CN107427007B - 用于治疗水肿的组合物和方法 - Google Patents

用于治疗水肿的组合物和方法 Download PDF

Info

Publication number
CN107427007B
CN107427007B CN201680016894.0A CN201680016894A CN107427007B CN 107427007 B CN107427007 B CN 107427007B CN 201680016894 A CN201680016894 A CN 201680016894A CN 107427007 B CN107427007 B CN 107427007B
Authority
CN
China
Prior art keywords
lymphatic
tacrolimus
mice
treatment
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680016894.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN107427007A (zh
Inventor
B.梅赫拉拉
J.加德涅尔
I.萨维特斯基
O.阿拉斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Priority to CN202210078205.6A priority Critical patent/CN114588154A/zh
Publication of CN107427007A publication Critical patent/CN107427007A/zh
Application granted granted Critical
Publication of CN107427007B publication Critical patent/CN107427007B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CN201680016894.0A 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法 Expired - Fee Related CN107427007B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210078205.6A CN114588154A (zh) 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112273P 2015-02-05 2015-02-05
US62/112,273 2015-02-05
PCT/US2016/016680 WO2016127013A1 (en) 2015-02-05 2016-02-05 Compositions and methods for treatment of edema

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210078205.6A Division CN114588154A (zh) 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法

Publications (2)

Publication Number Publication Date
CN107427007A CN107427007A (zh) 2017-12-01
CN107427007B true CN107427007B (zh) 2022-02-11

Family

ID=56564721

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680016894.0A Expired - Fee Related CN107427007B (zh) 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法
CN202210078205.6A Pending CN114588154A (zh) 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210078205.6A Pending CN114588154A (zh) 2015-02-05 2016-02-05 用于治疗水肿的组合物和方法

Country Status (8)

Country Link
US (5) US10251871B2 (https=)
EP (1) EP3253211B1 (https=)
JP (2) JP6704403B2 (https=)
CN (2) CN107427007B (https=)
AU (2) AU2016215173B2 (https=)
ES (1) ES3040783T3 (https=)
HK (1) HK1247789A1 (https=)
WO (1) WO2016127013A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107427007B (zh) * 2015-02-05 2022-02-11 纪念斯隆凯特林癌症中心 用于治疗水肿的组合物和方法
CA3033863C (en) * 2016-08-18 2021-09-14 Memorial Sloan Kettering Cancer Center Inhibition of sphingosine 1-phosphate receptor for treatment and prevention of lymphedema
EP4427815A3 (en) * 2018-09-14 2024-11-06 Puretech Lyt 100, Inc. Deuterium-enriched pirfenidone and methods of use thereof
AU2019375206A1 (en) * 2018-11-05 2021-06-24 Apramitha Innovations Private Limited Teriflunomide topical pharmaceutical compositions
EP4121049A4 (en) * 2020-03-18 2024-04-03 Puretech Lyt 100, Inc. Methods of treating lymphedema with deupirfenidone
CN112642065B (zh) * 2020-12-28 2022-08-02 锐可医疗科技(上海)有限公司 激光治疗仪及存储介质
WO2024059336A1 (en) * 2022-09-18 2024-03-21 Memorial Sloan Kettering Cancer Center Inhibition of protease-activated receptor 2 (par2) pathway for treatment and prevention of lymphedema

