CN107361357A - A kind of preparation method of the health products of anticancer - Google Patents

A kind of preparation method of the health products of anticancer Download PDF

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Publication number
CN107361357A
CN107361357A CN201710468295.9A CN201710468295A CN107361357A CN 107361357 A CN107361357 A CN 107361357A CN 201710468295 A CN201710468295 A CN 201710468295A CN 107361357 A CN107361357 A CN 107361357A
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parts
chinese
root
anticancer
health products
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李建华
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Suzhou Li Liangji Health Industry Co Ltd
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Suzhou Li Liangji Health Industry Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/20Natural extracts
    • A23V2250/21Plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

This application discloses a kind of preparation method of the health products of anticancer, dextrin, agate card, ganoderma lucidum, Chinese gall, raspberry, donkey-hide gelatin, Ligusticum wallichii, Fructus Monordicae extract, the fruit of Chinese wolfberry, golden cypress, antelope's horn, black false hellebore root, the root of Chinese clematis, stiff silkworm and magnesium stearate are weighed;Remove obstruction in channels to relieve pain, dispersing pathogen accumulation, training tonifying spleen and stomach vigour, benefiting qi for promoting production of blood;Strengthen energy, improve fertility, treatment climacteric metancholia, rheumatism, anemia, soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, anticancer dispersing, swelling and pain relieving, nourishing qi and blood;Synergy is produced in prescription between each component, so as to bring, anticancer and anti-leukocythemia and other effects act on, anti- acute myocardial ischemia, expand blood vessel, hypotensive, antibacterial and it is antitumor have it is notable the effect of, without obvious toxic-side effects, long-term use has no side effect to human body, can extensively produce and constantly replace current material.

Description

A kind of preparation method of the health products of anticancer
Technical field
The application belongs to field of health care products, more particularly to a kind of preparation method of the health products of anticancer.
Background technology
Cancer is due to the excessive multiplication hyperplasia of body abnormal cell, so as to damage health, the disease of threat to life.Research It was found that 80%~90% cancer and environmental factor, such as geographical conditions, life style, eating habit are relevant.Diet care is to anti- Cancer is for cancer all extremely important.Diet has the relation of countless ties with tumour, and the fuse cord of cancer can be ignited by eating mistake, and it is right to eat The effect of anti-cancer can then be played.Appropriate food truly has the effect of pathogenic, diseases prevention, improves body immunity.Medical research shows: Have medical care effect to human body is small particle anion.Because only that the anion of small particle is just easy to the blood through human body Brain barrier, play its biological effect.
Agate card is mainly produced in South America Andes and Chinese yunnan Lijing, is a kind of crucifer.Leaf Ellipse, rhizome likeness in form turnip radish, edible is a kind of natural food, and nutrition is enriched.The hypocotyl of agate card may be in Golden either faint yellow, red, purple, blueness, black or green.Flaxen most common, and shape, taste are preferably also. Agate card is rich in high unit nutrient, there is the function of nourishing and fit keeping function to human body.Black agate card is to be acknowledged as the best agate card of effect, Yield is few.Agate card originates in High aititude mountain area, is suitably filled in High aititude, low latitudes, high day and night temperature, subacidity sandy loam, sunlight Grown in the soil of foot;Plantation area is with being distributed mainly on the Yulong Xueshan of South America state Andes and Chinese yunnan Lijing There is suitable kind of soil of larger area area, this two big main producing region.And the area such as other areas of Chinese yunnan and Xinjiang, Tibet also has less Amount plantation.
Medically, cancer refers to the malignant tumour originating from epithelial tissue, is most common one kind in malignant tumour.Relatively Answer, the malignant tumour originating from mesenchymal tissue is referred to as sarcoma.There are a small number of malignant tumours not named by mentioned above principle, as kidney is female Cytoma, malignant teratoma etc.." cancer " described in general people traditionally refers to all malignant tumours.Tumour is body each Under the factor effect of kind tumorigenesis, the cell of local organization loses on gene level causes paraplasm to the normal regulation that it grows The neoformation formed with differentiation.Neoformation does not stop growing, his growth is not by normal machine once being formed because the cause of disease eliminates Body Physiological effect, but destruction normal structure and organ, this point are especially apparent in malignant tumour.Compared with benign tumour, dislike Property tumor growth rate it is fast, in infiltrative growth, bleeding, necrosis, ulcer etc. easily occurs, and often have DISTANT METASTASES IN, causes human body Become thin, be powerless, anaemia, poor appetite, heating and serious organ function are impaired etc., ultimately cause death.
