CN107375510A - A kind of preparation method of cordate houttuynia particle - Google Patents
A kind of preparation method of cordate houttuynia particle Download PDFInfo
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- CN107375510A CN107375510A CN201710725642.1A CN201710725642A CN107375510A CN 107375510 A CN107375510 A CN 107375510A CN 201710725642 A CN201710725642 A CN 201710725642A CN 107375510 A CN107375510 A CN 107375510A
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- Prior art keywords
- cordate houttuynia
- particle
- preparation
- mixed serum
- enzymolysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a kind of preparation method of cordate houttuynia particle, including herein below：First cordate houttuynia color protection, fixing are handled, then add appropriate yellow rice wine and vinegar frying；Microwave radiation heat treatment, mashing are carried out again, are eventually adding cellulase, pectase mixed enzyme solution digests to obtain cordate houttuynia enzymolysis liquid；Cordate houttuynia enzymolysis liquid is spray-dried to obtain fine powder, softwood then is made with ethanol, particle is made in obtained softwood；The present invention passes through microwave and enzymolysis processing, the active ingredient in cordate houttuynia can not only fully be separated out, and it is not easy to be damaged, the present invention removes astringent taste first by citric acid color protection, then through fixing, can improve color and luster, the mouthfeel of cordate houttuynia particle, the preparation method time of the present invention is short, production efficiency is high, and particle has effect, the medical value such as antibacterial, antiviral, raising immunity of organisms, diuresis high.
Description
Technical field
The present invention relates to a kind of extraction processing method of Chinese medicine, and in particular to a kind of preparation method of cordate houttuynia particle.
Background technology
Cordate houttuynia is a kind of natural plant, has antibacterial, antivirus action, is usually used in anti-cold Chinese medicine preparation, and
Cordate houttuynia is in pharmaceutical formulation during boiling extraction at present, and contained oiliness impurity component largely separates out so that extract solution can not be dense
Shorten the clear cream of high concentration into, its result necessarily cause medicine excipient amount must be at double increase, the effect of making medicine demultiplication,
So that cost increases.
Chinese herbal granules good effect, are domestic drug markets the features such as taking, be easy to carry due to fast with absorbing
Main flow formulation；The Normal practice of granule is：Whole Chinese medicines of formula are mixed and decocted, filtrate is condensed into relative density and is
1.30-1.35 thick paste, particle is can be made into by the 4-5 times of auxiliary type agent measured is added in this thick paste.
The content of the invention
In order to alleviate shortcomings and deficiencies of the prior art, it is an object of the invention to provide a kind of making of cordate houttuynia particle
Method.
To achieve these goals, the present invention adopts the following technical scheme that：
The preparation method of cordate houttuynia particle, including herein below：
（1）Growth selection is luxuriant, no disease and pests harm, fresh and tender cordate houttuynia, clean, segment, cordate houttuynia is first positioned over 0.03-
Color protection in 0.05wt% citric acid solutions, then it is placed in again in 12.5-15.0% acetums and soaks 1-2h, taking-up is rinsed well,
It is then placed in fixing in green-keeping machine to handle, fixing temperature is 120-130 DEG C, time 10-12s；
（2）Cordate houttuynia after above-mentioned fixing is put into frying pan, then adds appropriate yellow rice wine and vinegar, half of slow fire frying
Hour, it is standby after cooling；
（3）By step（2）Cordate houttuynia after frying carries out microwave radiation heat treatment, microwave power 400-500w, and the time is
10-15 minutes, then add the 5-10 times of deionized water measured and be mixed with beating, obtain mixed serum；
（4）In above-mentioned steps（3）Mixed serum in add cellulase, pectase mixed enzyme solution, described cellulase adds
Enter the 1.0-1.5% that amount is mixed serum, pectase addition is the 0.6-0.8% of mixed serum；Adjust pH to 4.5-5.0, water
Bath is heated to 45-50 DEG C, enzymolysis time 25-35 minutes；After the completion of enzymolysis, filter centrifugation is carried out, obtains cordate houttuynia enzymolysis liquid；
（5）Above-mentioned cordate houttuynia enzymolysis liquid is spray-dried to obtain fine powder, softwood then is made with ethanol, obtained softwood is made
Grain.
Described step（3）The microwave power of middle microwave radiation heat treatment is 450w, and the time is 15 minutes.
Described step（4）Cellulase addition is the 1.25% of mixed serum, and pectase addition is mixed serum
0.73%.
Beneficial effects of the present invention：
The present invention can not only fully separate out the active ingredient in cordate houttuynia, and be not easy by broken by microwave and enzymolysis processing
Bad, the present invention removes astringent taste first by citric acid color protection, then through fixing, can improve color and luster, the mouthfeel of cordate houttuynia particle, this hair
The bright preparation method time is short, and production efficiency is high, and particle has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis,
Medical value is high.
