CN107440098A - A kind of full nutrition special medicine purposes emulsion and preparation method thereof - Google Patents

A kind of full nutrition special medicine purposes emulsion and preparation method thereof Download PDF

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Publication number
CN107440098A
CN107440098A CN201710685810.9A CN201710685810A CN107440098A CN 107440098 A CN107440098 A CN 107440098A CN 201710685810 A CN201710685810 A CN 201710685810A CN 107440098 A CN107440098 A CN 107440098A
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vitamin
calcium
full nutrition
sodium
special medicine
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来燕
金永洋
翁洪刚
王博
钱启军
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Zhejiang Yi Element Food Co Ltd
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Zhejiang Yi Element Food Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention relates to full nutrition formula food, discloses a kind of full nutrition special medicine purposes formula emulsion and preparation method thereof, the emulsion contains protein, carbohydrate, fat, compound stabilizer, acidity regulator, vitamin A, vitamin D3, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, D calcium pantothenates, folic acid, biotin, vitamin C, inositol, L carnitine tartrates, calcium, iodine, magnesium, iron, zinc, sodium, manganese, copper, potassium, phosphorus, Glu, yeast beta-dextran etc., reasonable mixture ratio, limited diet, metabolic disorder, post-operative recovery, the nutritional need for the crowd that has a delicate constitution can be met, make emulsion that there is good stability by compound stabilizer, adding other is beneficial to the nutriment of human body, improves nutrition；Medical effect is improved, reduces comprehensive spend；Different material is handled respectively in preparation process, raw material availability is high, and dissolving is abundant, finished product stable homogeneous.

Description

A kind of full nutrition special medicine purposes emulsion and preparation method thereof
Technical field
The present invention relates to full nutrition formula food, more particularly to a kind of full nutrition special medicine purposes emulsion and its preparation Method.
Background technology
Full nutrition formula food is the special medicine purposes that can meet target group's nutritional need as single source of nutrition Formula food.Full nutrition medical food be suitable for it is most of still belong to normal patient without dysbolism, gastrointestinal function, be particularly into Appetite is less or full diet can not meet the patient of its nutritional need, and the patient before and after surgical operation is carried out is also suitable.This Class medical food can improve nutrition condition, correct negative nitrogen balance, strengthen Abwehrkraft des Koepers；In surgery, preoperative use patient has foot Enough nutrition deposits, can increase the tolerance to performing the operation and anaesthetizing；Postoperative supplement, the complication such as infection are advantageously reduced, promoted The healing of wound.Full nutrition medical food contains energy supply and matches suitable carbohydrate, protein and fat, also containing comprehensive and abundant Vitamin, mineral matter.Using such product for a long time as unique enteral nutrition source, body health can be maintained, promotes disease Recover.
Current wholefood based on electuary, it is necessary to user voluntarily brews, it is inconvenient for use, and user is difficult to handle Water temperature and water are controlled, causes the liquid after brewing not homogeneous enough, stably, dissolving is insufficient.The full nutrition formula food of emulsion-type Because component is complicated, the shortcomings that generally existing stability difference, Chinese invention patent application text that publication No. is CN106616987A Part discloses a kind of dual anti-oxygen formulation nutrition emulsion, under optimal component content, emulsion is had good stability.This technology Scheme is made emulsion still have preferable stability after long-time, sought simultaneously by a kind of new proportioning using compound stabilizer Support more fully, it is more extensive to be applicable crowd.
The content of the invention
The present invention for being formulated the shortcomings that single in the prior art, there is provided a kind of full nutrition special medicine purposes emulsion and Its preparation method, coordinate enhancing stability by compound stabilizer and other supplementary materials of optimal proportion, add fixed mixing ratio Promotion cell mucous membrane recover, improve immunity material, avoid patient recur and and malnutritive related complication, improvement Nutrition intake, improves medical effect, and this product is applied to limited diet, metabolic disorder, post-operative recovery, people of weak constitution group.
In order to solve the above-mentioned technical problem, the present invention is addressed by following technical proposals：A kind of special doctor of full nutrition Purposes emulsion is learned, it is characterized in that the product includes following component per 1000g：
Preferably, protein is the mixture of milk protein powder, concentrated whey protein powder and soybean protein isolate, often The 1000g products include 19~63g of milk protein powder, 4~14g of concentrated whey protein powder, 2~6g of soybean protein isolate.
