CN107349256A - A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield - Google Patents
A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield Download PDFInfo
- Publication number
- CN107349256A CN107349256A CN201710595557.8A CN201710595557A CN107349256A CN 107349256 A CN107349256 A CN 107349256A CN 201710595557 A CN201710595557 A CN 201710595557A CN 107349256 A CN107349256 A CN 107349256A
- Authority
- CN
- China
- Prior art keywords
- scutellaria baicalensis
- medicinal material
- fresh
- conditions
- dried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, using fresh Scutellaria baicalensis medicinal material as raw material, using baking oven flash baking, fresh Scutellaria baicalensis medicinal material is dried into 10~20h under the conditions of 40 DEG C, fresh Scutellaria baicalensis medicinal material is dried into 6~24h under the conditions of 60 DEG C；Fresh Scutellaria baicalensis medicinal material is dried into 2~8h under the conditions of 80 DEG C, scutelloside and flavone derivative active constituent content after drying process in radix scutellariae medicinal materials are generally higher than conventional method, and moisture is less than or equal to 13%, and uniform quality, stably.The present invention is by controlling drying process, promote the formation and accumulation of the flavonoid glycoside compositions such as scutelloside, with obtain appropriate humidity, have high level scutelloside radix scutellariae medicinal materials raw material, for producing baikal skullcap root decoction pieces, extract and related preparations using scutelloside as main active component, and then raising and stable radix scutellariae medicinal materials quality especially content of baicalin.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield.
Background technology
Radix scutellariae alias Radix Scutellariae, tsuchikane tea root, it is lamiaceae labiatae scutellaria herbaceos perennial Scutellaria
Baicalensis Georgi dry root, is the famous traditional Chinese medicine in China, and history tree is on the books.Traditional Chinese Medicine is thought
Radix scutellariae taste bitter and cold, return lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, arresting bleeding and miscarriage prevention and other effects.Modern Chinese medicine
The flavone derivatives such as scutelloside that medicine research has shown that to contain in radix scutellariae, wogonoside, baicalein, wogonin have disease-resistant original
Body, anti-inflammatory, analgesia, antiallergy, the effect such as antitumor, enhancing is immune.
Radix scutellariae has had more than the history of 2000 in clinical practice, and in addition to traditional Chinese medical science formula herbs, it is former to be largely used as Chinese patent drug
Material, according to《National Chinese patent drug catalogue》The statistics of first, 70% Chinese patent drug contain radix scutellariae.At present, radix scutellariae
And its demand of extract increases year by year, have become one of large Chinese medicine in China.According to 2015 editions《Chinese Pharmacopoeia》, it is yellow
Content of baicalin is not less than 9.0% in a kind of reed mentioned in ancient books medicinal material, but baikal skullcap root decoction pieces quality is very different in the market, generally existing scutelloside
Conversion ratio is low.For a long time, radix scutellariae medicinal materials are as other most of Chinese medicines, and main drying means is Exposure to Sunlight after harvesting,
And using the degree of drying and moisture as unique discriminant criterion, Chinese Pharmacopoeia provides that its standard is moisture≤13.0%, so
And about the rare report of dynamic rule of chemical composition in the drying process of the place of production.Radix scutellariae collecting time is
Preferably, now boreal climate turns cold, Exposure to Sunlight deficiency, dries and spends time length, causes Habitat producing heat treatment not thorough, often results in Huang
A kind of reed mentioned in ancient books active constituent content degradation even goes mouldy, while current standard system is unsound, and critical process link is failed to understand, and then leads
Medicinal material and prepared slice quality is caused to be difficult to be effectively controlled.
The content of the invention
Technical problem solved by the invention is to provide a kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, with
Solves the shortcomings that in above-mentioned background technology.
Technical problem solved by the invention is realized using following technical scheme：
A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, is comprised the following steps that：
By the fresh Scutellaria baicalensis medicinal material of collection, using baking oven flash baking, fresh Scutellaria baicalensis medicinal material is dried under the conditions of 40 DEG C
10~20h, fresh Scutellaria baicalensis medicinal material is dried into 6~24h under the conditions of 60 DEG C；Fresh Scutellaria baicalensis medicinal material is dried into 2~8h under the conditions of 80 DEG C,
Scutelloside and flavone derivative active constituent content after drying process in radix scutellariae medicinal materials are generally higher than conventional method, water
Point content is less than or equal to 13%, and uniform quality, stably.
In the present invention, fresh Scutellaria baicalensis medicinal material is lamiaceae labiatae scutellaria plant radix scutellariae.
In the present invention, in fresh Scutellaria baicalensis medicinal material drying course, 16h is dried under the conditions of 40 DEG C, is dried under the conditions of 60 DEG C
10h；6h is dried under the conditions of 80 DEG C.