Agate card belongs to separate row Vegetable spp plant, has many general character with other separate row Vegetable spp plants on taxonomic features.Solely About 175 kinds of row Lepidium plant, the whole world has widely distributed;For 1 year to perennial herb or fruticuli, often with single mao, glandular hairs, Column hair;Stem is single or most, branch.For leaf herbaceous stem to papery, it is deep to pinniform to wide ellipse, full edge, ora serrata that wire bores shape Split, there is petiole, or base portion innermost being shape embraces stem.Raceme basidixed and axillary;Sepal rectangle or wire lanceolar, slightly concave, base Portion is not into cryptomere, tool white or red edge;Petal white, it is a small number of with pink or slightly yellow, it is linear to cochlear, compare sepal It is short, degenerate or do not deposit sometimes;6, stamen, is often degenerated to 2 or 4, has small nectary between base portion;Style is short or does not deposit, column cap head Shape, slightly two split sometimes;Ovary often has 2 ovules.Silicle is avette, obovate, circle or ellipse, flat, cracking, have it is narrow every Film, fruit lobe have keel, or the top tip has wing.Seed elliptical or oval shape, it is aptery or have wing;Cotyledon stands with radicle behind, very Few edge leans on radicle.
The cause of disease of malignant tumour not yet understands completely.Epidemiological study and experiment and clinical observation for many years, find ring Border has a major impact with behavior to human malignancies.About more than 80% malignant tumour has with environmental factor according to estimates Close.Various environment and heredity carcinogenic factor may cause the DNA damage of cell non-lethal in a manner of cooperateing with or be sequential, So as to activate proto-oncogene or inactivate the suppressor of tumour, plus the change of apoptosis gene and DNA-repair gene, make thin Born of the same parents convert.The cell being converted can be in first polyclonal property hyperplasia, by a very long multistage evolution process, wherein certain The relatively unrestricted amplification of individual clone, by addition mutation, the subclone of selectively formed different characteristics, so as to be infiltrated and turned Shifting ability, form malignant tumour.Therefore, tumour is essentially a kind of genopathy.
The health products of in the market can substantially be divided into general health food, health medicine, cosmetics, health treatment Deng.Health food has food quality, such as tea, wine, honeybee product, drink, Tang Pin, fresh juice, herbal cuisine, has color, perfume (or spice), shape, matter It is required that the no requirement (NR) typically on dosage;Health medicine has trophism, food natural medicine property, answers partner treatment to use, There is usage and dosage requirement, at present the medicine of band " strong " word lot number;Cosmetics have the property of cosmetics, only local not small Modification, and have Transdermal absorption, effect effect in external application, such as health-care perfume, creams, mouthwash;Health treatment has daily The property of daily necessities, such as fitness equipment, massager, water mangetizer, strong sachet, clothes shoes and hats, pad blanket.With everybody health care The continuous enhancing of consciousness, health food market are also unprecedented hot.In hot market, the quality of various products is also ginseng Difference is uneven.Next just teach how everybody selects regular suitable health food.
Chinese health products industry process is fast-developing for many years, gradually grows.Although still facing lot of challenges, The development prospect of National Health Foods industry is bright.Under the market demand, technological progress and the promotion of management update, China Health products industry development space is huge.Consumer groups' diversification, health products sales mode franchiseization, a surname will be presented in future development Arq mode is weeded out the old and bring forth the new and health products are into the main trend of current consumption four.Design one kind is safe, disintegration time is short, decomposes shape State is good, easily absorbs, and the preparation method of health products rapid-action and without the anticancer for finding obvious toxic side effect is very necessary 's.
The content of the invention
The technical problem of solution:
The application is directed to above-mentioned technical problem, there is provided a kind of preparation method of the health products of anticancer, solves existing health products anticancer The technical problems such as effect is poor, disintegration time is long and is not easy to absorb.