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1688305A (zh) * 2002-08-10 2005-10-26 贝塞斯达药物股份有限公司 不会引起液体潴流、水肿或充血性心力衰竭的新ppar配体
CN101443004A (zh) * 2006-03-23 2009-05-27 马库赛特公司 用于与血管通透性有关的疾病或病症的制剂和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158371A1 (en) * 2002-02-12 2005-07-21 Sumitomo Pharmaceuticals Co., Ltd. Novel external agent
JPWO2005011669A1 (ja) * 2003-08-05 2006-09-14 大日本住友製薬株式会社 経皮投与用医薬組成物
WO2007103687A2 (en) * 2006-03-01 2007-09-13 Tristrata, Inc. Composition and method for topical treatment of tar-responsive dermatological disorders
CN101484167B (zh) * 2006-06-15 2012-07-04 上海睿星基因技术有限公司 吡啶酮类衍生物预防和治疗放射性肺损伤的用途
CA2680825C (en) * 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
WO2010048716A1 (en) * 2008-10-29 2010-05-06 Pacific Therapeutics Ltd. Composition and method for treating fibrosis
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
US20120130144A1 (en) * 2009-02-04 2012-05-24 Bipar Sciences, Inc. Treatment of lung cancer with a nitrobenzamide compound in combination with a growth factor inhibitor
DE102010015143A1 (de) * 2010-04-16 2011-10-20 Cts Chemical Industries Ltd. Stabile flüssige ölige gebrauchsfertige Formulierungen, Herstellung davon und Verwendung davon
CN107427007B (zh) * 2015-02-05 2022-02-11 纪念斯隆凯特林癌症中心 用于治疗水肿的组合物和方法
US10292961B2 (en) * 2015-07-15 2019-05-21 Hangzhou Dac Biotech Co., Ltd. Disulfur bridge linkers for conjugation of a cell-binding molecule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1688305A (zh) * 2002-08-10 2005-10-26 贝塞斯达药物股份有限公司 不会引起液体潴流、水肿或充血性心力衰竭的新ppar配体
CN101443004A (zh) * 2006-03-23 2009-05-27 马库赛特公司 用于与血管通透性有关的疾病或病症的制剂和方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Nicholas W. Clavin等.TGF-β1 is a negative regulator of lymphatic regeneration during wound repair.《AJP - Heart and Circulatory Physiology》.2008,第295卷H2113-H2114. *
TGF-β1 is a negative regulator of lymphatic regeneration during wound repair;Nicholas W. Clavin等;《AJP - Heart and Circulatory Physiology》;20081010;第295卷;H2113-H2114 *

Also Published As

Publication number Publication date
JP6926263B2 (ja) 2021-08-25
JP2020114830A (ja) 2020-07-30
US20210069164A1 (en) 2021-03-11
EP3253211A1 (en) 2017-12-13
US20200016137A1 (en) 2020-01-16
AU2016215173B2 (en) 2019-11-21
AU2020201161A1 (en) 2020-03-05
US20250235436A1 (en) 2025-07-24
AU2020201161B2 (en) 2021-07-15
CN114588154A (zh) 2022-06-07
US12144805B2 (en) 2024-11-19
EP3253211A4 (en) 2018-10-31
JP6704403B2 (ja) 2020-06-03
EP3253211B1 (en) 2025-06-11
ES3040783T3 (en) 2025-11-04
AU2016215173A1 (en) 2017-08-24
JP2018504436A (ja) 2018-02-15
US20230241043A1 (en) 2023-08-03
US10251871B2 (en) 2019-04-09
US20180028514A1 (en) 2018-02-01
US10874651B2 (en) 2020-12-29
HK1247789A1 (zh) 2018-10-05
WO2016127013A1 (en) 2016-08-11
CN107427007A (zh) 2017-12-01
US11583523B2 (en) 2023-02-21
CA2975879A1 (en) 2016-08-11

Similar Documents

Publication Publication Date Title
CN107427007B (zh) 用于治疗水肿的组合物和方法
Kawai et al. PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β
Yu et al. Combining TGF-β inhibition and angiotensin II blockade results in enhanced antifibrotic effect
Lee et al. Enalapril inhibits nuclear factor-κB signaling in intestinal epithelial cells and peritoneal macrophages and attenuates experimental colitis in mice
CA3033863C (en) Inhibition of sphingosine 1-phosphate receptor for treatment and prevention of lymphedema
AU2023202294B2 (en) Compositions and methods for immune-mediated cancer therapy
Guyonnet et al. Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury
US20230132275A1 (en) Use of cdon inhibitors for the treatment of endothelial dysfunction
CA2975879C (en) Compositions and methods for treatment of edema
Miyata et al. Renoprotective effects of direct renin inhibition in glomerulonephritis
US20200330459A1 (en) Methods and pharmaceutical compositions for the treatment of age-related cardiometabolic diseases
US20240117052A1 (en) Antibody for cancer treatment conjugated to tumor environment-sensitive traceless-cleavable polyethylene glycol and manufacturing method thereof
NESSA Evaluation of the effects of pre-injury exercise in a mouse hindlimb model of secondary lymphedema
Uchida et al. Renal damage inhibited in mice lacking angiotensinogen gene subjected to unilateral ureteral obstruction
Pollock Articles in PresS. Am J Physiol Renal Physiol (August 20, 2014). doi: 10.1152/ajprenal. 00698.2013

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20220211

CF01 Termination of patent right due to non-payment of annual fee