CN107361744A - The identification device and method of a kind of parathyroid gland - Google Patents
The identification device and method of a kind of parathyroid gland Download PDFInfo
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- CN107361744A CN107361744A CN201710639716.XA CN201710639716A CN107361744A CN 107361744 A CN107361744 A CN 107361744A CN 201710639716 A CN201710639716 A CN 201710639716A CN 107361744 A CN107361744 A CN 107361744A
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- 210000002990 parathyroid gland Anatomy 0.000 title claims abstract description 141
- 238000000034 method Methods 0.000 title claims abstract description 27
- 210000001685 thyroid gland Anatomy 0.000 claims abstract description 61
- 239000000835 fiber Substances 0.000 claims abstract description 60
- 238000013500 data storage Methods 0.000 claims abstract description 4
- 230000007613 environmental effect Effects 0.000 claims description 28
- 230000005284 excitation Effects 0.000 claims description 25
- 239000013307 optical fiber Substances 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 8
- 210000004907 gland Anatomy 0.000 claims description 8
- 244000273618 Sphenoclea zeylanica Species 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 238000005259 measurement Methods 0.000 claims description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 230000003760 hair shine Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 15
- 230000001276 controlling effect Effects 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 4
- 230000001960 triggered effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 208000034783 hypoesthesia Diseases 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000016253 exhaustion Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- -1 methylenum careuleum Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000000849 parathyroid Effects 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention provides a kind of identification device of parathyroid gland and method；Described device includes：Power supply, the near-infrared autofluorescence being sequentially connected excite device, fiber optic rod, near-infrared autofluorescence collecting device, signal processing component and prompting device；The near-infrared autofluorescence excites the second switch for being connected with and being connected between first switch, the signal processing component and power supply for controlling the signal processing component to carry out data storage between device and power supply；It is sound end that the remote near-infrared autofluorescence of the fiber optic rod, which excites one end of device,；When carrying out parathyroid gland identification, by the disconnection and the closure that control the first switch, and the triggering second switch, and the sound end is excited, collected and analyzed near-infrared autofluorescence close to doctor's area-of-interest, the parathyroid gland is identified.The present invention can efficiently and quickly identify the parathyroid gland around thyroid gland, improve the efficiency of thyroid gland related surgical, and provide safety guarantee for thyroid gland related surgical.
Description
Technical field
The present invention relates to biological tissue's property identification technical field, and in particular to a kind of identification device of parathyroid gland and side
Method.
Background technology
In thyroid surgery, the identification of parathyroid gland is always one of huge challenge that doctor faces.By first shape
Gland is responsible for regulating and controlling the calcium level of human body, and the stabilization of human internal environment is played an important role.Normal human has by 4 first shapes
Gland is distributed in around thyroid gland, and these parathyroid gland volume very little, especially its anatomical position are not fixed, and with the leaching of surrounding
It is closely similar the tissue such as to fawn on, causes physician discretion difficult.If doctor cuts off by parathyroid gland or infringement first shape by mistake in art
Gland blood is transported, then patient is postoperative will to meet with serious and irreversible hypocalcemia, cause numbness in hands and feet, tic of limbs or even breathe
The symptoms such as exhaustion, the life security and quality of life of patient can be caused to have a strong impact on.Therefore, one is identified in the art of parathyroid gland
It is directly that Thyroid Surgery doctor pays close attention to.
At present, the identification of parathyroid gland relies primarily on experienced doctor's naked eyes and identified.In operation, doctor wears amplification
Sem observation operative region, find the tissue of doubtful parathyroid gland.Doctor, which observes the mode judged, can bring great subjective error,
The risk of operation is even more drastically increased especially for the doctor to lack experience.Under many circumstances, doctor still can not
Conclude the property of tissue, at this moment can take Partial Resection tissue of interest, and carry out the mode of frozen section inspection in art, confirm
Whether the position is parathyroid gland, is further continued for carrying out subsequent operation.And in art frozen section not only can to tissue cause it is certain
Injury, and at least need to spend 30 minutes, procedure and efficiency are had a strong impact on, increases the burden of doctor and patient.Make
It is also that recent application assists in identifying parathyroid gland to clinic to tissue stainings such as lymph nodes with coloring agent such as methylenum careuleum, nano-sized carbon etc.
A new technology, although this staining technique can provide certain contrast, simultaneously unspecific staining agent, still can deposit
In the risk of false judgment.
Therefore, design is a kind of can survey in physical examination and have the parathyroid gland identification device and method of high-contrast in real time,
It is urgent problem to be solved to improve current operation present situation.
The content of the invention
For in the prior art the defects of, the present invention provides a kind of identification device and method of parathyroid gland；Can be effective
And the parathyroid gland around thyroid gland is rapidly identified, and the efficiency of thyroid gland related surgical is improved, and it is related for thyroid gland
Operation provides safety guarantee.
