CN107349232A - Nutritious supplementary pharmaceutical and its preparation method and application - Google Patents

Nutritious supplementary pharmaceutical and its preparation method and application Download PDF

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CN107349232A
CN107349232A CN201710332369.6A CN201710332369A CN107349232A CN 107349232 A CN107349232 A CN 107349232A CN 201710332369 A CN201710332369 A CN 201710332369A CN 107349232 A CN107349232 A CN 107349232A
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nutritious supplementary
supplementary pharmaceutical
parts
hydroxytyrosol
moringa
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迈克尔·托马斯·麦克纳马拉
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Sunshine Medical Operation Co Ltd
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Sunshine Medical Operation Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The invention provides a kind of nutritious supplementary pharmaceutical, including Moringa extract, hydroxytyrosol and pipering.The nutritious supplementary pharmaceutical of the present invention can further comprise upper dietetic product and/or pharmaceutically acceptable carrier and/or auxiliary material so that peroral dosage form is made.The nutritious supplementary pharmaceutical of the present invention has remarkable anti-oxidant and antiphlogistic effects, available for preparing health products and medicine.

Description

Nutritious supplementary pharmaceutical and its preparation method and application
Technical field
The invention belongs to medicines and health protection field, in particular it relates to a kind of nutritious supplementary pharmaceutical and preparation method thereof and Using.
Background technology
In order to extend the life-span of the mankind and provide than more ready-made in the past medicine and medical scheme, in the past few decades In, although being made that huge progress, the incidence of many serious diseases continues increasing.These diseases of facing mankind Disease includes some fatal and popular diseases, including myocardial infarction (also referred to as having a heart attack), apoplexy, cancer, glycosuria Disease, hypertension, arthritis, obesity, COPD (COPD) and other cigarettes and air pollution relevant disease and Neurodegenerative disease such as Alzheimer disease and Parkinson's.
The cost and research activities of medical research are unprecedentedly surging.These research activities show, most of at present dead to the mankind Die and cause the major disease of tremendous influence to be prevented.This prevention depends on several factors, most of and gene genetic, drink Food, habits and customs are relevant with environmental problem.
Inflammation and its relevant disease
Today, the common physiologic feature of many most common and serious disease was relevant with the pathology for being referred to as inflammation.Slowly Property body inflammation be one be used for a series of body chemistries reaction and phenomenon broad terms, its metabolic state to body There is significant impact with process.
Inflammation is beneficial to human body.For example, excessively receive solar ultraviolet irradiation, can cause erythrosis and tan severely with Occur.In this case, inflammation excessively receive as body solar ultraviolet irradiation immune response, advantageously reduce by Acute and chronic damage caused by skin.
Influenza virus infection can cause body temperature to raise, and be referred to as having a fever.Fever is the inflammatory mechanism to protect the health of body, It is intended to reduce survival ability and the survival of intrusive viruses.Therefore, such inflammation is beneficial to the health of the mankind, and sometimes It is vital.
When for example hot pan in the surface of skin contact to the heat of the mankind, inflammation also occurs.In this case, Inflammation makes body produce a series of immunology and Circulatory response, to repair because contact high temperature damages to caused by skin Evil.Therefore, in several cases, inflammation is helpful to the health of body.
However, the generation and exacerbation of inflammation and specified disease caused by chronic body illness have very big relation.Coronary heart disease, Cancer, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, arthritis, obesity and Alzheimer disease are demonstrate,proved It is bright relevant with the chronic abnormal rise of inflammation in vivo.Specific biomarker, particularly C reactive protein (CRP) can be entered Row is measured to prove these inflammation.
Inflammation is also likely to be that calorie is intensive, the direct result of the excessive food of natural deletions fiber consumption, which increase The risk of increased weight.Such increased weight can produce the accumulation of stomach fat and interior fat.Unnecessary stomach fat and The increase of the yield of the inflammatory molecule that is referred to as cell factor of the interior fat with that can enter the circulatory system has very big pass System.So, they can cause the inflammatory response of body, so as to increase the risk of relevant disease.
A kind of most obvious inflammatory molecule is interleukin-6 (IL-6) caused by stomach fat.In portal vein High-caliber IL-6 is measured, the vein of wherein portal vein from consumption stomach fat receives blood.In addition, high-caliber IL-6 with The CRP of high blood level is directly related.
Disease caused by a kind of common and inflammation that is known is atherosclerosis.Inflammatory cytokine compound can The integrality of the crucial vascular endothelial cell of body, such as the arteria carotis of the coronary artery of heart and neck can be changed.Subsequent Inflammatory response promotes abnormal accumulation of the adipocyte in arterial endothelial cell.Such case is referred to as atherosclerosis, such as Fruit, which is developed as one pleases, may result in blood vessel diameter and significantly reduces.
Fat aggregation in vascular wall is referred to as patch.In some cases, it is complete may to lose its for unstable patch Whole property, especially in height inflammatory conditions or experience oxidative stress, cause plaque rupture.This phenomenon and the spot from damage Block is relevant with the blood leakage of final thrombus, and wherein thrombus is clot.The formation of arterial thrombus be cause most heart and The reason for a variety of apoplexy.
Chronic body inflammation is relevant with fasting blood glucose level rise, at the same with ferroheme A1cIncrease it is relevant.It is overweight and have The obese individuals of excessive internal organ and stomach fat are nor coincidence, they also can be to the influence of the circulation insulin as caused by pancreas Resistance is produced, ultimately results in the long-term rise of blood sugar level.This is referred to as diabetes B.
Also easily increase suffers from the risk of malignant tumour to patient with chronic body inflammation.Some most common human carcinomas Disease, including lung cancer, colorectal cancer, breast cancer, liver cancer, stomach cancer and prostate cancer are easily sent out compared with other healthy individuals Life is with the chronic increased patient of body level of inflammation.
Individual body phase of the verified patient with stages alzheimer's disease and Parkinson's disease of researcher with being not suffering from these diseases Than having higher levels of level of inflammation.
Oxidative stress and its relevant disease
In human body, oxidation is the important physiology course of production energy.However, during production energy, oxygen spreads out Raw free radical is also produced.Sometimes the generation of such free radical is uncontrolled and the histocyte of the mankind may be made Into a series of injuries.
Under its simplest pattern, when the amount deficiency that excessive free radical or anti-oxidizing compounds be present, or two kinds of feelings Condition simultaneously in the presence of, the oxidative stress of appearance is potentially to the process of histologic lesion.Caused by unopposed free radical activity Infringement be classified as oxidative stress.
