CN107427538A - Nourishing tonic containing honeybee - Google Patents
Nourishing tonic containing honeybee Download PDFInfo
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- CN107427538A CN107427538A CN201680021368.3A CN201680021368A CN107427538A CN 107427538 A CN107427538 A CN 107427538A CN 201680021368 A CN201680021368 A CN 201680021368A CN 107427538 A CN107427538 A CN 107427538A
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- China
- Prior art keywords
- honeybee
- male
- improvement
- antifatigue
- sexual function
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
Abstract
The present invention provides a kind of strong essence-replenishing preparation containing honeybee, a kind of improvement of sexual function agent containing honeybee, a kind of male climacteric condition improver containing honeybee and a kind of antifatigue containing honeybee.
Description
Technical field
The present invention relates to a kind of strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and antifatigue.
Background technology
It is found that male climacteric as male faced on aging the problem of one of.Supposition there are about 40%
The male of 40 years old~60 years old lives through the male climacteric of certain degree.
If suffer from male climacteric disturbance, it will experience strongly various symptoms (for example, it is depressed, dejected, irritated, uneasy,
Neuroticism, sense of fatigue, disanimation, muscles inflammation, arthritis, muscular strength reduction, heating, sweating, memory reduction, sleep barrier
Hinder, concentrated force reduces, the human body consumes sense, erectile dysfunction (ED), sexual desire reduce, disappearance felt etc. of ejaculating).As being confirmed whether it is
The method of male climacteric disturbance, have and Xue Zhong Testis ketone concentration and the method for survey are determined by blood test.There is finger at present
Plucking the morbidity for showing male climacteric disturbance, the various pressure in work and family are extremely related to mature stage male, in recent years
Come, the doubtful middle high year male for suffering from climacteric obstacle has increased tendency.
Male climacteric disturbance is reduced to background to increase the androgen of rheological properties, it may appear that similar with Menopause obstacle
Vegetative dystonie shape and Spirit nerve symptoms of disease, and can show at most of conditions further low with function of male
Under morbid state (the bright man of virtue and ability in mountain difficult to understand book male climacteric LOH syndrome i male climacteric disturbance D. from the heart treat internal medicine viewpoint
From the point of view of ((strain) Nan Shantang) 2007. of page 24).The secretion of sex hormones of the another aspect , headed by Testis ketone is via under hypothalamus-brain
Hypophysis-spermary system is adjusted that (the bright man of virtue and ability in mountain difficult to understand book male in a manner of negative feedback to the hormonal secretion for wrapping the ketone containing Testis
The diagnosis C. hormone measure of climacteric obstacle LOH syndrome i I male climacteric disturbances and its evaluation page 65 ((strain) Nan Shantang)
2007.).Therefore, the measured value of a Gen Ju Testis sterol, it is difficult that male climacteric disturbance is judged.
In general, reducing and find that the You Li Testis ketone in blood has the vigor that feels reduces the tested of tendency
Person, it is diagnosed as increasing age male gonad hypofunction disease group (LOH syndromes), adapts to androgen replacement in order to maintain QOL and treat
Method.However, the international popularizations of the hormone replacement therapy Yi of women, in contrast, the treatment for male only uses to ED
PDE5 inhibitor etc. is popularized, in addition and non-medical object.
For example, the various composition of Shi Testis sterol rising is reported in patent document 1~3.
Radix codonpsis tangshen glycosides (Tangshenoside) class contained by Radix Codonopsis platymiscium, codonopsis lanceolata are reported in patent document 1
The reduction of saponin(e (Lancemaside-A) and Syringin (Syringin) for Xue Zhong Testis sterol is inhibited.
Trans-Geranylgeraniol Ju You Testis sterol humidifications are reported in patent document 2.
The combination that black vinegar related raw material and the raw material and specified raw material are reported in patent document 3 can dramatically Cu Jin Testis and consolidate
The secretion of alcohol.
However, androgen replacement also has the possibility for producing side effect, on as prostate tumor marker
Therefore PSA (PSA) it is important to note that need a kind of menopause symptom of no androgen effect to delay at present
And agent.
