CN104366511A - High-density reinforced protein oral liquid - Google Patents

High-density reinforced protein oral liquid Download PDF

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CN104366511A
CN104366511A CN201410520351.5A CN201410520351A CN104366511A CN 104366511 A CN104366511 A CN 104366511A CN 201410520351 A CN201410520351 A CN 201410520351A CN 104366511 A CN104366511 A CN 104366511A
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protein
nitrogen
vitamin
oligopeptide
water
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李明刚
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a high-density reinforced protein oral liquid and belongs to the technical field of nutrient supplements. The high-density reinforced protein oral liquid comprises 30-35% of protein oligopeptide (MW<5000D), reinforces nanoliposome vitamin C, nanoliposome vitamin E and zinc gluconate and guarantees vitamin stability. The high-density reinforced protein oral liquid improves protein and vitamin absorptivity and bioavailability, and can be widely used for weak patients, patients before and after operation, and patients with a plurality of clinical diseases.

Description

A kind of high concentration strengthening protein oral liquor
Technical field
The present invention relates to a kind of high concentration strengthening protein oral liquor, belong to nutrient prime replenisher field.
Background technology
The standard GB/T 29922-2013--special medicine purposes formula food general rule that on July 1st, 2014 implements, this food indicating that a class is new is about to come on stage.Special medicine purposes formula food (Food forSpecial Medical Purposes, FSMP) refer in order to satisfied feed is limited, Disorder of Digestion and A orption, metabolic disorder or particular disease states crowd to the special requirement of nutrient or meals, the formula food that special processing is formulated.
What special medicine purposes formula food adopted is standardized science, equilibrium, comprehensively nutrient formulation, long-term or short-term can meet the nutritional need of patient easily.Special medicine purposes formula food is the based food between bread and cheese and medicine, based on powdery or liquid state and volume is larger, because it contains various nutritional labeling and nutritional support effect clinically, the usual category being included in food in the world.
A large amount of evidences and clinical practice show, nutritional support has a very important role for the result for the treatment of of patient and rehabilitation.Just this series products is generally used clinically abroad as far back as last century eight, the nineties, very extensive in developed country's application such as European Countries, the U.S., Canada, Australia, New Zealand, Japan, and in succession formulated the standard of special medicine purposes formula food and relevant supporting management measure, be product indispensable in clinical treatment.Improving nutrition situation, promoting patients ' recovery, shortening the hospital stays, saving the aspects such as payment for medical care and played great function.This series products has been listed in medical insurance reimbursement scope by many countries.
In China, this series products is clinical and blank that is market always, but along with socioeconomic development, the arriving of aging society, medical expense and medical insurance increasing pressure large, people, to the growing interest of nutrient knowledge and Nutritional Status, add information interchange both domestic and external, and increasing nutritionist, doctor, clinical nutrition teacher and patient itself payes attention to the nutrition condition during disease.Chinese is populous, introduces this series products, will improve part chronic, plays a positive role in the disease treatment of the special populations such as old age, children and pregnant woman.
It is reported, many patients in intensive care unit cause life exhausted because of the shortage of nutrition.Statistics show, and in hospital of western countries, the patient of 25%-30% causes because of malnutrition, and Asia is about 40%.Wherein, nutrition worsens more in the while in hospital more the people of 70%.In Europe, underfed cost reaches 11,000,000,000 Euros, is mainly derived from malnutrition and complication thereof, hospitalization cost and recovers the economic loss that the undesirable secondary disease brought causes.Therefore, develop the nutraceutical of high-quality, patient can be helped to recover physical efficiency, even change because of disease that gene mutation causes, thus make patient obtain better result for the treatment of, get well with the shorter time.
A kind of oral liquid containing calcium and proteins and preparation technology thereof is provided in prior art, described oral liquid is stuck with paste extract, multi-medicament extract and flavouring refined honey liquid by bone and formed, described preparation technology comprises and prepares bone paste extract respectively, multi-medicament extract and flavouring refined honey liquid, then above-mentioned three kinds of solution are prepared burden in proportion, through high-temp sterilizing, be cooled to room temperature, filter institute obtain filtrate and make.This kind of oral liquid has effect that beneficial marrow strengthens bone, qi-supplementing, blood-engendering, cures mainly woman gestationperiod, lactation, children's, student and old man's calcium deficiency, the disease of anaemia and health-care effect.