Under normal physiological conditions, all atoms have paired outer-shell electron, and therefore have to adjacent tissue There is obvious reactivity.Free radical is defined as, containing single not paired electronics, substantially increasing its tissue reactive. Under biotic environment, due to these free radicals or compound may not make any distinction between with neighbouring molecule and cell effect, because The tissue reactive of this this free radical is probably breakneck.
Free radical may produce known " electronic theft " (electron stealing) phenomenon, cause tissue oxidizing And destination organization molecule may be made to lose activity.If the concentration of free radical is sufficiently large, these reactions are likely to result in extensively Cellular damage.
According to anti-oxidizing compounds relative bioavailability is neutralized, the degree of tissue damage may relax or reduce.This Class antioxidant directly and radical reaction, and neutralizes their reactivity, and linked groups' toxicity with low degree.
Oxidative stress may cause oxide-containing chemical material excessive, be referred to as active oxygen (ROS).The drastically rise of ROS concentration There may be obvious cellular damage.
Oxidative stress may be produced by many reasons, including diet is bad, toxin, radiation, medicine and air pollution.The world Upper multiple regional surrounding airs contain substantial amounts of pollutant.Some air pollutants may be exactly free radical in itself, such as two Nitrogen oxide.The acute and chronic result exposed to this extensive air pollutants is that the oxidative stress in intrapulmonary occurs, as long as Pollutant is inhaled into or into the circulatory system, soon causes extensive system oxidation stress.
The lung selective oxidation as caused by air pollution may stress again cause more extensive inflammatory reaction, and it may Cause more free radicals again in vivo.When lacking the antioxidant of sufficient amount, described histologic lesion is serious.
Especially, DNA in nucleus may be influenceed by being related to the free radical tissue damage of cell tissue nucleic acid.So, Therefore the cell effect for causing cancer to occur may be caused by being chronically exposed in pollutant.
Particle diameter is less than 10 μm of particle in airborne particulates, especially aerodynamics, because its oxidative stress is anti- The a large amount of generations and the generation of free radical answered, may be to the healthy particularly hazardous of the mankind.
Without examining, this kind of particulate air pollutant may also result in significant bodily tissue injury, locally and systemically Inflammation, and cancer cell ultimately generate, and other induction inflammation related diseases.
In some geographic areas, air pollution has become the subject matter of city people's health.Especially, different sizes and The air pollution composition granule of composition especially has notable work in the ability of injury human health in the ability for cause oxidative stress With.Ultramicro powder and other processes and tiny particular matter less than 0.1 μm may be inhaled into and in vivo by macrophage Absorbed with epithelial cell.It is this to absorb the tendency with very strong reduction human body oxidative stress.
In addition, other air pollutants, such as polycyclic aromatic hydrocarbon hydrocarbon (PAH), equally substantially increase oxidation Stress be with the danger of final tissue damage.
Anti-oxidizing compounds such as Tea Polyphenols and Flavonoid substances have the ability for removing these free radicals, it is meant that they Eliminate the danger that these free radicals enter human cell.In this case, these nutrient for plants, Tea Polyphenols and flavonoids Material reduces free radical to cell and the infringement prevented.
The neutralization of free radical has a variety of benefits to human body.The benefit includes reducing coronary heart disease, cranial vascular disease, cancer With other tumour syndromes, diabetes, obesity, nerve degenerative diseases, arthritis, pollution and cigarette related tissue damage and add The risk of speed tissue aging.
Another common factors for improving interior free yl concentration is muscular training, the especially aerobic exercise of high intensity. Increased Skeletal Muscle Contraction produces a large amount of excessive free radical compounds.
The generation of this free radicals a large amount of as caused by motion, hinders ability to act of the muscle in optimum level, extends Recovery period of overexercise, and the danger of muscle damage may be improved, it is referred to as pulled muscle or muscle tear.
The clinical research for performing high intensity interval tranining (HIIT) sportsman is shown, when sportsman take it is oral anti-oxidant During agent, its energy production and athletic performance are optimal.It has been shown that HIIT its there is the bone that suppression is referred to as human body " energy plants " The ability of bone Muscle Mitochondria, to eliminate the accumulation of the free radical related to moving.
The content of the invention
Technical problem solved by the invention is to lack in the prior art while have anti-oxidant with antiinflammatory action and in people The high nutritious supplementary pharmaceutical of internal bioavailability.In order to solve the technical problem, the invention provides a kind of nutritious supplementary pharmaceutical And its preparation method and application.
On the one hand, the invention provides a kind of nutritious supplementary pharmaceutical, count in parts by weight, the nutritious supplementary pharmaceutical includes：It is peppery Wooden extract 60-80 parts, hydroxytyrosol 10-20 parts, and pipering 10-20 parts.
Foregoing nutritious supplementary pharmaceutical, is counted in parts by weight, and the nutritious supplementary pharmaceutical includes：Moringa extract 65-75 parts, hydroxyl 12-18 parts of base tyrosol, and 12-18 parts of pipering.
Foregoing nutritious supplementary pharmaceutical, is counted in parts by weight, and the nutritious supplementary pharmaceutical includes：70 parts of Moringa extract, hydroxyl 15 parts of tyrosol, and 15 parts of pipering.
Foregoing nutritious supplementary pharmaceutical, the Moringa extract come from leaf of Moringa, Moringa seed and/or Moringa flower；It is preferred that Ground, the Moringa extract come from Moringa flower.
Foregoing nutritious supplementary pharmaceutical, the hydroxytyrosol come from olive fruits, olive water extract and/or olive oil.
Foregoing nutritious supplementary pharmaceutical, the nutritious supplementary pharmaceutical further comprise that dietetic product is upper and/or can pharmaceutically connect The carrier and/or auxiliary material received.
Foregoing nutritious supplementary pharmaceutical, the nutritious supplementary pharmaceutical are made into peroral dosage form；Preferably, the peroral dosage form is scattered Agent, tablet, capsule, granule, oral liquid or pill.
On the other hand, the invention provides the preparation method of foregoing nutritious supplementary pharmaceutical, the preparation method to include：According to Predetermined ratio prepares Moringa extract, hydroxytyrosol and pipering；And Moringa extract, hydroxytyrosol and pipering are mixed Close.
Foregoing preparation method, the Moringa extract use supercritical CO2Abstraction technique and/or moisture film extraction filtering skill Art is prepared.
Foregoing preparation method, the hydroxytyrosol are prepared using moisture film extraction filtering technique.
Foregoing preparation method, the pipering use supercritical CO2Abstraction technique is prepared.
On the other hand, the invention provides foregoing nutritious supplementary pharmaceutical to prepare health products or medicine with antioxidation Application in product.