In order to solve the above technical problems, the present invention provides following technical scheme：
On the one hand, the present invention provides a kind of identification device of parathyroid gland, and described device includes：Power supply, connect successively
The near-infrared autofluorescence connect excites device, fiber optic rod, near-infrared autofluorescence collecting device, signal processing component and prompting device
Part；
The near-infrared autofluorescence, which excites, is connected with first switch, the signal transacting group between device and power supply
The second switch for controlling the signal processing component to carry out data storage is connected between part and power supply；
It is sound end that the remote near-infrared autofluorescence of the fiber optic rod, which excites one end of device,；
When carrying out parathyroid gland identification, by controlling disconnection and the closure of the first switch, and triggering described the
Two switches, and the sound end is sent out the near-infrared autofluorescence received close to doctor's area-of-interest, the sound end
Deliver to the near-infrared autofluorescence collecting device, the near-infrared autofluorescence collecting device will filter the near-infrared after focusing on
Autofluorescence is transmitted to signal processing component so that the signal processing component records each auto fluorescence intensity data and gone forward side by side
Row identification, and corresponding prompt message is provided according to the recognition result control prompting device.
Further, the fiber optic rod includes：Hollow stem, the excitation fiber being co-axially located in the hollow stem and collection
Optical fiber；
The excitation fiber excites device to be connected with the near-infrared autofluorescence, and it is described collection optical fiber with it is described closely it is red
Outer autofluorescence collecting device connection；
When carrying out parathyroid gland identification, the excitation fiber excites thyroid near-infrared autologous glimmering through the sound end
The near-infrared autofluorescence of light and parathyroid gland future position, the collection optical fiber is by environmental background noise signal, thyroid near
Infrared autofluorescence and the near-infrared autofluorescence of parathyroid gland future position through the near-infrared autofluorescence collecting device successively
Transmit to the signal processing component so that the signal processing component records the environmental background noise signal, thyroid
Near-infrared autofluorescence and the near-infrared autofluorescence of parathyroid gland future position are simultaneously analyzed, and control it is described prompting device to
Go out corresponding prompt message.
Further, the near-infrared autofluorescence excites device to include：It is laser diode, same with the laser diode
What axle was set excites condenser lens；
The laser diode is connected to the first switch；
It is described to excite condenser lens to be connected to the excitation fiber；
When carrying out parathyroid gland identification, condenser lens is excited described in the LASER Light Source warp that the laser diode is launched
After convergence, then through the excitation fiber arrival sound end so that the LASER Light Source shines out through the sound end.
Further, the near-infrared autofluorescence collecting device includes：The bandpass filter and collection being coaxially disposed are poly-
Focus lens；
The bandpass filter is connected with the collection optical fiber, and the collection condenser lens connects the signal transacting group
Part；
When the sound end receives environmental background noise signal or near-infrared autofluorescence signal, the collection optical fiber
The signal is transmitted to the bandpass filter and filtered, the signal after optical filtering is transmitted to institute through the collection condenser lens again
State signal processing component.
Further, the signal processing component includes：The light intensity sensor and signal processor being sequentially connected；
The signal processor is connected to the second switch；The light intensity sensor connects with the collection condenser lens
Connect, and the signal processor is connected to the prompting device；
After the signal that the light intensity sensor receives after the optical filtering collected condenser lens and sent, after this is filtered
Signal is converted into data signal, and the digital data transmission to the signal processor, the signal processor are being received, remembered
After recording and analyzing the data signal, the prompting device is controlled to be prompted accordingly.
Further, described device also includes：Device case；
The power supply, near-infrared autofluorescence excite device, near-infrared autofluorescence collecting device, signal transacting group
Part is arranged in described device housing；
The fiber optic rod is arranged on the side outer wall of described device housing.
Further, the outer wall of described device housing is provided with button and triggering button；
The button is connected through described device housing with the first switch inside the device case, and the button is used
It is opened or closed in controlling the first switch；
The triggering button is connected through described device housing with the second switch inside the device case, described to touch
Hair button is used to trigger the second switch closure.
Further, it is described prompting device be arranged on the outer wall of described device housing, and it is described prompting device with it is described
Signal processor connects；
The prompting device is buzzer, voice guard or audible-visual annunciator.
Further, the signal processor is fpga chip.
On the other hand, the present invention also provides a kind of recognition methods of parathyroid gland, and methods described applies the parathyroid gland
Identification device realize that methods described includes：
The first switch is disconnected, triggers the second switch so that the second switch is in opening, controls institute
State sound end detection environmental background noise signal SdSo that the signal processing component is autologous glimmering through fiber optic rod and near-infrared successively
Collection optics receive and store the environmental background noise signal Sd, the signal processing component controls the prompting device to send
Corresponding prompting, disconnects the second switch afterwards；
The first switch is closed, controls the sound end close to thyroid gland, triggers the second switch again, it is described near
Infrared autofluorescence excites sound end of the device through fiber optic rod to excite thyroid gland near-infrared autofluorescence signal so that the signal
Processing component receives through the fiber optic rod and near-infrared autofluorescence collecting device successively, record thyroid gland near-infrared autofluorescence
Signal, and using the signal intensity of the thyroid gland near-infrared autofluorescence signal as reference data value Sj, the signal transacting group
Part controls the prompting device to send corresponding prompting, disconnects the second switch afterwards；
A certain parathyroid gland future position of the sound end in parathyroid gland estimation range is controlled, again described in triggering
Second switch, the near-infrared autofluorescence excite sound end of the device through fiber optic rod to excite the near-infrared of parathyroid gland future position
Autofluorescence signal so that the signal processing component connects through the fiber optic rod and near-infrared autofluorescence collecting device successively
Receive, record the near-infrared autofluorescence signal intensity S of parathyroid gland future position return；
The signal processing component judge the parathyroid gland future position return near-infrared autofluorescence signal intensity S whether
Meet (S-Sd)≥2*(Sj-Sd)；
If the signal processing component learns that the near-infrared autofluorescence that a certain parathyroid gland future position returns is believed through judging
Number strength S meets (S-Sd)≥2*(Sj-Sd), then the signal processing component judges that current parathyroid gland future position is first
Gland position by shape, otherwise the current parathyroid gland future position of signal processing component judgement is not parathyroid gland position；
And the signal processing component control prompting device sends corresponding prompting；Triggering next time is waited to survey afterwards
Amount, until measurement terminates.
