CN1074139A - 光辐射治疗仪 - Google Patents

光辐射治疗仪 Download PDF

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CN1074139A
CN1074139A CN92100043.XA CN92100043A CN1074139A CN 1074139 A CN1074139 A CN 1074139A CN 92100043 A CN92100043 A CN 92100043A CN 1074139 A CN1074139 A CN 1074139A
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张瑞明
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Dalian Bomu Instrument & Apparatus Co Ltd
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Priority to AU10191/92A priority patent/AU1019192A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/201—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with beam delivery through a hollow tube, e.g. forming an articulated arm ; Hand-pieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation

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Abstract

一种光辐射治疗仪，特别是一种利用光辐射对于 人的体表或腔体表面的病变部位产生热效果的光辐 射治疗仪，其特点是光源为温度可达1900—2100K 的热光源，并有能对传导的大部分光产生全反射的光 导体。本仪器结构简单，对光线利用率高，对宫颈糜 烂的治疗有很好的效果。

Description

本发明涉及一种光幅射治疗仪，特别是一种利用光线在人的腔体内表面或体表病变部位产生热效果的光幅射治疗仪。
对于某些人体腔体部位的疾病，例如宫颈糜烂可用激光照射的方法治疗。对于激光治疗仪，例如中国鹭岛公司出产的LD-10B二氧化碳激光治疗仪，仪器的操作复杂，而且激光对病变部位的烧灼温度较高，容易使患者感到不适和疼痛。激光治疗仪的另一个不足之处是光束很细，在使用中有的病变部位会照射不到，对较大面积的病变部位的医治不彻底。
还有一些光幅射治疗仪，它们的光导装置有种种缺陷，使光幅射在集中和传导过程中能量损失较大，这样就需要加大光源的功率，同时要在光导部件外部加装散热装置，以免烫伤与光导部件周围接触的人体组织。
本发明的目的之一是在光幅射治疗仪中提供其它幅射源取代激光，对病变部位产生热效果，并使光源部件的结构简单。
本发明的另一目的是提供比激光光束（直径≤2mm）粗的光束，使病变的所有部位都被照射到。
本发明的又一目的是提供在一定波长的幅射光束，使它们在幅射到病变部位及正常部位时达到的温度与激光达到的温度相比较低。
本发明的又一目的之一是提供一种光导体，使治疗的光在光导体中的传导损失很小。
本发明的目的还在于提供一些根据光学原理制成的反光，聚光装置，最大限度的利用光源所产生的光幅射的能量。
本发明涉及一种光幅射治疗仪，特别是一种利用光幅射在人的腔体内表面和体表病变部位产生热效果的光幅射治疗仪，包括壳体，装于壳体内的光源和反光镜，反光镜位于光源后方，特点是光源为温度可达1900-2100K的热幅射源，光源前方装有伸出壳体以外的能对传导的大部分光幅射产生全反射的光导体。
温度可达1900-2100K的光源，例如卤钨灯，发出的光的波长大部分在0.4～5m之间，能使受照射的病变细胞的蛋白质固化，造成病变细胞坏死。
光导体，例如红外透射石英玻璃棒，光导管，光纤缆等，因外部是光疏媒质或折射率小的材料，可使光源的前方散射和反射镜反射到前方的大部分光在光导体内部全反射传导，最后光源的大部分光幅射可集中照射到病变部位，光导体越靠近光源，接受的光幅射越多。
在光导体是红外透射石英玻璃棒的情况，棒本身的材料对传导的红外线吸收很少，能更有效地利用光源的光。
在光导体与光源间可加装两个凸面相对的球面或非球面平凸柱形透镜，这样可将散射和反射到它上面的光集中成较均匀的近似平行光，使到达光导体入射端的光幅射更均匀集中，进一步减少光幅射的传导损失。这种附加透镜对光导和是光纤缆，光导管或红外透射石英玻璃棒的情况都适合。
光导体外部可有保护套，光导体与保护套之间用支承固定，使保护套与光导体之间的空隙，空隙间可填充合适的光疏媒质，优选是空气。
光导体可并排附加一个成像光导纤维，这样可以在治疗过程中观察照射的部位和治疗的情况。对于光导体是光纤缆的情况，可在光纤缆中放置至少一根成像光导纤维。为更清楚，更大范围地观察，成像光导纤维端部可装接窥镜。
反光镜的表面可以用金属镀膜。各种金属对不同频率的光的反射能力不同。对于本发明所用的光源，即绝大多数发射的光在0.4～5m波长内的光，优选铜作镀膜。
在壳体上可装设冷却孔道，对壳体和反光镜冷却。
本发明的光幅射治疗仪与现有技术相比，具有以下优点：
1、采用了装置简单，对病变部位治疗的温度较低，照射面积大，疗效好的光幅射源。
2、采用了传导中光损失很小的光导体及附加装置，使光的利用率高，热损失小。
本发明的光幅射治疗器经临床使用，对不同年龄，不同病变程度的宫颈糜烂患者都有满意的效果。对500例临床治疗的统计表明有效率接近100%，一次治愈率达98%。三个月后对病人随访，病人的病变处没有复发，病变部位的弹性恢复正常，宫颈表面恢复平滑并且没有明显的疤痕。
图1是实施例1中光幅射治疗仪的结构示意图;
图2是有保护套，并在光导体与套间隙填有光疏媒质的光导装置结构示意图;
图3是将图2中光导体的端面作成斜切面的示意图;
图4是装有平凸透镜的光线治疗仪的结构示意图;
图5是光导体为光纤缆的光导体的横剖面示意图;
图6是光导体为光导管的光导体的横剖面示意图。
实施例1
参见图1，光幅射治疗仪包括壳体6，反光镜4，碘钨灯2和红外透射石英玻璃棒1。壳体为直径50mm，长60mm的园柱状铝质壳，铝壳在反光镜后面设有冷却水道5。反光镜凹面镀有0.2mm厚的铜镀层。反光镜的前焦点附近装有55伏，500瓦的碘钨灯。灯的前方装有靠近光源，并穿出壳体的红外透射石英玻璃棒（中国锦州石英玻璃厂出口），棒直径A约10mm，长B约100mm。棒的近灯端距灯约1mm。
如图2所示，图1所述装置也可在棒外加保护套，套8与棒体9之间有间隙7。
如图3所示，图1所述装置的棒的发射端也可作成45°的斜切面。
实施例2
如图4所示，光幅射治疗仪包括壳体16，功率为150瓦的碘钨灯17，反光镜（附着在壳体18上），非球面平凸柱形透镜13、14;光纤缆12。光源前方内筒15上装有两个凸面相对接触的非面平凸柱形透镜，光纤缆与平凸透镜相距约3mm。光纤缆的发射端装有滤色透镜11。光纤缆直径C约为10mm，长约150mm。
图5是光纤缆的横剖面示意图。外套19可以由刚性或可弯曲材料制成。多根光纤放入外套中。
本实施例的光导体也可使用光导管，光导管的横剖面示意图如图6所示。其中21为红外透射石英玻璃棒，22为表面镀铜的金属管。