On the other hand, the invention provides foregoing nutritious supplementary pharmaceutical to prepare health products or medicine with antiinflammatory action In application.
On the other hand, the invention provides foregoing nutritious supplementary pharmaceutical prepare prevention and/or treat it is following any one Or the application in the health products or medicine of a variety of diseases：Oxidative stress, chronic inflammation, angiocardiopathy (CVD), artery sclerosis, Cancer, Arterial Hypertention, diabetes, Health cost, pollution are drawn caused by hypercholesterolemia and similar relevant disease, cigarette The oxidative stress and tissue damage, age-related body aging, overweight and fat, bacterium infection, nervus retrogression disease risen The loss and motion loss that disease, skin symptom, ultraviolet trigger.
The beneficial effects of the invention are as follows：The nutritious supplementary pharmaceutical of the present invention is anti-oxidant and antiphlogistic effects are notable, to a variety of diseases Or symptom has good prevention or therapeutic action.The nutritious supplementary pharmaceutical of the present invention has that novel formula, cost be cheap, curative effect shows The advantages that writing, having no toxic side effect, and it is applicable to industrialized production.
Embodiment
In order to be fully understood by the purpose of the present invention, feature and effect, by following embodiments, the present invention is made detailed Describe in detail bright.For the process of the present invention in addition to the description below, remaining uses the conventional method or device of this area.
Moringa (Moringa oleifera)
Moringa is a kind of edible trees, is grown on dry torrid areas in the world, and apply more and more In nutriment.It contains abundant protein and various nutrient elements.In leaf protein quality it is high due to, it It has been widely used for treatment malnutrition and Other diseases.
Moringa is rich in antioxidant phenols, flavonoids and carotenoid compounds.Oxidation resistant plant chemical substance is improving It is more and more useful in terms of human health.Their purposes comes from antioxidant and has been demonstrated that free radical in human body can be reduced The fact that concentration.
The seed of Moringa is also valuable protein source, and it, which is rich in, methionine and cysteine.These amino acid It is highly beneficial to health.In human body, cysteine can promote the generation of natural glutathione, and glutathione is effective day Right antioxidant.Because Moringa has abundant anti-oxidizing compounds and its special protein amino acid content, and these Composition promotes the generation of natural glutathione antioxidant agent, and therefore, Moringa has the property to human health.
Free radical is compound, molecule and the atom for losing an outer-shell electron, thus gives their unstable properties. In order to become more stable, free radical may obtain the electronics lost from the tissue of health and body fluid, therefore, this Property is harmful to human body.This phenomenon is referred to as " electronic theft " (electron stealing).So, it has been shown that This property of free radical may increase the risk of disease progression, including angiocardiopathy, cancer and other tumours, degeneration With diseases associated with inflammation, diabetes, obesity, nerve degenerative diseases.
Except its oxidation resistance, Moringa has been asserted the effect with anti-inflammatory.Alhakmani et al. is studied in vitro The effect of Moringa anti-inflammatory (Asian Pacific Journal of Tropical Biomedicine 2013；3(8)：623- 627).These antiphlogistic effects compare with commercially available Primary Reference anti-inflammatory agent C14H10Cl2NNaO2.They measure ovalbumin Thermal induction protein denaturation, and point out, the antiphlogistic effects of Moringa flower extract are similar to the antiphlogistic effects of C14H10Cl2NNaO2.
Identical research indicates the antioxidant content and feature of Moringa.Moringa flower contains 19.31mg/g nutgall Acid, equivalent to total phenol in dried extract.
Leaf of Moringa has also been proved to the serum levels that can reduce obese patient's LDL-C. (Journal of Ethnopharmacology.2000 Jan in the research that Ghasi et al. is delivered；69(1)：21-5), As a result show, the total serum cholesterol in patients level for the high fat diet that feeding extracts from leaf of Moringa reduces 14.35%.It is this The influence for reducing serum cholesterol has statistical significance.It follows that Moringa leaf has clear and definite hypocholesterolemia Disease activity, is beneficial to people on the line.
Hydroxytyrosol (Hydroxytyrosol)
The cardiovascular health benefits of Mediterranean diet, first by de Lorgeril (Circulation.1999；99：779- Et al. 785) it was described and delivered as scientific discovery in 1999, it was demonstrated that in the patient having a heart attack in the past, ground Middle extra large diet is to repeating heart attack with the protective effect for being up to 4 years (4 years are the long term follow-up phases most long in the research).
Similar research shows that all other hazards are identical, such as obesity, smoking, inactive and other diet Bad, because certain reason stays in, the regional people of Mediterranean basin are more healthy than in the other local adults in the world, and the life-span is more It is long.Mediterranean diet includes abundant fresh daily water fruits and vegetables, full cereal, nut, berry, olive, red wine, moderate The fish and poultry of intake, the dairy products of low intake, red meat, manufactured meat and candy, and particularly routine uses olive oil, Particularly Extra Virgin.
Further scientific research clearly illustrates that the main beneficial compound in Mediterranean diet is present in olive, special It is not in olive oil.Show after carrying out substantial amounts of comparative studies to the olive oil of different cultivars and grade, with original olive oil and Non-primary olive oil is compared, and higher quality and more refined Extra Virgin are more helpful to health.
Extra Virgin is different from common olive oil and virgin oil due to its excellent polyphenol content.Therefore Draw a conclusion, most of health benefits come from olive polyphenol in Mediterranean diet.
So far, in terms of anti-oxidant and anti-inflammatory power, maximally effective polyphenol is hydroxyl junket in olive fruit and olive oil Alcohol.Hydroxytyrosol is that olive oil has the reason for high stability.The parent compound of hydroxytyrosol is oleuropein, and its is main Found in olive leaf.The reason for it is the toil pungent of olive, and hydroxytyrosol is relatively tasteless.
The widest population studies for assessing Extra Virgin effect are always PREDIMED researchs (Estruch, et al.N Engl J Med2013；368∶1279—1290).This is the large-scale Prevention Research carried out in Spain, is related to 7447 patients for suffering from high blood pressure disease.Research conclusion shows, supplements the Mediterranean of one liter of Extra Virgin weekly Diet significantly reduces the incidence of disease of angiocardiopathy.
Because monounsaturated fatty acids (MUFA) of the olive oil containing unsoundness, it is initially considered that these healthy greases rise Positive health discovery is come from, it is relevant with Mediterranean diet.However, when olive oil with other types of plant oil such as to day When certain herbaceous plants with big flowers oil and the safflower oil unsaturated oleic acid aliphatic acid of list of similar content (also contain) compare, other vegetable oil do not have generation and The positive health benefits of Mediterranean diet identical.
