Lower step：
(1) prepared by cyclodextrine derivatives：Weigh cyclodextrin and be dissolved in water, the solution that concentration is 2% (m/v) is made, in stirring condition
Under konjaku glucomannan is added in a manner of equal increments, stir to solution clarify after, be added dropwise sodium tripolyphosphate solution, it is described
Final concentration of 1~2% (m/v) of sodium tripolyphosphate in the solution, continue 30~60min of stirring, be vortexed 5~10min, by liquid
15min is centrifuged under 20000rpm rotating speed, precipitation is taken, vacuum freeze drying 12h, produces cyclodextrin grafting fiber konjaku glucomannan
Derivative；
(2) preparation of compound：Weigh active components of plants to be dissolved with ethanol, be slowly added dropwise and derive into the cyclodextrin dissolved in advance
Thing saturated aqueous solution, magnetic therapy stirring 30~60min of hydration reaction, is stored at room temperature 1~2h, is dried under reduced pressure, cross 80~150 mesh sieves,
Produce cyclodextrin complexes.
6. sun-proof renovation agent according to claim 5, it is characterised in that konjaku glucomannan adds in the step (1)
Enter 10~30% that amount is cyclodextrin weight.
7. sun-proof renovation agent according to claim 1 or 2, it is characterised in that the preparation of described pearl active peptide includes
Following steps：
(1) pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios, add 60% (m/v) sodium lactate aqueous solution, and ultrasound is mixed
It is even, add malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.2~0.5%, in room
Under temperature, normal pressure forward current is first passed through into solution, is passed through after being passed through the reverse 5~10s of current processing of normal pressure after 10~15s of processing
High-frequency high-voltage current, cut off the electricity supply after handling 60~90min, obtain treatment fluid；
(2) appropriate glycine buffer is added dropwise in the treatment fluid obtained toward step (1), modulation pH to neutrality, is then centrifuged for, receives
Collect supernatant, supernatant is dried under reduced pressure, produced.
8. the sun-proof renovation agent described in claim 7, it is characterised in that lead in the preparation process (1) of described pearl active peptide
It is 12s to enter normal pressure forward current processing time, and it is 6s to be passed through the normal pressure reverse current processing time.
9. the sun-proof renovation agent described in claim 7, it is characterised in that high in the preparation process (1) of described pearl active peptide
The frequency of frequency high-tension current is 6000~9000 hertz, and voltage is 4000~8000 volts.
10. a kind of sun-proof renovation agent as described in claim 1-9 is any is in preparing with sun-proof repair function cosmetics
Using.
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