CN107412427A - A kind of Control for Ejiao Buxue particle and preparation method thereof - Google Patents
A kind of Control for Ejiao Buxue particle and preparation method thereof Download PDFInfo
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- CN107412427A CN107412427A CN201710778572.6A CN201710778572A CN107412427A CN 107412427 A CN107412427 A CN 107412427A CN 201710778572 A CN201710778572 A CN 201710778572A CN 107412427 A CN107412427 A CN 107412427A
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- 239000002245 particle Substances 0.000 title claims abstract description 38
- 108010052008 colla corii asini Proteins 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 108010010803 Gelatin Proteins 0.000 claims abstract description 30
- 239000008273 gelatin Substances 0.000 claims abstract description 30
- 229920000159 gelatin Polymers 0.000 claims abstract description 30
- 235000019322 gelatine Nutrition 0.000 claims abstract description 30
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 30
- 238000000605 extraction Methods 0.000 claims abstract description 15
- 241000756943 Codonopsis Species 0.000 claims abstract description 14
- 241000405414 Rehmannia Species 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000007787 solid Substances 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims description 40
- 239000000084 colloidal system Substances 0.000 claims description 29
- 239000003292 glue Substances 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 17
- 241000283074 Equus asinus Species 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 13
- 229920000297 Rayon Polymers 0.000 claims description 12
- 238000012545 processing Methods 0.000 claims description 12
- 244000068988 Glycine max Species 0.000 claims description 11
- 235000010469 Glycine max Nutrition 0.000 claims description 11
- 239000012535 impurity Substances 0.000 claims description 11
- 238000011049 filling Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 235000019991 rice wine Nutrition 0.000 claims description 9
- 239000011435 rock Substances 0.000 claims description 9
- 238000013461 design Methods 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 8
- 239000005416 organic matter Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 238000005520 cutting process Methods 0.000 claims description 4
- 230000008030 elimination Effects 0.000 claims description 4
- 238000003379 elimination reaction Methods 0.000 claims description 4
- 239000011229 interlayer Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000005057 refrigeration Methods 0.000 claims description 2
- 239000006260 foam Substances 0.000 claims 1
- 235000014101 wine Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 2
- 210000003743 erythrocyte Anatomy 0.000 description 24
- 102000001554 Hemoglobins Human genes 0.000 description 23
- 108010054147 Hemoglobins Proteins 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 18
- 239000008280 blood Substances 0.000 description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000009636 Huang Qi Substances 0.000 description 2
- 244000241838 Lycium barbarum Species 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003050 macronutrient Effects 0.000 description 2
- 235000021073 macronutrients Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000011246 composite particle Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
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- 238000002137 ultrasound extraction Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The present invention relates to a kind of Control for Ejiao Buxue particle and preparation method thereof.The Control for Ejiao Buxue particle；It is raw materials used in terms of mass fraction including following components：45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis.Wherein donkey-hide gelatin is prepared using special process.The preparation method of the Control for Ejiao Buxue particle is：After being well mixed with the prepared rhizome of rehmannia, the Radix Codonopsis that take, by the solid mass ratio 46 of liquid:1 adds water；Then in 105-120 DEG C of pressurised extraction, extract solution is obtained；Extract solution is filtered with after concentration, will be added with the donkey-hide gelatin taken；After being concentrated into the 1.3g/L of density 1.25, pelletize, sterilize, be packaged to be finished product.The product good absorbing effect that the present invention is developed.
Description
Technical field
The present invention relates to a kind of Control for Ejiao Buxue particle and preparation method thereof；Belong to donkey-hide gelatin health products and be related to technology of preparing
Field.
Background technology
Traditional Chinese medicine thinks that donkey-hide gelatin nature and flavor are sweet, flat, there is the effect of nourishing yin and supplementing blood, antiabortive.It was found that donkey-hide gelatin contains more hatching eggs
White matter, amino acid, calcium etc., there is significant facilitation to the red blood cell, hemoglobin and packed cell volume of ischemic animal.Energy
Improve blood calcium balance, promote the generation of red blood cell.In addition, donkey-hide gelatin can also have significant facilitation to the function of bone marrow cell.