Preferably, carbohydrate is the mixture of maltodextrin, white granulated sugar, soybean polyoses and inulin, should per 1000g Product includes 71~175g of maltodextrin, 14~32g of white granulated sugar, 5~11g of soybean polyoses, 6~13g of inulin.
Preferably, adipose-derived one kind or several in soybean oil, coconut oil, sunflower oil, corn oil, rapeseed oil Kind.
Preferably, compound stabilizer includes the mixture of stabilizer and emulsion stabilizer, stabilizer is sodium tripolyphosphate, Include 0.003~0.302g of sodium tripolyphosphate per the 1000g products, emulsion stabilizer is gellan gum, xanthans and list, diglycerol The mixture of fatty acid ester, per 1000g, the product includes 0.002~0.193g of gellan gum, 0.002~0.161g of xanthans, list, 0.003~0.294g of diglycerine fatty acid ester.
Preferably, acidity regulator is the mixture of sodium citrate and sodium acid carbonate, per 1000g, the product includes lemon Sour 0.007~0.665g of sodium, 0.003~0.285g of sodium acid carbonate.
Preferably, sodium is derived from sodium acid carbonate, sodium dihydrogen phosphate, sodium citrate, sodium chloride and disodium hydrogen phosphate It is one or more of.
Preferably, potassium is derived from K-IAO, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride One or more.
Preferably, copper derives from the one or more in copper sulphate, copper gluconate, copper citrate and copper carbonate.
Preferably, magnesium is derived from magnesium sulfate, magnesium chloride, magnesia, magnesium carbonate, magnesium monohydrogen phosphate and magnesium gluconate It is one or more of.
Preferably, iron is from ferrous sulfate, ferrous gluconate, ferric citrate, ferrous fumarate, citric acid One or more in iron, ferric pyrophosphate and sodium iron ethylene diamine tetra acetate.
Preferably, zinc derives from zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, zinc citrate, zinc chloride and second One or more in sour zinc.
Preferably, manganese derive from manganese sulfate, manganese chloride, manganese carbonate, manganese citrate and manganese gluconate in one kind or It is several.
Preferably, calcium source is in calcium carbonate and calcium gluconate, calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, chlorination One or more in calcium, tricalcium phosphate, calcium glycerophosphate, calcium oxide, calcium sulfate, wherein the product includes carbonic acid per 1000g 0.05~1.7g of calcium.
Preferably, phosphorus derives from the one or more in tricalcium phosphate and calcium monohydrogen phosphate.
Preferably, iodine derives from the one or more in Potassiumiodate, KI and sodium iodide.
Preferably, selenium derives from the one or more in sodium selenate and sodium selenite.
In the present invention in the present invention, protein comes from milk protein powder, concentrated whey protein powder and soybean protein isolate, carries For the protein of needed by human body；
Carbohydrate comes from maltodextrin, white granulated sugar and soybean polyoses, there is provided the carbohydrate of needed by human body；
Fat is from refining vegetable oils such as soybean oil, coconut oil, sunflower oil, corn oil, rapeseed oils；
Gellan gum, xanthans, list, diglycerine fatty acid ester are emulsion stabilizer, make emulsion finished product stable uniform；
Sodium tripolyphosphate is stabilizer, and stabilizer coordinates with emulsion stabilizer, has to the stability of emulsion finished product and greatly carries Rise；
Sodium citrate is acidity regulator, adjusts latex pH, there is provided the sodium of needed by human body, citrate are easily metabolized, Avoid the intake of excess of chloride ion；
Sodium acid carbonate is acidity regulator, adjusts latex pH, there is provided the sodium of needed by human body；
Vitamin A (retinol acetate) is vitamin needed by human；
Vitamin D3(Vitamin D3) provides vitamin needed by human；
Vitamin E (dl- α-D-α-tocopherol acetate) provides vitamin needed by human；
Vitamin K1(phytondione) provides vitamin needed by human；
Vitamin B1(thiamine hydrochloride) provides vitamin needed by human；
Vitamin B2(riboflavin) provides vitamin needed by human；
Vitamin B6(puridoxine hydrochloride) provides vitamin needed by human；
Vitamin B12(cyanocobalamin) provides vitamin needed by human；
Niacinamide provides vitamin needed by human；
D-VB5 calcium provides vitamin needed by human；
Folic acid provides vitamin needed by human；
Biotin provides vitamin needed by human；