A kind of biological collagen oral liquor and preparation method thereof is additionally provided in prior art, the method step: 1) biological collagen processed: choosing is healthy, virus-free, fragrant pig within 3 months monthly ages, clean, slaughter, peeling → unhairing, degrease layer → sterilization, sterilization → pigskin water cleans up → physiological saline boiling pigskin, treat its one-tenth gelatin → molecular weight be that 5 ~ 80,000 collagens carry out high-temperature acidic degraded, pH value 4 ~ 6, by collagen transient heating to 180 ~ 250 DEG C, be cooled to 15 ~ 25 DEG C immediately, less than the ten thousand → filtration of its molecular weight and molecular weight to 1 is purified, be separated and remove grease, obtain collagen, 2) biological collagen oral liquor processed: get weight concentration 5 ~ 15% collagen liquid 100 weight portion, calcium salt 1.5 ~ 5 weight portion stirs evenly, mixed liquor filters, and sterilizing, obtains biological collagen oral liquor.This oral liquid has a good therapeutic effect to bone split, disconnected symphysis and other osteopathy; Also tool beauty treatment, the strong health-care effect such as skin, develop immunitypty.
A kind of collagen oral liquid is additionally provided in prior art, belong to field of health drinks, it is characterized in that: adopt Isin glue collagen peptide, vitamin E, vitamin C, arginine, isoflavones, Tea Polyphenols, beta carotene and apple polyphenol to be primary raw material, essence and water is added in composition, collagen peptide in composition is micromolecular collagen, effective increase absorbs, and composition adopts raw-food material simultaneously, and edible safety is reliable.
A kind of snail protein oral liquor is additionally provided in prior art, containing snail protein 15 grams, cephalo Chinese caterpillar fungus 50 grams, fruit of Chinese magnoliavine 80-100 gram, 60 grams, almond, scopolia acutangula 5-10 gram, honey 200 milliliters, its preparation technology is by Homogeneous phase mixing such as snail protein hydrolysis liquid, the immersion liquid of five tastes subflow, cephalo worm extract, almond juice, scopolia acutangula extract, honey, and after filtration, the technique such as sterilizing makes.Be cough for treatment consumptive disease to breathe heavily and establish, have relieving cough and asthma, effect of nourishing lung and kidney, often interval is taken, and has the health-care effect of strong physique.
Additionally provide the collagen oral liquid that a kind of bioavilability improves in prior art, comprise the collagen of biological absorbable and increase the stabilizing agent of collagen dispersion.Collagen oral liquid of the present invention contains the collagen of the biological absorbable of high level, and its molecular weight is 2500 ~ 3500D, and content is not less than 10% (g/ml).The stabilizing agent of the increase collagen dispersion that the present invention adopts is selected from hydroxypropyl methylcellulose, sodium alginate, sodium carboxymethylcellulose, methylcellulose, xanthans and HLB value 7 ~ 13 and contains the nonionic surface active agent of aliphatic chain.Collagen oral liquid of the present invention can be used for improving skin and preventing bone and joint diseases.
Additionally provide a kind of collagen oral liquid in prior art, comprise the raw material components of following weight portion: 100 parts, collagen marine oligopeptide powder, tocopherol 0.5-1.0 part, Catergen .5-3.5 part, arginine 0.5-1.0 part, AJC 60-70 part, honey 5-10 part, beta carotene 0.005-0.01 part, Sucralose 0.1-0.2 part, malic acid 6-8 part, polyoxyethylene sorbitan monooleate 2-3 part, xanthans 0.8-1.0 part and water 700-720 part; In preparation process, in advance by pre-emulsification embedding process, by tocopherol, apple concentrate and polyoxyethylene sorbitan monooleate carry out pre-treatment, form tocopherol embedding micellar solution; The even clear of oral liquid product of preparation, safe and reliable, have no side effect, and through the clinical testing of bodily fuctions, have the advantages that to improve skin water supplement function.
Additionally provide a kind of collagen peptide-oligosacchargel-aloe gel-aloe liquid beverage in prior art, it comprises component: collagen peptide, compound sugar, inspissated juice or dried fruit juice, plant extracts and water; Wherein, described plant extracts comprises aloe gel; Percentage, the content of each component is: collagen peptide 9% ~ 13%; Compound sugar 3% ~ 10%; Inspissated juice/dried fruit juice 1% ~ 3.5%; Plant extracts 2% ~ 7%; Surplus is water.The interior hydroxyproline of product of the present invention, oligopeptide and aloe polysaccharide can play increase skin elasticity at human body, reduce wrinkle, comprehensive cosmetology effect, experiment proves, drink of the present invention has conspicuousness effect to raising moisture content of skin, solves common collagen oral liquid and can not play the problem of comprehensively improving looks.