These find to confirm (Mol Nutr Food Res.2007Oct by P é rez-Jim é nez et al.；51(10)： 1199-208).It has recorded the anti-inflammatory of olive oil, anti-oxidant and less thrombosis effect can not contain due only to its MUFA Amount.
Therefore, Extra Virgin and other types of olive oil are analyzed in detail, analysis shows, it is and normal Rule are compared with virgin oil, and Extra Virgin contains more phenolic compounds (also referred to as polyphenols), special It is not more hydroxytyrosols, improves the higher level of health benefits.
The hydroxytyrosol and other polyphenolic substances found in olive and Extra Virgin is in medical science and section Learn and widely studied and delivered in the periodical literature of the peer review.They clearly show to have human health great Interests, it is both the basis of prevention, and the adminicle of patient of the treatment with specified disease.
Pipering (Piperine)
Pipering (black pepper piper longum (piper longum) extract) is a kind of bioavilability reinforcing agent.Pipering The characteristics of main attractive is that it inhibits the drug biotransformation of enzymatic in liver to react.Pipering effectively inhibits liver With the aryl hydrocarbon hydroxylase and glucuronyl transferase in enteron aisle.It is attributed to pipering the Bioaugnentation effect portion of pipering Act on the result of the ultra microstructure of microvillus on intestinal brush border.
Although current research shows that Moringa extract and hydroxytyrosol have certain anti-oxidant and antiinflammatory action, pepper Alkali has Bioaugnentation effect, still, the present inventor by research it has unexpectedly been discovered that, when Moringa extract, hydroxyl When base tyrosol and pipering are combined according to certain specific ratio, anti-oxidant and antiphlogistic effects are significantly higher than these three materials Effect when being combined according to other proportionings.
Specifically, according to an aspect of the present invention, the invention provides a kind of nutritious supplementary pharmaceutical, count in parts by weight, The nutritious supplementary pharmaceutical includes：Moringa extract 60-80 parts, hydroxytyrosol 10-20 parts, and pipering 10-20 parts；Preferably, The nutritious supplementary pharmaceutical includes：Moringa extract 65-75 parts, 12-18 parts of hydroxytyrosol, and pipering 12-18 parts；More preferably Ground, the nutritious supplementary pharmaceutical include：70 parts of Moringa extract, 15 parts of hydroxytyrosol, and 15 parts of pipering.
The present inventor by research it has unexpectedly been discovered that, when Moringa extract, hydroxytyrosol and pipering are pressed When being combined according to ratio of the invention, cooperated between three, there is synergy.At these three into the basis of subassembly Anti-oxidation characteristics after the upper prevention from suffering from the diseases for providing height, the advantages of passing through each of which and combination, reduce or eliminate chronic body Body inflammation and oxidative stress, reduce the concentration of internal free radical and active oxygen (ROS)；These three anti-oxidant and anti-inflammatory components lead to Cross and be combined with each other, act on the mankind and animal body to prevent specified disease, this ability is further enhanced by pipering, pepper Alkali can by increase take in nutrient for plants compound intestinal absorption, and by reduce its in liver and intestinal wall inside Metabolism eliminates, and then increases the bioavilability of the nutrient for plants compound of its intake.On the other hand, when Moringa extract, When hydroxytyrosol and pipering are combined according to aforementioned proportion, by with hydroxytyrosol and Moringa extract bioactivity plant Nutrient acts synergistically, and the positive health effect of pipering is also greatly improved and amplified.These effects include：It is anti- Scorching, anti-oxidant, anti-rotation shifting, antibacterial, anti-mutation and antitumor and anti-apoptotic, these effects are that pipering is good for humans and animals Kang Youyi other properties, and these effects of pipering are strengthened in the presence of hydroxytyrosol and Moringa extract With further activation.In addition to playing the function of bioperformance enhancing agent, by suppressing and being quenched free free radical and activity Oxygen species, and by reducing peroxidatic reaction of lipid and actively impact intracellular mercaptan state, antioxidant molecule and antioxygen Change enzyme, pipering is also prevented from oxidative stress associated tissue damage.
Moringa extract, hydroxytyrosol and pipering are not combined according to the ratio of the present invention, three's synergy, and not The replenishers matched using the present invention are compared, and the anti-oxidant and antiphlogistic effects of nutritious supplementary pharmaceutical of the invention are not only significantly carried Height, and effect is lasting.Compared with only taking any one or two kinds in Moringa extract, hydroxytyrosol and pipering, or Person, compared with not using the replenishers that the present invention matches, the antioxidant effect of nutritious supplementary pharmaceutical of the invention is significantly higher than three kinds The independent effect sum of component.It is a kind of systematically measure and compare food and the method for the oxidation resistance of replenishers be measurement oxygen from By base absorbability (ORAC).The ORAC of hydroxytyrosol is 68,576 TE/ grams of micromoles, and the ORAC of Moringa extract is 1576 micro- Mole TE/ grams, the ORAC of pipering is very small and is comparatively speaking insignificant, therefore the ORAC of hydroxytyrosol carries than Moringa Take thing big 45 times.And for the nutritious supplementary pharmaceutical of the present invention, its effect effect sum more independent than each component big at least 20%.
In the nutritious supplementary pharmaceutical of the present invention, the main component of the Moringa extract be oxidant Tea Polyphenols, flavonoids and Carotenoid compounds etc., it can extract from leaf of Moringa, Moringa seed and/or Moringa flower, it is preferred to use supercritical CO2Extraction Technology and/or moisture film is taken to extract filtering technique and extracted.Both extractive techniques avoid having used ethanol, methanol or other What chemical reagent.Moisture film extraction filtering technique only uses water as solvent, and supercritical CO2Abstraction technique is (for example, using high pressure The supercritical CO of (100-150 bars) and low temperature (40 degrees Celsius)2Abstraction technique) under elevated pressure conditions only using being perfectly safe Carbon dioxide.Moisture film extracts filtering technique while avoiding using chemical solvent, Moringa extract has been reached total phenol generalization Compound (polyphenol) and flavonoids (other bioactivity beneficial compounds) have highest concentration.The Moringa being obtained by extraction by water The antioxidation activity of extract extracts active high than other solvents such as methanol, acetone, ethanol and chloroform.In order to obtain most Supercritical CO is preferred in excellent anti-inflammatory bioactivity, the extract in Moringa flower2Extraction process produces.Therefore, it is of the invention Using the extract and supercritical CO of moisture film extraction filtering technique2Composition that the extract of abstraction technique is formed is realized most High-caliber phenols is anti-oxidant and anti-inflammatory bioactivity.