Can conspicuousness increasing leukocyte number, rise blood pressure, prevent haemorrhagic shock.So donkey-hide gelatin is commonly used for the good medicine quilt enriched blood
Widely use；But in the product of enriching blood containing donkey-hide gelatin developed at present, it is general longer that it takes the cycle.
The content of the invention
The present invention be directed to weak point existing for existing Control for Ejiao Buxue particle, there is provided it is a kind of only need 20-25 days it is continuous
Take the Control for Ejiao Buxue particle with regard to that can take effect.Also provide its preparation method simultaneously.
A kind of Control for Ejiao Buxue particle of the present invention；It is raw materials used, counted with mass fraction and be made up of following components：
200 parts of donkey-hide gelatin, 300 parts of cultivated land, 300 parts of Radix Codonopsis, 500 parts of the Radix Astragali, 300 parts of matrimony vine；
The donkey-hide gelatin is prepared according to the following steps：
Step 1
After donkey hide impurity elimination, soaked 5-10 days in 20-35 DEG C under water sealing condition；Quality is pressed after shaving, broken, washing
Than water：Donkey hide=6-2:1；Water is added into the donkey hide taken, after adding water, under air-proof condition, will warm up 105-120 DEG C；
Stirring extraction 15-20 hours；Liquid is released, obtains the first liquid, residual residue in container；Water is added in toward residual residue,
Under air-proof condition, 105-120 DEG C will warm up；Stirring extraction 15-20 hours, liquid is released, obtains second liquid；After adding water,
The filling rate of container is 40-50%；
Step 2
Coarse filtration is first carried out to the first liquid and second liquid and then carries out smart filtering, after essence filtering, it is dense to carry out vacuum
Contracting；The weight/mass percentage composition for obtaining water is 48-52% thick glue liquid；
Step 3
It is placed in after colloid obtained by step 2 is carried out into filtration treatment in the concentrator of open type, before heating, filtering per ton
Colloid obtained by step 2 afterwards, the area control with air contact surfaces is 3.14-7.065m2；It is heated to seething with excitement, stirs, removes table
Face offscum, impurity；When the water content in colloid is 33-36%, the soya-bean oil, yellow rice wine and the rock sugar water that add after filtering；Continue
Agitating and heating, when the water content in colloid is 24-26wt%, stop heating；Continue after stirring 0.5-1.5 hours, in 23-26
DEG C receive glue fill basin；After receiving glue filling basin, in 2-5 DEG C of gel；Design size carries out cutting glue after gel, obtains blob of viscose；
Step 4
Blob of viscose obtained by step 3 is placed in 1-5 DEG C of refrigerating chamber after refrigeration 6-10 hours, carries out glue processing of drying in the air；Dry in the air glue
After processing, it is dried in D level clean areas, obtains the donkey-hide gelatin；Air humidity in the refrigerating chamber is 50-70%；Dry in the air glue
To control temperature is 16-25 DEG C for processing, humidity 50-65%, time are 1-2 days；The temperature of the drying is 25-30 DEG C, time
For 1-2 days.
A kind of Control for Ejiao Buxue particle of the present invention；Also contain in the Control for Ejiao Buxue particle by sucrose Jia Shui, add
Inverted sugar obtained from heat.
A kind of Control for Ejiao Buxue particle of the present invention；Heating-up temperature in step 1 is preferably 105-110 DEG C.
A kind of Control for Ejiao Buxue particle of the present invention；The place of production of the donkey hide be preferably in northeast, Xinjiang or Gansu extremely
It is few one.
A kind of Control for Ejiao Buxue particle of the present invention；In step 2, the hole of filter screen used in the coarse filtration is 100 mesh.
A kind of Control for Ejiao Buxue particle of the present invention；In step 2, the hole of filter screen is 260 mesh used in the essence filtering.
A kind of Control for Ejiao Buxue particle of the present invention；In step 2, when being concentrated in vacuo, it is -0.02 to control vacuum
~-0.06Pa；It is 80-90 DEG C to control temperature.
For Improving The Quality of Products, in step 2, after essence filtering, it is aided with centrifugal filtration.