In addition, it is used as ED curatives using as " silaenafil " of PDE5 inhibitor.However, although silaenafil is of short duration
Property medicine, but report have side effect and drug interaction.For example, the blood pressure of the nitric acid agent for nitroglycerin etc. is reduced and made
For, because silaenafil can promote the effect, therefore by them and with being taboo, in addition, its effect for eyes
It is considered as having cyanopsia, diplopia, erythropia etc..
By the way, honeybee ate in various countries and region as nutrient sources such as protein since the ancient times.In recent years, will
The powder of gained is widely known by the people as the healthy food of raw material after honeybee crushing is dried.The healthy food is had rich in honeybee
Some protein, amino acid, vitamin and mineral matter.As disclosed in Patent Document 4, although known honeybee has antioxygen
Change acts on, but still there have other much to act on to be unknown by the people.
Prior art literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 2006-306889 publications
Patent document 2：No. 5382512 publications of Japanese Patent Publication No.
Patent document 3：Japanese Unexamined Patent Publication 2013-181031 publications
Patent document 4：The publication of Japanese Patent Publication No. 5405067
The content of the invention
Invent problem to be solved
It will not make androgen rising and safe strong essence-replenishing preparation, property work(it is an object of the present invention to provide a kind of
Can improver, male climacteric condition improver and antifatigue.
The present inventor etc. further investigate repeatedly in order to reach above-mentioned purpose, the result is that having obtained following achievement in research：
Honeybee has strong strong essence effect, improvement of sexual function effect, the improvement result and antifatigue effect of male climacteric symptom, and
And honeybee will not rise androgen, there is high security.
Further study based on these achievements in research and repeatedly, so as to complete the present invention, the invention provides following
Strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and antifatigue etc..
1st, a kind of strong essence-replenishing preparation containing honeybee.
2nd, a kind of improvement of sexual function agent containing honeybee.
3rd, a kind of male climacteric condition improver containing honeybee.
4th, a kind of antifatigue containing honeybee.
5th, a kind of vigor elevator containing honeybee.
6th, the strong essence-replenishing preparation as described in the 1st, the improvement of sexual function agent as described in the 2nd, as described in the 3rd
Male climacteric condition improver, the antifatigue as described in the 4th and the vigor elevator as described in the 5th, wherein,
Foregoing honeybee is treated by proteolytic enzyme.
7th, a kind of strong strong essence containing honeybee is used, improvement of sexual function is used, male climacteric symptom improves and uses, be anti-tired
Labor with and/or lifting vigor composition.
8th, a kind of strong strong essence containing honeybee is used, improvement of sexual function is used, male climacteric symptom improves and uses, be anti-tired
Labor with and/or lifting vigor food compositions.
9th, the composition as described in the 7th or the 8th, wherein, foregoing honeybee is treated by proteolytic enzyme.
10th, a kind of strong strong precision method, improvement of sexual function method, male climacteric symptom ameliorative way, fatigue changes
Kind method and lifting vigor method, wherein, including the process that honeybee of effective dose is delivered medicine to mammal.
11st, the method as described in the 10th, wherein, foregoing honeybee is treated by proteolytic enzyme.
12nd, a kind of honeybee manufacturing strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver, anti-
Application in tired agent and vigor elevator.
13rd, the application as described in the 12nd, wherein, foregoing honeybee is treated by proteolytic enzyme.
The effect of invention
Because there is honeybee the improvement result of strong strong essence effect, improvement of sexual function effect, male climacteric symptom to change
Kind effect and antifatigue effect, therefore as strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and resist tired
It is useful for the active ingredient of labor agent.Also, honeybee will not rise androgen, therefore there is high security.