In a kind of preferred embodiment, the extraction of Moringa includes following workshop section：
1. the plant material collection stage
Before the extraction stage, first the Moringa plant of harvest and seed material are screened, are cleaned, sterilized and ground, To produce the biological active component of final products.
First by the leaf of plant and seed transport carries out cleaning to extraction factory and plant part sorts.In order that antioxygen It is maximum to change phenolic resin, flavonoids, the yield of carotenoid Phytochemistry compound, it is necessary to select whole plant material Select and handling process systematization.This will need following device：
(1) it is used for the conveyer belt and system for collecting plant material
(2) disleave and vibratory sieve separation device, to screen a variety of plant positions
(3) washing and sorting line, for cleaning and screening vegetable matter
2. the plant material primary treatment stage
Moringa plant material must be mechanically and chemically handled to maximize the extraction of bioactive compound.
Mainly extracted using distilled water to avoid using organic solvent.Use isolation technics, particularly film skill Art, to carry out flooding and purifying process.These technologies include ultrafiltration, filter, dialysis and electrodialysis successively.
Water soluble active component is extracted in hot water of the temperature less than 80 DEG C, such as anti-oxidant phenolic aldehyde, flavonoids and class are recklessly Radish extract plant chemical compound.Using supercritical CO2Abstraction technique extracts other hydrophobic substances, such as saturation and insatiable hunger The aliphatic acid of sum.
There is variable hydrophobicity and partial hydrophilicity from the bioactivity vegetalization material of Moringa extraction, therefore can be with Using supercritical CO2Abstraction technique and water film filtering technology extract these materials.Using analysis extraction Characterization of The Products come closely Monitoring optimization extraction.The standard of Such analysis includes：Uniformity, heat endurance, humidity, fragrance, freezing point, electric conductivity, pH and Gelling ability.
Carefully for the formulation of concern final products to produce various pulvis, tablet, capsule and liquid extract, this is very Important.
In a word, the Moringa extraction equipment needed for above-mentioned technique is as follows：
(1) plant and seed grinding device, including industrial grinding mills and plant and seed shredding machine.
(2) supercritical fluid CO2Extraction equipment, extracted for hydrophobic plant chemical compound.
(3) solvent extraction system.This is directed to use with for water-soluble substances or the extraction of the water or ethanol of non-water soluble substance Device.
(4) the thick system for carrying, collecting and storing for Moringa, by stainless cylinder of steel and copper pipe of reservoir group into.
(5) system in extraction process needed for bulk liquids transhipment, is made up of pump and pipeline.
3. separation and enriching stage
Crude extract (including water and alcoholic solution) must be refined by using the isolation technics of filtering and Distallation systm. Then, obtained fraction is further concentrated by evaporating, to obtain the bioactive substance of higher concentration.
Further improve the concentration of purified extract using membrane technology, the membrane technology is that nanofiltration, counter-infiltration, freezing are dense Contracting, it is evaporated in vacuo.
The equipment in these stages includes：Membrane filtration system, for collecting the stainless cylinder of steel and reservoir system of liquid among liquid, For transporting the pump and pipe-line system of liquid, concentration and drainage equipment：Vacuum, fluid bed and thin film evaporator.
4. refining stage
Then, the liquid fraction of the concentration obtained to separation and concentration process further carries out refining operation, to incite somebody to action Specific compound (polyphenol and flavonoids) separates with other materials (salt, sugar and protein).This effectively increases bioactivity The yield and purity of compound.Further, it is necessary to convert liquids to stable formulation such as powder, and therefore need to dry system System.
Equipment：
(1) chromatographic system, it is equipped with the industrial columns of ion-exchange chromatography
(2) drying system：Fluidized bed drying system, spray drying system, freeze-drier
In the nutritious supplementary pharmaceutical of the present invention, the hydroxytyrosol extracts from olive fruits, olive water extract and/or olive Oil, it is preferred to use moisture film technology (i.e. moisture film extraction filtering technique or water film filtering technology).Using water as unique solvent, keep away Exempt to use chemical substance, the antioxidation activity of maximum can be realized by water film filtering technology.Membrane filtration technique including the use of ultrafiltration, Filter, dialysis and electrodialysis.The concentration of purified extract can be carried out in the steps below using membrane technology：Nanofiltration, counter-infiltration, freezing Concentration and vacuum evaporation.
There are many methods to be used for extracting pipering from black pepper.It should be noted that start extraction process it Before, it is necessary to first black pepper is ground using industrial grinding mills.
Pipering can be extracted using dichloromethane.Using aqueous cosolvent, it can bring high yield and high selectivity. The conventional method of another kind be using potassium hydroxide solution solvent-free residue of the processing from black pepper ethanol extract so as to Remove the insoluble residue washed in resin and warm ethanol.Alkaloid is crystallized during this by cooling.This is directed to use with Water and ethanol extractor for water-soluble substances.
Discounting for cost issues, supercritical CO is preferably used under elevated pressure conditions2Abstraction technique come extract recklessly Green pepper alkali, because this method is only using harmless and overall safety carbon dioxide and to bring high-purity, high yield under high pressure The pipering of amount.
In addition to the above-mentioned content referred to, the other specific process parameters and condition that are related in the above method are this area skills Art personnel can determine that the appropriate adjustment of process conditions will not be to extract in nutrition of the invention according to needs of production Effect played in replenishers produces materially affect.
The nutritious supplementary pharmaceutical of the present invention can be adopted Moringa extract, hydroxytyrosol and the pipering of extraction according to aforementioned proportion Formed with conventional method is well mixed.
The nutritious supplementary pharmaceutical of the present invention can further comprise that dietetic product is upper and/or pharmaceutically acceptable carrier with/ Or auxiliary material, for example, filler, disintegrant, lubricant, suspending agent, adhesive, sweetener, flavouring, preservative etc..Filler Including：Starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose etc..Disintegrant includes：Carboxymethyl forms sediment Powder sodium, PVPP, low-substituted hydroxypropyl cellulose, Ac-Di-Sol etc..Lubricant includes：It is stearic Sour magnesium, lauryl sodium sulfate, talcum powder, silica etc..Suspending agent includes：Polyvinylpyrrolidone, microcrystalline cellulose, sugarcane Sugar, agar, hydroxypropyl methyl cellulose etc., adhesive includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose Deng.Sweetener includes：Saccharin sodium, aspartame, sucrose, honey element, enoxolone etc..Flavouring includes：Sweetener and various Essence, preservative include：Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, chlorhexidine acetate, Eucalyptus oil etc..By adding corresponding carrier and/or auxiliary material, oral agents can be further made in nutritious supplementary pharmaceutical of the invention Type, for example, powder, tablet, capsule, granule, oral liquid or pill etc..In actual production, those skilled in the art can The dosage of carrier and auxiliary material is determined according to being actually needed, to reach optimal using effect.