Vitamin C (L-AA sodium) provides vitamin needed by human；
Inositol provides vitamin needed by human；
VBT tartrate provides vitamin needed by human；
Calcium carbonate, calcium gluconate, calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium chloride, tricalcium phosphate, phosphoglycerol Calcium, calcium oxide and calcium sulfate provide electrolytic calcium ion test；
Potassiumiodate, KI and sodium iodide provide the trace iodine of needed by human body；
Magnesium sulfate, magnesium chloride, magnesia, magnesium carbonate, magnesium monohydrogen phosphate and magnesium gluconate provide electrolyte magnesium；
Ferrous sulfate, ferrous gluconate, ferric citrate, ferrous fumarate, ironic citrate, ferric pyrophosphate and ethylenediamine Tetraacethyl ferrisodium provides the trace elements iron of needed by human body；
Zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, zinc citrate, zinc chloride and zinc acetate provide needed by human body Trace element zinc；
Sodium selenate and sodium selenite will provide the trace elements of selenium of needed by human body；
Manganese sulfate, manganese chloride, manganese carbonate, manganese citrate and manganese gluconate provide the trace element manganese of needed by human body；
Copper sulphate, copper gluconate, copper citrate and copper carbonate provide the trace copper of needed by human body；
K-IAO, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride provide the electrolyte of needed by human body Potassium；
Tricalcium phosphate and calcium monohydrogen phosphate provide the phosphorus of needed by human body；
Glu can promote cell mucous membrane to recover；
Yeast beta-dextran can improve body immunity；
Choline bitartrate assists fat metabolism and transhipment；
Taurine maintains brain normal function, improves memory, protects eyesight.
The preparation method of above-mentioned full nutrition special medicine purposes emulsion：
Step 1：The purified water of normal temperature is added in mixing tank, adds fat and protein, shearing；
Step 2：Compound stabilizer is uniformly mixed with carbohydrate in a reservoir, obtains compound stabilizer and carbon aquation The mixture of compound；
Step 3：The mixture of compound stabilizer and carbohydrate is added in the batch mixing filling in stirring, circulation is cut Cut；
Step 4：After feed liquid during batch mixing is filled stirs 3~9min, Glu, yeast beta-dextran, carbonic acid are added Calcium and the mineral matter in source as calcium；
Step 5：Using as phosphorus, iodine, sodium, magnesium, iron, zinc, selenium, manganese, copper, potassium source minerals and vitamins A, dimension life Plain D3, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, D-VB5 calcium, leaf Acid, biotin, vitamin C, inositol, VBT tartrate, choline bitartrate and taurine are dissolved in normal temperature purified water, Obtain small powder solution；
Step 6：Small powder solution is added in the batch mixing filling under stirring；
Step 7：The feed liquid mixed during batch mixing is filled is squeezed into shearing tank, stirring shearing；
Step 8：The feed liquid sheared in tank after stirring shearing is passed through into 60~200 mesh screens；
Step 9：Feed liquid after filtering is squeezed into constant volume tank, determined under static state with 20~30 DEG C of purified water moisturizings Hold, stirring, add acidity regulator；
Step 10：Feed liquid is passed through into 80~200 mesh screens；
Step 11：Feed liquid is subjected to homogenization.
Preferably, normal temperature purified water is 20~30 DEG C of purified water；
Shear time is 8~18min in step 1；
The circulation shear time is 7~20min in step 3；
It is 6~20min that shear time is stirred in step 7；
Mixing time in step 9 is 2~18min；
Homogenizing temperature in step 11 is 60~80 DEG C, and homogenization pressure is 200~450MPa/8Mpa.
Purified water is 20~30 DEG C of normal temperature purified water, and the water of normal temperature state makes emulsion finished product more stable；Raw material is pressed Classification difference remixes after changing powder hydration or dissolving respectively, makes dissolution of raw material mixing more abundant；Homogeneous is carried out after filtering, goes grease removal Fat grain, the finished product system prepared by this technique are more stable (reference picture 1,2)；It is above-mentioned to prepare without inert gas environment Without high temperature in journey, preparation condition requires low.
