CN107405364A - 自然杀伤细胞及其用途 - Google Patents

自然杀伤细胞及其用途 Download PDF

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Publication number
CN107405364A
CN107405364A CN201580077231.5A CN201580077231A CN107405364A CN 107405364 A CN107405364 A CN 107405364A CN 201580077231 A CN201580077231 A CN 201580077231A CN 107405364 A CN107405364 A CN 107405364A
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cells
concentration
culture medium
cell
csf
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布莱恩·墨菲
瓦内萨·沃斯基纳里安-贝尔斯
安德里亚·诺德伯格
基思·威尔逊
康琳
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Clarity Acquisition II LLC
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Anthrogenesis Corp
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CN201580077231.5A 2014-12-31 2015-12-30 自然杀伤细胞及其用途 Pending CN107405364A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098560P 2014-12-31 2014-12-31
US62/098,560 2014-12-31
PCT/US2015/068055 WO2016109661A1 (en) 2014-12-31 2015-12-30 Natural killer cells and uses thereof

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US (2) US20180008637A1 (https=)
EP (1) EP3240552A4 (https=)
JP (3) JP2018502115A (https=)
KR (2) KR20230146101A (https=)
CN (1) CN107405364A (https=)
AU (2) AU2015374055A1 (https=)
BR (1) BR112017014269A2 (https=)
CA (1) CA2972662A1 (https=)
EA (1) EA201791443A1 (https=)
IL (1) IL253248A0 (https=)
NZ (1) NZ733213A (https=)
WO (1) WO2016109661A1 (https=)

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CN109310710A (zh) * 2015-10-15 2019-02-05 细胞结构公司 自然杀伤细胞和ilc3细胞及其用途
WO2020084567A1 (en) * 2018-10-25 2020-04-30 Purecell Biomedical Technology Company Limited Medium system and method for ex vivo expansion of nk cells
CN113046314A (zh) * 2021-03-30 2021-06-29 中国科学技术大学 一种人脐血或骨髓造血干细胞体外诱导扩增蜕膜样自然杀伤细胞的方法
CN113227357A (zh) * 2018-10-01 2021-08-06 根特大学 人造血干细胞向具有增强的抗体依赖性细胞毒性活性的成熟自然杀伤细胞的加速的分化
CN113337466A (zh) * 2021-07-13 2021-09-03 杭州原生生物科技有限公司 一种无血清nk分化培养基及其制备方法
CN113652393A (zh) * 2020-05-12 2021-11-16 内蒙古大学 一种提高牛胚胎干细胞多能性的方法
CN115381959A (zh) * 2022-09-30 2022-11-25 上海纳米技术及应用国家工程研究中心有限公司 一种治疗肝癌的联合用药
US20230028680A1 (en) * 2018-11-30 2023-01-26 Celularity Inc. Expansion of natural killer cells and ilc3 cells with novel aromatic compounds

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EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
EP3350316B1 (en) * 2015-09-15 2024-05-08 Stichting Radboud universitair medisch centrum IMPROVED METHOD FOR EX VIVO EXPANSION CD34+HSPCs INTO NK CELLS USING AN ARYL HYDROCARBON RECEPTOR ANTAGONIST
US20200179341A1 (en) * 2016-11-04 2020-06-11 Ohio State Innovation Foundation Methods and compositions for treating multiple myeloma and increasing antibody dependent cell cytotoxicity by targeting the aryl hydrocarbon receptor
JP2020503043A (ja) * 2016-12-30 2020-01-30 セルラリティ インコーポレイテッド 遺伝子改変されたナチュラルキラー細胞
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
CA3056591A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
BR112020003116A2 (pt) * 2017-08-17 2020-08-04 Ikena Oncology, Inc. inibidores de ahr e usos dos mesmos
KR102167548B1 (ko) * 2017-09-21 2020-10-19 한국생명공학연구원 자연살해세포의 제조방법 및 그의 용도
WO2019059713A2 (ko) * 2017-09-21 2019-03-28 한국생명공학연구원 자연살해세포의 제조방법 및 그의 용도
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
CN112135618A (zh) * 2018-02-20 2020-12-25 蒙特利尔大学 体内介导免疫应答的nk和dc细胞的扩增
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
KR20210016567A (ko) 2018-05-30 2021-02-16 글리코스템 떼라퓨틱스 비.브이. Car nk 세포
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
WO2020124256A1 (en) * 2018-12-21 2020-06-25 Stemcell Technologies Canada Inc. Media and methods for differentiating natural killer cells
JP7335001B2 (ja) * 2019-01-18 2023-08-29 アセポディア バイオテクノロジーズ リミテッド 新規ｃｄ１６＋ナチュラルキラーおよびｃｄ１６＋ナチュラルキラー細胞の培養方法
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
KR102298639B1 (ko) * 2019-03-28 2021-09-07 한국생명공학연구원 면역세포의 제조방법 및 그의 용도
CN110079529A (zh) * 2019-04-28 2019-08-02 成都美杰赛尔生物科技有限公司 用于靶向敲除人NKG2A/KLRC1基因的sgRNA、表达载体、试剂盒及其用途
US20220265712A1 (en) * 2019-06-14 2022-08-25 Celularity Inc. Populations of natural killer cells for treating cancers
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells

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Cited By (9)

* Cited by examiner, † Cited by third party
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