Technical scheme:
A kind of preparation method of the health products of anticancer, comprises the following steps:
The first step:100 parts of dextrin, agate card 25-35 parts, ganoderma lucidum 15-25 parts, Chinese gall 8-10 are weighed according to parts by weight proportioning Part, raspberry 10-12 parts, donkey-hide gelatin 14-16 parts, Ligusticum wallichii 6-8 parts, Fructus Monordicae extract 16-20 parts, fruit of Chinese wolfberry 12-14 parts, golden cypress 10-12 parts, antelope's horn 8-10 parts, black false hellebore root 3-5 parts, root of Chinese clematis 5-7 parts, stiff silkworm 4-6 parts and magnesium stearate 0.5-4.5 parts;
Second step:By the agate card after net system, cutting and ganoderma lucidum according to the one Chinese Pharmacopoeia annex IID of version in 2010 steaming method, system Into medicine materical crude slice;
3rd step:Raspberry, Ligusticum wallichii, the fruit of Chinese wolfberry, black false hellebore root, antelope's horn, the root of Chinese clematis and golden cypress are extracted through alcohol reflux, ethanol Amount is 5-7 times of quality of medicinal material and measured that ethanol volumetric concentration is 80%, and point 2 refluxing extractions, flow back 70-90min every time, and merging carries Liquid is taken, filters, filtrate decompression concentration and recovery ethanol, obtains alcohol extracting concentrate;
4th step:Add donkey-hide gelatin, Fructus Monordicae extract, Chinese gall and stiff silkworm to dry, 100 mesh sieves are crossed after crushing, drunk with agate card Piece, lucid ganoderma decoction piece and the dregs of a decoction after the alcohol reflux extraction that volumetric concentration is 80% merge, and boil, filter through decocting, concentration is cold But, add ethanol, centrifuged after alcohol precipitation, centrifugate is merged with the alcohol extracting concentrate of the 3rd step, in 85-95 DEG C of condition after being concentrated under reduced pressure Under be dried in vacuo, obtain extract dry powder, dextrin added after well mixed, add after water wetting be made it is well mixed thick Cream;
5th step:Above-mentioned thick paste crushed after being dried is made into particle, controls the moisture of particle to be eventually adding stearic acid in 3-5% Magnesium, plain piece is pressed into after mixing.
As a preferred technical solution of the present invention:The amount of water added by 4th step is the 17-19 of bulk drug quality Times, 40-60min is soaked, is decocted 2-4 times, each 1-2 hours, merges decocting liquid three times, filtering, concentrates filtrate to 60 DEG C when to survey relative density be 1g/ml, cooling, add ethanol to be stirred to alcohol content up to 40%, centrifuged after placement 40-50 hours, 4600-4800 revs/min of centrifuge speed, precipitation is discarded, reclaim centrifugate.
As a preferred technical solution of the present invention:The raw materials by weight portion of the health products of anticancer in the first step Proportioning is as follows:100 parts of dextrin, 25 parts of agate card, 15 parts of ganoderma lucidum, 8 parts of Chinese gall, 10 parts of raspberry, 14 parts of donkey-hide gelatin, 6 parts of Ligusticum wallichii, sieve 16 parts of Chinese berry extract, 12 parts of the fruit of Chinese wolfberry, 10 parts of golden cypress, 8 parts of antelope's horn, 3 parts of black false hellebore root, 5 parts of the root of Chinese clematis, 4 parts of stiff silkworm and hard 0.5 part of fatty acid magnesium.
As a preferred technical solution of the present invention:The raw materials by weight portion of the health products of anticancer in the first step Proportioning is as follows:100 parts of dextrin, 35 parts of agate card, 25 parts of ganoderma lucidum, 10 parts of Chinese gall, 12 parts of raspberry, 16 parts of donkey-hide gelatin, 8 parts of Ligusticum wallichii, 20 parts of Fructus Monordicae extract, 14 parts of the fruit of Chinese wolfberry, 12 parts of golden cypress, 10 parts of antelope's horn, 5 parts of black false hellebore root, 7 parts of the root of Chinese clematis, 6 parts of stiff silkworm and 4.5 parts of magnesium stearate.
As a preferred technical solution of the present invention:The raw materials by weight portion of the health products of anticancer in the first step Proportioning is as follows:100 parts of dextrin, 30 parts of agate card, 20 parts of ganoderma lucidum, 9 parts of Chinese gall, 11 parts of raspberry, 15 parts of donkey-hide gelatin, 7 parts of Ligusticum wallichii, sieve 18 parts of Chinese berry extract, 13 parts of the fruit of Chinese wolfberry, 11 parts of golden cypress, 9 parts of antelope's horn, 4 parts of black false hellebore root, 6 parts of the root of Chinese clematis, 5 parts of stiff silkworm and hard 2.5 parts of fatty acid magnesium.