The present invention has significant technique effect as a result of above technical scheme：Reasonable mixture ratio, diet can be met The daily nutritional need of limited, metabolic disorder, post-operative recovery, people of weak constitution group, has emulsion by compound stabilizer Good stability, adding other is beneficial to the nutriment of human body, improves nutrition；Postoperative patient uses 2-3 days, can reduce Patient readmission rate, recurrence and the complication related to malnutrition；Improve the intake of nutrition, improve the function of nutrition, very To the final result for improving clinical nutrition；Medical effect is improved, improves quality of life of patients, reduces sick comprehensive cost.Preparation side Method is high to raw material availability, and dissolving is abundant, and finished product is stable, homogeneous.
Brief description of the drawings
Fig. 1 is the microscope figure of the non-homogeneous of full nutrition special medicine purposes emulsion.
Fig. 2 is the microscope figure after full nutrition special medicine purposes emulsion homogeneous.
Embodiment
Embodiment 1
According to the form below takes required raw material：
500g normal temperature purified waters are added in mixing tank, add soybean oil, coconut oil, milk protein powder, condensed whey egg White powder, soybean protein isolate, high speed shear fully dissolve for 8 minutes to protein liquid, it is no caking, without particle, without grease float when, it is quiet Sealing closes.
In a reservoir by gellan gum, xanthans, list, diglycerine fatty acid ester, sodium tripolyphosphate, maltodextrin, white granulated sugar, Inulin, soybean polyoses are added after uniformly mixing in the batch mixing filling in stirring, the mixing in circulation shear 7min to mixing tank Thing dissolving is complete, no caking, without floccule, without particle.
After feed liquid stirring 6min during batch mixing is filled, Glu, yeast beta-dextran and calcium carbonate are added.
By remaining dissolution of raw material in 30g normal temperature purified waters, the aqueous solution is obtained, the aqueous solution is added under stirring During batch mixing fills.
The feed liquid mixed during batch mixing is filled is squeezed into shearing tank, by 80 mesh screens after stirring shearing 14min, incited somebody to action Feed liquid after filter is squeezed into constant volume tank, is under static state 1000g with normal temperature purified water moisturizing to feed liquid, stirs 2min, will Feed liquid passes through 150 mesh screens.
Feed liquid is subjected to homogenization, 60 DEG C of homogenizing temperature, homogenization pressure 450MPa/8Mpa, it is special to produce full nutrition Medical usage emulsion.
Following component is contained per 1000g by full nutrition special medicine purposes emulsion finished product prepared by the above method：
Title Quality Title Quality
Protein 37.6g Carbohydrate 116.5g
Fat 32.9g Compound stabilizer 395mg
Acidity regulator 56.4mg Vitamin A 78μg
Vitamin D3 11.2μg Vitamin E 1.87mg
Vitamin K1 53.6μg Vitamin B1 1.69mg
Vitamin B2 2mg Vitamin B6 1.8mg
Vitamin B12 5.5μg Niacinamide 7.5mg
D-VB5 calcium 10.2mg Folic acid 273μg
Biotin 39.4μg Vitamin C 94mg
Inositol 84mg VBT tartrate 137.8mg
Calcium 639mg Phosphorus 479mg
Iodine 80.8μg Sodium 0.99g
Magnesium 216mg Iron 11.2mg
Zinc 11.2mg Selenium 95.9μg
Manganese 376μg Copper 545μg
Potassium 1.3g Glu 2.4g
Yeast beta-dextran 9.4mg Choline bitartrate 560mg
Taurine 82.7mg
Product nutritional ingredient such as following table：
Normal temperature laboratory is placed in after emulsion is sealed, lighting and ventilation well locates the testing result such as following table after preserving 12 months：
Embodiment 2
According to the form below takes required raw material：
Preparation process is substantially the same manner as Example 1, distinguishes and passes through 60 mesh screens, step 10 in the feed liquid in step 8 In feed liquid pass through 80 mesh screens.