Additionally provide a kind of with mammal skin collagen in prior art, and add the Biofunctional beautifying health oral liquid of active SOD, the collagen that human body skin day by day reduces can be supplemented, there is conditioner body surface chrotoplast metabolic function, anti-ageing at raising body, recover skin elasticity and wettability, recover the aspects such as human body appearance, have obvious effect; And provide the method that the preparation of collagen oral liquid and contained mammal skin collagen extract, there is simple process, with short production cycle, yield is high, cost is low, be therefore easy to suitability for industrialized production and apply
There are the following problems for above-mentioned prior art: the molecular weight of (1) albumen is too large, and elderly and infirm, digestion and absorption function infull person, patients after surgery etc. is lower to its absorptivity; (2) lack strengthening composition, though or have enhanced nutrient, its absorptivity is low, the aqueous solution is unstable.
Summary of the invention
For overcoming the shortcoming existed in prior art, goal of the invention of the present invention is to provide a kind of high concentration strengthening protein oral liquor, and its absorptivity is high.
For realizing described goal of the invention, the invention provides a kind of strengthening protein oral liquor, it is characterized in that, comprising: containing albumen oligopeptide, nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate.
Preferably, every 100 milliliters of oral liquids contain albumen oligopeptide, the vitamin E of 0.5 ~ 300mg, the vitamin C of 10 ~ 500mg, the zinc gluconate of 5-20mg of 30 ~ 35g.
Preferably, albumen oligopeptide molecular weight < 5000D.
Preferably, albumen oligopeptide is the hydrolysate of animal collagen, animal muscle protein or lactalbumin.
Compared with prior art, high concentration strengthening protein oral liquor absorptivity provided by the invention is high.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is elaborated.
Embodiment one:
The high concentration strengthening protein oral liquor that first embodiment of the invention provides, its component comprises: every 1000mL is containing albumen oligopeptide 300g, nano liposomes vitamin E 1000mg, vitamin C 500mg, zinc gluconate 20mg.
High concentration strengthening protein oral liquor prepares by the following method:
S01: phosphatidase 5 g, cholesterol 1g, tween 1g (Tween 80) are dissolved in 30ml ethanol (or chloroform, methyl alcohol or carrene etc.), then eggplant-shape bottle is put into, on water-bath evaporimeter (bath temperature 55 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution A;
S02: add vitamin E in solution A, 1000mg, on water-bath evaporimeter (bath temperature 55 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution B
S03: take vitamin C 500g, zinc gluconate 20mg and to be dissolved in 10ml distilled water and (bath temperature 55 DEG C ± 1 DEG C) constantly stirs and obtain water-soluble solution C on water-bath evaporimeter;
S04: water-soluble solution C is mixed with solution B, and (bath temperature 55 DEG C ± 1 DEG C) continuous stirring obtains soluble solution D on water-bath evaporimeter;
S05: to solution D reduction vaporization to remove desolventizing;
S06: use spy formula Ultrasound Instrument to make the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparent to emulsion;
S07: use Microfluidizer under 100MPa pressure to emulsion breast even 2 times;
S08: add distilled water to 800ml;
S09: add collagen oligopeptide 300g, on water-bath evaporimeter (bath temperature 55 DEG C ± 1 DEG C), is stirred to dissolving;
S10: add distilled water to 1000ml on water-bath evaporimeter (bath temperature 55 DEG C ± 1 DEG C), stir, then filter packing, obtain and comprise the albumen oligopeptide (MW < 5000D) that concentration is 30%, and strengthening is with the strengthening protein oral liquor of nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate.
Embodiment two
The high concentration strengthening protein oral liquor that second embodiment of the invention provides, its component comprises: every 1000mL is containing albumen oligopeptide 350g, nano liposomes vitamin E 3g vitamin C 5g zinc gluconate 200mg.