Beneficial effect：Formation and accumulation of the invention by controlling the flavonoid glycoside composition such as drying process, promotion scutelloside,
With obtain appropriate humidity, have high level scutelloside radix scutellariae medicinal materials raw material, for produce based on scutelloside activity into
Baikal skullcap root decoction pieces, extract and the related preparations divided, and then raising and stable radix scutellariae medicinal materials quality especially content of baicalin.
Brief description of the drawings
Fig. 1 is the radix scutellariae medicinal materials HPLC collection of illustrative plates figures in presently preferred embodiments of the present invention.
For the radix scutellariae medicinal materials in presently preferred embodiments of the present invention, scutelloside and other compositions in 40 DEG C of drying courses contain Fig. 2
Measure changing trend diagram.
For the radix scutellariae medicinal materials in presently preferred embodiments of the present invention, scutelloside and other compositions in 60 DEG C of drying courses contain Fig. 3
Measure changing trend diagram.
For the radix scutellariae medicinal materials in presently preferred embodiments of the present invention, scutelloside and other compositions in 80 DEG C of drying courses contain Fig. 4
Measure changing trend diagram.
Embodiment
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, tie below
Conjunction is specifically illustrating, and the present invention is expanded on further.
Embodiment 1
A kind of method preparation method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, is comprised the following steps that：
Raw material fresh Scutellaria baicalensis medicinal material is adopted in Hebei, life in 2 years, will be whole after the fresh Scutellaria baicalensis medicinal material removing surface silt of collection
Root is put into -20 DEG C of refrigerators and preserved, and oven drying is used when to be prepared, be respectively dried under the conditions of 40 DEG C 6h, 8h, 10h, 12h,
After 16h, 20h, the fresh Scutellaria baicalensis medicinal material dried is sampled, to judge fresh Scutellaria baicalensis medicinal material drying degree, water content and effectively
Component content, micro-judgment method：1. cut surface character differential method：Observe after usual root, rhizome, limb and bark-type traditional Chinese medicines material fracture
Section color and luster, section color and luster is consistent, middle and outer layer without obvious line of demarcation person, show to have parched, if section color and luster is not
Unanimously, illustrate not yet to parch inside medicinal material, or section color and luster still with it is fresh when it is identical, this is all undried mark；2. quality
Differential method：Dried drug material it is hard, crisp, tooth is stung, record book in accordion form is all laborious, soft texture, then not yet dry.Moisture in sample
Measure according to《Chinese Pharmacopoeia》(one) annex IX the first methods of H (oven drying method) are measured, scutelloside in sample, wogonoside,
The assay of 4 kinds of principle active components of baicalein and wogonin uses HPLC methods；
Experimental result：As shown in Fig. 1~Fig. 2, the flavones ingredient such as scutelloside is under the conditions of 40 DEG C in fresh Scutellaria baicalensis medicinal material
In the trend of falling N-type that first reduces, be further added by, then reduce in drying course, most notable of which is scutelloside, its content by
9.73% in fresh Scutellaria baicalensis medicinal material, 5.58% is first reduced to, is further added by highest 15.18%, then reducing tends to 10.84%
Steadily, in the case where setting experiment condition, its optimal drying condition is：40 DEG C dry 16h, and now sample moisture reaches pharmacopeia mark
Standard, content of baicalin reach maximum；But this optimization drying condition can be with baking oven volume, radix scutellariae sample size and whole root herb diameter
It is different and be varied from, need to appropriately adjust in actual applications.
Embodiment 2
Raw material fresh Scutellaria baicalensis medicinal material is adopted in Hebei, life in 2 years, will be whole after the fresh Scutellaria baicalensis medicinal material removing surface silt of collection
Root is put into -20 DEG C of refrigerators and preserved, and oven drying is used when to be prepared, be respectively dried under the conditions of 60 DEG C 2h, 4h, 6h, 8h, 10h,
After 12h, 24h, the fresh Scutellaria baicalensis medicinal material dried is sampled, to judge fresh Scutellaria baicalensis medicinal material drying degree, water content and effectively
Component content, micro-judgment method：1. cut surface character differential method：Observe after usual root, rhizome, limb and bark-type traditional Chinese medicines material fracture
Section color and luster, section color and luster is consistent, middle and outer layer without obvious line of demarcation person, show to have parched, if section color and luster is not
Unanimously, illustrate not yet to parch inside medicinal material, or section color and luster still with it is fresh when it is identical, this is all undried mark；2. quality
Differential method：Dried drug material it is hard, crisp, tooth is stung, record book in accordion form is all laborious, soft texture, then not yet dry.Sample moisture in sample
Assay according to《Chinese Pharmacopoeia》(one) annex IX the first methods of H (oven drying method) are measured, and scutelloside, the Chinese are yellow in sample
A kind of reed mentioned in ancient books glycosides, the assay of 4 kinds of principle active components of baicalein and wogonin use HPLC methods；
Experimental result：As shown in Figure 1, Figure 3, in fresh Scutellaria baicalensis medicinal material the flavones ingredient such as scutelloside in 60 DEG C of drying courses
In in first increase the trend that reduces afterwards, most notable of which is scutelloside, and its content is by 9.73% in fresh Scutellaria baicalensis medicinal material, elder generation
9.17% is reduced to, is further added by that it is steady to tend to 10.68% to highest 13.39%, then reduction；In the case where setting experiment condition, its
Optimal drying condition is：60 DEG C dry 10h, and now sample moisture reaches standards of pharmacopoeia, and content of baicalin reaches maximum；But
This optimization drying condition can be varied from baking oven volume, radix scutellariae sample size and whole root herb diameter difference, actually should
It need to be appropriately adjusted in.