Brief description of the drawings
Fig. 1 be represent absorb test meal before and after (a) AMS fractions (total), (b) AMS fractions (sexual factor), (c) AMS
The chart of fraction (physical factors).Average value ± SE*p<0.05**p<0.01
Fig. 2 be represent absorb test meal before and after IIEF5 chart.Average value ± SE*p<0.05**p<0.01
Fig. 3 be represent absorb test meal before and after Morning erection number chart.Average value ± SE*p<0.05**p<
0.01
Fig. 4 be represent absorb test meal before and after sense of fatigue VAS chart.Average value ± SE*p<0.05**p<0.01
Fig. 5 be represent absorb test meal before and after SDS chart.Average value ± SE*p<0.05**p<0.01
Fig. 6 be represent absorb test meal before and after (a) TT, (b) FT chart.Average value ± SE*p<0.05**p<0.01
Embodiment
Hereinafter, the present invention is described in detail.
The strong essence-replenishing preparation of the present invention, improvement of sexual function agent, the feature of male climacteric condition improver and antifatigue
It is to contain honeybee.
Strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and the antifatigue of the present invention will not make
Androgen rises, therefore has high security.
Androgen is also known as the general name of the steroid hormone of male hormones, wherein, except Dai tables Testis ketone with
Outside, also comprising Shuan Qing Testis ketone, dehydrobenzene, androsterone, androstenedione, epiandrosterone etc..
Herein, honeybee refers to larva and the pupa of honeybee.There is no particular restriction for the species of honeybee, can widely use：Japanese honeybee,
Honeybee known to the honeybee of apis mellifera etc., Africanized bee honeybee, wasp (including black wasp), hornet, bumblebee etc..It is preferably sweet
Honeybee, from the viewpoint of being readily available, more preferably apis mellifera.No matter it should be noted that, although male female, but preferably
For drone.
As long as larva and pupa are by egg hatching, there is no particular restriction.Wherein, by 16~23 days after preferably hatching
The larva of honeybee and pupa, the larva by the honeybee of 18~21 days and pupa after more preferably hatching.
Honeybee accumulates nutritional ingredient in vivo.Particularly, drone is used as the raw material of traditional Chinese medicine since ancient times, and its is equal
Weighing apparatus ground include containing must amino acid various amino acid, but also rich in protein, lipid, carbohydrate, vitamin B group, folic acid,
The mineral matters such as the vitamin such as niacin, pantothenic acid group, Yi Jixin, selenium (Selenium).Physiological activity and pharmacology as honeybee are made
With, it is known to antibacterial action, anti-inflammatory effect, antivirus action, antiprotozoan effect, elimination tinnitus effect etc..
Raw honeybee and raw honeybee of working process state are used as to honeybee of the present invention.Honeybee crossed as working process,
Specifically include：Honeybee (raw or dried object) after crushing；Dried honeybee (raw or crushed material)；Honeybee after heating
(life, dried object or crushed material)；Use the extract obtained by extraction honeybee such as water, hydrous ethanol.Preferably include：By honeybee
(life) dry after by crushing and the dried powder of honeybee that modulates.
If without especially indicating, term " honeybee " of the invention just includes：Raw honeybee；Honeybee is implemented and dries, crush
Or the machining object heated；Use the extraction obtained by the extraction such as water, hydrous ethanol honeybee (including raw, dried object and crushed material)
Thing；And by treated honeybee of proteolytic enzyme (peptase) and its machining object.
As drying means, known method used by normal food processing can be used, such as：Aeration-drying, sunlight
The natural drying dried etc., dry force drying, freeze-drying etc. are allowed to heating such as electricity.Preferably it is freeze-dried.Need
Illustrate, drying time, there is no particular restriction, can include for example：In the natural drying using ventilation, weather-drying etc.
In the case of, about 3 days；In the case where using with the force drying of the heating such as electricity, carried out at about 50 DEG C about 1~3 day.It is logical
Often, it is below 10 mass % that moisture, which is dried, and preferably drying is below 5 mass %.It should be noted that such as using logical
The situation of the natural drying of wind, weather-drying etc. is such, moisture is difficult to dry be below 10 mass % in the case of, can be
Thereafter further enter to exercise the processing of moisture reduction using freeze drier.
Known method can be used to carry out pulverization process (powdered processing), such as：Carried out using grinder (grinder)
The method of crushing；Method pulverized using stone mortar etc..