Beneficial effect:
A kind of preparation method of the health products of anticancer of the present invention using above technical scheme compared with prior art, have with Lower technique effect:1st, preparation method is simple, and cost is cheap, and formula is simple, and compatibility is reasonable, it then follows the principle of tcm treatment according to syndrome differentiation, It is formulated each taste medicine to complement each other, there is the effect of obvious anticancer, nontoxic to human body, the health care for being improved immunity is made It is safe with, product;2nd, remove obstruction in channels to relieve pain, dispersing pathogen accumulation, training tonifying spleen and stomach vigour, benefiting qi for promoting production of blood;3rd, strengthen energy, improve life Educate power, treatment climacteric metancholia, rheumatism, anemia, soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, anticancer dispersing, detumescence Analgesic, nourishing qi and blood;4th, synergy, so as to bring, anticancer and anti-leukocythemia and other effects are produced in prescription between each component Effect, anti-acute myocardial ischemia expand blood vessel, hypotensive, antibacterial and it is antitumor there is the effect of notable, make without obvious poison is secondary With long-term use has no side effect to human body, can extensively produce and constantly replace current material.
Embodiment
Embodiment 1:
100 parts of dextrin, 25 parts of agate card, 15 parts of ganoderma lucidum, 8 parts of Chinese gall, 10 parts of raspberry, donkey-hide gelatin are weighed according to parts by weight proportioning 14 parts, 6 parts of Ligusticum wallichii, 16 parts of Fructus Monordicae extract, 12 parts of the fruit of Chinese wolfberry, 10 parts of golden cypress, 8 parts of antelope's horn, 3 parts of black false hellebore root, the root of Chinese clematis 5 0.5 part of part, 4 parts of stiff silkworm and magnesium stearate.
By the agate card after net system, cutting and ganoderma lucidum according to the one Chinese Pharmacopoeia annex IID of version in 2010 steaming method, drink is made Piece.
Raspberry, Ligusticum wallichii, the fruit of Chinese wolfberry, black false hellebore root, antelope's horn, the root of Chinese clematis and golden cypress are extracted through alcohol reflux, amount of alcohol It is 5 times of amounts of quality of medicinal material, ethanol volumetric concentration is 80%, and point 2 refluxing extractions, flow back 70min every time, merges extract solution, mistake Filter, filtrate decompression concentration and recovery ethanol, obtains alcohol extracting concentrate.
Donkey-hide gelatin, Fructus Monordicae extract, Chinese gall and stiff silkworm is added to dry, after crushing cross 100 mesh sieves, with agate card medicine materical crude slice, Lucid ganoderma decoction piece and the dregs of a decoction after the alcohol reflux extraction that volumetric concentration is 80% merge, and are boiled through decocting, the amount of added water is raw material 17 times of medicine quality, 40min is soaked, decoct 2 times, 1 hour every time, merge decocting liquid three times, filtering, concentrate filtrate to It is 1g/ml that relative density is surveyed at 60 DEG C, cooling, adds ethanol to be stirred to alcohol content up to 40%, and placement centrifuges after 40 hours, from 4600 revs/min of scheming speed, precipitation is discarded, reclaim centrifugate, centrifugate is merged with the alcohol extracting concentrate of the 3rd step, decompression is dense It is dried in vacuo after contracting under the conditions of 85 DEG C, obtains extract dry powder, dextrin is added after well mixed, is made after adding water wetting Well mixed thick paste.
Above-mentioned thick paste crushed after being dried is made into particle, controls the moisture of particle to be eventually adding magnesium stearate, mix 3% After be pressed into plain piece.
Preparation method is simple, and cost is cheap, and formula is simple, and compatibility is reasonable, it then follows the principle of tcm treatment according to syndrome differentiation, formula are each Taste medicine complements each other, and has the effect of obvious anticancer, nontoxic to human body, is improved the health-care effect of immunity, product It is safe;Remove obstruction in channels to relieve pain, dispersing pathogen accumulation, training tonifying spleen and stomach vigour, benefiting qi for promoting production of blood;Strengthen energy, improve fertility, treatment more Term syndrome, rheumatism, anemia, soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, anticancer dispersing, swelling and pain relieving, QI invigorating are supported Blood;Synergy is produced in prescription between each component, so as to bring, anticancer and anti-leukocythemia and other effects effect, resists the acute heart Myocardial ischemia, expand blood vessel, hypotensive, antibacterial and it is antitumor have it is notable the effect of, no obvious toxic-side effects, long-term use to people Body has no side effect, and can extensively produce and constantly replace current material.