Embodiment 3
A kind of method preparation method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, is comprised the following steps that：
Raw material fresh Scutellaria baicalensis medicinal material is adopted in Hebei, life in 2 years, will be whole after the fresh Scutellaria baicalensis medicinal material removing surface silt of collection
Root is put into -20 DEG C of refrigerators and preserved, and oven drying is used when to be prepared, be respectively dried under the conditions of 80 DEG C respectively at 2h, 4h, 6h,
After 8h, the fresh Scutellaria baicalensis medicinal material dried is sampled, to judge that fresh Scutellaria baicalensis medicinal material drying degree, water content and active ingredient contain
Amount, micro-judgment method：1. cut surface character differential method：Observe the section after usual root, rhizome, limb and bark-type traditional Chinese medicines material fracture
Color and luster, section color and luster is consistent, middle and outer layer without obvious line of demarcation person, show to have parched, if section color and luster is inconsistent, say
Not yet parched inside bright medicinal material, or section color and luster still with it is fresh when it is identical, this is all undried mark；2. quality differential method：
Dried drug material it is hard, crisp, tooth is stung, record book in accordion form is all laborious, soft texture, then not yet dry.Moisture in sample is sampled to survey
It is fixed according to《Chinese Pharmacopoeia》(one) annex IX the first methods of H (oven drying method) are measured, scutelloside, wogonoside, Huang in sample
The assay of a kind of reed mentioned in ancient books element and 4 kinds of principle active components of wogonin uses HPLC methods；
Experimental result：As Figure 1 and Figure 4, in fresh Scutellaria baicalensis medicinal material the flavones ingredient such as scutelloside in 80 DEG C of drying courses
In in first increasing the trend that reduces afterwards, most notable of which is scutelloside, and its content is first increased by 9.73% in fresh medicinal material
To highest 12.40%, it is steady to tend to 11.62% for then reduction.In the case where setting experiment condition, its optimal drying condition is：80℃
6h is dried, now sample moisture reaches standards of pharmacopoeia, and content of baicalin reaches maximum；But this optimization drying condition can be with
Baking oven volume, radix scutellariae sample size and whole root herb diameter are different and are varied from, and need to appropriately adjust in actual applications.
General principle, principal character and the major advantage of the present invention has been shown and described above.The technical staff of the industry
It should be appreciated that the present invention is not limited to the above embodiments, simply illustrate the present invention described in above-described embodiment and specification
Principle, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these change and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Thing defines.
Claims (3)
- A kind of 1. method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, it is characterised in that comprise the following steps that：By the fresh Scutellaria baicalensis medicinal material of collection, using baking oven flash baking, fresh Scutellaria baicalensis medicinal material is dried 10 under the conditions of 40 DEG C~ 20h, fresh Scutellaria baicalensis medicinal material is dried into 6~24h under the conditions of 60 DEG C；Fresh Scutellaria baicalensis medicinal material is dried into 2~8h under the conditions of 80 DEG C, passed through Scutelloside and flavone derivative active constituent content after drying process in radix scutellariae medicinal materials are generally higher than conventional method, and moisture contains Amount is less than or equal to 13%, and uniform quality, stably.
- 2. a kind of method preparation method for improving baicalin in Scutellaria baicalensis Georgi constituents yield, it is characterised in that fresh Scutellaria baicalensis medicinal material is Lamiaceae labiatae scutellaria plant radix scutellariae.
