CN107348138A - A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal and application thereof - Google Patents
A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal and application thereof Download PDFInfo
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- CN107348138A CN107348138A CN201710596271.1A CN201710596271A CN107348138A CN 107348138 A CN107348138 A CN 107348138A CN 201710596271 A CN201710596271 A CN 201710596271A CN 107348138 A CN107348138 A CN 107348138A
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- fresh
- chinese herbal
- intestinal canal
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- 241000251468 Actinopterygii Species 0.000 title claims abstract description 71
- 239000013505 freshwater Substances 0.000 title claims abstract description 59
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 46
- 239000003674 animal food additive Substances 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 239000000654 additive Substances 0.000 claims abstract description 14
- 230000000996 additive effect Effects 0.000 claims abstract description 14
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- 244000234609 Portulaca oleracea Species 0.000 description 1
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- QNZLIVROMORQFH-BQBZGAKWSA-N Pro-Gly-Cys Chemical compound C1C[C@H](NC1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O QNZLIVROMORQFH-BQBZGAKWSA-N 0.000 description 1
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- SEFNTZYRPGBDCY-IHRRRGAJSA-N Tyr-Arg-Cys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(=O)O)N)O SEFNTZYRPGBDCY-IHRRRGAJSA-N 0.000 description 1
- DCOOGDCRFXXQNW-ZKWXMUAHSA-N Val-Asn-Cys Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)O)N DCOOGDCRFXXQNW-ZKWXMUAHSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/123—Bulgaricus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Abstract
The invention discloses a kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal and application thereof, composition and its parts by weight are：13 17 parts of polygonum flaccidum, 19 23 parts of honeysuckle, 12 16 parts of Radix Isatidis, 10 14 parts of hawthorn, 8 12 parts of Herba Andrographitis, 58 parts of Chinese gall, 58 parts of chrysanthemum indicum, 35 parts of the tuber of dwarf lilyturf, 35 parts of wax-apple, 35 parts of marine alga.Have the beneficial effect that：The additive of the present invention is respectively into belonging to renewable resource, compatibility is reasonable, there is antibacterial, antiviral, it can suppress and prevent the generation of the harmful bacterias such as cause of disease coliform, clostridium, salmonella, increase beneficial bacteria of intestinal tract, maintain the gut flora of health, fresh-water fishes function of intestinal canal can efficiently be improved, intestinal microecology balance and optimal immune state are kept, the digestibility of nutriment is improved, improves animal body immunity.
Description
Technical field
The present invention relates to aquaculture feeds processing technique field, more particularly in a kind of improvement fresh-water fishes function of intestinal canal
Herbal medicine feed addictive and application thereof.
Background technology
Enteric microorganism plays very important effect, good intestinal microflora in fish growth growth course
Fish can be helped preferably to digest and assimilate nutriment, maintain the health of fish body.The enteric microorganism environment of health can
To adjust the immunologic function of fish, help to decompose cellulose, lignin, chitin and pectin that can not be digested after eating etc..And
Field planting and diffusion of the harmful bacteria in enteron aisle can be prevented.The wild fish water environment higher due to being in microecosystem stability
In, therefore seldom morbidity；And the fish of artificial feeding are in changeable microecosystem, are easily created to condition pathogen and cause micro- life
The chance of thing imbalance.And Chinese herbal medicine has increasingly attracted attention as a kind of natural Substitutes For Antibiotic, fish production is real
Trample and also demonstrate that, Chinese herbal medicine as mixed feeding agent or feed addictive while aquatic livestock production performance and feed efficiency is improved,
And can fully ensures that the health of human body, has the double action of the property of medicine and trophism concurrently, is traditional chemical synthesis feed addictive
Incomparable, intensive, large-scale production the needs for the current culture fishery that is particularly suitable for use in.Therefore, replaced with Chinese herbal medicine
It will be had been to be concerned by more and more people for the additive of antibiotic, its purposes prospect also can be more extensive.But current Chinese medicine is raised
The research level of feed additives is relatively low, and manufacture craft simple coarse, the technological element of a product is relatively low, and quality is not sufficiently stable, all such
Class problem seriously governs the popularization and application of Chinese medicine fodder addition.