There is no particular restriction for the method for heating honeybee, preferably enumerates using 70~120 DEG C of progress heat-treating methods.Can
Easily honeybee (including raw, dried object and crushed material) is put into the water of boiling and heated.In order to avoid as far as possible
The active ingredient dissolution such as various vitamins, amino acid, preferably the method for scorching honeybee by steam is used as heating.
Following method can be used in extracting process：To honeybee (including raw, dried object and triturate) addition water, hydrous ethanol etc.
After being stirred, the method for supernatant is obtained by centrifugation；Method for carrying out being filtrated to get filtrate using filter paper etc..
For honeybee and its machining object, by by proteolysis ferment treatment, making albumen contained by honeybee and its machining object
Matter is degraded, so as to expect to obtain a kind of ferment treatment thing that can be suppressed to the allergic reaction caused by the protein
(low-allergen ferment treatment thing).
For used proteolytic enzyme during honeybee and its machining object progress ferment treatment, peptide can be suitably enumerated
Enzyme.At least one of used peptase acts on as long as there is endopeptidase and exopeptidase acts on effect.
As the proteolytic enzyme at least with endopeptidase activity, can enumerate：From animal (such as：Trypsase, pancreas coagulate
Galactase etc.), from plant (such as：Papain etc.), from microorganism (such as：Lactic acid bacteria, yeast, mould, withered grass
Bacillus, actinomyces etc.) endopeptidase.
At least there is the proteolytic enzyme of endopeptidase activity, can enumerate：Carboxypeptidase, amido peptase, from microorganism (example
Such as：Lactic acid bacteria, aspergillus bacterium, rhizopus etc.) exopeptidase, in the lump with the pancreatin of endopeptidase activity, pepsin etc..
Among various enzymes as described above, as the preferred of the enzyme with both endopeptidase activity and endopeptidase activity
Example, can be enumerated：Peptase (the trade name that streptomyces griseus (Streptomyces griseus) is produced：Actin enzyme AS), rice
Peptase (the trade name that aspergillus (Aspergillus oryzae) is produced：Protease A, flavor protease), Aspergillus melleus
Peptase (the trade name that (Aspergillus melleus) is produced：Protease P) etc..
In addition, the preference as the enzyme with exopeptidase effect, can be enumerated：Rice aspergillus (Aspergillus oryzae)
Peptase (the trade name produced：Delicate flavour enzyme G, Promod192P, Promod 194P, Sumizyme FLAP), Aspergillus sojae
Peptase (the trade name that (Aspergillus sojae) is produced：Sternzym B15024), the peptase (commodity that are produced of aspergillus
Name：Kokulase P), the peptase (trade name produced of Rhizopus oryzae (Rhizopus oryzae)：Peptase R) etc..
And then as the preference of the peptase acted on endopeptidase, it can enumerate：Hay bacillus (Bacillus
Subtilis peptase (the trade name) produced：Orientase 22BF, Nukureishin), bacillus licheniformis (Bacillus
Licheniformis peptase (the trade name) produced：Alkali protease), bacillus stearothermophilus (Bacillus
Stearothermophilus peptase (the trade name) produced：Protease S), bacillus amyloliquefaciens (Bacillus
Amyloliquefaciens peptase (the trade name) produced：Neutral proteinase), the peptase (trade name produced of bacillus：
Protamex) etc..
For in order to reduce hypersensitive ferment treatment of honeybee and its machining object, such as can be according to Japanese Unexamined Patent Publication
The record of 2009-159997 publications is carried out.
For strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and antifatigue of the invention
Speech, as long as not hindering the effect of the present invention, additional composition can be included.In the case of comprising the additional composition of correlation, as strong
Essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and the ratio of honeybee in antifatigue, can be illustrated as 0.01
~99 mass %, preferably 1~80 mass %, more preferably 10~70 mass %, more preferably 20~50 mass %.
The strong essence-replenishing preparation of the present invention, improvement of sexual function agent, the form of male climacteric condition improver and antifatigue
It is not particularly limited, there can be the system such as powdered, graininess, tablet shape, capsule shape, liquid, suspension, emulsion form
Dosage form state.
Strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and the antifatigue of the present invention can be appropriate
Ground uses the composition of food compositions, medicine part outer article and pharmaceuticals (particularly oral drugs).
Strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and the antifatigue of the present invention also includes
Following meaning：By health care, maintain, improve health etc. for the purpose of diet product (for example, healthy food, functional food, nutrition group
Compound (nutritional composition), nutritious subsidy food, replenishers, health food, specific health food,
Trophic function food or feature represent food), medicine part outer article and pharmaceuticals (particularly oral drugs).It is in addition, of the invention
Strong essence-replenishing preparation, improvement of sexual function agent, male climacteric condition improver and antifatigue also include following meaning：Assign strong
What strong strong smart effect, improvement of sexual function effect, male climacteric symptom improvement result, antifatigue effect and lifting vigor acted on adds
Add agent.
Excipient, polishing material, mineral matter class, vitamin class, flavonoids, quinone can be compounded into above-mentioned diet product as needed
Class, Polyphenols, amino acid, nucleic acid, necessary aliphatic acid, freshener, bonding agent, sweetening material, disintegrant, lubricant, colouring agent, perfume (or spice)
Material, stabilizer, preservative, sustained release regulator, surfactant, lytic agent, wetting agent etc..
The species of above-mentioned diet product is not particularly limited, and can be enumerated for example：Beverage class be (coffee, fruit juice, tea beverage etc
Wine of cold drink, milk beverage, sour milk beverage, boruga, soda, Janpanese sake, foreign wine, fruit kind etc etc.)；Smear
Sauce class (custard cream etc.)；Cream class (fruit cream etc.)；Cake class (chocolate, baked donut, group, puff, chewing gum, jelly, sugar
Fruit, biscuit, cake, pudding etc.)；Japanese snack categories (big good fortune, cake, steamed bun, Vinny Castilla, filling honey, red bean jelly etc.)；Frozen confection class
(ice cream, ice-cream stick, snow treasured etc.)；Foodstuff (curry, Niu Bowl, it is miscellaneous cook a meal, miso shiru, soup, meat pulp, pasta, pickles, jam
Deng)；Flavoring class (baste, the material for being sprinkled into mixed food, flavoring agent, cake etc.) etc..
Dosage unit form during as replenishers is not particularly limited, and can be properly selected, and can enumerate such as tablet, glue
Wafer, granule, liquor, powder etc..
As the ratio of honeybee contained by above-mentioned diet product, such as 0.01~99 mass %, preferably 1~80 matter can be enumerated
Measure %, more preferably 10~70 mass %, further preferred 20~50 mass % concentration.
The intake of above-mentioned diet product can be fitted according to the various conditions such as the body weight of taker, age, sex, symptom are taken the photograph
Locality setting.
Adjusted by the strong essence-replenishing preparation of the present invention, improvement of sexual function agent, male climacteric condition improver and antifatigue
In the case of being made as medicine part outer article or pharmaceuticals, honeybee preparation can be referred to as.In medicine part outer article or pharmaceuticals, Ke Yidan
The form of body uses above-mentioned honeybee, can be also used in mixed way with other medical components described in the Japanese Pharmacopoeia such as vitamin, crude drug.
Adjusted by the strong essence-replenishing preparation of the present invention, improvement of sexual function agent, male climacteric condition improver and antifatigue
In the case of being made as medicine part outer article or pharmaceuticals, can by honeybee and the permissible avirulent carrier of pharmaceuticals, diluent or
Excipient be together modulated to tablet (comprising uncoated tablets, sugar coated tablet, foaming tablet, film coating tablet, chewable tablet,
Oral tablet), capsule, pill, powder agent (powder), granula subtilis, granule, liquor, suspension, emulsion, syrup, paste
Etc. form, orally available preparation is made.
Can be according to agent of the various conditions such as the body weight of patient, age, sex, symptom to above-mentioned medicine part outer article or pharmaceuticals
Amount is suitably set, it is generally desirable to, daily honeybee is more than 0.5g, preferably more than 0.7g, more preferably more than 1g.