A kind of Control for Ejiao Buxue particle of the present invention；In step 3, the concentrator of the open type is the dense of sandwich
Contracting pot；The interlayer is used to be passed through superheated water.The temperature of superheated water is 102-105 DEG C.
A kind of Control for Ejiao Buxue particle of the present invention；In step 3, it is rearmounted that colloid obtained by step 2 is subjected to filtration treatment
In the concentrator of open type, before heating, colloid, the area control with air contact surfaces are obtained by step 2 after filtering per ton
3.14-7.065m2。
A kind of Control for Ejiao Buxue particle of the present invention；In step 3, before adding soya-bean oil, yellow rice wine, rock sugar, with gained colloid
In, the quality of organic matter of the molecular weight less than or equal to 3000 accounts for the 97-98.5% of organic matter quality in a word.
A kind of Control for Ejiao Buxue particle of the present invention；In step 4, after drying process, the OD values of blob of viscose are 2.0-3.0.
A kind of preparation method of Control for Ejiao Buxue particle of the present invention；Comprise the steps：
Match somebody with somebody by the raw material components of design and take 45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis；By with prepared rhizome of rehmannia, the Radix Codonopsis taken
After well mixed, by the solid mass ratio 4-6 of liquid:1 adds water；Then in 100-120 DEG C of pressurised extraction, extract solution is obtained；Extraction
Liquid is filtered with after concentration, will be added with the donkey-hide gelatin taken；Density is concentrated into after 1.25-1.3g/L, to pelletize, sterilizing, packing
To finished product.
Control for Ejiao Buxue particle that is of the invention designed and preparing；5 days are taken as one with the dosage by each 20g sooner or later
The course for the treatment of, using hypoferric anemia case as case；The selection standard of case is：
Each 100 people of men and women's sample,
Hemoglobin is 76-92g/L in the blood of male sample, hemoglobin is 66-82g/L in the blood of female's sample
Red blood cell number is 2.8-3.2*10 in the blood of male sample12Individual/L, female's sample blood in red blood cell number be
2.4‐2.8*1012Individual/L；
After continuously taking 11 courses for the treatment of, in male sample, the hemoglobin of only 4 is less than 98g/L and red blood cell number is small
In 3.25*1012Individual/L.Have 96 hemoglobin be more than 98g/L (average value for calculating male sample is 105.5g/L) and
Red blood cell number is more than 3.25*1012(average value for calculating male sample is 3.31*10 to individual/L12Individual/L).In female's sample, only
The hemoglobin of 7 is less than 88g/L and red blood cell number is less than 2.83*1012Individual/L.The hemoglobin for having 93 is more than
The 88g/L average value of female's sample (calculate be 103.2g/L) and red blood cell number is more than 2.83*1012Individual/L (calculates female's sample
Average value be 2.90*1012Individual/L).
Principle and advantage
The present invention realizes the purpose of products obtained therefrom efficient absorption by each component and the synergy of preparation.
The present invention has attempted under confined conditions, first carries out appropriate water seal fermentation；Then in sealing and appropriate container
Filling rate under conditions of, in appropriate high temperature, high pressure donkey-hide gelatin is extracted；Promote donkey hide using appropriate HTHP
In, the extraction and decomposition of macro-nutrients；The nutriment decomposited easily facilitates absorption of human body；Appropriate containers simultaneously
Filling rate when can also control extraction well, the content of oxygen；Appropriate oxygen content will not only cause the small molecule decomposited
Active material fast decoupled；Be advantageous to its surface oxygen uptake on the contrary, and then stablize the purpose of its structure.Coarse filtration is selected afterwards
And essence filtering, most of impurity in slurry is removed；Then the vacuum concentration (concentrating for the first time) of felicity condition is used,
Appropriate vacuum concentration not only contributes to water, and also helps entering a decomposition and keeping activity for macro-nutrients；
It is 48-52wt% to be concentrated in vacuo to water content, using appropriate water, realizes the holding of its suitable active；Then in unlimited system
Under it is concentrated again, when concentrating again, utilize extraneous oxygen to realize further removal of impurities；But the time of removing impurities by oxidation
It is unsuitable long, at the same area contact with oxygen be not easy to it is excessive, once it is long and/or excessive, it will nutrients in influence finished product
The content of matter.When opening wide concentration, control when water content is 33-36wt%, soya-bean oil, yellow rice wine and the ice added after appropriate filtering
Syrup, using the synergy of soya-bean oil, yellow rice wine and rock sugar, realize its holding to small molecule nutriment.Enriching blood simultaneously
When prepared by composite particles, by the effect of other drugs and preparation method, this is not exclusively advantageous for improving mouthfeel, also further promoted
The absorption of active principle is entered.