Following component is contained per 1000g by full nutrition special medicine purposes emulsion finished product prepared by the above method：
Title Quality (g) Title Quality (g)
Protein 25g Carbohydrate 231g
Fat 20g Compound stabilizer 600mg
Acidity regulator 950mg Vitamin A 9mg
Vitamin D3 100μg Vitamin E 2mg
Vitamin K1 9.9mg Vitamin B1 49mg
Vitamin B2 100mg Vitamin B6 99mg
Vitamin B12 8.9mg Niacinamide 1mg
D-VB5 calcium 680mg Folic acid 10g
Biotin 900μg Vitamin C 1g
Inositol 30mg VBT tartrate 1mg
Calcium 9.2g Phosphorus 6.7g
Iodine 10μg Sodium 400mg
Magnesium 10mg Iron 990mg
Zinc 990mg Selenium 8.4mg
Manganese 10μg Copper 10μg
Potassium 100mg Glu 10g
Yeast beta-dextran 31g Choline bitartrate 1mg
Taurine 1mg
Normal temperature laboratory is placed in after emulsion is sealed, lighting and ventilation is well located each composition of testing result after preserving 12 months and declined Lapse rate is substantially the same manner as Example 1.
Embodiment 3
According to the form below takes required raw material：
Preparation process is substantially the same manner as Example 1, distinguishes and passes through 200 mesh screens, step 10 in the feed liquid in step 8 In feed liquid pass through 200 mesh screens.
Following component is contained per 1000g by full nutrition special medicine purposes emulsion finished product prepared by the above method：
Title Quality Title Quality
Protein 83g Carbohydrate 96g
Fat 70g Compound stabilizer 80mg
Acidity regulator 950mg Vitamin A 10μg
Vitamin D3 1μg Vitamin E 580mg
Vitamin K1 1μg Vitamin B1 100μg
Vitamin B2 87mg Vitamin B6 100μg
Vitamin B12 1μg Niacinamide 640mg
D-VB5 calcium 500μg Folic acid 1mg
Biotin 10μg Vitamin C 10mg
Inositol 1g VBT tartrate 700mg
Calcium 200mg Phosphorus 80mg
Iodine 900μg Sodium 10g
Magnesium 1g Iron 1mg
Zinc 1mg Selenium 20μg
Manganese 7.6mg Copper 4.3mg
Potassium 9g Glu 2g
Yeast beta-dextran 10mg Choline bitartrate 970mg
Taurine 100mg
Normal temperature laboratory is placed in after emulsion is sealed, lighting and ventilation is well located each composition of testing result after preserving 12 months and declined Lapse rate is substantially the same manner as Example 1.
Embodiment 4
Substantially the same manner as Example 1, its difference is, raw material on the left of following table is replaced with into right side raw material：
Embodiment 5
Substantially the same manner as Example 1, its difference is, raw material on the left of following table is replaced with into right side raw material：
Embodiment 6
Substantially the same manner as Example 1, its difference is, raw material on the left of following table is replaced with into right side raw material：
Embodiment 7
Substantially the same manner as Example 1, its difference is, raw material on the left of following table is replaced with into right side raw material：
Comparative example 1
Substantially the same manner as Example 1, its difference is that comparative example 1 is free of Glu.
Experimental result
Emulsion containing Glu is to the infiltrative effect of inflammatory response syndrome Intestinal Mucosal Injury in Patients Undergoing.
Experimental group uses the emulsion in embodiment 1, and control group is the emulsion in comparative example 1, after 28 days, infection conditions Such as following table.
Number of the infected It is uninfected by number Total number of persons
Experimental group (uses the emulsion of embodiment 1) 11 32 43
Control group (uses the emulsion without Glu) 17 16 33
Comparative example 2
Substantially the same manner as Example 1, its difference is that comparative example 2 is free of yeast beta-dextran.
Experimental result
Emulsion containing beta glucan is to the postoperative CK-MB of coronary artery bypass grafting (CABG) art and cardiac muscle The effect of TnT.