As shown from the above technical solution, the identification device and method of a kind of parathyroid gland provided by the invention；Described device
Including：Power supply, the near-infrared autofluorescence being sequentially connected excite device, fiber optic rod, near-infrared autofluorescence collecting device,
Signal processing component and prompting device；The near-infrared autofluorescence, which excites, to be connected with first and opens between device and power supply
Close, be connected between the fiber optic rod and power supply and opened for controlling the signal processing component to carry out the second of data storage
Close；It is sound end that the remote near-infrared autofluorescence of the fiber optic rod, which excites one end of device,；Carrying out parathyroid gland knowledge
When other, by controlling disconnection and the closure of the first switch, and the triggering second switch, and the sound end is close
The near-infrared autofluorescence received is sent to the near-infrared autofluorescence and collected by doctor's area-of-interest, the sound end
Device, the near-infrared autofluorescence collecting device will filter focus on after near-infrared autofluorescence transmit to signal transacting group
Part so that the signal processing component records each auto fluorescence intensity data and is identified, and according to recognition result control
Make the prompting device and provide corresponding prompt message.The present invention can be identified efficiently and quickly by the first shape around thyroid gland
Gland, the efficiency of thyroid gland related surgical is improved, and safety guarantee is provided for thyroid gland related surgical.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are the present invention
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis
These accompanying drawings obtain other accompanying drawings.
Fig. 1 is a kind of a kind of structural representation of embodiment of the identification device of parathyroid gland of the present invention；
Fig. 2 is the structural representation of the fiber optic rod in the identification device of the parathyroid gland of the present invention；
Fig. 3 is that the near-infrared autofluorescence in the identification device of the parathyroid gland of the present invention excites the structural representation of device
Figure；
Fig. 4 is the structural representation of the near-infrared autofluorescence collecting device in the identification device of the parathyroid gland of the present invention
Figure；
Fig. 5 is the structural representation of the signal processing component in the identification device of the parathyroid gland of the present invention；
Fig. 6 is a kind of structural representation of another embodiment of the identification device of parathyroid gland of the present invention；
Fig. 7 is a kind of schematic flow sheet of the recognition methods of parathyroid gland of the present invention；
Wherein, 1- power supplies；2- near-infrared autofluorescences excite device；21- laser diodes；22- excites focusing saturating
Mirror；3- fiber optic rods；31- sound ends；32- hollow stems；33- excitation fibers；34- collects optical fiber；4- near-infrareds autofluorescence is collected
Device；41- bandpass filters；42- collects condenser lens；5- signal processing components；51- light intensity sensors；52- signal transactings
Device；6- prompts device；7- first switches；8- second switches；9- device cases.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In accompanying drawing, clear, complete description is carried out to the technical scheme in the embodiment of the present invention, it is clear that described embodiment is
Part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
Near-infrared autofluorescence technology be one quickly grown in recent years in real time in body method for tissue identification, by near red
Wave section excites and collects fluorescence signal, and the difference using contained fluorescent material concentration in different tissues causes signal intensity not
Together, the differentiation of histological types is realized.Because regulation of the parathyroid gland to human body calcium level plays vital effect,
Its internal associated hormone level can have notable difference with surrounding tissue.Correlative study shows, the near-infrared in parathyroid gland
Luminescent substance concentration is significantly higher than the tissue such as thyroid gland around and lymph node, is excited by near infrared light, it is seen that parathyroid gland is sent out
Penetrate fluorescence intensity and be significantly stronger than surrounding tissue.This method causes parathyroid gland and surrounding tissue to have in spectral intensity greatly
Contrast, possibility is provided for identification in the art of parathyroid gland.Based on above-mentioned principle, the invention provides a kind of parathyroid gland
Identification device, exciting and collecting by near-infrared autofluorescence, it can efficiently and quickly identify the first around thyroid gland
Gland by shape, the operation risk caused by the false judgment to parathyroid gland is reliably avoid in operation, is thyroid gland
Related surgical provides safety guarantee, and effectively increases the efficiency of thyroid gland related surgical, so alleviate simultaneously doctor and
The burden of patient.