Embodiment
Embodiment 1
In terms of mass fraction.The raw materials used composition of Control for Ejiao Buxue particle is designed, the raw material is in terms of mass fraction
It is made up of following components：
45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis；
Wherein, the preparation method of donkey-hide gelatin is：
Step 1
After donkey hide impurity elimination, soaked 3 days in 30 DEG C under water sealing condition；After unhairing, broken, washing in mass ratio, water：Donkey
Skin=5：1；Water is added into the donkey hide taken, after adding water, under air-proof condition, will warm up 105 DEG C；Stirring extraction 18 is small
When；Liquid is released, obtains the first liquid, residual residue in container；Water is added in toward residual residue, under air-proof condition, will be added
Heat is to 120 DEG C；Stirring extraction 15 hours, releases liquid, obtains second liquid；After adding water, the filling rate of container is 45%；
The content of organic matter in residual substance is detected, testing result is：The content of organic matter is less than 2.5%.
Step 2
By volume, the first liquid：Second liquid=1:1 mixing, then first carry out coarse filtration, carry out smart filtering again, essence
After filtering, it is concentrated in vacuo；The weight/mass percentage composition for obtaining water is 52% colloid；, the hole of filter screen used in the coarse filtration
Gap is 100 mesh, and the hole of filter screen is 260 mesh used in the essence filtering., when being concentrated in vacuo, it is -0.04Pa to control vacuum
(reading on table)；It is 90 DEG C to control temperature.
Step 3
It is placed in after carrying out filtration treatment to colloid obtained by step 2 in the concentration pan of sandwich, hot water heating is led into interlayer
To boiling, (before heating, colloid obtained by step 2 after filtering per ton, the area control with air contact surfaces is 7.065m2) stirring,
Remove surface offscum, impurity；When the water content in colloid is 30-35wt%, the soya-bean oil, yellow rice wine and the rock sugar that add after filtering
Water；Continue to heat, when the water content in colloid is 23-25wt%, stop heating；After continuing stirring 1 hour, glue is received at 60 DEG C
Fill basin；After receiving glue filling basin, in 4 DEG C of gels；Design size carries out cutting glue after gel, obtains blob of viscose；It is total by colloid obtained by step 2
The 2% of quality adds soya-bean oil；Yellow rice wine is added by 0.1% of colloid gross mass obtained by step 2；By the total matter of colloid obtained by step 2
The 10% of amount adds rock sugar；
Step 4
By blob of viscose obtained by step 3, blob of viscose is placed in 4 DEG C of refrigerating chamber to the (air humidity of refrigerating chamber after refrigerating 8 hours
For the glue processing that 70%), carries out drying in the air；After the glue that dries in the air processing, it is dried in D level clean areas, is broken into particle, obtain the donkey-hide gelatin；
Air humidity in the refrigerating chamber is 70%；To control temperature is 18 DEG C for the glue that dries in the air processing, humidity 60%, time are 2 days；It is described
Dry temperature is 30 DEG C, the time is 1 day.
The preparation method of the Control for Ejiao Buxue particle is：
45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis are taken by the group distribution of design；It will be mixed with the prepared rhizome of rehmannia, the Radix Codonopsis that take
After uniformly, by the solid mass ratio 5.6 of liquid:1 adds water；Then in 100-120 DEG C of pressurised extraction, extract solution is obtained；Extract solution passes through
After filtering and concentration, it will be added with the donkey-hide gelatin taken；Density is concentrated into after 1.28g/L, to pelletize, sterilizing, being packaged to be finished product.
