CN107411092A - A kind of throat lozenge and preparation method thereof - Google Patents

A kind of throat lozenge and preparation method thereof Download PDF

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Publication number
CN107411092A
CN107411092A CN201710707956.9A CN201710707956A CN107411092A CN 107411092 A CN107411092 A CN 107411092A CN 201710707956 A CN201710707956 A CN 201710707956A CN 107411092 A CN107411092 A CN 107411092A
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Prior art keywords
parts
throat lozenge
throat
prepared
weight
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CN201710707956.9A
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Chinese (zh)
Inventor
陈家胜
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Ningguo Balanced Health Management Co Ltd
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Ningguo Balanced Health Management Co Ltd
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Priority to CN201710707956.9A priority Critical patent/CN107411092A/en
Publication of CN107411092A publication Critical patent/CN107411092A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of throat lozenge, and it is prepared by the raw material of following parts by weight:20 30 parts of Rosa roxburghii, 10 25 parts of balloonflower root, 10 20 parts of dandelion, 12 18 parts of hawthorn, 12 20 parts of rose, 16 20 parts of Chinese olive, 10 25 parts of nutmeg, 26 parts of Fermented Soybean, have throat moistening function.

Description

A kind of throat lozenge and preparation method thereof
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of throat lozenge and preparation method thereof.
Background technology
Throat lozenge is made up of main ingredient and auxiliary material, and Western medicine is mainly made up of some antibiosis anti-inflammatory drugs or Cidex-7;Chinese medicine There is the Chinese herbal medicine of antibacterial and anti-inflammation functions with some, such as honeysuckle, radix scutellariae, Radix Isatidis, rheum officinale, water melon frost, borneol and clearing profit The composition such as the sterculia seed of larynx, cicada slough, balloonflower root, fritillaria thunbergii, Momordica grosvenori, the radix scrophulariae tuber of dwarf lilyturf, FRUCTUS TERMINALIAE IMMATURUS, radix glycyrrhizae;Virtue is commonly incorporated into auxiliary material Pastil, sweetener, such as eucalyptus oil, menthol, sucrose material, play auxiliary treatment and improve mouthfeel.In the market Throat lozenge various types, but really the kind with effect is seldom.
The content of the invention
Goal of the invention:In order to solve the above problems, it is an object of the invention to provide a kind of throat lozenge and preparation method thereof.
Technical scheme:The purpose of the present invention is realized by following scheme:
A kind of throat lozenge, it is prepared by the raw material of following parts by weight:Rosa roxburghii 20-30 parts, balloonflower root 10-25 parts, Pu Public English 10-20 parts, hawthorn 12-18 parts, rose 12-20 parts, Chinese olive 16-20 parts, nutmeg 10-25 parts, Fermented Soybean 2-6 parts.
The throat lozenge, it is prepared by the raw material of following parts by weight:25 parts of Rosa roxburghii, 18 parts of balloonflower root, dandelion 15 Part, 16 parts of hawthorn, 16 parts of rose, 18 parts of Chinese olive, 15 parts of nutmeg, 4 parts of Fermented Soybean.
The throat lozenge, preparation method comprise the following steps:Above-mentioned Chinese medicine is taken, respectively plus 10 times of weight waters decoct 2 times, often Secondary 1 hour, merge extract solution, filtration, relative density is 1.10-1.20 clear cream when filtrate decompression is concentrated into 50 degree, cooling, is added Ethanol makes alcohol content volume ratio stir evenly up to 70%, stand 12 hours, filtration, filtrate recycling ethanol is concentrated under reduced pressure into without alcohol taste Relative density is 1.20-1.30 clear cream at 50 degree, spray drying, obtains extract powder, tabletting, is prepared into throat lozenge.
Application of the throat lozenge in throat lozenge health food is prepared.
Beneficial effect:The present invention has throat moistening function.
Embodiment
Form by the following examples, the above of the present invention is described in further detail again, but should not be by this The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal Belong to the scope of the present invention.
Embodiment 1:Take 20 parts of Rosa roxburghii, 25 parts of balloonflower root, 10 parts of dandelion, 18 parts of hawthorn, 12 parts of rose, 20 parts of Chinese olive, 10 parts of nutmeg, 6 parts of Fermented Soybean, respectively plus 10 times of weight waters decoct 2 times, 1 hour every time, merge extract solution, filtration, filtrate subtracts Relative density is 1.10 clear cream when pressure is concentrated into 50 degree, cooling, adds ethanol alcohol content volume ratio is stirred evenly, is stood up to 70% 12 hours, filtration, filtrate recycling ethanol was to without alcohol taste, and relative density is 1.30 clear cream when being concentrated under reduced pressure into 50 degree, and spraying is dry It is dry, extract powder is obtained, tabletting, is prepared into throat lozenge.
Embodiment 2:Take 30 parts of Rosa roxburghii, 10 parts of balloonflower root, 20 parts of dandelion, 12 parts of hawthorn, 20 parts of rose, 16 parts of Chinese olive, 25 parts of nutmeg, 2 parts of Fermented Soybean, respectively plus 10 times of weight waters decoct 2 times, 1 hour every time, merge extract solution, filtration, filtrate subtracts Relative density is 1.20 clear cream when pressure is concentrated into 50 degree, cooling, adds ethanol alcohol content volume ratio is stirred evenly, is stood up to 70% 12 hours, filtration, filtrate recycling ethanol was to without alcohol taste, and relative density is 1.20 clear cream when being concentrated under reduced pressure into 50 degree, and spraying is dry It is dry, extract powder is obtained, tabletting, is prepared into throat lozenge.
Embodiment 3:Take 25 parts of Rosa roxburghii, 18 parts of balloonflower root, 15 parts of dandelion, 16 parts of hawthorn, 16 parts of rose, 18 parts of Chinese olive, 15 parts of nutmeg, 4 parts of Fermented Soybean, respectively plus 10 times of weight waters decoct 2 times, 1 hour every time, merge extract solution, filtration, filtrate subtracts Relative density is 1.15 clear cream when pressure is concentrated into 50 degree, cooling, adds ethanol alcohol content volume ratio is stirred evenly, is stood up to 70% 12 hours, filtration, filtrate recycling ethanol was to without alcohol taste, and relative density is 1.25 clear cream when being concentrated under reduced pressure into 50 degree, and spraying is dry It is dry, extract powder is obtained, tabletting, is prepared into throat lozenge.
Embodiment 4:Clinical research of the present invention to pharyngitis patient
General information:The present invention is by taking pharyngitis patient as an example, and by randomly selecting wherein 100 patients, orally, 2 tablets once, Every 2g, taken three times in the morning, afternoon and evening per bu.The course for the treatment of is most short 1 month, most long for 1 year.Wherein 50 people take implementation of the present invention Throat lozenge prepared by the method for example 1, another 50 people take the only tablet containing auxiliary material.
Diagnostic criteria:Pharyngeal chronic congestion, aggravate, in kermesinus, or dendroid congested, swallow rear wall lymph foilicie hyperplasia, Or lateral pharyngeal band enlargement, pharynx mucosal hyperplasia are plump;Or it is drying, atrophy, thinning, have secretion attachment, have each above-mentioned symptom and 1 or More than 1 checks finding, you can diagnosis pharyngitis.
Criterion of therapeutical effect:Recovery from illness:Clinical symptoms all disappear, and laboratory checks normal.Take a turn for the better:Clinical symptom relief, the state of an illness Controlled, laboratory examination improvement or normal.It is invalid:No significant improvement or aggravated in clinical symptoms.
Treatment statistics are shown in Table 1.
1 two groups of curative effects of table compare
Group n Recovery from illness Take a turn for the better It is invalid Total effective rate (%)
Treatment group 50 24 19 6 88
Blank group 50 1 0 49 2
It can be seen that the beneficial effects of the invention are as follows:The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, does Piece agent, it is in good taste, drink for a long time, being capable of throat-clearing throat-moistening.