Claims (12)

1、一种光幅射治疗仪，特别是一种利用光幅射对于人的体表或腔体内表面的病变部位产生热效果的光幅射治疗仪，包括壳体，装于壳体内的光源和反光镜，反光镜位于光源后方，其特征在于：
A、光源为温度可达1900-2100K的热光源；
B、光源前方装有伸出壳体以外的能对传导的大部分光产生全反射的光导体。
2、如权利要求1所述的光幅射治疗仪，其特征在于，光源是卤钨灯。
3、如权利要求1或2所述的光幅射治疗仪，其特征在于，光导体是红外透射石英玻璃棒。
4、如权利要求1或2所述的光幅射治疗仪，其特征在于，光导体是光纤缆。
5、如权利要求1或2所述的光幅射治疗仪，其特征在于，光导体是光导管。
6、如权利要求1所述的光幅射治疗仪，其特征在于，在光源与光导体之间加有两个凸面相对的球面或非球而平凸柱形透镜。
7、如权利要求1或2所述的光幅射治疗仪，其特征在于，光导体外部有保护套，所述光导体与保护套之间用支承固定，使保护套与光导体之间有空隙，空隙间可填充合适的光疏媒质，优选是空气。
8、如权利要求1或2所述的光幅射治疗仪，其特征在于，所述的光导体的发射面为斜切面。
9、如权利要求1或2所述的光幅射治疗仪，其特征在于，所述光导体可附带有成像光导纤维，光导纤维端部装有窥镜。
10、如权利要求1或2所述的光幅射治疗仪，其特征在于，壳体上装有冷却装置。
11、一种光幅射治疗仪，特别是一种利用光幅射在人的体表或腔体内表面病变部位产生热效果的光幅射治疗仪，包括壳体，装于壳体内的光源和反光镜，反光镜位于光源的后方，光导体，光导体位于光源的前方并伸出壳体以外，其特征在于：
A、光源为卤钨灯;
B、光导体为红外透射石英玻璃棒;
12、一种光幅射治疗仪，特别是一种利用光幅射在人的体表或腔体内表面病变部位产生热效果的光幅射治疗仪，包括壳体，装于壳体内的光源和反光镜，反光镜位于光源后方，光导体，光导体位于光源的前方并伸出壳体以外，其特征在于：
A、光源为卤钨灯;
B、光源与光导体之间加有两个凸面相对的球面或非球面的平凸柱形透镜。
CN92100043.XA 1991-01-14 1992-01-09 光辐射治疗仪 Expired - Fee Related CN1029389C (zh)