Control for Ejiao Buxue particle that is of the invention designed and preparing；5 days are taken as one with the dosage by each 20g sooner or later
The course for the treatment of, using hypoferric anemia case as case；The selection standard of case is：
Each 100 people of men and women's sample,
Hemoglobin is 76-92g/L in the blood of male sample, hemoglobin is 66-82g/L in the blood of female's sample
Red blood cell number is 2.8-3.2*10 in the blood of male sample12Individual/L, female's sample blood in red blood cell number be
2.4‐2.8*1012Individual/L；
After continuously taking 11 courses for the treatment of, in male sample, the hemoglobin of only 4 is less than 98g/L and red blood cell number is small
In 3.25*1012Individual/L.Have 96 hemoglobin be more than 98g/L (average value for calculating male sample is 105.5g/L) and
Red blood cell number is more than 3.25*1012(average value for calculating male sample is 3.31*10 to individual/L12Individual/L).In female's sample, only
The hemoglobin of 7 is less than 88g/L and red blood cell number is less than 2.83*1012Individual/L.The hemoglobin for having 93 is more than
The 88g/L average value of female's sample (calculate be 103.2g/L) and red blood cell number is more than 2.83*1012Individual/L (calculates female's sample
Average value be 2.90*1012Individual/L).
Embodiment 2
In terms of mass fraction.Design Control for Ejiao Buxue particle component be：200 parts of donkey-hide gelatin, 300 parts of cultivated land, Radix Codonopsis 300
Part, 500 parts of the Radix Astragali, 300 parts of matrimony vine；
Wherein, the preparation method of donkey-hide gelatin is：
Step 1
After donkey hide impurity elimination, fermented 5 days in 30 DEG C under water sealing condition；After unhairing, broken, washing in mass ratio, water：Donkey
Skin=5：1；Water is added into the donkey hide taken, after adding water, under air-proof condition, will warm up 118 DEG C；Stirring extraction 15 is small
When；Liquid is released, obtains the first liquid, residual residue in container；Water is added in toward residual residue, under air-proof condition, will be added
Heat is to 120 DEG C；Stirring extraction 15 hours, releases liquid, obtains second liquid；After adding water, the filling rate of container is 48%；
The content of organic matter in residual substance is detected, testing result is：The content of organic matter is less than 2%.
Step 2
By volume, the first liquid：Second liquid=2:1 mixing, then first carry out coarse filtration, carry out smart filtering again, essence
After filtering, it is concentrated in vacuo；The weight/mass percentage composition for obtaining water is 50% colloid；, the hole of filter screen used in the coarse filtration
Gap is 100 mesh, and the hole of filter screen is 260 mesh used in the essence filtering., when being concentrated in vacuo, it is -0.04Pa to control vacuum
(meter reading is -0.04Pa)；It is 90 DEG C to control temperature.
Step 3
It is placed in after carrying out filtration treatment to colloid obtained by step 2 in the concentration pan of sandwich, hot water heating is led into interlayer
To boiling, (before heating, colloid obtained by step 2 after filtering per ton, the area control with air contact surfaces is 6.28m2) stirring,
Remove surface offscum, impurity；When the water content in colloid is 30-35wt%, the soya-bean oil, yellow rice wine and the rock sugar that add after filtering
Water；Continue to heat, when the water content in colloid is 23-25wt%, stop heating；After continuing stirring 1 hour, glue is received at 60 DEG C
Fill basin；After receiving glue filling basin, in 4 DEG C of gels；Design size carries out cutting glue after gel, obtains blob of viscose；It is total by colloid obtained by step 2
The 2% of quality adds soya-bean oil；Yellow rice wine is added by 0.1% of colloid gross mass obtained by step 2；By the total matter of colloid obtained by step 2
The 10% of amount adds rock sugar；
Step 4
By blob of viscose obtained by step 3, blob of viscose is placed in 4 DEG C of refrigerating chamber to the (air humidity of refrigerating chamber after refrigerating 8 hours
For the glue processing that 70%), carries out drying in the air；After the glue that dries in the air processing, it is dried in D level clean areas, obtains the donkey-hide gelatin；The glue that dries in the air processing control
Temperature is 18 DEG C, humidity 60%, time are 1 day；The temperature of the drying is 30 DEG C, the time is 2 days.