Prior art such as Authorization Notice No. is the B of CN 103300224 Chinese invention patent, discloses a kind of preventing and treating mullet
The feed addictive of enteritis disease, the composition and its parts by weight of the feed addictive are：Fresh Asiatic plantain 5.0-8.0 parts, fresh pilose bushclover herb
5.0-8.0 parts, fresh camphortree leaf 5.0-8.0 parts, fresh calamus 15.0-20.0 parts, wolf's milk 3.0-5.0 parts, dry polygonum flaccidum 3.0-5.0
Part, purslane 10.0-15.0 parts, garlic 5.0-8.0 parts, phoenix-tail fern 1.0-2.0 parts, pilose bushclover herb 1.0-2.0 parts, salt 5.0-
8.0 parts, carrier 58.0-79.0 parts.The immune and oxidation resistance of mullet can be improved after this powder additive by adding, and improving should
Swash, strengthen resistance against diseases, antibiont medicine need not be added by being applicable the feed of this feed addictive, and the fishery -ies product produced is nothing
The green food of public hazards.But the feed addictive simply carries out raw material simply to mix and crush, and fails each raw material
Active ingredient discharge, for improve fish function of intestinal canal effect in terms of also there is certain room for promotion.
The content of the invention
It is an object of the invention to provide one kind to improve animal body immunity, can suppress and prevent the generation of harmful bacteria,
The gut flora of health is maintained, can efficiently improve the Chinese herbal feed of the improvement fresh-water fishes function of intestinal canal of fresh-water fishes function of intestinal canal
Additive and application thereof.
The present invention is directed to the problem of being mentioned in above-mentioned technology, and the technical scheme taken is：One kind improves fresh-water fishes enteron aisle work(
The Chinese herbal feed additive of energy, composition and its parts by weight are：Polygonum flaccidum 13-17 parts, honeysuckle 19-23 parts, Radix Isatidis 12-16
Part, hawthorn 10-14 parts, Herba Andrographitis 8-12 parts, Chinese gall 5-8 parts, chrysanthemum indicum 5-8 parts, tuber of dwarf lilyturf 3-5 part, wax-apple 3-5 parts, marine alga
3-5 parts.For above-mentioned additive respectively into renewable resource is belonged to, compatibility is reasonable, has the function that antibacterial, antiviral, can be obvious
Grazing rate and survival rate of the freshwater fish in breeding process are improved, immunity of organisms can be strengthened, promotes enterogastric peristalsis, protection has
Field planting of the beneficial bacteria in enteron aisle, improvement and reconstruction to fresh-water fishes gut flora play an important role.
It is a kind of improve fresh-water fishes function of intestinal canal Chinese herbal feed additive preparation method, preparation method specifically include with
Lower step：
Lactobacillus bulgaricus and lactobacillus acidophilus are purchased from Henan Hao Yang bio tech ltd.
Pretreatment of raw material：Polygonum flaccidum, honeysuckle, Radix Isatidis, hawthorn, Herba Andrographitis, Chinese gall, chrysanthemum indicum, wheat are measured by formula
Winter, wax-apple, marine alga, 50-70 mesh is crushed to, is well mixed, produces mixed powder, standby, suitable mixed powder particle diameter can increase
Add the contact area of mixed powder and water, it is possible to increase leaching rates, shorten extraction time, reduce energy consumption, save processing cost；
Ultrasonic-leaching：Into mixed powder using solid-liquid ratio as 1:7-10 adds water, is well mixed, ultrasonic-leaching 25-35min,
Centrifugation, produces leaching liquor, because ultrasonic wave has unique mechanical crushing effect and cavitation effect, for extracting mixed powder
When, material molecular motion frequency and speed can be increased, improve material molecule leaching velocity and effective active composition extracted amount, greatly
It is big to shorten extraction time, reduce the Oxidative demage of active component；
Zymotic fluid is prepared：Leaching liquor 95-97 parts, agar 0.8-1.2 parts, sucrose 2-3 parts, potassium dihydrogen phosphate 0.3- are taken by weight
0.5 part, active peptides 0.0005-0.0007 parts, are mixed evenly, and pH is adjusted into 6-7, sterilizing, produce zymotic fluid, above-mentioned work
The amino acid sequence of property polypeptide is HSHACASRCLRCRVLHPGCVNCYRCSR, and the active peptides have protein and amino acid
Incomparable physiological property, its mechanism of absorption are better than protein and amino acid, have very high nutritive value, rich in amino
Acid, dissolubility are good, it is not necessary to the step of being converted into amino acid by protein, directly can be absorbed by bacterium, so as to accelerate
The amount reproduction of microorganism, increases the fermentation efficiency of microorganism, substantially reduces fermentation time；