When preparing final nutritional supplement product, it is necessary to which the production system of such as tablet and capsule, what is be related to is specific Equipment is to prepare capsule and the powder compressibility needed for tablet.In addition, when preparing final nutritional supplement product, also relate to And packing stage, i.e., final products are packed with solid dosage forms or liquid dosage form, be primarily related to be used for encapsulating products Blister packaging equipment and bottling line for fluid product.
Take in the restriction of application
According to another aspect of the present invention, it is turned into the invention provides foregoing nutritious supplementary pharmaceutical in preparation with antioxygen Application in health products or medicine.
According to another aspect of the present invention, there is antiinflammatory action in preparation the invention provides foregoing nutritious supplementary pharmaceutical Health products or medicine in application.
According to another aspect of the present invention, the invention provides foregoing nutritious supplementary pharmaceutical to prepare prevention and/or control Treat the application in the health products or medicine of any one or more following disease：Oxidative stress, chronic inflammation, angiocardiopathy (CVD), artery sclerosis, cancer, Arterial Hypertention, diabetes, caused by hypercholesterolemia and similar relevant disease, cigarette Oxidative stress and tissue damage, age-related body aging, overweight and fat, bacterium sense caused by Health cost, pollution The loss and motion loss that dye, nerve degenerative diseases, skin symptom, ultraviolet trigger.
Specifically, nutritious supplementary pharmaceutical of the invention has significant prevention and/or therapeutic effect to following disease or symptom：
1. angiocardiopathy, for example, apoplexy, myocardial infarction, artery sclerosis etc..The nutritious supplementary pharmaceutical of the present invention passes through reduction Inflammation reduces the risk of angiocardiopathy with anti-oxidant feature is improved, and the ability of thrombus grumeleuse is formed simultaneously by reducing blood Them are reduced in the block capability of coronary artery and arteria carotis inner chamber so as to effectively prevent internal thrombus (clot) formation.
2. cancer, such as breast cancer, colon cancer, prostate cancer, cancer of pancreas, lung cancer, and some other tumours.This hair Bright nutritious supplementary pharmaceutical can suppress growth of cancer cells or directly kill cancer cell, and effectively suppress cancer blood circulation.In addition, this The chemical signal of generation blood vessel of the nutritious supplementary pharmaceutical of invention to being sent by cancer cell, which has, directly suppresses anti-angiogenesis work With so as to which the survival rate for the cancer cell for causing to contact with nutritious supplementary pharmaceutical of the invention reduces.
The research of inventor also has confirmed another mechanism of pre- anti-cancer, and it is based on passing through CNR1 promoters site The change of DNA methylation carrys out transient state up-regulation CNR1 tumor suppressor genes.
3. diabetes.Research in laboratory scope shows, periodically takes the diabetes of the nutritious supplementary pharmaceutical of the present invention Patient, show its fasting blood glucose level and the horizontal reduction of glycated hemoglobin (HbA1c).
Wherein, HbA1c is the subgroup for circulating red blood cell (red blood cell), and in diabetes and pre-diabetic, it contains Amount is higher than normal range (NR) (4-5.6%).Scope is that 5.7-6.4% HbA1c high value is consistent with pre-diabetes condition, from And add the risk for suffering from diabetes.6.5% or higher level is consistent with the diagnosis to diabetes.The nutritional supplementation of the present invention Agent can reduce diabetes and the HbA1c of pre-diabetic is horizontal.
4. cholesterol, particularly serum cholesterol.The nutritious supplementary pharmaceutical of the present invention is to reducing serum low-density LP (LDL-C) has remarkable effect.
In addition, the nutritious supplementary pharmaceutical of the present invention can cause the aobvious of the serum-concentration of OxLDL ELISA (ox-LDL) Work reduction and referred to as the inflammation blood plasma biomarker of plasma C-reactive protein (CRP) significantly reduce.LDL-C pairs of oxidation The harm of cardiovascular health is bigger, because the LDL-C of oxidation produces artery, (particularly heart and arteria carotis is coronal dynamic Arteries and veins) fat lesion atherosclerotic plaque ability it is stronger.
In addition, the nutritious supplementary pharmaceutical of the present invention can increase the serum levels of HDL (HDL cholesterol), this It is beneficial in terms of reducing the health risk for suffering from artery sclerosis.The research of inventor also shows that the nutritious supplementary pharmaceutical of the present invention improves HDL cholesterol efflux abilities, this can improve the healthy curve of user by improving the physiological function of body, so as to clear The artery that reason has been influenceed by atherosclerosis.
5. hypertension.Research in laboratory scope shows that nutritious supplementary pharmaceutical of the invention significantly reduces systolic pressure And diastolic pressure.
Inventor has found that nutritious supplementary pharmaceutical of the invention is significant to reduce blood pressure and improve with slight high blood by studying The endothelial function of the young woman of pressure.Due to, it is known that the function of arterial wall endothelial cell rises important in hyperpietic is treated Effect, therefore endothelial function is extremely important in the elevated patient of blood pressure.Inner skin cell function is better, and blood pressure is more normal.
6. extend the life-span.The zoopery that inventor is carried out shows, periodically takes in the nutritious supplementary pharmaceutical of the present invention daily The life of the control group adult mice of nutritious supplementary pharmaceutical of the life-span of adult mice than not taking in present invention 2-4 months. The positive health effect expection enumerated herein can produce the effect in similar extension life-span to people.
The research of inventor is it is also shown that the nutritious supplementary pharmaceutical of the present invention can slow down cell ageing by some physiological phenomenons Process.The nutritious supplementary pharmaceutical of the present invention can energetically resist epigenetics (such as DNA methylation) change, and resist telomere Cut down.The nutritious supplementary pharmaceutical of the present invention can also prevent mitochondria dysfunction and stem cell is exhausted and cell ageing.This hair Bright nutritious supplementary pharmaceutical can prevent the oxidative damage to inhereditary material, so as to promote genome stable.
7. smoking.It is well known that one of harmful mechanism of harmfulness of smoking health is drawn with main and secondary smoking The body inflammation-related risen.This inflammation causes various disease-angiocardiopathies and cancer to be most common two kinds.
The nutritious supplementary pharmaceutical of the present invention can：1) prevents oxidative stress caused by smoke from cigarette：2) prevents nicotine from drawing The lung's antioxidase damage risen and increased lipid peroxidation：3) is prevented between smoke from cigarette and bronchial wall tissue The inflammation damnification directly contacted；4) prevents the angiogenesispromoting effect of nicotine, suppresses the growth of tumour and cancer.