The preparation method of the Control for Ejiao Buxue particle is：
The raw materials used composition of Control for Ejiao Buxue particle is designed, the raw material is in terms of mass fraction by following component groups
Into：
45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis；
After being well mixed with the prepared rhizome of rehmannia, the Radix Codonopsis that take, by the solid mass ratio 6 of liquid:1 adds water；Then at 100-120 DEG C
Pressurised extraction, obtain extract solution；Extract solution is filtered with after concentration, will be added with the donkey-hide gelatin taken；It is 1.28g/L to be concentrated into density
Afterwards, pelletize, sterilize, be packaged to be finished product.
Control for Ejiao Buxue particle that is of the invention designed and preparing；5 days are taken as one with the dosage by each 20g sooner or later
The course for the treatment of, using hypoferric anemia case as case；The selection standard of case is：
Each 100 people of men and women's sample,
Hemoglobin is 76-92g/L in the blood of male sample, hemoglobin is 66-82g/L in the blood of female's sample
Red blood cell number is 2.8-3.2*10 in the blood of male sample12Individual/L, female's sample blood in red blood cell number be
2.4‐2.8*1012Individual/L；
It is continuous to take the products obtained therefrom of embodiment 2, after 11 courses for the treatment of, in sample, the hemoglobin of only 4 be less than 98g/L,
And red blood cell number is less than 3.25*1012Individual/L.The hemoglobin for having 96 (calculates the average value of male sample more than 98g/L
For 105.5g/L) and red blood cell number be more than 3.25*1012(average value for calculating male sample is 3.308*10 to individual/L12Individual/
L).In female's sample, the hemoglobin of only 6 is less than 88g/L and red blood cell number is less than 2.83*1012Individual/L.There are 94
Hemoglobin be more than the 88g/L average value of female's sample (calculate be 103.2 2g/L) and red blood cell number is more than 2.83*
1012(average value for calculating female's sample is 2.899*10 to individual/L12Individual/L).
Comparative example 1
Fresh donkey hide is taken, after removing flesh and blood, is crushed, under the system of opening wide, 2 ultrasonic extractions is carried out in 60 DEG C, carries every time
It is 2 hours to take the time；Then operated according to the step 2 of embodiment 1,3,4；Difference is：In step 3, mistake per ton
Colloid obtained by step 2 after filter, the area control with air contact surfaces is 15m2, and it is not added with soya-bean oil.
According to the formula of embodiment 1, with taking raw material；
Other his Feedstock treating processes are consistent with embodiment 1.
Taking for sample is completely the same with the principle of embodiment 1；When it takes 50 days, its effect is：
In male sample, the hemoglobin for having 7 is less than 98g/L and red blood cell number is less than 3.25*1012Individual/L.Female's sample
In, the hemoglobin of only 12 is less than 88g/L and red blood cell number is less than 2.83*1012Individual/L.Continue to take to 60 days, adjust
Look into, in male sample, the hemoglobin for there are 5 is less than 98g/L and red blood cell number is less than 3.25*1012Individual/L.In female's sample, have
The hemoglobin of 8 is less than 88g/L and red blood cell number is less than 2.83*1012Individual/L.The effect base of like product on the market
This maintains an equal level.