Fermentation：Lactobacillus bulgaricus and lactobacillus acidophilus will be inoculated with zymotic fluid, inoculum concentration is 2.5-3.5%, in 32-38
Ferment 8-10h at DEG C, produces zymotic fluid, and microorganism utilizes the protein in medicinal herbs in the enzyme system degraded of itself secretion in the step
And polysaccharide, make it become to be easy to the amino acid, small peptide and low molecule carbohydrate digested and assimilated, while can be by the toxic component in medicine
Effectively weaken or be converted into benefit materials, and can generates the various biological active matters with anti-oxidation efficacy during the fermentation
Matter, substantially increase the quality of tunning；
Post processing：It is 1 by zymotic fluid weight ratio:0.5-1 wheat bran adsorbs with defatted rice bran mixture, and fermented liquid is with mixing
The volume ratio of thing is 1:1-1.5, absorption are dried 2-3h after terminating at 40-50 DEG C, crushed, and producing improves fresh-water fishes function of intestinal canal
Chinese herbal feed additive, the additive not only can efficiently improve fresh-water fishes function of intestinal canal, keep intestinal microecology balance
With optimal immune state, the digestibility of nutriment is improved, improves animal body immunity, and the additive has clearly
Thermal detoxification, the effect for sterilizing antibacterial, can suppress and prevent the harmful bacterias such as cause of disease coliform, clostridium, salmonella
Occur, increase beneficial bacteria of intestinal tract, maintain the gut flora of health, reduce stench and harmful components are formed, the excrement of discharge is disappeared
Except stench, meat quality of fish quality is improved while breeding environment is protected.
A kind of purposes for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, the feed addictive are directly appended to
Fed in fresh water fish feed, the addition of feed addictive is the 0.05-0.08% of fresh water fish feed weight, and the feed, which removes, to be had
Outside the trophic function of normal diet, the two-fold advantage also with Chinese herbal medicine and probiotics, it can efficiently nurse one's health fresh-water fishes enteron aisle and be good for
Health, treat both principal and secondary aspect of disease, reinvigoration, keep intestinal microecology balance and optimal immune state, improve digesting and assimilating for nutriment
Rate, fresh-water fishes immunity of organisms is improved, improve breeding income, reduce cultivation risk；The feed does not have to add antibiotic again, to light
Water fish has no adverse effects, safe to use, the problems such as in the absence of medicament residue and drug resistance, there is wide market prospects.
Compared with prior art, the advantage of the invention is that：
1. for additive of the present invention respectively into renewable resource is belonged to, compatibility is reasonable, there is antibacterial, antiviral, Neng Gouming
The aobvious grazing rate and survival rate for improving freshwater fish in breeding process, can strengthen immunity of organisms, promote enterogastric peristalsis, protection
Field planting of the beneficial bacterium in enteron aisle, improvement and reconstruction to fresh-water fishes gut flora play an important role.
2. the of the invention additive not only can efficiently improve fresh-water fishes function of intestinal canal, intestinal microecology balance and most is kept
Good immune state, the digestibility of nutriment is improved, improve animal body immunity, and with clearing heat and detoxicating, sterilization
The effect of antibacterial, it can suppress and prevent the generation of the harmful bacterias such as cause of disease coliform, clostridium, salmonella, increase intestines
Road probiotics, the gut flora of health is maintained, reduce stench and harmful components are formed, the excrement of discharge is eliminated stench, protecting
Meat quality of fish quality is improved while protecting breeding environment.
3. the protein and polysaccharide in middle medicinal herbs can be made it become to be easy to the ammonia digested and assimilated by the preparation method of the present invention
Base acid, small peptide and low molecule carbohydrate, while the toxic component in medicine can effectively be weakened or is converted into benefit materials, carry significantly
The high quality of tunning.
Specific embodiment
The present invention program is described further below by embodiment：
Embodiment 1：
A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, composition and its parts by weight are：15 parts of polygonum flaccidum, honeysuckle
21 parts, 14 parts of Radix Isatidis, 12 parts of hawthorn, 10 parts of Herba Andrographitis, 7 parts of Chinese gall, 6 parts of chrysanthemum indicum, 4 parts of the tuber of dwarf lilyturf, 4 parts of wax-apple, marine alga 4
Part.