Embodiments of the invention one provide a kind of a kind of embodiment of the identification device of parathyroid gland, referring to figure
1, the identification device of the parathyroid gland specifically includes following content：
Power supply 1, the near-infrared autofluorescence being sequentially connected excite device 2, fiber optic rod 3, near-infrared autofluorescence to receive
Collect device 4, signal processing component 5 and prompting device 6；The remote near-infrared autofluorescence of the fiber optic rod 3 excites device 2
One end be sound end 31.Device 2 is excited to power it is understood that power supply 1 is near-infrared autofluorescence so that near red
Outer autofluorescence excites device 2 to send LASER Light Source, and the LASER Light Source is transmitted to the fiber optic rod 3, the optical fiber
Bar 3 exports the LASER Light Source to outside, and receives the near-infrared autofluorescence signal of outside, by near-infrared autofluorescence signal
Send to near-infrared autofluorescence collecting device 4, the near-infrared autofluorescence collecting device 4 will filter the near-infrared after focusing on
Autofluorescence signal, which is sent to the signal processing component 5, the signal processing component 5, is judging near-infrared autofluorescence signal
When corresponding perimeter is parathyroid gland, the prompting device 6 is controlled to be prompted so that user's energy of the identification device
The position of parathyroid gland around the thyroid gland of enough fast positioning identified persons.It is described to excite when carrying out parathyroid gland identification
Optical fiber excites thyroid near-infrared autofluorescence and the near-infrared autofluorescence of parathyroid gland future position, institute through the sound end
State collect optical fiber by the near-infrared of environmental background noise signal, thyroid near-infrared autofluorescence and parathyroid gland future position from
Body fluorescence transmits to the signal processing component successively through the near-infrared autofluorescence collecting device so that the signal transacting
The near-infrared of environmental background noise signal, thyroid near-infrared autofluorescence and parathyroid gland future position described in component record is certainly
Body fluorescence is simultaneously analyzed, and controls the prompting device to provide corresponding prompt message.
The near-infrared autofluorescence, which excites, is connected with first switch 7, at the signal between device 2 and power supply 1
Second switch 8 is connected between reason component 5 and power supply 1；When using the identification device, control the first switch 7 disconnected
Open or close, and triggering second switch 8, and the sound end 31 is excited, collected and analyzed close to doctor's area-of-interest
Near-infrared autofluorescence, the parathyroid gland is identified.It is understood that in thyroid gland related surgical, Yi Shenghuo
Doctor's Assistant etc. holds the identification device of the parathyroid gland, and disconnects the first switch 7, triggering second switch 8, described in control
Sound end 31 detects environmental background noise signal SdSo that the signal processing component 5 receives and stores the environmental background and makes an uproar
Acoustical signal Sd；The first switch 7 is closed, second switch 8 is triggered again, controls the sound end 31 close to thyroid gland so that
The signal processing component 5 receives thyroid gland near-infrared autofluorescence signal intensity, and by the thyroid gland near-infrared autofluorescence
Signal intensity is as reference data value Sj；Control a certain parathyroid gland of the sound end 31 in parathyroid gland estimation range
Future position, second switch 8 is triggered again so that what the described real-time reception of signal processing component 5 parathyroid gland future position returned
Near-infrared autofluorescence signal intensity S；The signal processing component 5 judges that the near-infrared that the parathyroid gland future position returns is autologous
Whether fluorescence signal intensity S meets (S-Sd)≥2*(Sj-Sd)；If the signal processing component 5 is learnt by a certain first shape through judging
The near-infrared autofluorescence signal intensity S that gland future position returns meets (S-Sd)≥2*(Sj-Sd), then the signal processing component 5
It is parathyroid gland position to judge current parathyroid gland future position；And the signal processing component 5 controls described carry
Show that device 6 sends prompting so that doctor or Doctor's Assistant can accurately know the parathyroid gland position of patient.
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention, simple in construction and user
Just, can efficiently and quickly be identified by the first shape around thyroid gland on the premise of the operation of doctor's normal surgical is not influenceed
Gland, it reliably avoid in operation the operation risk caused by the false judgment to parathyroid gland.
Embodiments of the invention two provide a kind of specific embodiment party of fiber optic rod 3 in the identification device of above-mentioned parathyroid gland
Formula, referring to Fig. 2, the fiber optic rod 3 specifically includes following content：
Hollow stem 32, the excitation fiber 33 being co-axially located in the hollow stem 32 and collection optical fiber 34；The exciting light
Fibre 33 excites device 2 to be connected with the near-infrared autofluorescence, and the collection optical fiber 34 is received with the near-infrared autofluorescence
Collection device 4 connects.It is understood that when the second switch 8 closes and the first switch 7 disconnects, the fiber optic rod 3
Environmental background noise signal is collected through the sound end 31, and the environmental background noise signal is transmitted autologous to the near-infrared
Phosphor collection device 4.
It is understood that the excitation fiber 33 and the data of collection optical fiber 34 can be entered by practical application request
Row is set, and to cause the application of the identification device of parathyroid gland best, excitation fiber 33 can be arranged on to more collection light
Among fibre 34, wherein excitation fiber 33 could be arranged at least one, and less than the quantity for collecting optical fiber 34, collect optical fiber 34
At least one is could be arranged to, to be advisable between 4 to 10.
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention, by improving the knot of fiber optic rod 3
The reliability of structure, and then improve the application reliability of the identification device of whole parathyroid gland.
Embodiments of the invention three provide near-infrared autofluorescence in the identification device of above-mentioned parathyroid gland and excite device 2
A kind of embodiment, referring to Fig. 3, the near-infrared autofluorescence excites device 2 to specifically include following content：
What laser diode 21 and the laser diode 21 were coaxially disposed excites condenser lens 22；The pole of laser two
Pipe 21 is connected to the first switch 7；It is described to excite condenser lens 22 to be connected to the excitation fiber 33.It is understood that
When the first switch 7 closes, condenser lens 22 is excited to converge described in the LASER Light Source warp that the laser diode 21 is launched
After poly-, then through the excitation fiber 33 reach the sound end 31 so that the LASER Light Source irradiates through the sound end 31
Go.
