CN107405364A - 自然杀伤细胞及其用途 - Google Patents

自然杀伤细胞及其用途 Download PDF

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CN107405364A
CN107405364A CN201580077231.5A CN201580077231A CN107405364A CN 107405364 A CN107405364 A CN 107405364A CN 201580077231 A CN201580077231 A CN 201580077231A CN 107405364 A CN107405364 A CN 107405364A
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cells
concentration
culture medium
cell
csf
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布莱恩·墨菲
瓦内萨·沃斯基纳里安-贝尔斯
安德里亚·诺德伯格
基思·威尔逊
康琳
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Clarity Acquisition II LLC
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Anthrogenesis Corp
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CN201580077231.5A 2014-12-31 2015-12-30 自然杀伤细胞及其用途 Pending CN107405364A (zh)

Applications Claiming Priority (3)

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US201462098560P 2014-12-31 2014-12-31
US62/098,560 2014-12-31
PCT/US2015/068055 WO2016109661A1 (en) 2014-12-31 2015-12-30 Natural killer cells and uses thereof

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US (2) US20180008637A1 (https=)
EP (1) EP3240552A4 (https=)
JP (3) JP2018502115A (https=)
KR (2) KR20230146101A (https=)
CN (1) CN107405364A (https=)
AU (2) AU2015374055A1 (https=)
BR (1) BR112017014269A2 (https=)
CA (1) CA2972662A1 (https=)
EA (1) EA201791443A1 (https=)
IL (1) IL253248A0 (https=)
NZ (1) NZ733213A (https=)
WO (1) WO2016109661A1 (https=)

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CN109310710A (zh) * 2015-10-15 2019-02-05 细胞结构公司 自然杀伤细胞和ilc3细胞及其用途
WO2020084567A1 (en) * 2018-10-25 2020-04-30 Purecell Biomedical Technology Company Limited Medium system and method for ex vivo expansion of nk cells
CN113046314A (zh) * 2021-03-30 2021-06-29 中国科学技术大学 一种人脐血或骨髓造血干细胞体外诱导扩增蜕膜样自然杀伤细胞的方法
CN113227357A (zh) * 2018-10-01 2021-08-06 根特大学 人造血干细胞向具有增强的抗体依赖性细胞毒性活性的成熟自然杀伤细胞的加速的分化
CN113337466A (zh) * 2021-07-13 2021-09-03 杭州原生生物科技有限公司 一种无血清nk分化培养基及其制备方法
CN113652393A (zh) * 2020-05-12 2021-11-16 内蒙古大学 一种提高牛胚胎干细胞多能性的方法
CN115381959A (zh) * 2022-09-30 2022-11-25 上海纳米技术及应用国家工程研究中心有限公司 一种治疗肝癌的联合用药
US20230028680A1 (en) * 2018-11-30 2023-01-26 Celularity Inc. Expansion of natural killer cells and ilc3 cells with novel aromatic compounds

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EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
EP3350316B1 (en) * 2015-09-15 2024-05-08 Stichting Radboud universitair medisch centrum IMPROVED METHOD FOR EX VIVO EXPANSION CD34+HSPCs INTO NK CELLS USING AN ARYL HYDROCARBON RECEPTOR ANTAGONIST
WO2018085775A1 (en) * 2016-11-04 2018-05-11 Ohio State Innovation Foundation Methods and compositions for treating multiple myeloma and increasing antibody dependent cell cytotoxicity by targeting the aryl hydrocarbon receptor
JP2020503043A (ja) * 2016-12-30 2020-01-30 セルラリティ インコーポレイテッド 遺伝子改変されたナチュラルキラー細胞
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
WO2019036657A1 (en) * 2017-08-17 2019-02-21 Kyn Therapeutics AHR INHIBITORS AND USES THEREOF
WO2019059713A2 (ko) * 2017-09-21 2019-03-28 한국생명공학연구원 자연살해세포의 제조방법 및 그의 용도
KR102167548B1 (ko) 2017-09-21 2020-10-19 한국생명공학연구원 자연살해세포의 제조방법 및 그의 용도
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
US12011460B2 (en) 2018-02-20 2024-06-18 Universite De Montreal Expansion of NK and DC cells in vivo mediating immune response
CN112055717B (zh) 2018-04-02 2024-04-26 新加坡国立大学 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
JP2021525066A (ja) 2018-05-30 2021-09-24 グリコステム セラピューティクス ベスローテン フェンノートシャップ Ｃａｒ ｎｋ細胞
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
WO2020124256A1 (en) * 2018-12-21 2020-06-25 Stemcell Technologies Canada Inc. Media and methods for differentiating natural killer cells
CA3125503A1 (en) * 2019-01-18 2020-07-23 Acepodia Biotechnologies Ltd. A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2020197318A1 (ko) * 2019-03-28 2020-10-01 한국생명공학연구원 Car 유전자가 도입된 nk 세포의 제조방법 및 그의 용도
CN110079529A (zh) * 2019-04-28 2019-08-02 成都美杰赛尔生物科技有限公司 用于靶向敲除人NKG2A/KLRC1基因的sgRNA、表达载体、试剂盒及其用途
WO2020252464A1 (en) * 2019-06-14 2020-12-17 Celularity Inc. Populations of natural killer cells for treating cancers
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310710A (zh) * 2015-10-15 2019-02-05 细胞结构公司 自然杀伤细胞和ilc3细胞及其用途
CN113227357A (zh) * 2018-10-01 2021-08-06 根特大学 人造血干细胞向具有增强的抗体依赖性细胞毒性活性的成熟自然杀伤细胞的加速的分化
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US20180008637A1 (en) 2018-01-11
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