Embodiment 2:
According to parts by weight proportioning weigh 100 parts of dextrin, 35 parts of agate card, 25 parts of ganoderma lucidum, 10 parts of Chinese gall, 12 parts of raspberry, Ah 16 parts of glue, 8 parts of Ligusticum wallichii, 20 parts of Fructus Monordicae extract, 14 parts of the fruit of Chinese wolfberry, 12 parts of golden cypress, 10 parts of antelope's horn, 5 parts of black false hellebore root, Wheeling 4.5 parts of celestial 7 parts, 6 parts of stiff silkworm and magnesium stearate.
By the agate card after net system, cutting and ganoderma lucidum according to the one Chinese Pharmacopoeia annex IID of version in 2010 steaming method, drink is made Piece.
Raspberry, Ligusticum wallichii, the fruit of Chinese wolfberry, black false hellebore root, antelope's horn, the root of Chinese clematis and golden cypress are extracted through alcohol reflux, amount of alcohol It is 7 times of amounts of quality of medicinal material, ethanol volumetric concentration is 80%, and point 2 refluxing extractions, flow back 90min every time, merges extract solution, mistake Filter, filtrate decompression concentration and recovery ethanol, obtains alcohol extracting concentrate.
Donkey-hide gelatin, Fructus Monordicae extract, Chinese gall and stiff silkworm is added to dry, after crushing cross 100 mesh sieves, with agate card medicine materical crude slice, Lucid ganoderma decoction piece and the dregs of a decoction after the alcohol reflux extraction that volumetric concentration is 80% merge, and are boiled through decocting, the amount of added water is raw material 19 times of medicine quality, 60min is soaked, decoct 4 times, 2 hours every time, merge decocting liquid three times, filtering, concentrate filtrate to It is 1g/ml that relative density is surveyed at 60 DEG C, cooling, adds ethanol to be stirred to alcohol content up to 40%, and placement centrifuges after 50 hours, from 4800 revs/min of scheming speed, precipitation is discarded, reclaim centrifugate, centrifugate is merged with the alcohol extracting concentrate of the 3rd step, decompression is dense It is dried in vacuo after contracting under the conditions of 95 DEG C, obtains extract dry powder, dextrin is added after well mixed, is made after adding water wetting Well mixed thick paste.
Above-mentioned thick paste crushed after being dried is made into particle, controls the moisture of particle to be eventually adding magnesium stearate, mix 5% After be pressed into plain piece.
Preparation method is simple, and cost is cheap, and formula is simple, and compatibility is reasonable, it then follows the principle of tcm treatment according to syndrome differentiation, formula are each Taste medicine complements each other, and has the effect of obvious anticancer, nontoxic to human body, is improved the health-care effect of immunity, product It is safe;Remove obstruction in channels to relieve pain, dispersing pathogen accumulation, training tonifying spleen and stomach vigour, benefiting qi for promoting production of blood;Strengthen energy, improve fertility, treatment more Term syndrome, rheumatism, anemia, soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, anticancer dispersing, swelling and pain relieving, QI invigorating are supported Blood;Synergy is produced in prescription between each component, so as to bring, anticancer and anti-leukocythemia and other effects effect, resists the acute heart Myocardial ischemia, expand blood vessel, hypotensive, antibacterial and it is antitumor have it is notable the effect of, no obvious toxic-side effects, long-term use to people Body has no side effect, and can extensively produce and constantly replace current material.
Embodiment 3:
100 parts of dextrin, 30 parts of agate card, 20 parts of ganoderma lucidum, 9 parts of Chinese gall, 11 parts of raspberry, donkey-hide gelatin are weighed according to parts by weight proportioning 15 parts, 7 parts of Ligusticum wallichii, 18 parts of Fructus Monordicae extract, 13 parts of the fruit of Chinese wolfberry, 11 parts of golden cypress, 9 parts of antelope's horn, 4 parts of black false hellebore root, the root of Chinese clematis 6 2.5 parts of part, 5 parts of stiff silkworm and magnesium stearate.