Embodiment two provides high concentration to strengthen protein oral liquor and prepares by the following method:
S01: phosphatidase 5 g, cholesterol 1g, tween 1g (Tween 80) are dissolved in 30ml ethanol (or chloroform, methyl alcohol or carrene etc.), then eggplant-shape bottle is put into, on water-bath evaporimeter (bath temperature 45 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution A;
S02: add vitamin E in solution A, 3g, on water-bath evaporimeter (bath temperature 45 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution B
S03: take vitamin C 5g, zinc gluconate 200mg and to be dissolved in 10ml distilled water and (bath temperature 45 DEG C ± 1 DEG C) constantly stirs and obtain water-soluble solution C on water-bath evaporimeter;
S04: water-soluble solution C is mixed with solution B, and (bath temperature 45 DEG C ± 1 DEG C) continuous stirring obtains soluble solution D on water-bath evaporimeter;
S05: to solution D reduction vaporization to remove desolventizing;
S06: use spy formula Ultrasound Instrument to make the abundant aquation of lipid membrane 80 minutes under ice-water bath condition, until become transparent to emulsion;
S07: use Microfluidizer under 100MPa pressure to emulsion breast even 6 times;
S08: add distilled water to 800ml;
S09: add collagen oligopeptide 300g, on water-bath evaporimeter (bath temperature 45 DEG C ± 1 DEG C), is stirred to dissolving;
S10: add distilled water to 1000ml on water-bath evaporimeter (bath temperature 45 DEG C ± 1 DEG C), stir, then filter packing, obtain and comprise the albumen oligopeptide (MW < 5000D) that concentration is 35%, and strengthening is with the strengthening protein oral liquor of nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate.
Embodiment three
The high concentration strengthening protein oral liquor that the embodiment of the present invention three provides, every 1000mL is containing albumen oligopeptide 320g, nano liposomes vitamin E 5mg, vitamin C 100mg, zinc gluconate 5mg.
The high concentration strengthening protein oral liquor that embodiment three provides prepares by the following method:
S01: phosphatidase 5 g, cholesterol 1g, tween 1g (Tween 80) are dissolved in 30ml ethanol (or chloroform, methyl alcohol or carrene etc.), then eggplant-shape bottle is put into, on water-bath evaporimeter (bath temperature 50 DEG C ± 1 DEG C), be stirred to and dissolve to obtain solution A;
S02: add the E 5mg that supports one's family in solution A, on water-bath evaporimeter (bath temperature 50 DEG C ± 1 DEG C), is stirred to and dissolves to obtain solution B
S03: take vitamin C 100mg, zinc gluconate 5mg and to be dissolved in 10ml distilled water and (bath temperature 45 DEG C ± 1 DEG C) constantly stirs and obtain water-soluble solution C on water-bath evaporimeter;
S04: water-soluble solution C is mixed with solution B, and (bath temperature 50 DEG C ± 1 DEG C) continuous stirring obtains soluble solution D on water-bath evaporimeter;
S05: to solution D reduction vaporization to remove desolventizing;
S06: use spy formula Ultrasound Instrument to make the abundant aquation 20-60 minute of lipid membrane under ice-water bath condition, until become transparent to emulsion;
S07: use Microfluidizer under 100MPa pressure to emulsion breast even 8 times;
S08: add distilled water to 800ml;
S09: add collagen oligopeptide 320g, on water-bath evaporimeter (bath temperature 50 DEG C ± 1 DEG C), is stirred to dissolving;
S10: add distilled water to 1000ml on water-bath evaporimeter (bath temperature 50 DEG C ± 1 DEG C), stir, then filter packing, obtain and comprise the albumen oligopeptide (MW < 5000D) that concentration is 32%, and strengthening is with the strengthening protein oral liquor of nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate.
The high concentration strengthening protein oral liquor utilizing the embodiment of the present invention one to provide is tested:
One, materials and methods
1 test specimen
Oligopeptide nutritious protein liquid is prepared by method provided by the invention
2 animals used as test, grouping and hello oxygen method
2-1, experimental animal:
Male SD rat 30, body weight 180 ~ 200g, is provided by Peking University's experimental animal center.
2-2, test grouping: rat is divided into 3 groups at random after laboratory adapts to 3 days, that is: water group (control group A) is fed in normal diet+filling, Fish protein group (control group B) and the Fish protein of normal diet+30% oligomeric (MW < 5000D) are fed in normal diet+filling, fill with and feed (experimental group C), each treated animal body weight no significant difference.
2-3, feeding method
Rat is after Animal House adaptability feeds (recording the appetite of every rat during this), and C group rat fills with the Fish protein oligopeptide beverage 2mL feeding 30%, 1 time/d; B group rat fills with the fish protein drink 2mL feeding 30%, 1 time/d; The pure water of A group rat oral gavage equivalent.After all animal's diet balance 1 week, start to raise separately in stainless steel rat metabolism cage respectively.With the input standard that the average appetite (about 25g) of the minimum rat of food ration is the every daily diet of rats all during metabolic test, guarantee that the energy that every rat is taken in is mutually equal.Collect respectively, measure and process 72h excrement and urine, preserve with 20%H2SO4.