As long as the effect of the present invention can be played, then the ratio of honeybee has no especially contained by above-mentioned medicine part outer article or pharmaceuticals
Limitation, can enumerate such as 0.01~99 mass %, preferably 1~80 mass %, more preferably 10~70 mass %, further preferred 20
~50 mass % concentration.
The strong essence-replenishing preparation of present invention mentioned above, improvement of sexual function agent, male climacteric condition improver and anti-tired
Labor agent is suitable for inclusion in the mammal (being preferably the mankind, particularly preferably male) of the mankind.
Diet product, medicine part outer article and the pharmaceuticals of the present invention have strong strong essence effect, improvement of sexual function effect, male
Improvement result, antifatigue effect and the lifting vigor effect of menopause symptom.Further, since the diet product of the present invention, medical portion
Outer product and pharmaceuticals will not rise androgen, therefore have high security.
Embodiment
Hereinafter, the present invention is further described by embodiment.But the present invention is not limited to these embodiments.
[test example]
＜ subject ＞
Carry out survey and check (health examination, doctor's interrogation, blood test, survey etc.), will (1) 35 years old with
Less than more than 27 points 49 points persons, (3) You Li Testis ketone in male, (2) male climacteric interrogation table (following AMS) below upper 60 year old
For 8.5pg/mL less than 11.8pg/mL person, (4) are married or have different in nature object, totally 11 are used as subject.
＜ test methods ＞
11 subjects continuous soft capsule shape of intake daily in 12 weeks contains honeybee food capsule 6, wherein every
Capsule contains honeybee 180mg.The nutritional ingredient of every tested food capsule is as shown in the table.
【Table 1】
| Nutritional ingredient | Test meal |
| Heat (kcal) | 10.3 |
| Protein (g) | 0.8 |
| Lipid (g) | 0.6 |
| Carbohydrate (g) | 0.3 |
| Sodium (mg) | 7.8 |
It should be noted that subject before 1 week of day on-test untill intake terminates, remember daily in diary
Record includes subjective symptoms, life information of no Morning erection etc..
In on-test and intake start after carry out within the 12nd week doctor examination, survey, health examination, blood are examined
Look into and uroscopy, Dui Zong Testis ketone (hereinafter referred to as TT), You Li Testis ketone (hereinafter referred to as FT), increase age male's symptom adjust Check tickets (with
Lower abbreviation AMS), SDS (Self-rating depression scale, hereinafter referred to as SDS), international erection work(
The energy simple version of grade form (hereinafter referred to as IIEF5) and sense of fatigue VAS are evaluated.In addition, also by the Morning erection during experiment
Number is set to assessment item.
Widely used in the symptom interrogation of LOH syndromes oneself to charge in the questionnaire of formula, AMS fractions are by psychological factor
5 projects (25 points), the project of physical factors 7 (35 points), (85 points) compositions of total 17 projects of the project of sexual function factor 5 (25 points).
Projects with "None", " slight ", " medium ", " serious ", " very serious " this 5 evaluated, entered respectively with 1~5 point
Row scoring.Fraction is more high then to represent that symptom is more serious.
SDS is the index for representing depressive state degree, is made up of 20 inquiry projects of inquiry depressive symptom.Fraction is higher
Then represent that symptom is more serious.
IIEF5 be by international index of erectile function table (International Index of Erectile Function,
Hereinafter referred to as IIEF) the simple index for 5 projects, it is the international finger that the effect of the screening and the treatment that are used in ED judges
Mark.Fraction is more low then to represent that symptom is more serious.
Sense of fatigue is following index：According to VAS methods, using the left end of 10cm straight line as " never experience cross completely not
The best perception of fatigue can be felt ", using right-hand member as " the tired worst sensation that must do not done anying that never experience is crossed ",
Correspondence position record on straight line × number, by left end to the distance values of position recorded, the situation that numerical value reduces represents
Fatigue is improved.
＜ statistical analyses ＞
The average value and standard deviation of every group of each data are tried to achieve, to AMS fractions, IIEF5, SDS, Morning erection number and fatigue
Feel the digit difference test that VAS carries out Wilcoxon.