8. air pollution.Similar to smoke from cigarette, air pollution can cause oxidative stress, reduce body antioxidase, and And it is proinflammatory disease.The nutritious supplementary pharmaceutical of the present invention can protect the body from free radical and oxidative stress, and this protection is subsequent The sequelae of oxidative stress and air pollution is also possible to prevent, such as COPD and cancer.
9. skin protection.Exposure is harmful to skin health in ultraviolet (UV) radiation.Ultraviolet can damage skin Bottom scaffolding protein (being referred to as collagen and elastin laminin) suppress skin corium fibroblast metabolism produce collagen and Elastin laminin, and generation also causes dermal tissue insult free radical.
The nutritious supplementary pharmaceutical of the present invention helps to protect skin by eliminating skin free radical, so as to limit the group of correlation Damage is knitted, also enhances the generation of glutathione in addition, this also contributes to the injury for protecting the skin from free radical.
The nutritious supplementary pharmaceutical of the present invention has direct inhibitory action to cancer cell, so as to contribute to the skin of protection exposure From the cutaneum carcinoma of UV inductions, such as the invasion and attack of melanoma.
10. arthritis.Arthritis be it is a kind of influence body joints inflammatory disease, including backbone, buttocks, knee, shoulder, Ancon, ankle, wrist, pin and pin.Soft tissue inflammation and cartilage inflammation of the nutritious supplementary pharmaceutical of the present invention to arthritis and correlation With prevention and direct therapeutic action.
11. body weight.The present inventor is by studying discovery, the increasing that nutritious supplementary pharmaceutical of the invention can lose weight Add, so as to effectively prevent and treat obesity.
12. skin whitening.The nutritious supplementary pharmaceutical of the present invention can directly reduce the generation of melanin and increase glutathione Generation in vivo, so as to be advantageous to skin whitening.
13. mental health.The nutritious supplementary pharmaceutical of the present invention is by promoting elimination intracerebral amyloid-beta to provide god Through protection, so as to the prevention and treatment for nerve degenerative diseases such as alzheimer disease (AD) etc..
14. infection.Experiment in vitro proves that nutritious supplementary pharmaceutical of the invention has the property of antibacterial, therefore the battalion of the present invention Foster replenishers can be as the antiseptic applied to prevention enteron aisle and respiratory tract infection.
15. gene clock (Gene Clock).According to the research of inventor, clock Physiological effect base is had been reported that now Because (clock circadian regulator gene) CLOCK CpGs 1 and 8 ratios to methylate are shown and single unsaturation Aliphatic acid (MUFA) (Milagro, F.I.et al.Clock, PER2and relevant with the intake of polyunsaturated fatty acid (PUFA) BMAL1DNA methylation：Association with obesity and metabolic syndrome Characteristics and monounsaturated fat intake.Chronobiol.Int.2012,29,1180- 1194.).Once such material containing MUFA is Extra Virgin, it is also enriched in aldehydes matter, such as hydroxytyrosol, So hydroxytyrosol phenolic component of the invention has good effect for up-regulation CLOCK genes and BMAL1 gene activities. CLOCK genes (clock gene) are responsible for the biological clock rhythm system of body in itself, and the 24 of the systematic direction gene expression are small Shi Jielv.The gene is relevant with fat and metabolic syndrome.Researcher has been found that the trouble with visceratonia abdominal fat obesity Person and patient with metabolic syndrome show the symptom (timer interrupt) of circadian rhythm disorders, and the illness can produce larger Increased weight and then fat tendency, further development can cause diabetes and atherosclerosis (G ó mez- Santos, C.et al.Circadian rhythm of clock genes in human adipose Explants.Obesity 2009,17,1481-1485).The nutritious supplementary pharmaceutical of the present invention can regulate and control CLOCK gene activations way Footpath, so as to help to prevent and reduce to cause the factor in terms of the gene of obesity and metabolic syndrome.
Causality (Yoshino J, Klein S is also likely to be present between the suppression of CLOCK genes and diabetes B (Jul 2013).″A Novel Link Between Circadian Clocks and Adipose Tissue Energy Metabolism".Diabetes.62(7)：2175-7).Therefore, the regulation and control to CLOCK genes help to prevent or reduce by 2 types The seriousness of diabetes.
The research of inventor displays that the epigenetic variation of CLOCK genes is relevant with breast cancer incidence raising, and this is Because the reduction that methylates of the CLOCK promoter regions of the women to suffer from breast cancer.The nutritious supplementary pharmaceutical of the present invention being capable of actively impact These are mutated and reduce their influences to CLOCK genes, so as to reduce the risk to suffer from breast cancer.
The research of inventor displays that, causes have height between the somatic mutation of colorectal cancer and CLOCK mutation Correlation.The nutritious supplementary pharmaceutical of the present invention helps to stablize CLOCK genes to prevent CLOCK mutation, pre- so as to contribute to CLOCK is mutated in the anti-microsatellite instability target gene for causing colorectal cancer.
Effect of the nutritious supplementary pharmaceutical of the present invention on CLOCK gene expressions can also influence circadian rhythm period, thus regulate and control Sleep pattern.CLOCK and CYCLE albumen (circulating protein) (dBMAL genes) can form dimer, the compound finally with Period (gene of per, Per 1) and timeless (tim genes) promoter combine so as to raise (stimulations) per genes with Tim genes.Therefore, nutritious supplementary pharmaceutical of the invention is the adjusting control agent of CLOCK genes.The regulation activity, which can treat and prevent, sleeps Dormancy rhythm disorder, and can treat and prevent in the associated disorders caused by the travelling of multiple time zones, the i.e. time difference.
Embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to described reality Apply among a scope.The experimental method of unreceipted actual conditions in the following example, conventionally and condition, or according to business Product specification selects.
Embodiment 1
The composition of the nutritious supplementary pharmaceutical of embodiment 1 is Moringa extract 70mg, hydroxytyrosol 15mg and pipering 15mg.
Preparation method：
Moringa extract 70mg, hydroxytyrosol 15mg and pipering 15mg are well mixed, the nutrition for producing embodiment 1 is mended Fill agent.
Embodiment 2
The composition of the nutritious supplementary pharmaceutical of embodiment 2 is Moringa extract 60mg, hydroxytyrosol 20mg and pipering 20mg.
Preparation method：
Moringa extract 60mg, hydroxytyrosol 20mg and pipering 20mg are well mixed, the nutrition for producing embodiment 2 is mended Fill agent.