It is understood that the model of the laser diode 21 can also be configured according to the actual requirements, with 785nm
Laser diode 21 is advisable；Meanwhile to ensure to excite demand and tissue irradiation energy safety, 785nm laser diodes 21
Power Control between 80-100mW.After exciting light is converged by condenser lens, import excitation fiber 33 and transmit to spy
In head end 31, exciting for near-infrared autofluorescence is realized.
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention, by improving near-infrared certainly
The reliability of structure of body fluorescence excitation device 2, and then improve the application reliability of the identification device of whole parathyroid gland.
Embodiments of the invention four provide near-infrared autofluorescence collecting device 4 in the identification device of above-mentioned parathyroid gland
A kind of embodiment, referring to Fig. 4, the near-infrared autofluorescence collecting device 4 specifically includes following content：
The bandpass filter 41 and collection condenser lens 42 being coaxially disposed；The bandpass filter 41 and the collection optical fiber
34 connections, and the collection condenser lens 42 connects the signal processing component 5；It is understood that in the sound end 31
When receiving environmental background noise signal or near-infrared autofluorescence signal, the collection optical fiber 34 transmits the signal to described
Bandpass filter 41 is filtered, and the signal after optical filtering is transmitted to the signal processing component through the collection condenser lens 42 again
5。
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention is autologous by carrying near-infrared
The reliability of structure of phosphor collection device 4, and then improve the application reliability of the identification device of whole parathyroid gland.
One kind that embodiments of the invention five provide signal processing component 5 in the identification device of above-mentioned parathyroid gland is specific
Embodiment, referring to Fig. 5, the signal processing component 5 specifically includes following content：
The light intensity sensor 51 and signal processor 52 being sequentially connected；The signal processor 52 is connected to described second and opened
Close 8；The light intensity sensor 51 is connected with the collection condenser lens 42, and the signal processor 52 is connected to the prompting
Device 6.It is understood that the signal after the optical filtering that the light intensity sensor 51 receives collection condenser lens 42 transmission
Afterwards, the signal after filtering is converted into data signal, and by the digital data transmission to the signal processor 52, the letter
Number processor 52 is prompted after receiving, recording and analyzing the data signal, controlling the prompting device 6.
It is understood that the signal processor 52 is fpga chip；The prompting device 6 sets described device housing
On 9 outer wall, and the prompting device 6 is connected with the signal processor 52；The prompting device 6 is buzzer, sound report
Alert device or audible-visual annunciator.Light intensity sensor 51 is by environmental background noise signal and excites autofluorescence signal to be converted to digital letter
Number transmit to fpga chip；In fpga chip analysis, environmental background noise is recorded first, next records thyroid autologous glimmering
Light signal strength as analysis a reference value, when the area-of-interest denoising fluorescence intensity collected be the denoising a reference value at least
At more than twice, it is believed that the region is parathyroid gland, while the FPGA controls prompting device 6 sends early warning, prompts doctor should
Region is parathyroid gland.
If it is understood that prompt the control instruction that device is buzzer, prompts device to be sent according to fpga chip
Buzzing prompting is carried out, the buzzing prompting of different frequency can also be sent according to the difference of control instruction type so that user's energy
It is enough directly perceived understand currently measure obtained data be specially environmental background noise signal, thyroid near-infrared autofluorescence still
The near-infrared autofluorescence of parathyroid gland.Similar, can be according to the different controls received when prompting device is voice guard
System order sends different prompt tone or voice broadcast, and, device is prompted when being audible-visual annunciator, can be according to receiving not
Same control command sends different photoelectricity or voice message.
For example, the voice guard being arranged on the outer wall of device case 9 is provided with 3 indicator lamps, when user's first time
When triggering second switch, fpga chip thinks that it is specially environmental background noise signal currently to measure obtained data, when background is made an uproar
When sound record finishes, the indicator lamp of the corresponding environmental background noise signal designation of fpga chip control lights and sends prompt tone；When
During second of triggering second switch of user, fpga chip thinks that it is specially thyroid near-infrared currently to measure obtained data
Autofluorescence, when thyroid near-infrared autofluorescence record finishes, the corresponding thyroid near-infrared of fpga chip control is certainly
The indicator lamp of body fluorescence instruction lights and sends prompt tone；When user's third time until triggering second before power-off erasing data
During switch, fpga chip is thought currently to measure the near-infrared autofluorescence that obtained data are specially parathyroid gland future position, this
If when the future position signal intensity meet parathyroid gland signal strength conditions, the corresponding parathyroid gland of fpga chip control it is near red
The indicator lamp of outer autofluorescence instruction lights green light and sends prompt tone；If on the contrary be unsatisfactory for parathyroid gland signal strength conditions,
Then fpga chip controls the near-infrared autofluorescence indicator lamp of corresponding parathyroid gland to flash the redlight and sends prompt tone.
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention can be efficiently and quickly
The parathyroid gland around thyroid gland is identified, reliably avoid and caused in operation due to the false judgment to parathyroid gland
Operation risk, provide safety guarantee for thyroid gland related surgical, and effectively increase the efficiency of thyroid gland related surgical, enter
And the burden of doctor and patient are alleviated simultaneously.