By the agate card after net system, cutting and ganoderma lucidum according to the one Chinese Pharmacopoeia annex IID of version in 2010 steaming method, drink is made Piece.
Raspberry, Ligusticum wallichii, the fruit of Chinese wolfberry, black false hellebore root, antelope's horn, the root of Chinese clematis and golden cypress are extracted through alcohol reflux, amount of alcohol It is 6 times of amounts of quality of medicinal material, ethanol volumetric concentration is 80%, and point 2 refluxing extractions, flow back 80min every time, merges extract solution, mistake Filter, filtrate decompression concentration and recovery ethanol, obtains alcohol extracting concentrate.
Donkey-hide gelatin, Fructus Monordicae extract, Chinese gall and stiff silkworm is added to dry, after crushing cross 100 mesh sieves, with agate card medicine materical crude slice, Lucid ganoderma decoction piece and the dregs of a decoction after the alcohol reflux extraction that volumetric concentration is 80% merge, and are boiled through decocting, the amount of added water is raw material 18 times of medicine quality, 50min is soaked, decoct 3 times, 1.5 hours every time, merge decocting liquid three times, filtering, filtrate decompression is concentrated Be 1g/ml to relative density is surveyed at 60 DEG C, cooling, add ethanol to be stirred to alcohol content up to 40%, placement centrifuges after 45 hours, 4700 revs/min of centrifuge speed, precipitation is discarded, reclaim centrifugate, centrifugate is merged with the alcohol extracting concentrate of the 3rd step, depressurized It is dried in vacuo after concentration under the conditions of 90 DEG C, obtains extract dry powder, dextrin is added after well mixed, is made after adding water wetting Into well mixed thick paste.
Above-mentioned thick paste crushed after being dried is made into particle, controls the moisture of particle to be eventually adding magnesium stearate, mix 4% After be pressed into plain piece.
Preparation method is simple, and cost is cheap, and formula is simple, and compatibility is reasonable, it then follows the principle of tcm treatment according to syndrome differentiation, formula are each Taste medicine complements each other, and has the effect of obvious anticancer, nontoxic to human body, is improved the health-care effect of immunity, product It is safe;Remove obstruction in channels to relieve pain, dispersing pathogen accumulation, training tonifying spleen and stomach vigour, benefiting qi for promoting production of blood;Strengthen energy, improve fertility, treatment more Term syndrome, rheumatism, anemia, soothing liver-qi stagnation, clearing heat and detoxicating, promoting blood circulation and removing blood stasis, anticancer dispersing, swelling and pain relieving, QI invigorating are supported Blood;Synergy is produced in prescription between each component, so as to bring, anticancer and anti-leukocythemia and other effects effect, resists the acute heart Myocardial ischemia, expand blood vessel, hypotensive, antibacterial and it is antitumor have it is notable the effect of, no obvious toxic-side effects, long-term use to people Body has no side effect, and can extensively produce and constantly replace current material.
With 300 clinical tests, max age 80 years old, wherein minimal ages 40 years old, male patient 150, female patient It 150, orally, 1-3 times on the one, a 1-2 piece, need to continuously use 15 days, effective percentage 81.23%, continuously take 30 days, it is efficient 85.34%, half a year effective percentage 91.71% is continuously taken, is continuously taken 1 year, effective percentage 97.36%.
All medicinal materials of formula in above example can be with commercially available.
The above embodiments are intended to illustrate the present invention, rather than limitation, therefore with the present invention's Any change in claims suitable implication and scope, all it is considered as being included within the scope of the claims.