A kind of preparation method for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, including it is pretreatment of raw material, super
Sound wave extraction, zymotic fluid are prepared, fermented, post processing, specifically include following steps：
1）Pretreatment of raw material：By formula measure polygonum flaccidum, honeysuckle, Radix Isatidis, hawthorn, Herba Andrographitis, Chinese gall, chrysanthemum indicum, the tuber of dwarf lilyturf,
Wax-apple, marine alga, mechanical crushing to 60 mesh, it is well mixed, produces mixed powder, standby, suitable mixed powder particle diameter can increase
The contact area of mixed powder and water, it is possible to increase leaching rates, shorten extraction time, reduce energy consumption, save processing cost；
2）Ultrasonic-leaching：Into mixed powder using solid-liquid ratio as 1:9 add water, and mechanical agitation is 25 in temperature to being well mixed
DEG C, power be 350W ultrasonic wave in extract 30min, rotating speed be 3800r/min centrifuge in centrifuge 15min, supernatant
As leaching liquor,, can be with during for extracting mixed powder because ultrasonic wave has unique mechanical crushing effect and cavitation effect
Increase material molecular motion frequency and speed, improve material molecule leaching velocity and effective active composition extracted amount, greatly shorten
Extraction time, reduce the Oxidative demage of active component；
3）Zymotic fluid is prepared：96 parts of leaching liquor, 1 part of agar, 2.5 parts of sucrose, 0.4 part of potassium dihydrogen phosphate, activity are taken by weight
0.0006 part of polypeptide, mechanical agitation is well mixed, and pH is adjusted into 6.5, and in 121 DEG C of autoclaving 20min, room is cooled to after taking-up
Temperature, zymotic fluid is produced, the amino acid sequence of above-mentioned active peptides is HSHACASRCLRCRVLHPGCVNCYRCSR, and the activity is more
Peptide has protein and the incomparable physiological property of amino acid, and its mechanism of absorption is better than protein and amino acid, has very high
Nutritive value, it is good rich in amino acid, dissolubility, it is not necessary to the step of being converted into amino acid by protein, can be directly thin
Bacterium absorbs, and so as to accelerate the amount reproduction of microorganism, increases the fermentation efficiency of microorganism, when substantially reducing fermentation
Between；
4）Fermentation：It is 3% by lactobacillus bulgaricus and lactobacillus acidophilus, inoculum concentration is inoculated with zymotic fluid, is fermented at 35 DEG C
9h, zymotic fluid is produced, microorganism makes it using protein and polysaccharide in medicinal herbs in the enzyme system degraded of itself secretion in the step
Become to be easy to the amino acid, small peptide and low molecule carbohydrate digested and assimilated, at the same the toxic component in medicine can effectively be weakened or
Benefit materials are converted into, and can generates the various bioactive substances with anti-oxidation efficacy, carried significantly during the fermentation
The high quality of tunning；
5）Post processing：It is 1 by zymotic fluid weight ratio:0.8 wheat bran adsorbs with defatted rice bran mixture, and fermented liquid is with mixing
The volume ratio of thing is 1:1.2,2.5h is dried in absorption at 45 DEG C after terminating, crossed 40 mesh sieves after mechanical crushing, produced improvement fresh water
The Chinese herbal feed additive of fish function of intestinal canal, the additive not only can efficiently improve fresh-water fishes function of intestinal canal, keep enteron aisle
Microecological balance and optimal immune state, the digestibility of nutriment is improved, improve animal body immunity, and this adds
Add agent that there is clearing heat and detoxicating, sterilization antibacterial, can suppress and prevent cause of disease coliform, clostridium, salmonella
Deng the generation of harmful bacteria, increase beneficial bacteria of intestinal tract, maintain the gut flora of health, reduce stench and harmful components are formed, make row
The excrement gone out eliminates stench, and meat quality of fish quality is improved while breeding environment is protected.
A kind of purposes for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, the feed addictive are directly appended to
Fed in fresh water fish feed, the addition of feed addictive is the 0.07% of fresh water fish feed weight, and the feed, which removes, has common raise
Outside the trophic function of material, the two-fold advantage also with Chinese herbal medicine and probiotics, fresh-water fishes intestinal health, sample can be efficiently nursed one's health
It is simultaneous to control, reinvigoration, intestinal microecology balance and optimal immune state are kept, improve the digestibility of nutriment, improve
Fresh-water fishes immunity of organisms, breeding income is improved, reduce cultivation risk；The feed does not have to add antibiotic again, to spot trout salmon
Fish has no adverse effects, safe to use, the problems such as in the absence of medicament residue and drug resistance, there is wide market prospects.