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Application Number Priority Date Filing Date Title
CN91100301.0A CN1018429B (zh) 1991-01-14 1991-01-14 光治疗器
CN92100043.XA CN1029389C (zh) 1991-01-14 1992-01-09 光辐射治疗仪
AU10191/92A AU1019192A (en) 1991-01-14 1992-01-13 Optical radiation instrument
EP92100477A EP0495443A1 (en) 1991-01-14 1992-01-14 Optical radiation treatment instrument
JP4040056A JPH06125998A (ja) 1991-01-14 1992-01-14 光学照射治療器具

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Application Number Priority Date Filing Date Title
CN91100301.0A CN1018429B (zh) 1991-01-14 1991-01-14 光治疗器
CN92100043.XA CN1029389C (zh) 1991-01-14 1992-01-09 光辐射治疗仪

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CN1038230C (zh) * 1994-10-25 1998-05-06 北京科电微波电子公司 红光烧伤治疗仪
CN102141211A (zh) * 2010-01-29 2011-08-03 丰田合成株式会社 光源装置
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5435805A (en) 1992-08-12 1995-07-25 Vidamed, Inc. Medical probe device with optical viewing capability
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US5542915A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Thermal mapping catheter with ultrasound probe
US5421819A (en) 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
CN1038479C (zh) * 1992-07-21 1998-05-27 徐业林 光学健身治疗仪
US5720719A (en) 1992-08-12 1998-02-24 Vidamed, Inc. Ablative catheter with conformable body
US5556377A (en) 1992-08-12 1996-09-17 Vidamed, Inc. Medical probe apparatus with laser and/or microwave monolithic integrated circuit probe
US5672153A (en) 1992-08-12 1997-09-30 Vidamed, Inc. Medical probe device and method
US5630794A (en) 1992-08-12 1997-05-20 Vidamed, Inc. Catheter tip and method of manufacturing
US5720718A (en) 1992-08-12 1998-02-24 Vidamed, Inc. Medical probe apparatus with enhanced RF, resistance heating, and microwave ablation capabilities
US5514131A (en) 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5456662A (en) 1993-02-02 1995-10-10 Edwards; Stuart D. Method for reducing snoring by RF ablation of the uvula
DE4443964C1 (de) * 1994-12-09 1996-04-04 Schwarzmaier Hans Joachim Dr Vorrichtung zum Bestrahlen von Körpergewebe mit Laserlicht
DE19641216A1 (de) * 1996-09-26 1998-04-02 Wilkens Heinrike Dr Med Bestrahlungsvorrichtung, insbesondere zur kosmetischen, diagnostischen und therapeutischen Lichtanwendung
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US20200046428A1 (en) * 2016-10-21 2020-02-13 Lazcath Pty Ltd Fibre optic assembly
CN106823135B (zh) * 2017-03-27 2024-06-07 武汉优瑞科技有限公司 一种低频脉冲综合治疗仪
CN112972905B (zh) * 2021-02-23 2022-06-10 长沙中至健医疗科技有限公司 一种双波长高均匀性的高能光谱治疗装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1800277A (en) * 1925-05-28 1931-04-14 Edward W Boerstler Method for producing therapeutic rays
DE2717421A1 (de) * 1974-05-21 1978-11-16 Nath Guenther Koagulator
DE2511037A1 (de) * 1975-03-13 1976-09-23 Nath Guenther Bestrahlungsgeraet mit einer elektrischen lampe und einem diese in abstand umgebendem abschirmgehaeuse
DE2607249C2 (de) * 1976-02-23 1986-09-18 Nath, Guenther, Dr., 8000 Muenchen Bestrahlungsgerät für den ultravioletten Spektralbereich
DE2846471A1 (de) * 1978-10-25 1980-05-08 Nath Guenther Bestrahlungsgeraet fuer dentalzwecke
DE3347730A1 (de) * 1983-12-31 1985-07-04 Ursel Pesch Inh. Hans-Peter Pesch, 2090 Winsen Bestrahlungsgeraet fuer heilzwecke und verfahren zur steuerung des wellenlaengenbereichs der strahlung einer infrarot-lampe
US4805987A (en) * 1987-12-29 1989-02-21 Laakmann Katherine D Hollow lightpipe using a low refractive index inner layer
DE3803763A1 (de) * 1988-02-08 1989-08-17 Vught Barbara Van Optisches bestrahlungsgeraet fuer biologische materie

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1037581C (zh) * 1993-12-17 1998-03-04 中国科学院安徽光学精密机械研究所 一种光谱辐射治疗仪
CN1038230C (zh) * 1994-10-25 1998-05-06 北京科电微波电子公司 红光烧伤治疗仪
CN102141211A (zh) * 2010-01-29 2011-08-03 丰田合成株式会社 光源装置
CN106235893A (zh) * 2016-08-31 2016-12-21 圆融健康科技（深圳）有限公司 锅盖、锅及锅内食物保鲜方法
CN106235893B (zh) * 2016-08-31 2019-08-13 圆融健康科技（深圳）有限公司 锅盖、锅及锅内食物保鲜方法

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CN1029389C (zh) 1995-08-02
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JPH06125998A (ja) 1994-05-10
AU1019192A (en) 1992-07-16

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