Claims (4)

1. a kind of throat lozenge, it is characterised in that it is prepared by the raw material of following parts by weight:Rosa roxburghii 20-30 parts, balloonflower root It is 10-25 parts, dandelion 10-20 parts, hawthorn 12-18 parts, rose 12-20 parts, Chinese olive 16-20 parts, nutmeg 10-25 parts, light Fermented soya bean 2-6 parts.
2. throat lozenge according to claim 1, it is characterised in that it is prepared by the raw material of following parts by weight:Rosa roxburghii 25 parts, 18 parts of balloonflower root, 15 parts of dandelion, 16 parts of hawthorn, 16 parts of rose, 18 parts of Chinese olive, 15 parts of nutmeg, 4 parts of Fermented Soybean.
3. throat lozenge according to claim 1, it is characterised in that preparation method comprises the following steps:Above-mentioned Chinese medicine is taken, respectively Add 10 times of weight waters to decoct 2 times, 1 hour every time, merge extract solution, filtration, relative density is when filtrate decompression is concentrated into 50 degree 1.10-1.20 clear cream, cooling, ethanol is added alcohol content volume ratio is stirred evenly up to 70%, is stood 12 hours, filtration, filtrate is reclaimed For ethanol to without alcohol taste, relative density is 1.20-1.30 clear cream when being concentrated under reduced pressure into 50 degree, spray drying, obtains extract powder, is pressed Piece, it is prepared into throat lozenge.
4. application of the throat lozenge in throat lozenge health food according to claim 1.
CN201710707956.9A 2017-08-17 2017-08-17 A kind of throat lozenge and preparation method thereof Withdrawn CN107411092A (en)

Priority Applications (1)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101919989A (en) * 2009-06-11 2010-12-22 北京亚东生物制药有限公司 Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof
CN101940246A (en) * 2010-07-24 2011-01-12 刘爱武 Honeysuckle throat-moistening tea
CN102187922A (en) * 2011-05-24 2011-09-21 安徽立顿生物药业有限公司 Tea bag for clearing lung and moistening throat
CN105596572A (en) * 2016-01-19 2016-05-25 广西复鑫益生物科技有限公司 Throat-relieving traditional Chinese medicine composition and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101919989A (en) * 2009-06-11 2010-12-22 北京亚东生物制药有限公司 Traditional Chinese medicine composition for treating pharyngitis and preparation method thereof
CN101940246A (en) * 2010-07-24 2011-01-12 刘爱武 Honeysuckle throat-moistening tea
CN102187922A (en) * 2011-05-24 2011-09-21 安徽立顿生物药业有限公司 Tea bag for clearing lung and moistening throat
CN105596572A (en) * 2016-01-19 2016-05-25 广西复鑫益生物科技有限公司 Throat-relieving traditional Chinese medicine composition and preparation method thereof

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