3, test index and method
3-1, application micro-Kjeldahl measure rat nitrogen metabolism.Get 0.2g/mL sample and the concentrated sulfuric acid, catalytic unit in kjeldahl flask, hot digestion on adjustable formula electric hot plate, until digestive juice from faint yellow fade to that pale blue is green clearly time, cooling, adding distil water dilutes, and is settled to 50mL; Get the digestive juice 3mL after dilution to distill in kjeldahl determination distilling apparatus, in bottle to be subjected, mixed liquor indicator fades to green by light gray redness, distillation 2min, mobile receiving flask, make to accept liquid level and leave the condensation mouth of pipe, continue distillation 1min, then use standard salt acidometric titration, terminal colour becomes light bois de rose by green, record hydrochloric acid consumption.Computing formula: daily sample nitrogen content=(sample consumes hydrochloric acid content-blank and consumes hydrochloric acid content) × 14 × concentration of hydrochloric acid × extension rate × daily sample total amount.
3-2 test index
Nitrogen balance=intake of nitrogen-excretion nitrogen quantity
Nitrogen storage rate=(intake of nitrogen-excretion nitrogen quantity)/intake of nitrogen
Nitrogen net utilization=nitrogen storage allowance/intake of nitrogen
Apparent digestibility=(intake of nitrogen-fecal nitrogen)/intake of nitrogen
3-3, statistical method
All data all represent with " average ± standard deviation ", though with CA2SIO fx-100 device and SPSS statistical package (one-wayANOVA) calculate, statistical analysis.Significance is P < 0.005.
Two, result and discussion
1,30% Fish protein oligopeptide is supplemented on the impact of rat nitrogen balance
Find in research, 3 treated animals are all in positive nitrogen equilibrium state.Contrast A group is fed normal diet+water, and its mean value is 01039 ± 01028; Contrast B group is fed normal diet+30% fish protein drink group, and playing a nitrogen balance value is 01453 ± 01013.Supplement 30% Fish protein oligopeptide rat nitrogen balance value the highest, after prompting supplements albumen oligopeptide, enter the nitrogen of body at most (as shown in table 1).
Table 1 supplements the impact of soybean oligopeptide on rat nitrogen balance:
2, soybean oligopeptide is supplemented on the impact of rat storage rate
Find in research, contrast A group feed+water, its nitrogen storage rate is 61093% ± 41247%; Contrast B group is fed normal diet+soybean protein isolate, and its nitrogen storage rate is 421128% ± 41494%; Normal diet+soybean oligopeptide and experimental group (C group) is fed, its nitrogen storage rate is 651968% ± 11827%; Supplement soybean oligopeptide group rat nitrogen storage rate the highest, higher by 56159% than supplementary soybean protein isolate group (P > 0105), nitrogen storage rate refers to that the nitrogen quantity that body stores accounts for total percentage taking in nitrogen, is also one of a kind of conventional index weighing internal metabolism.Nitrogen storage rate is high then illustrates that the retentivity of body to nitrogen is high, and the rat nitrogen storage rate of supplementing soybean oligopeptide group is the highest, and after soybean oligopeptide is taken in prompting, guarantor's nitrogen power of body significantly increases (as shown in table 2).
Table 2 supplements the impact of soybean oligopeptide on rat nitrogen storage rate
3,30% fish oligopeptide is supplemented on the impact of rat nitrogen net utilization
Find in research, contrast A group is fed normal diet+water, and its nitrogen net utilization is 91403% ± 61554%; Contrast B group is fed normal diet+30% Fish protein, and its nitrogen net utilization is 611412% ± 61824%; And experimental group (C group) normal diet of feeding+supplementing 30% fish oligopeptide, its nitrogen use efficiency is 961023% ± 21659%.Supplement 30% fish oligopeptide rat nitrogen net utilization the highest, higher by 56136% than supplementary Fish protein group (P > 0.105), than feeding water group high by 9211209% (P > 0105).Nitrogen net utilization refers to that clean nitrogen quantity accounts for total percentage taking in nitrogen.The nitrogen net utilization that body stores is high then illustrates that the utilization rate of body to nitrogen is high.The rat nitrogen net utilization supplementing 30% fish oligopeptide group is the highest, after prompting picked-up supplements 30% fish oligopeptide, body to the utilization of nitrogen more entirely, more thoroughly, therefore, supplements the standard (as shown in table 3) that 30% fish oligopeptide conforms with high-quality nitrogenous source.