Embodiments of the invention six provide another embodiment of the identification device of above-mentioned parathyroid gland, referring to
Fig. 6, the identification device of the parathyroid gland also specifically include following content：
Device case 9；The power supply 1, near-infrared autofluorescence excite device 2, near-infrared autofluorescence collector
Part 4, signal processing component 5 are arranged in described device housing 9；The prompting device 6 is arranged on the outer of described device housing 9
On wall, and the prompting device 6 is connected with the signal processing component 5；The fiber optic rod 3 is arranged on described device housing 9
On the outer wall of side.
In a kind of specific embodiment, the outer wall of described device housing 9 is provided with button and triggering button；The button
It is connected through described device housing 9 with the first switch 7 inside the device case 9, the button is used to control described the
One switch 7 is opened or closed；The triggering button is opened through described device housing 9 with described second inside the device case 9
8 connections are closed, the triggering button closes for triggering the second switch 8.
It is understood that button can be 1 unidirectional button, for controlling the first switch 7 to be opened or closed.
It was found from foregoing description, the identification device of the parathyroid gland in embodiments of the invention, pass through the whole of whole device
Design is closed, improves the reliability and service life of device application, while reduces and manufactures cost.
For further instruction this programme, present invention also offers a kind of application example of the identification device of parathyroid gland,
The identification device of the parathyroid gland specifically includes following content：
Power supply 1；Near-infrared autofluorescence excites device 2, for producing 785nm near-infrared excitation lights；Sound end 31,
For exciting and collecting fluorescence signal；Near-infrared autofluorescence collecting device 4, the near of designated band is obtained for filtering and converging
Infrared excitation autofluorescence；Signal processing component 5 and prompting device 6, intensive analysis and offer for realizing collection fluorescence carry
Show and inform.
Near-infrared autofluorescence excites device 2, mainly by 785nm laser diodes 21 and excites condenser lens 22 to form.
To ensure to excite demand and tissue irradiation energy safety, the Power Controls of 785nm laser diodes 21 80-100mW it
Between.After exciting condenser lens 22 to converge exciting light, import excitation fiber 33 and transmit into sound end 31, realize near red
Outer autofluorescence excites.
Sound end 31, mainly it is made up of 1 center excitation fiber 33 and uniform ring around 6 collection optical fiber 34 of surrounding, light
400 μm of fibre core footpath, numerical aperture NA are 0.22, realize the maximization for exciting phosphor collection efficiency.6 collection optical fiber 34 are nearly red
Outer autofluorescence, which is collected, to be transmitted to device 4 and collects.
Near-infrared autofluorescence collecting device 4, mainly it is made up of 820nm bandpass filters 41 and collection condenser lens 42.
Because parathyroid hormone from body fluorescence bands is distributed in 820nm or so, therefore Selection Center wavelength is in 820nm, bandwidth 5nm's
Bandpass filter, other interference light are filtered out, obtain wave band interested excites autofluorescence, after collecting condenser lens 42 and focusing on
Deliver to signal processing component 5 and carry out Intensity Analysis.
Signal processing component 5 and prompting device 6, are mainly made up of light intensity sensor 51, fpga chip and buzzer.Light intensity
Sensor 51 is by environmental background noise signal and excites autofluorescence signal to be converted to digital data transmission to fpga chip；
In fpga chip analysis, environmental background noise is recorded first, and next records thyroid autofluorescence signal intensity as analysis
A reference value, when the area-of-interest denoising fluorescence intensity collected is more than at least twice of the denoising a reference value, it is believed that should
Region is parathyroid gland, while FPGA control buzzers send early warning, and it is parathyroid gland to prompt the doctor region.
The power supply 1 is embodied in power supply circuit, and the near-infrared in the identification device of parathyroid gland is autologous glimmering
Light excites device circuitry to be controlled by first switch 7, and the circuit of signal processor 52 in signal processing component is controlled by second switch 8
System, when needing to measure a certain position, the region is directed at, opens first switch and trigger the i.e. achievable measurement of second switch.
It was found from foregoing description, the identification device of the parathyroid gland in application example of the invention, it is first shut off first and opens
Close, trigger second switch, gather environmental background noise；Secondly first switch is opened, by alignment probe thyroid gland and triggering second
Switch realizes fluorescence excitation, collects thyroid gland near-infrared autofluorescence signal and records in the chips, as identification parathyroid gland
Benchmark；And by alignment probe area-of-interest and second switch excitation signal is triggered, when the denoised signal intensity being collected into
At more than twice of at least denoising reference signal, it is believed that the region is parathyroid gland, buzzer warning prompting；Can effectively and
The parathyroid gland around thyroid gland is rapidly identified, reliably avoid in operation due to the false judgment to parathyroid gland
Caused by operation risk, provide safety guarantee for thyroid gland related surgical, and effectively increase thyroid gland related surgical
Efficiency, and then the burden of doctor and patient are alleviated simultaneously.
Embodiments of the invention seven provide the identification for the parathyroid gland realized using the identification device of above-mentioned parathyroid gland
A kind of embodiment of method, referring to Fig. 7, the recognition methods of the parathyroid gland specifically includes following content：
Step 100：The first switch is disconnected, triggers the second switch, controls the sound end detection environmental background
Noise signal SdSo that the signal processing component is received and stored through fiber optic rod and near-infrared autofluorescence collecting device successively
The environmental background noise signal Sd, when ambient noise record finishes, the signal processing component controls the prompting device hair
Go out corresponding prompting；Disconnect the second switch.