T corresponding to being carried out to TT, FT, health examination, blood test and blood biochemistry checking is examined.
The statistical analysis method of any one uses two-tailed test, and level of significance is 5% and 1%.
＜ results ＞
1 efficiency evaluation project
1)AMS
For AMS fractions, with absorb start when compared with, it is possible to find " total " (Fig. 1-a) at the end of intake
" sexual factor " (Fig. 1-b) " physical factors " (Fig. 1-c) significantly decreases.
2)IIEF5
In the front and rear comparison of test meal intake, it is possible to find IIEF5 has obvious increase (Fig. 2) at the end of intake.
3) Morning erection number
In the front and rear comparison of test meal intake, it is possible to find Morning erection number has obvious increase at the end of intake
(Fig. 3).
4) sense of fatigue VAS
In the front and rear comparison of test meal intake, it is possible to find sense of fatigue significantly decreases (Fig. 4) at the end of intake.
5)SDS
In the front and rear comparison of test meal intake, it is possible to find depressive symptom significantly decreases at the end of intake (schemes
5)。
2 safety evaluatio projects
Confirm TT and FT (Fig. 6), health examination, blood test, blood biochemistry checking and the uroscopy of every subject,
Do not find to trigger the variation of clinically problem.
During experiment, subject does not have found subjective symptoms.In addition, in the examination carried out during intake, do not have yet
It was found that any phenomenon suitable with harmful phenomenon.
＜ conclusions ＞
If make 11 males living less than 60 years old hypodynamic more than 35 years old in daily life continuous 12 weeks per daily ingestion 6
The soft capsule of the food containing honeybee, then can find：AMS is decreased obviously, IIEF5 and Morning erection number are significantly increased, right
It is decreased obviously in VAS the and SDS surveys of fatigue evaluation.Another aspect , Zong Testis acetone numbers and You Li Testis acetone numbers do not become
Change.That is, it was found that honeybee will not rise Testis acetone numbers, and it has the improvement, antifatigue of male climacteric symptom
Effect and resistance to compression effect.
Prescription example
The prescription example of the following presentation present invention.
The soft capsule of prescription example 1
Add edible oil and fat, beeswax and bean plant lecithin in honeybee of 1080mg 1/6 amount, and by they
In filling to the soft capsule containing gelatin and caramel colorant, soft capsule preparation is obtained.
The soft capsule of prescription example 2
By 180mg honeybee and edible oil and fat, γ-aminobutyric acid, glycerine, bean plant lecithin, beeswax, vitamin
B2 and Anacobin mixing, and they are filled into the soft capsule containing gelatin and caramel colorant, obtain soft capsule system
Agent.
The soft capsule of prescription example 3
By 100mg honeybee and edible oil and fat, agate card extract powder, eastern Ge Ali extracts powder, aweto
Filament powder, mix containing Zn-contained yeast, Piper longum extract powder, beeswax and bean plant lecithin, they are filled to containing
In the soft capsule of gelatin and cacao color, soft capsule preparation is obtained.
Claims (4)
1. a kind of strong essence-replenishing preparation, it contains honeybee.
2. a kind of improvement of sexual function agent, it contains honeybee.
3. a kind of male climacteric condition improver, it contains honeybee.