Embodiment 2：
A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, composition and its parts by weight are：13 parts of polygonum flaccidum, honeysuckle
23 parts, 13 parts of Radix Isatidis, 14 parts of hawthorn, 8 parts of Herba Andrographitis, 7 parts of Chinese gall, 6 parts of chrysanthemum indicum, 3 parts of the tuber of dwarf lilyturf, 5 parts of wax-apple, marine alga 3
Part.
It is a kind of improve fresh-water fishes function of intestinal canal Chinese herbal feed additive preparation method, preparation method specifically include with
Lower step：
1）Each formula ratio is measured by formula, is crushed to 70 mesh, is well mixed, produces mixed powder, standby, suitable mixed powder
Particle diameter can increase the contact area of mixed powder and water, it is possible to increase leaching rates, shorten extraction time, reduce energy consumption, save
Processing cost；
2）Into mixed powder using solid-liquid ratio as 1:7 add water, are well mixed, ultrasonic-leaching 35min, centrifugation, produce leaching liquor,
Because ultrasonic wave has unique mechanical crushing effect and cavitation effect, during for extracting mixed powder, material point can be increased
Sub- motion frequency and speed, material molecule leaching velocity and effective active composition extracted amount are improved, extraction time is greatly shortened, subtracts
The Oxidative demage of few active component；
3）95 parts of leaching liquor, 1.2 parts of agar, 2 parts of sucrose, 0.5 part of potassium dihydrogen phosphate, active peptides 0.0007 are taken by weight
Part, it is mixed evenly, pH is adjusted to 7, sterilizing, produces zymotic fluid, the amino acid sequence of above-mentioned active peptides is
HSHACASRCLRCRVLHPGCVNCYRCSR, the active peptides have protein and the incomparable physiological property of amino acid, its
Mechanism of absorption is better than protein and amino acid, has very high nutritive value, good rich in amino acid, dissolubility, it is not necessary to pass through
Protein is converted into the step of amino acid, directly can be absorbed by bacterium, so as to accelerate the amount reproduction of microorganism, increase
The fermentation efficiency of microorganism, substantially reduces fermentation time；
4）By the lactobacillus bulgaricus of inoculation 2.5% and 3.5% lactobacillus acidophilus in zymotic fluid, ferment 10h at 38 DEG C, i.e.,
Zymotic fluid is obtained, microorganism becomes it using protein and polysaccharide in medicinal herbs in the enzyme system degraded of itself secretion in the step
It is easy to the amino acid, small peptide and low molecule carbohydrate digested and assimilated, while the toxic component in medicine effectively can be weakened or be converted
For benefit materials, and can generates the various bioactive substances with anti-oxidation efficacy, substantially increased during the fermentation
The quality of tunning；
5）It is 1 by zymotic fluid weight ratio:0.5 wheat bran adsorbs with defatted rice bran mixture, the body of fermented liquid and mixture
Product is than being 1:1, absorption dries 3h after terminating at 40 DEG C, crushes, and the Chinese herbal feed for producing improvement fresh-water fishes function of intestinal canal adds
Adding agent, the additive not only can efficiently improve fresh-water fishes function of intestinal canal, keep intestinal microecology balance and optimal immune state,
The digestibility of nutriment is improved, improves animal body immunity, and the additive has clearing heat and detoxicating, sterilization antibacterial
Effect, can suppress and prevent the generation of the harmful bacterias such as cause of disease coliform, clostridium, salmonella, increase enteron aisle benefit
Raw bacterium, the gut flora of health is maintained, reduce stench and harmful components are formed, the excrement of discharge is eliminated stench, supported in protection
Meat quality of fish quality is improved while growing environment.
A kind of purposes for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, the feed addictive are directly appended to
Fed in fresh water fish feed, the addition of feed addictive is the 0.05% of fresh water fish feed weight, and the feed, which removes, has common raise
Outside the trophic function of material, the two-fold advantage also with Chinese herbal medicine and probiotics, fresh-water fishes intestinal health, sample can be efficiently nursed one's health
It is simultaneous to control, reinvigoration, intestinal microecology balance and optimal immune state are kept, improve the digestibility of nutriment, improve
Fresh-water fishes immunity of organisms, breeding income is improved, reduce cultivation risk；The feed does not have to add antibiotic again, to spot trout salmon
Fish has no adverse effects, safe to use, the problems such as in the absence of medicament residue and drug resistance, there is wide market prospects.