Experimental group uses the emulsion in embodiment 1, and control group is the emulsion in comparative example 2, and continuous 5 days by 21 before surgery Name CABG patient is divided into the emulsion in the emulsion and comparative example 2 taken in embodiment 1, preoperative, and the postoperative 1st, take out within the 3rd and the 5th day Blood sampling is to analyze acute phase reactant, hematology, cell factor and myocardium enzyme.As a result show that research beta glucan tolerance is good It is good.Compared with control group, postoperative 1st day, 2 CK-MBs of group were significantly lower than control group (p=0.028), myocardium myo Calcium protein T is also significantly lower than control group (p=0.028).
In a word, presently preferred embodiments of the present invention, all equalizations made according to scope of the present invention patent be the foregoing is only Change and modification, it should all belong to the covering scope of patent of the present invention.

Claims (19)

  1. A kind of 1. full nutrition special medicine purposes emulsion, it is characterized in that the product includes following component per 1000g：
  2. A kind of 2. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Protein is milk egg The mixture of white powder, concentrated whey protein powder and soybean protein isolate, included per the 1000g products 19~63g of milk protein powder, 4~14g of concentrated whey protein powder, 2~6g of soybean protein isolate.
  3. A kind of 3. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Carbohydrate is wheat Bud dextrin, white granulated sugar, the mixture of soybean polyoses and inulin, per 1000g, the product includes 71~175g of maltodextrin, white granulated sugar 14~32g, 5~11g of soybean polyoses, 6~13g of inulin.
  4. A kind of 4. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：It is adipose-derived in soybean One or more in oil, coconut oil, sunflower oil, corn oil, rapeseed oil.
  5. A kind of 5. full nutrition special medicine purposes emulsion according to claim 1 or 2, it is characterised in that：Compound stabilizer Mixture including stabilizer and emulsion stabilizer, stabilizer are sodium tripolyphosphate, and per 1000g, the product includes sodium tripolyphosphate 0.003~0.302g, emulsion stabilizer are gellan gum, xanthans and list, and the mixture of diglycerine fatty acid ester should per 1000g Product include 0.002~0.193g of gellan gum, 0.002~0.161g of xanthans, list, diglycerine fatty acid ester 0.003~ 0.294g。
  6. A kind of 6. full nutrition special medicine purposes emulsion according to claim 1 or 2, it is characterised in that：Acidity regulator For sodium citrate and the mixture of sodium acid carbonate, per 1000g, the product includes 0.007~0.665g of sodium citrate, sodium acid carbonate 0.003~0.285g.
  7. A kind of 7. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Sodium derives from bicarbonate One or more in sodium, sodium dihydrogen phosphate, sodium citrate, sodium chloride and disodium hydrogen phosphate.
  8. A kind of 8. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Potassium derives from glucose One or more in sour potassium, potassium citrate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and potassium chloride.
  9. A kind of 9. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Copper derives from sulfuric acid One or more in copper, copper gluconate, copper citrate and copper carbonate.
  10. A kind of 10. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Magnesium derives from sulfuric acid One or more in magnesium, magnesium chloride, magnesia, magnesium carbonate, magnesium monohydrogen phosphate and magnesium gluconate.
  11. A kind of 11. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Iron derives from sulfuric acid In ferrous iron, ferrous gluconate, ferric citrate, ferrous fumarate, ironic citrate, ferric pyrophosphate and sodium iron ethylene diamine tetra acetate One or more.
  12. A kind of 12. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Zinc derives from sulfuric acid One or more in zinc, zinc gluconate, zinc oxide, zinc lactate, zinc citrate, zinc chloride and zinc acetate.
  13. A kind of 13. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Manganese derives from sulfuric acid One or more in manganese, manganese chloride, manganese carbonate, manganese citrate and manganese gluconate.
  14. A kind of 14. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Calcium source is in carbonic acid Calcium and calcium gluconate, calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, calcium chloride, tricalcium phosphate, calcium glycerophosphate, calcium oxide, One or more in calcium sulfate, wherein the product includes 0.05~1.7g of calcium carbonate per 1000g.
  15. A kind of 15. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Phosphorus derives from phosphoric acid One or more in DFP and calcium monohydrogen phosphate.
  16. A kind of 16. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Iodine derives from acid iodide One or more in potassium, KI and sodium iodide.
  17. A kind of 17. full nutrition special medicine purposes emulsion according to claim 1, it is characterised in that：Selenium derives from selenic acid One or more in sodium and sodium selenite.