4. a kind of antifatigue, it contains honeybee.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-085118 | 2015-04-17 | ||
| JP2015085118 | 2015-04-17 | ||
| PCT/JP2016/061822 WO2016167254A1 (en) | 2015-04-17 | 2016-04-12 | Nutrient tonic containing bee larvae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107427538A true CN107427538A (en) | 2017-12-01 |
Family
ID=57126769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680021368.3A Pending CN107427538A (en) | 2015-04-17 | 2016-04-12 | Nourishing tonic containing honeybee |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6483244B2 (en) |
| CN (1) | CN107427538A (en) |
| SG (1) | SG11201708300YA (en) |
| TW (1) | TW201642882A (en) |
| WO (1) | WO2016167254A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102334546B1 (en) * | 2019-12-10 | 2021-12-03 | 대한민국 | Composition for anti-inflammatory comprising male pupa extract |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036722A (en) * | 2006-03-15 | 2007-09-19 | 张丽英 | Health-caring food for easing and improving climacteric Syndrome of men and the preparation thereof |
| CN102134545A (en) * | 2010-12-10 | 2011-07-27 | 黄淑辉 | Bee pupa prepared wine and preparation method thereof |
| CN103750094A (en) * | 2013-06-29 | 2014-04-30 | 明光市昊昊蜂业有限公司 | Male hachinoko health-care paste and preparation method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731339A (en) * | 1995-04-28 | 1998-03-24 | Zonagen, Inc. | Methods and formulations for modulating the human sexual response |
| ITRM20020620A1 (en) * | 2002-12-13 | 2004-06-14 | Sigma Tau Ind Farmaceuti | USE OF CARNITINE FOR THE PREVENTION AND / OR TREATMENT OF DISORDERS CAUSED BY ANDROPAUSE. |
| JP2005179307A (en) * | 2003-12-22 | 2005-07-07 | Lion Corp | Climacterium syndrome treating agent and medicinal preparation containing the same |
| JP2007024822A (en) * | 2005-07-21 | 2007-02-01 | Aska Pharmaceutical Co Ltd | Discriminating method of male menopause or depression |
| JP4526467B2 (en) * | 2005-10-26 | 2010-08-18 | アサヒビール株式会社 | Nourishing tonic beverage |
| ES2861583T3 (en) * | 2007-10-10 | 2021-10-06 | Kyowa Hakko Bio Co Ltd | Rapid-acting oral preparation that can increase the level of arginine in the blood and comprises citrulline and arginine |
| RU2376978C2 (en) * | 2007-12-29 | 2009-12-27 | Валентин Васильевич Хижа | Complex api preparation in form of suppositories for treatment of andrological diseases and method of obtaining it |
| JP4917584B2 (en) * | 2008-06-23 | 2012-04-18 | アピ株式会社 | Processed solubilized bees, method for producing the same, antioxidant, ACE inhibitor, antihypertensive agent, dermal fibroblast proliferation promoter, fatigue recovery agent, blood flow improving agent, and solubilized bees Pharmaceuticals, cosmetics or food / drinks contained |
| JP2009159997A (en) * | 2009-04-27 | 2009-07-23 | Yamada Bee Farm Corp | Food composition containing bee larva of lowered molecular weight and production method thereof |
-
2016
- 2016-04-12 SG SG11201708300YA patent/SG11201708300YA/en unknown
- 2016-04-12 CN CN201680021368.3A patent/CN107427538A/en active Pending
- 2016-04-12 JP JP2017512543A patent/JP6483244B2/en active Active
- 2016-04-12 WO PCT/JP2016/061822 patent/WO2016167254A1/en active Application Filing
- 2016-04-15 TW TW105111807A patent/TW201642882A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036722A (en) * | 2006-03-15 | 2007-09-19 | 张丽英 | Health-caring food for easing and improving climacteric Syndrome of men and the preparation thereof |
| CN102134545A (en) * | 2010-12-10 | 2011-07-27 | 黄淑辉 | Bee pupa prepared wine and preparation method thereof |
| CN103750094A (en) * | 2013-06-29 | 2014-04-30 | 明光市昊昊蜂业有限公司 | Male hachinoko health-care paste and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| MARIANNE COUSIN ET AL.: "Size changes in honey bee larvae oenocytes induced by exposure to paraquat an very low concentrations", 《PLOS ONE》 * |
| 中国蜂产品供求信息网: "蜂蛹（蜂王幼虫）的作用及功效", 《百度文库》 * |
| 孙启跃等: "鲜雄蜂蛹生产关键技术初探", 《中国畜禽种业》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201642882A (en) | 2016-12-16 |
| JP6483244B2 (en) | 2019-03-13 |
| JPWO2016167254A1 (en) | 2018-01-11 |
| WO2016167254A1 (en) | 2016-10-20 |
| SG11201708300YA (en) | 2017-11-29 |
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