Embodiment 3：
A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, composition and its parts by weight are：17 parts of polygonum flaccidum, honeysuckle
19 parts, 15 parts of Radix Isatidis, 11 parts of hawthorn, 11 parts of Herba Andrographitis, 5 parts of Chinese gall, 8 parts of chrysanthemum indicum, 3 parts of the tuber of dwarf lilyturf, 3 parts of wax-apple, marine alga 4
Part.
A kind of preparation method for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, is concretely comprised the following steps：By formula
Each formulation material is measured, is crushed to 50 mesh, is well mixed；Into mixed powder using solid-liquid ratio as 1:10 add water, are well mixed, and surpass
Sound wave extracts 35min, centrifuges to obtain leaching liquor；97 parts of leaching liquor, 0.8 part of agar, 2.2 parts of sucrose, biphosphate are taken by weight
0.35 part of potassium, 0.0007 part of active peptides, are mixed evenly, and pH is adjusted into 6, sterilizing, produces zymotic fluid；It will be connect in zymotic fluid
The lactobacillus bulgaricus of kind 3.5% and 2.5% lactobacillus acidophilus, ferment 10h at 32 DEG C；It is 1 by zymotic fluid weight ratio:
1 wheat bran adsorbs with defatted rice bran mixture, and the volume ratio of fermented liquid and mixture is 1:1.5, adsorb after terminating at 50 DEG C
Lower dry 2h, crush, produce the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal.
A kind of purposes for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, the feed addictive are directly appended to
Fed in fresh water fish feed, the addition of feed addictive is the 0.08% of fresh water fish feed weight.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme is described in detail embodiment described above, it should be understood that it is described above only
For the specific embodiment of the present invention, it is not intended to limit the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should be included in the scope of the protection.
SEQUENCE LISTING
<110>Tonghua Teachers College
<120>A kind of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal and application thereof
<130> 1
<160> 1
<170> PatentIn version 3.5
<210> 1
<211> 27
<212> PRT
<213>It is artificial synthesized
<400> 1
His Ser His Ala Cys Ala Ser Arg Cys Leu Arg Cys Arg Val Leu His
1 5 10 15
Pro Gly Cys Val Asn Cys Tyr Arg Cys Ser Arg
20 25
Claims (10)
- A kind of 1. Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, it is characterised in that：The composition of the additive and Its parts by weight is：Polygonum flaccidum 13-17 parts, honeysuckle 19-23 parts, Radix Isatidis 12-16 parts, hawthorn 10-14 parts, Herba Andrographitis 8-12 parts, Chinese gall 5-8 parts, chrysanthemum indicum 5-8 parts, tuber of dwarf lilyturf 3-5 part, wax-apple 3-5 parts, marine alga 3-5 parts.
- A kind of 2. Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 1, it is characterised in that： The preparation method of the additive comprises the following steps：1）Pretreatment of raw material：By formula measure polygonum flaccidum, honeysuckle, Radix Isatidis, hawthorn, Herba Andrographitis, Chinese gall, chrysanthemum indicum, the tuber of dwarf lilyturf, Wax-apple, marine alga, crush, be well mixed, produce mixed powder, it is standby；2）Ultrasonic-leaching：Add water into mixed powder, be well mixed, ultrasonic-leaching, centrifugation, produce leaching liquor；3）Zymotic fluid is prepared：Each zymotic fluid dispensing is taken by weight, is mixed evenly, and regulation pH is adjusted, and sterilizing, produces fermentation Liquid；4）Fermentation：Lactobacillus bulgaricus and lactobacillus acidophilus will be inoculated with zymotic fluid, fermentation, produces zymotic fluid；5）Post processing：Zymotic fluid wheat bran and defatted rice bran mixture are adsorbed, absorption dry, pulverize after terminating, and produce improvement The Chinese herbal feed additive of fresh-water fishes function of intestinal canal.
- 3. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：The composition of zymotic fluid and its parts by weight are in the step 3：Leaching liquor 95-97 parts, agar 0.8-1.2 parts, sugarcane Sugared 2-3 parts, potassium dihydrogen phosphate 0.3-0.5 parts, active peptides 0.0005-0.0007 parts.