Embodiment
Embodiment 1：
The preparation method of cordate houttuynia particle, including herein below：
（1）Growth selection is luxuriant, no disease and pests harm, fresh and tender cordate houttuynia, clean, segment, cordate houttuynia is first positioned over 0.03-
Color protection in 0.05wt% citric acid solutions, then it is placed in again in 12.5-15.0% acetums and soaks 1-2h, taking-up is rinsed well,
It is then placed in fixing in green-keeping machine to handle, fixing temperature is 120-130 DEG C, time 10-12s；
（2）Cordate houttuynia after above-mentioned fixing is put into frying pan, then adds appropriate yellow rice wine and vinegar, half of slow fire frying
Hour, it is standby after cooling；
（3）By step（2）Cordate houttuynia after frying carries out microwave radiation heat treatment, microwave power 450w, and the time is 15 points
Clock, then add the 5-10 times of deionized water measured and be mixed with beating, obtain mixed serum；
（4）In above-mentioned steps（3）Mixed serum in add cellulase, pectase mixed enzyme solution, described cellulase adds
Enter 1.25% that amount is mixed serum, pectase addition is the 0.73% of mixed serum；Adjust pH to 4.5-5.0, heating water bath
To 45-50 DEG C, enzymolysis time 25-35 minutes；After the completion of enzymolysis, filter centrifugation is carried out, obtains cordate houttuynia enzymolysis liquid；
（5）Above-mentioned cordate houttuynia enzymolysis liquid is spray-dried to obtain fine powder, softwood then is made with ethanol, obtained softwood is made
Grain.
Claims (3)
1. a kind of preparation method of cordate houttuynia particle, it is characterised in that including herein below：
（1）Growth selection is luxuriant, no disease and pests harm, fresh and tender cordate houttuynia, clean, segment, cordate houttuynia is first positioned over 0.03-
Color protection in 0.05wt% citric acid solutions, then it is placed in again in 12.5-15.0% acetums and soaks 1-2h, taking-up is rinsed well,
It is then placed in fixing in green-keeping machine to handle, fixing temperature is 120-130 DEG C, time 10-12s；
（2）Cordate houttuynia after above-mentioned fixing is put into frying pan, then adds appropriate yellow rice wine and vinegar, half of slow fire frying
Hour, it is standby after cooling；
（3）By step（2）Cordate houttuynia after frying carries out microwave radiation heat treatment, microwave power 400-500w, and the time is
10-15 minutes, then add the 5-10 times of deionized water measured and be mixed with beating, obtain mixed serum；
（4）In above-mentioned steps（3）Mixed serum in add cellulase, pectase mixed enzyme solution, described cellulase adds
Enter the 1.0-1.5% that amount is mixed serum, pectase addition is the 0.6-0.8% of mixed serum；Adjust pH to 4.5-5.0, water
Bath is heated to 45-50 DEG C, enzymolysis time 25-35 minutes；After the completion of enzymolysis, filter centrifugation is carried out, obtains cordate houttuynia enzymolysis liquid；
（5）Above-mentioned cordate houttuynia enzymolysis liquid is spray-dried to obtain fine powder, softwood then is made with ethanol, obtained softwood is made
Grain.
2. the preparation method of cordate houttuynia particle according to claim 1, it is characterised in that described step（3）Middle microwave
The microwave power of radiation heat treatment is 450w, and the time is 15 minutes.
3. the preparation method of cordate houttuynia particle according to claim 1, it is characterised in that described step（4）Middle fiber
Plain enzyme addition is the 1.25% of mixed serum, and pectase addition is the 0.73% of mixed serum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710725642.1A CN107375510A (en) | 2017-08-22 | 2017-08-22 | A kind of preparation method of cordate houttuynia particle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710725642.1A CN107375510A (en) | 2017-08-22 | 2017-08-22 | A kind of preparation method of cordate houttuynia particle |
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| Publication Number | Publication Date |
|---|---|
| CN107375510A true CN107375510A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710725642.1A Pending CN107375510A (en) | 2017-08-22 | 2017-08-22 | A kind of preparation method of cordate houttuynia particle |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568432A (en) * | 2018-08-29 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of cordate houttuynia granule |
| CN109568431A (en) * | 2018-08-29 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of flavour amino acid granule |
| CN112972552A (en) * | 2019-12-17 | 2021-06-18 | 赵永让 | Traditional Chinese medicine composition for relieving pain and diminishing inflammation and application thereof |
-
2017
- 2017-08-22 CN CN201710725642.1A patent/CN107375510A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568432A (en) * | 2018-08-29 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of cordate houttuynia granule |
| CN109568431A (en) * | 2018-08-29 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of flavour amino acid granule |
| CN112972552A (en) * | 2019-12-17 | 2021-06-18 | 赵永让 | Traditional Chinese medicine composition for relieving pain and diminishing inflammation and application thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171124 |