Step 200：The first switch is closed, controls the sound end to trigger described second again close to thyroid gland and open
Close, the near-infrared autofluorescence excites sound end of the device through fiber optic rod to send exciting light, while sound end obtains thyroid gland
Near-infrared autofluorescence signal so that the signal processing component is successively through the fiber optic rod and near-infrared autofluorescence collector
Part receives, record thyroid gland near-infrared autofluorescence signal, and by the signal intensity of the thyroid gland near-infrared autofluorescence signal
As reference data value Sj, when reference signal record finishes, the signal processing component controls the prompting device to send correspondingly
Prompting.Disconnect the second switch.
Step 300：A certain parathyroid gland future position of the sound end in parathyroid gland estimation range is controlled, again
The second switch is triggered, the near-infrared autofluorescence excites sound end of the device through fiber optic rod to send exciting light, visited simultaneously
Head end obtains the near-infrared autofluorescence signal of parathyroid gland future position so that the signal processing component is successively through the optical fiber
The near-infrared autofluorescence signal that bar and near-infrared autofluorescence collecting device received, recorded parathyroid gland future position return is strong
Spend S.
Step 400：The signal processing component judges the near-infrared autofluorescence signal that the parathyroid gland future position returns
Whether strength S meets (S-Sd)≥2*(Sj-Sd)；
Step 501：If the signal processing component learns the near-infrared of a certain parathyroid gland future position return certainly through judgement
Body fluorescence signal intensity S meets (S-Sd)≥2*(Sj-Sd), then the signal processing component judges current parathyroid gland prediction
Point is parathyroid gland position, while the signal processing component control prompting device sends corresponding prompting..
Step 502：If the signal processing component learns the near-infrared of a certain parathyroid gland future position return certainly through judgement
Body fluorescence signal intensity S is unsatisfactory for (S-Sd)≥2*(Sj-Sd), then the signal processing component judges that current parathyroid gland is pre-
Measuring point is not parathyroid gland position, while the signal processing component control prompting device sends corresponding prompting.
Step 600：Doctor decides whether to continue to measure other parathyroid gland future positions；
Step 700：Terminate measurement, device power-off, signal processing component erasing to should the environmental background of patient make an uproar
If sound, anlage,thyroid calibration signal and desiccated parathyroid future position signal data.
It was found from foregoing description, the recognition methods of the parathyroid gland in application example of the invention can be effectively and quick
Ground identifies the parathyroid gland around thyroid gland, reliably avoid and is drawn in operation due to the false judgment to parathyroid gland
The operation risk risen, safety guarantee is provided for thyroid gland related surgical, and effectively increases the efficiency of thyroid gland related surgical,
And then the burden of doctor and patient are alleviated simultaneously.
In the description of the invention, it is necessary to which the orientation of the instruction such as explanation, term " on ", " under " or position relationship are base
In orientation shown in the drawings or position relationship, description description of the invention and simplified, rather than instruction or hint are for only for ease of
Signified device or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to this
The limitation of invention.Unless otherwise clearly defined and limited, term " installation ", " connected ", " connection " should be interpreted broadly, example
Such as, can be fixedly connected or be detachably connected, or be integrally connected；Can mechanically connect or be electrically connected
Connect；Can be joined directly together, can also be indirectly connected by intermediary, can be the connection of two element internals.For this
For the those of ordinary skill in field, the concrete meaning of above-mentioned term in the present invention can be understood as the case may be.
It should also be noted that, herein, such as first and second or the like relational terms are used merely to one
Entity or operation make a distinction with another entity or operation, and not necessarily require or imply between these entities or operation
Any this actual relation or order be present.Moreover, term " comprising ", "comprising" or its any other variant are intended to contain
Lid nonexcludability includes, so that process, method, article or equipment including a series of elements not only will including those
Element, but also the other element including being not expressly set out, or it is this process, method, article or equipment also to include
Intrinsic key element.In the absence of more restrictions, the key element limited by sentence "including a ...", it is not excluded that
Other identical element also be present in process, method, article or equipment including the key element.
Above example is merely to illustrate technical scheme, rather than its limitations；Although with reference to the foregoing embodiments
The present invention is described in detail, it will be understood by those within the art that：It still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic；And these are changed or replaced
Change, the essence of appropriate technical solution is departed from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (10)
1. a kind of identification device of parathyroid gland, it is characterised in that described device includes：Power supply, be sequentially connected it is near red
Outer autofluorescence excites device, fiber optic rod, near-infrared autofluorescence collecting device, signal processing component and prompting device；
The near-infrared autofluorescence excite be connected between device and power supply first switch, the signal processing component with
The second switch for controlling the signal processing component to carry out data storage is connected between power supply；
It is sound end that the remote near-infrared autofluorescence of the fiber optic rod, which excites one end of device,；
When carrying out parathyroid gland identification, by controlling disconnection and the closure of the first switch, and triggering described second to open
Close, and by the sound end close to doctor's area-of-interest, the sound end by the near-infrared autofluorescence received send to
The near-infrared autofluorescence collecting device, the near-infrared autofluorescence collecting device will filter focus on after near-infrared it is autologous
Fluorescence is transmitted to signal processing component so that the signal processing component records each auto fluorescence intensity data and known
Not, and according to the recognition result control prompting device corresponding prompt message is provided.