Table 3 supplements 30% fish oligopeptide to the impact of rat nitrogen net utilization
4 discuss
Nitrogen substance in body has protein, amino acid, creatine, purine, pyrimidine, inosine, vitamin and amino sugar etc., and the nitrogen substance that wherein most important, metabolism is active, then nonprotein does not belong to.The nitrogen metabolism of usual body is identical with protein metabolism.And body is to the absorption of nitrogen, storage and utilization, then reflect the situation of body protein metabolism.Nitrogen balance weighs a kind of common counter of body internal protein metabolism, in fact refers to the contrast of body to nitrogen intake and discharge rate, namely take in nitrogen divided by excretion nitrogen.
The digestibility of protein is the degree that reflection food protein is digested, absorb.The percentage accounting for the nitrogen pool of absorption by the nitrogen quantity that body absorbs represents, namely (takes in nitrogen-fecal nitrogen)/takes in nitrogen.And the percentage that in body, the storage allowance of nitrogen accounts for total intake of nitrogen is the utilization rate of nitrogen.Certainly, the index of these reflection nitrogen metabolism is again the parameter weighing protein nutritive value height simultaneously.If the nitrogen quantity that a kind of absorptivity of protein is high, store is many, so it utilizes also complete, then the Functionality, quality and appealing design of this protein, is of high nutritive value.At present, about the idea that protein digestibility absorbs, tend to think under the digestive juice effect in alimentary canal (mainly small intestine) of protein in meals, resolve into oligopeptide (accounting for 2/3) and free amino acid, small peptide is then hydrolyzed into end-product small peptide further by the peptase of intestinal villi BBM (mainly aminopeptidase), small peptide then enters blood circulation by the peptide carrier cross-docking of intestinal villi BBM, enters tissue and participates in protein metabolism.Due to the existence of peptase in small intestinal cell BBM and cytosol, the polypeptide in enteric cavity is hydrolyzed into small peptide by aminopeptidase, and therefore, the direct absorption of small peptide becomes the principal mode that body takes in protein.
The present invention contains the albumen oligopeptide (MW < 5000D) of 30%, and strengthening is with nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate, ensure that the stability of vitamin, and improve albumen, the absorptivity of vitamin and bioavilability.Product appearance clear, thermodynamic stability are good, system is compatible good, can be widely used in the use of weak patient, perioperatively patient, clinical various diseases patient.
Below the effect describing component of the present invention, preparation method in detail in conjunction with the embodiments and reach, but embodiment is only, for demonstration, the present invention is described.Description is only for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.

Claims (4)

1. strengthen a protein oral liquor, it is characterized in that, comprising: containing albumen oligopeptide, nano liposomes vitamin C, nano liposomes vitamin E and zinc gluconate.
2. strengthening protein oral liquor according to claim 1, is characterized in that, every 100 milliliters of oral liquids contain albumen oligopeptide, the vitamin E of 0.5 ~ 300mg, the vitamin C of 10 ~ 500mg, the zinc gluconate of 5-20mg of 30 ~ 35g.
3. strengthening protein oral liquor according to claim 2, is characterized in that, albumen oligopeptide molecular weight < 5000D.
4. strengthening protein oral liquor according to claim 3, is characterized in that, albumen oligopeptide is the hydrolysate of animal collagen, animal muscle protein or lactalbumin.
CN201410520351.5A 2014-10-08 2014-10-08 High-density reinforced protein oral liquid Pending CN104366511A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106036916A (en) * 2016-06-02 2016-10-26 王斐芬 Postoperative repairing nutriment
CN106889619A (en) * 2017-03-06 2017-06-27 青岛海大华旗生物科技有限公司 It is a kind of to promote health food of post-operative recovery and preparation method thereof

Citations (1)

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CN103844273A (en) * 2014-03-07 2014-06-11 禄美生物科技（上海）有限公司 Collagen oral solution and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN103844273A (en) * 2014-03-07 2014-06-11 禄美生物科技（上海）有限公司 Collagen oral solution and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106036916A (en) * 2016-06-02 2016-10-26 王斐芬 Postoperative repairing nutriment
CN106889619A (en) * 2017-03-06 2017-06-27 青岛海大华旗生物科技有限公司 It is a kind of to promote health food of post-operative recovery and preparation method thereof

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Application publication date: 20150225