- 3. a kind of method preparation method for improving baicalin in Scutellaria baicalensis Georgi constituents yield according to claim 1, its feature It is, in fresh Scutellaria baicalensis medicinal material drying course, 16h is dried under the conditions of 40 DEG C, 10h is dried under the conditions of 60 DEG C；Under the conditions of 80 DEG C Dry 6h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710595557.8A CN107349256A (en) | 2017-07-20 | 2017-07-20 | A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710595557.8A CN107349256A (en) | 2017-07-20 | 2017-07-20 | A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107349256A true CN107349256A (en) | 2017-11-17 |
Family
ID=60285344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710595557.8A Pending CN107349256A (en) | 2017-07-20 | 2017-07-20 | A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107349256A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293187A (en) * | 2020-11-10 | 2021-02-02 | 盛实百草药业有限公司 | Cultivation method for improving content of alkannin |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104180619A (en) * | 2014-08-25 | 2014-12-03 | 济南康众医药科技开发有限公司 | Scutellaria baicalensis drying method |
| CN105716374A (en) * | 2016-03-14 | 2016-06-29 | 滨州医学院附属医院 | Drying treatment method for radix scutellariae |
-
2017
- 2017-07-20 CN CN201710595557.8A patent/CN107349256A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104180619A (en) * | 2014-08-25 | 2014-12-03 | 济南康众医药科技开发有限公司 | Scutellaria baicalensis drying method |
| CN105716374A (en) * | 2016-03-14 | 2016-06-29 | 滨州医学院附属医院 | Drying treatment method for radix scutellariae |
Non-Patent Citations (6)
| Title |
|---|
| 严军等: "徐长卿产地加工工艺优化研究", 《山东农业科学》 * |
| 张榕等: "晒干过程中黄芩药材黄酮类成分的动态变化", 《复旦学报(自然科学版)》 * |
| 潘永康等: "《现代干燥技术》", 31 May 2007, 化学工业出版社 * |
| 白永亮等: "桑叶干燥过程中黄酮类和生物碱类成分动态变化分析", 《中药材》 * |
| 葛秀允等: "不同加工方法对黄芩饮片质量影响的综合评价研究", 《时珍国医国药》 * |
| 钟革: "黄芩适宜加工条件初探", 《中国现代药物应用》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112293187A (en) * | 2020-11-10 | 2021-02-02 | 盛实百草药业有限公司 | Cultivation method for improving content of alkannin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102342359B (en) | Throat-soothing drop and preparation method thereof | |
| Li et al. | Traditional uses, phytochemistry, and pharmacology of Toxicodendron vernicifluum (Stokes) FA Barkley-a review | |
| CN104306908A (en) | Health-care composition for preventing respiratory system diseases caused by haze, and preparation method thereof | |
| KR101060309B1 (en) | Restorative herb medicine with jujube and manufacturing method thereof | |
| KR100707345B1 (en) | Steamed bellflower | |
| KR20070101441A (en) | Composition for improving liver function comprising herbal mixture extract | |
| CN104208393B (en) | It is a kind of to be used to prevent Chinese medicine composition of infectious bronchitis of chicken and preparation method thereof | |
| KR100771525B1 (en) | Composition for removing hangover comprising herbal mixture extract | |
| CN106389788A (en) | Medicine extract for strengthening anti-virus capability and immune function of livestock, preparation, and preparation method | |
| CN104161853B (en) | A kind of Chinese medicine composition for treating poultry hepatitis and preparation method thereof | |
| CN107349256A (en) | A kind of method for improving baicalin in Scutellaria baicalensis Georgi constituents yield | |
| CN104083602A (en) | Traditional Chinese medicine composition for treating respiratory tract infection and inflammation and preparation method thereof | |
| CN106923047A (en) | Rose chicken feed addictive, rose chicken feed and preparation method thereof | |
| CN104127558A (en) | Heat-clearing and detoxifying traditional Chinese medicine composition for livestock, and preparation method and application thereof | |
| CN103232930A (en) | Honeysuckle multi-function health preserving wine and preparation method thereof | |
| CN104258159A (en) | Ointment for treating skin eczema as well as preparation method and application thereof | |
| Cooper et al. | Natural products of silk road plants | |
| CN104799007A (en) | Chinese herbal medicine additive for enhancing disease resistance of Truogx sinensis and preparation method thereof | |
| CN103479870A (en) | Medicated bag for conditioning and treating hypertension, and preparation method thereof | |
| CN109568496B (en) | Detection method of traditional Chinese medicine composition for treating diabetes | |
| CN109528984A (en) | A kind of cream formula and preparation method by smearing breast treatment mammary gland disease | |
| CN114344434B (en) | Traditional Chinese medicine composition for treating pulmonary nodules and preparation method thereof | |
| KR102470454B1 (en) | Health functional food composition for anti-obesity comprising gynostemma pentaphyllum leaf extract and complex extract, and manufacturing method thereof | |
| Ye et al. | Medicinal Angiosperms of Asclepiadaceae and Periplocaceae | |
| CN107007745A (en) | A kind of medicine of black hair and preparation method thereof and its application method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171117 |