- 4. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 3, It is characterized in that：The amino acid sequence of active peptides is HSHACASRCLRCRVLHPGCVNCYRCSR in the step 3.
- 5. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：The solid-liquid ratio of mixed powder and water is 1 in the step 2:7-10.
- 6. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：The inoculum concentration of lactobacillus bulgaricus and lactobacillus acidophilus is 2.5-3.5% in the step 4.
- 7. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：Fermentation temperature is 32-38 DEG C in the step 4, time 8-10h.
- 8. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：The volume ratio of fermented liquid and mixture is 1 in the step 5:1-1.5, wheat bran and degreasing rice in mixture The weight ratio of chaff is 1:0.5-1.
- 9. a kind of preparation method of Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal according to claim 2, It is characterized in that：Drying temperature is 40-50 DEG C in the step 5, time 2-3h.
- A kind of 10. purposes for the Chinese herbal feed additive for improving fresh-water fishes function of intestinal canal, it is characterised in that：The purposes is： Feed addictive is directly appended to feed in fresh water fish feed, and the addition of feed addictive is fresh water fish feed weight 0.05-0.08%。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108157678A (en) * | 2017-12-29 | 2018-06-15 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing Auricularia polysaccharide preparing grass carp feed additive |
| CN114747694A (en) * | 2022-01-12 | 2022-07-15 | 贵州省水产研究所 | Sturgeon growth-promoting and immunity-increasing type compound Chinese herbal medicine fermentation preparation and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583810A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Fermentation type Chinese herbal medicinal immunopotentiator for erythroculter ilishaeformis |
| CN105194041A (en) * | 2015-11-11 | 2015-12-30 | 郑州后羿制药有限公司 | Chinese herbal medicinal fermented extract liquid for preventing and treating bacterial diseases of freshwater fish and preparation method of Chinese herbal medicinal fermented extract liquid |
| CN105661011A (en) * | 2016-01-22 | 2016-06-15 | 重庆民泰香料化工有限责任公司 | Functional bio-protein feed ferment and fermented protein feed |
| CN105746947A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Microecological preparation for improving intestinal function of Elopichthys bambusa |
| CN105994962A (en) * | 2016-06-17 | 2016-10-12 | 安庆市皖宜季牛水产养殖有限责任公司 | Digestion promoting mandarin fish feed with disease resisting effect |
| CN106071351A (en) * | 2016-06-03 | 2016-11-09 | 开县千山科技开发有限公司 | A kind of feed of grass carp and preparation method thereof |
| CN106071392A (en) * | 2016-06-17 | 2016-11-09 | 合肥丰瑞隆生物科技有限公司 | Feed additive of fresh-water fishes and preparation method thereof |
-
2017
- 2017-07-20 CN CN201710596271.1A patent/CN107348138A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583810A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Fermentation type Chinese herbal medicinal immunopotentiator for erythroculter ilishaeformis |
| CN105194041A (en) * | 2015-11-11 | 2015-12-30 | 郑州后羿制药有限公司 | Chinese herbal medicinal fermented extract liquid for preventing and treating bacterial diseases of freshwater fish and preparation method of Chinese herbal medicinal fermented extract liquid |
| CN105661011A (en) * | 2016-01-22 | 2016-06-15 | 重庆民泰香料化工有限责任公司 | Functional bio-protein feed ferment and fermented protein feed |
| CN105746947A (en) * | 2016-03-07 | 2016-07-13 | 五河县金满塘生态种养殖家庭农场 | Microecological preparation for improving intestinal function of Elopichthys bambusa |
| CN106071351A (en) * | 2016-06-03 | 2016-11-09 | 开县千山科技开发有限公司 | A kind of feed of grass carp and preparation method thereof |
| CN105994962A (en) * | 2016-06-17 | 2016-10-12 | 安庆市皖宜季牛水产养殖有限责任公司 | Digestion promoting mandarin fish feed with disease resisting effect |
| CN106071392A (en) * | 2016-06-17 | 2016-11-09 | 合肥丰瑞隆生物科技有限公司 | Feed additive of fresh-water fishes and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108157678A (en) * | 2017-12-29 | 2018-06-15 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing Auricularia polysaccharide preparing grass carp feed additive |
| CN114747694A (en) * | 2022-01-12 | 2022-07-15 | 贵州省水产研究所 | Sturgeon growth-promoting and immunity-increasing type compound Chinese herbal medicine fermentation preparation and preparation method thereof |
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