  18. 18. preparing the method for the full nutrition special medicine purposes emulsion any one of claim 1~17, its feature exists In：
    Step 1：The purified water of normal temperature is added in mixing tank, adds fat and protein, shearing；
    Step 2：Compound stabilizer is uniformly mixed with carbohydrate in a reservoir, obtains compound stabilizer and carbohydrate Mixture；
    Step 3：The mixture of compound stabilizer and carbohydrate is added in the batch mixing filling in stirring, circulation shear；
    Step 4：After feed liquid during batch mixing is filled stirs 3~9min, Glu, yeast beta-dextran, calcium and phosphorus are added Mineral origin；
    Step 5：Using as iodine, sodium, magnesium, iron, zinc, selenium, manganese, copper, potassium source minerals and vitamins A, vitamin D3, dimension Raw plain E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, D-VB5 calcium, folic acid, biology Element, vitamin C, inositol, VBT tartrate, choline bitartrate and taurine are dissolved in normal temperature purified water, are obtained small Expect solution；
    Step 6：Small powder solution is added in the batch mixing filling under stirring；
    Step 7：The feed liquid mixed during batch mixing is filled is squeezed into shearing tank, stirring shearing；
    Step 8：The feed liquid sheared in tank after stirring shearing is passed through into 60~200 mesh screens；
    Step 9：Feed liquid after filtering is squeezed into constant volume tank, under static state with 20~30 DEG C of purified water moisturizing constant volumes, stirred Mix, add acidity regulator；
    Step 10：Feed liquid is passed through into 80~200 mesh screens；
    Step 11：Feed liquid is subjected to homogenization.
  19. A kind of 19. preparation method of full nutrition special medicine purposes emulsion according to claim 9, it is characterised in that：Often Warm purified water is 20~30 DEG C of purified water；
    Shear time is 8~18min in step 1；
    The circulation shear time is 7~20min in step 3；
    It is 6~20min that shear time is stirred in step 7；
    Mixing time in step 9 is 2~18min；
    Homogenizing temperature in step 11 is 60~80 DEG C, and homogenization pressure is 200~450MPa/8Mpa.
CN201710685810.9A 2017-08-11 2017-08-11 A kind of full nutrition special medicine purposes emulsion and preparation method thereof Pending CN107440098A (en)

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CN107951015A (en) * 2017-12-29 2018-04-24 北京康爱营养科技股份有限公司 Full nutrient formulation powder and preparation method thereof
CN108157953A (en) * 2018-01-19 2018-06-15 山东理工大学 A kind of full nutrition formula food and preparation method thereof
CN108208798A (en) * 2017-12-29 2018-06-29 北京康爱营养科技股份有限公司 Full nutrient formulation liquid and preparation method thereof
CN108208812A (en) * 2018-01-30 2018-06-29 贵州中科金玖生物技术有限公司 Bedding type total nutrient formula powder, preparation method and product thereof
CN108294303A (en) * 2018-01-30 2018-07-20 贵州中科金玖生物技术有限公司 A kind of full nutrient formulation powder, preparation method and its product containing dietary fiber
CN108294302A (en) * 2018-01-30 2018-07-20 贵州中科金玖生物技术有限公司 A kind of full nutrient formulation powder, preparation method and its product
CN108741086A (en) * 2018-06-07 2018-11-06 山东理工大学 A kind of sports tonica and preparation method thereof suitable for long-term body-building
CN108936602A (en) * 2018-06-07 2018-12-07 山东理工大学 A kind of double protein sports tonica and preparation method thereof
CN108936621A (en) * 2018-07-24 2018-12-07 山东圣海保健品有限公司 Double protein full nutrition formula food and preparation method thereof
CN108991506A (en) * 2018-07-18 2018-12-14 辰欣药业股份有限公司 A kind of not fibrous medical formula food of predigestion high energy and preparation method thereof
CN109329949A (en) * 2018-12-07 2019-02-15 广东君悦营养医学有限公司 Full nutrition suspension and preparation method comprising HMB calcium and lactalbumin
CN110584084A (en) * 2019-10-17 2019-12-20 广州白云山汉方现代药业有限公司 Emulsion stabilizer and nutrient emulsion containing same