Claims (8)
- A kind of 1. Control for Ejiao Buxue particle；It is characterized in that：It is raw materials used, counted with mass fraction and be made up of following components：45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis；The donkey-hide gelatin is prepared according to the following steps：Step 1After donkey hide impurity elimination, soaked 5-10 days in 20-35 DEG C under water sealing condition；After shaving, broken, washing in mass ratio, water： Donkey hide=6-2:1；Water is added into the donkey hide taken, after adding water, under air-proof condition, will warm up 105-120 DEG C；Stirring carries Take 15-20 hours；Liquid is released, obtains the first liquid, residual residue in container；Water is added in toward residual residue, in sealing strip Under part, 105-120 DEG C will warm up；Stirring extraction 15-20 hours, liquid is released, obtains second liquid；After adding water, container Filling rate is 40-50%；Step 2Coarse filtration is first carried out to the first liquid and second liquid and then carries out smart filtering, after essence filtering, is concentrated in vacuo； The thick glue liquid that weight/mass percentage composition to water is 48-52%；Step 3It is placed in the concentrator of open type after colloid obtained by step 2 is carried out into filtration treatment, before heating, is walked after filtering per ton Rapid two gained colloid, the area control with air contact surfaces are 3.14-7.065m2；It is heated to seething with excitement, stirs, removes surface and float Foam, impurity；When the water content in colloid is 33-36%, the soya-bean oil, yellow rice wine and the rock sugar water that add after filtering；Continue to stir Heating, when the water content in colloid is 24-26wt%, stop heating；Continue after stirring 0.5-1.5 hours, in 23-26 DEG C of receipts Glue fills basin；After receiving glue filling basin, in 2-5 DEG C of gel；Design size carries out cutting glue after gel, obtains blob of viscose；Step 4Blob of viscose obtained by step 3 is placed in 1-5 DEG C of refrigerating chamber after refrigeration 6-10 hours, carries out glue processing of drying in the air；The glue that dries in the air processing Afterwards, it is dried in D level clean areas, obtains the donkey-hide gelatin；Air humidity in the refrigerating chamber is 50-70%；The glue that dries in the air processing To control temperature be 16-25 DEG C, humidity 50-65%, time are 7-15 days；The temperature of the drying is 25-30 DEG C, time 7- 15 days.
- A kind of 2. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：Heating-up temperature in step 1 is 105‐110℃。
- A kind of 3. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：The place of production of the donkey hide is selected from east It is at least one in north, Xinjiang or Gansu.
- A kind of 4. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：In step 2, the hole of filter screen used in the coarse filtration is 100 mesh, and the hole of filter screen is 260 mesh used in the essence filtering；In step 2, when being concentrated in vacuo, it is -0.02~-0.06Pa to control vacuum；It is 80-90 DEG C to control temperature.
- A kind of 5. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：In step 3, the concentrator of the open type is the concentration pan of sandwich；The interlayer is used to be passed through superheated water；Overheat The temperature of water is 102-105 DEG C.
- A kind of 6. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：In rapid three, soya-bean oil, Huang are added Before wine, rock sugar, with gained colloid, the quality of organic matter of the molecular weight less than or equal to 3000 accounts for the 97- of organic matter quality in a word 98.5%.
- A kind of 7. Control for Ejiao Buxue particle according to claim 1；It is characterized in that：In step 4, through drying process Afterwards, the OD values of blob of viscose are 2.0-3.0.
- A kind of 8. preparation method of the Control for Ejiao Buxue particle as described in claim 1-7 any one；It is characterized in that；Including Following step：45 parts of donkey-hide gelatin, 180 parts of prepared rhizome of rehmannia, 90 parts of Radix Codonopsis are taken by the group distribution of design；After being well mixed with the prepared rhizome of rehmannia, the Radix Codonopsis that take, by the solid mass ratio 4-6 of liquid:1 adds water；Then add at 100-120 DEG C Pressure extraction, obtains extract solution；Extract solution is filtered with after concentration, will be added with the donkey-hide gelatin taken；It is 1.25- to be concentrated into density After 1.3g/L, pelletize, sterilize, be packaged to be finished product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843434A (en) * | 2006-02-21 | 2006-10-11 | 徐新盛 | Pharmaceutical composition for treating qi and blood deficiency and its preparation method |
| CN101623299A (en) * | 2008-07-11 | 2010-01-13 | 司家勇 | Donkey-hide gelatin preparation and preparation method thereof |
-
2017
- 2017-08-31 CN CN201710778572.6A patent/CN107412427A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843434A (en) * | 2006-02-21 | 2006-10-11 | 徐新盛 | Pharmaceutical composition for treating qi and blood deficiency and its preparation method |
| CN101623299A (en) * | 2008-07-11 | 2010-01-13 | 司家勇 | Donkey-hide gelatin preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨梓懿: "《中药调剂与养护学》", 30 November 2005, 中国中医药出版社 * |
| 田景振: "《阿胶基础研究与应用》", 31 October 2015, 中国中医药出版社 * |
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Application publication date: 20171201 |