Claims (5)

1. a kind of preparation method of the health products of anticancer, it is characterised in that comprise the following steps:
The first step:100 parts of dextrin, agate card 25-35 parts, ganoderma lucidum 15-25 parts, Chinese gall 8-10 are weighed according to parts by weight proportioning Part, raspberry 10-12 parts, donkey-hide gelatin 14-16 parts, Ligusticum wallichii 6-8 parts, Fructus Monordicae extract 16-20 parts, fruit of Chinese wolfberry 12-14 parts, golden cypress 10-12 parts, antelope's horn 8-10 parts, black false hellebore root 3-5 parts, root of Chinese clematis 5-7 parts, stiff silkworm 4-6 parts and magnesium stearate 0.5-4.5 parts;
Second step:By the agate card after net system, cutting and ganoderma lucidum according to the one Chinese Pharmacopoeia annex IID of version in 2010 steaming method, system Into medicine materical crude slice;
3rd step:Raspberry, Ligusticum wallichii, the fruit of Chinese wolfberry, black false hellebore root, antelope's horn, the root of Chinese clematis and golden cypress are extracted through alcohol reflux, ethanol Amount is 5-7 times of quality of medicinal material and measured that ethanol volumetric concentration is 80%, and point 2 refluxing extractions, flow back 70-90min every time, and merging carries Liquid is taken, filters, filtrate decompression concentration and recovery ethanol, obtains alcohol extracting concentrate;
4th step:Add donkey-hide gelatin, Fructus Monordicae extract, Chinese gall and stiff silkworm to dry, 100 mesh sieves are crossed after crushing, drunk with agate card Piece, lucid ganoderma decoction piece and the dregs of a decoction after the alcohol reflux extraction that volumetric concentration is 80% merge, and boil, filter through decocting, concentration is cold But, add ethanol, centrifuged after alcohol precipitation, centrifugate is merged with the alcohol extracting concentrate of the 3rd step, in 85-95 DEG C of condition after being concentrated under reduced pressure Under be dried in vacuo, obtain extract dry powder, dextrin added after well mixed, add after water wetting be made it is well mixed thick Cream;
5th step:Above-mentioned thick paste crushed after being dried is made into particle, controls the moisture of particle to be eventually adding stearic acid in 3-5% Magnesium, plain piece is pressed into after mixing.
A kind of 2. preparation method of the health products of anticancer according to claim 1, it is characterised in that:Added by 4th step The amount of water is 17-19 times of bulk drug quality, soaks 40-60min, is decocted 2-4 times, each 1-2 hours, merges decocting three times Liquid, filtering, it is 1g/ml that relative density is surveyed when concentrating filtrate to 60 DEG C, cooling, adds ethanol to be stirred to alcohol content up to 40% Uniformly, centrifuged after placing 40-50 hours, 4600-4800 revs/min of centrifuge speed, discard precipitation, reclaim centrifugate.
A kind of 3. preparation method of the health products of anticancer according to claim 1, it is characterised in that:The first step moderate resistance The raw materials by weight portion proportioning of the health products of cancer is as follows:100 parts of dextrin, 25 parts of agate card, 15 parts of ganoderma lucidum, 8 parts of Chinese gall, cover basin 10 parts of son, 14 parts of donkey-hide gelatin, 6 parts of Ligusticum wallichii, 16 parts of Fructus Monordicae extract, 12 parts of the fruit of Chinese wolfberry, 10 parts of golden cypress, 8 parts of antelope's horn, black false hellebore root 0.5 part of 3 parts, 5 parts of the root of Chinese clematis, 4 parts of stiff silkworm and magnesium stearate.
A kind of 4. preparation method of the health products of anticancer according to claim 1, it is characterised in that:The first step moderate resistance The raw materials by weight portion proportioning of the health products of cancer is as follows:100 parts of dextrin, 35 parts of agate card, 25 parts of ganoderma lucidum, 10 parts of Chinese gall, cover 12 parts of basin, 16 parts of donkey-hide gelatin, 8 parts of Ligusticum wallichii, 20 parts of Fructus Monordicae extract, 14 parts of the fruit of Chinese wolfberry, 12 parts of golden cypress, 10 parts of antelope's horn, lamb's-quarters 4.5 parts of 5 parts of reed rhizome, 7 parts of the root of Chinese clematis, 6 parts of stiff silkworm and magnesium stearate.
A kind of 5. preparation method of the health products of anticancer according to claim 1, it is characterised in that:The first step moderate resistance The raw materials by weight portion proportioning of the health products of cancer is as follows:100 parts of dextrin, 30 parts of agate card, 20 parts of ganoderma lucidum, 9 parts of Chinese gall, cover basin 11 parts of son, 15 parts of donkey-hide gelatin, 7 parts of Ligusticum wallichii, 18 parts of Fructus Monordicae extract, 13 parts of the fruit of Chinese wolfberry, 11 parts of golden cypress, 9 parts of antelope's horn, black false hellebore root 2.5 parts of 4 parts, 6 parts of the root of Chinese clematis, 5 parts of stiff silkworm and magnesium stearate.
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