2. device according to claim 1, it is characterised in that the fiber optic rod includes：Hollow stem, be co-axially located at it is described
Excitation fiber and collection optical fiber in hollow stem；
The excitation fiber excites device to be connected with the near-infrared autofluorescence, and the collection optical fiber and the near-infrared are certainly
Body phosphor collection device connects；
When carrying out parathyroid gland identification, the excitation fiber through the sound end excite thyroid near-infrared autofluorescence and
The near-infrared autofluorescence of parathyroid gland future position, the optical fiber of collecting is by environmental background noise signal, thyroid near-infrared
Autofluorescence and the near-infrared autofluorescence of parathyroid gland future position are transmitted successively through the near-infrared autofluorescence collecting device
To the signal processing component so that the signal processing component records the environmental background noise signal, thyroid near red
Outer autofluorescence and the near-infrared autofluorescence of parathyroid gland future position are simultaneously analyzed, and control the prompting device to provide pair
Answer prompt message.
3. device according to claim 2, it is characterised in that the near-infrared autofluorescence excites device to include：Laser
What diode and the laser diode were coaxially disposed excites condenser lens；
The laser diode is connected to the first switch；
It is described to excite condenser lens to be connected to the excitation fiber；
When carrying out parathyroid gland identification, condenser lens is excited to converge described in the LASER Light Source warp that the laser diode is launched
Afterwards, then through the excitation fiber sound end is reached so that the LASER Light Source shines out through the sound end.
4. device according to claim 2, it is characterised in that the near-infrared autofluorescence collecting device includes：Coaxially
The bandpass filter and collection condenser lens of setting；
The bandpass filter is connected with the collection optical fiber, and the collection condenser lens connects the signal processing component；
When the sound end receives environmental background noise signal or near-infrared autofluorescence signal, the collection optical fiber should
Signal is transmitted to the bandpass filter and filtered, and the signal after optical filtering is transmitted to the letter through the collection condenser lens again
Number processing component.
5. device according to claim 4, it is characterised in that the signal processing component includes：The light intensity being sequentially connected
Sensor and signal processor；
The signal processor is connected to the second switch；The light intensity sensor is connected with the collection condenser lens, and
The signal processor is connected to the prompting device；
After the signal that the light intensity sensor receives after the optical filtering collected condenser lens and sent, the signal after this is filtered
Data signal is converted into, and the digital data transmission to the signal processor, the signal processor are being received, recorded simultaneously
After analyzing the data signal, the prompting device is controlled to be prompted accordingly.
6. device according to claim 1, it is characterised in that described device also includes：Device case；
The power supply, near-infrared autofluorescence excite device, near-infrared autofluorescence collecting device, signal processing component equal
It is arranged in described device housing；
The fiber optic rod is arranged on the side outer wall of described device housing.
7. device according to claim 6, it is characterised in that the outer wall of described device housing is provided with button and triggering is pressed
Key；
The button is connected through described device housing with the first switch inside the device case, and the button is used to control
The first switch is made to be opened or closed；
The triggering button is connected through described device housing with the second switch inside the device case, and the triggering is pressed
Key is used to trigger the second switch closure.
8. device according to claim 6, it is characterised in that the prompting device is arranged on the outer wall of described device housing
On, and the prompting device is connected with the signal processor；
The prompting device is buzzer, voice guard or audible-visual annunciator.
9. device according to claim 5, it is characterised in that the signal processor is fpga chip.
A kind of 10. recognition methods of parathyroid gland, it is characterised in that any one of methods described application claim 1 to 9 first
The identification device of gland is realized by shape, and methods described includes：
The first switch is disconnected, triggers the second switch so that the second switch is in opening, controls the spy
Head end detection environmental background noise signal SdSo that the signal processing component is received through fiber optic rod and near-infrared autofluorescence successively
Collection device receives and stores the environmental background noise signal Sd, the signal processing component controls the prompting device to send correspondingly
Prompting, disconnects the second switch afterwards；
The first switch is closed, controls the sound end to trigger the second switch, the near-infrared again close to thyroid gland
Autofluorescence excites sound end of the device through fiber optic rod to excite thyroid gland near-infrared autofluorescence signal so that the signal transacting
Component receives through the fiber optic rod and near-infrared autofluorescence collecting device successively, record thyroid gland near-infrared autofluorescence letter
Number, and using the signal intensity of the thyroid gland near-infrared autofluorescence signal as reference data value Sj, the signal processing component
Control the prompting device to send corresponding prompting, disconnect the second switch afterwards；
A certain parathyroid gland future position of the sound end in parathyroid gland estimation range is controlled, triggers described second again
Switch, the near-infrared autofluorescence excite sound end of the device through fiber optic rod to excite the near-infrared of parathyroid gland future position autologous
Fluorescence signal so that the signal processing component receives through the fiber optic rod and near-infrared autofluorescence collecting device successively, note
Record the near-infrared autofluorescence signal intensity S of parathyroid gland future position return；
The signal processing component judges whether the near-infrared autofluorescence signal intensity S that the parathyroid gland future position returns meets
(S-Sd)≥2*(Sj-Sd)；
If the signal processing component learns that the near-infrared autofluorescence signal that a certain parathyroid gland future position returns is strong through judging
Spend S and meet (S-Sd)≥2*(Sj-Sd), then the signal processing component judges that current parathyroid gland future position is by first shape
Gland position, otherwise the current parathyroid gland future position of signal processing component judgement is not parathyroid gland position；
And the signal processing component control prompting device sends corresponding prompting；Triggering measurement next time is waited afterwards, directly
Terminate to measurement.
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Application publication date: 20171121 |