CN110786514A (en) * 2019-10-15 2020-02-14 上海五德投资咨询有限公司 Liquid total nutrient supplement with low fat energy supply ratio and preparation method thereof
CN111194912A (en) * 2019-07-09 2020-05-26 北京市营养源研究所 Stable medical liquid enteral nutrition composition and preparation method thereof
CN112971147A (en) * 2021-03-05 2021-06-18 北京市营养源研究所 Magnesium salt composition for improving stability of total nutrient emulsion for special medical application
CN115474690A (en) * 2022-08-15 2022-12-16 华南理工大学 Total-nutrient special medical application formula food emulsion taking plant whole protein as only protein source and preparation method thereof
CN115644429A (en) * 2022-11-21 2023-01-31 华南理工大学 Whey protein-pulse protein co-stabilized full-nutrition special medical application formula food emulsion and preparation method thereof

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CN105455133A (en) * 2015-12-08 2016-04-06 西安力邦临床营养股份有限公司 Predigestion type total nutrient solution and preparation method thereof
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Cited By (21)

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CN107951015A (en) * 2017-12-29 2018-04-24 北京康爱营养科技股份有限公司 Full nutrient formulation powder and preparation method thereof
CN108208798A (en) * 2017-12-29 2018-06-29 北京康爱营养科技股份有限公司 Full nutrient formulation liquid and preparation method thereof
CN108157953A (en) * 2018-01-19 2018-06-15 山东理工大学 A kind of full nutrition formula food and preparation method thereof
CN108208812A (en) * 2018-01-30 2018-06-29 贵州中科金玖生物技术有限公司 Bedding type total nutrient formula powder, preparation method and product thereof
CN108294303A (en) * 2018-01-30 2018-07-20 贵州中科金玖生物技术有限公司 A kind of full nutrient formulation powder, preparation method and its product containing dietary fiber
CN108294302A (en) * 2018-01-30 2018-07-20 贵州中科金玖生物技术有限公司 A kind of full nutrient formulation powder, preparation method and its product
CN108741086A (en) * 2018-06-07 2018-11-06 山东理工大学 A kind of sports tonica and preparation method thereof suitable for long-term body-building
CN108936602A (en) * 2018-06-07 2018-12-07 山东理工大学 A kind of double protein sports tonica and preparation method thereof
CN108991506A (en) * 2018-07-18 2018-12-14 辰欣药业股份有限公司 A kind of not fibrous medical formula food of predigestion high energy and preparation method thereof
CN108936621A (en) * 2018-07-24 2018-12-07 山东圣海保健品有限公司 Double protein full nutrition formula food and preparation method thereof
CN109329949A (en) * 2018-12-07 2019-02-15 广东君悦营养医学有限公司 Full nutrition suspension and preparation method comprising HMB calcium and lactalbumin
CN111194912A (en) * 2019-07-09 2020-05-26 北京市营养源研究所 Stable medical liquid enteral nutrition composition and preparation method thereof
CN110786514A (en) * 2019-10-15 2020-02-14 上海五德投资咨询有限公司 Liquid total nutrient supplement with low fat energy supply ratio and preparation method thereof
CN110584084A (en) * 2019-10-17 2019-12-20 广州白云山汉方现代药业有限公司 Emulsion stabilizer and nutrient emulsion containing same
CN112971147A (en) * 2021-03-05 2021-06-18 北京市营养源研究所 Magnesium salt composition for improving stability of total nutrient emulsion for special medical application
CN112971147B (en) * 2021-03-05 2022-08-05 北京市营养源研究所有限公司 Magnesium salt composition for improving stability of total nutrient emulsion for special medical application
CN115474690A (en) * 2022-08-15 2022-12-16 华南理工大学 Total-nutrient special medical application formula food emulsion taking plant whole protein as only protein source and preparation method thereof
CN115474690B (en) * 2022-08-15 2023-11-10 华南理工大学 Total nutrient special medical formula food emulsion taking plant integrins as unique protein sources and preparation method thereof
WO2024037087A1 (en) * 2022-08-15 2024-02-22 华南理工大学 Total nutritional food emulsion for special medical purposes using plant intacted protein as unique protein source and preparation method therefor
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