Embodiment 3
The composition of the nutritious supplementary pharmaceutical of embodiment 3 is Moringa extract 80mg, hydroxytyrosol 10mg and pipering 10mg.
Preparation method：
Moringa extract 80mg, hydroxytyrosol 10mg and pipering 10mg are well mixed, the nutrition for producing embodiment 3 is mended Fill agent.
Embodiment 4
The composition of the nutritious supplementary pharmaceutical of embodiment 4 is Moringa extract 65mg, hydroxytyrosol 18mg and pipering 17mg.
Preparation method：
Moringa extract 65mg, hydroxytyrosol 18mg and pipering 17mg are well mixed, the nutrition for producing embodiment 4 is mended Fill agent.
Embodiment 5
The composition of the nutritious supplementary pharmaceutical of embodiment 5 is Moringa extract 75mg, hydroxytyrosol 12mg and pipering 13mg.
Preparation method：
Moringa extract 75mg, hydroxytyrosol 12mg and pipering 13mg are well mixed, the nutrition for producing embodiment 5 is mended Fill agent.
Embodiment 6
The composition of the nutritious supplementary pharmaceutical of embodiment 6 is Moringa extract 65mg, hydroxytyrosol 17mg and pipering 18mg.
Preparation method：
Moringa extract 65mg, hydroxytyrosol 17mg and pipering 18mg are well mixed, the nutrition for producing embodiment 6 is mended Fill agent.
Embodiment 7
The nutritional supplement product of embodiment 7 is oral liquid, and the capacity of every oral liquid is 15ml, including：Moringa extracts Thing 70mg, hydroxytyrosol 15mg and pipering 15mg, sucrose 20mg, and water 15ml.
Preparation method：By Moringa extract 70mg, hydroxytyrosol 15mg and pipering 15mg, sucrose 20mg is dissolved in 15ml water In, it is well mixed；Homogenization is then carried out in homogenizer, various nutritional ingredients is homogenized, obtains the stability of product Ensured to further；Then carry out filling, produce the oral liquid of embodiment 7.
Above-described embodiment is the preferable embodiment of the present invention, but the embodiment of present aspect is not by above-described embodiment Limitation, other any Spirit Essences without departing from the present invention with made under principle replacement, modification, combine, change, simplification Deng should be equivalent substitute mode, be included within protection scope of the present invention.Protection scope of the present invention should be with right What claim was limited is defined.

Claims (14)

1. a kind of nutritious supplementary pharmaceutical, it is characterised in that count in parts by weight, the nutritious supplementary pharmaceutical includes：Moringa extract 60- 80 parts, hydroxytyrosol 10-20 parts, and pipering 10-20 parts.
2. nutritious supplementary pharmaceutical according to claim 1, it is characterised in that count in parts by weight, the nutritious supplementary pharmaceutical bag Include：Moringa extract 65-75 parts, hydroxytyrosol 12-18 parts, and pipering 12-18 parts.
3. nutritious supplementary pharmaceutical according to claim 1 or 2, it is characterised in that count in parts by weight, the nutritious supplementary pharmaceutical Including：70 parts of Moringa extract, 15 parts of hydroxytyrosol, and 15 parts of pipering.
4. according to the nutritious supplementary pharmaceutical described in claim any one of 1-3, it is characterised in that the Moringa extract comes from peppery Wooden leaf, Moringa seed and/or Moringa flower.
5. according to the nutritious supplementary pharmaceutical described in claim any one of 1-4, it is characterised in that the hydroxytyrosol comes from olive Fruit, olive water extract and/or olive oil.
6. according to the nutritious supplementary pharmaceutical described in claim any one of 1-5, it is characterised in that the nutritious supplementary pharmaceutical further wraps Include that dietetic product is upper and/or pharmaceutically acceptable carrier and/or auxiliary material.
7. according to the nutritious supplementary pharmaceutical described in claim any one of 1-6, it is characterised in that the nutritious supplementary pharmaceutical is made into mouth Oral dosage form；Preferably, the peroral dosage form is powder, tablet, capsule, granule, oral liquid or pill.
8. the preparation method of the nutritious supplementary pharmaceutical described in claim any one of 1-7, it is characterised in that the preparation method bag Include：Prepare Moringa extract, hydroxytyrosol and pipering according to predetermined ratio；And by Moringa extract, hydroxytyrosol and Hu Green pepper alkali mixes.
9. preparation method according to claim 8, it is characterised in that the Moringa extract uses supercritical CO2Extract skill Art and/or moisture film extraction filtering technique are prepared.
10. preparation method according to claim 8 or claim 9, it is characterised in that the hydroxytyrosol is using moisture film extraction filtering Technology is prepared.
11. according to the preparation method described in claim any one of 8-10, it is characterised in that the pipering uses supercritical CO2 Abstraction technique is prepared.
12. the nutritious supplementary pharmaceutical described in claim any one of 1-7 is in health products or medicine with antioxidation are prepared Application.
13. the nutritious supplementary pharmaceutical described in claim any one of 1-7 is in health products or medicine with antiinflammatory action are prepared Using.
14. nutritious supplementary pharmaceutical described in claim any one of 1-7 prepare prevention and/or treat it is following any one or more Application in the health products or medicine of disease or symptom：Oxidative stress, chronic inflammation, angiocardiopathy (CVD), artery sclerosis, Cancer, Arterial Hypertention, diabetes, Health cost, pollution are drawn caused by hypercholesterolemia and similar relevant disease, cigarette The oxidative stress and tissue damage, age-related body aging, overweight and fat, bacterium infection, nervus retrogression disease risen The loss and motion loss that disease, skin symptom, ultraviolet trigger.
CN201710332369.6A 2017-05-11 2017-05-11 Nutritious supplementary pharmaceutical and its preparation method and application Pending CN107349232A (en)

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CN102972672A (en) * 2012-11-23 2013-03-20 西安泰科迈医药科技有限公司 Drug composite effervescent granule for supplementing nutrition and preparation method thereof
CN103690537A (en) * 2013-12-17 2014-04-02 中国人民解放军军事医学科学院放射与辐射医学研究所 Novel medicinal application of piperine
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Publication number Priority date Publication date Assignee Title
CN102972672A (en) * 2012-11-23 2013-03-20 西安泰科迈医药科技有限公司 Drug composite effervescent granule for supplementing nutrition and preparation method thereof
US20140227198A1 (en) * 2013-02-13 2014-08-14 GRADS Holdings LLLP Shelf-stable olive extract-containing compositions and methods of use thereof
CN103690537A (en) * 2013-12-17 2014-04-02 中国人民解放军军事医学科学院放射与辐射医学研究所 Novel medicinal application of piperine

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