CN107325545A - One kind sustained release medicine-chest filled type slow-release material - Google Patents
One kind sustained release medicine-chest filled type slow-release material Download PDFInfo
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- CN107325545A CN107325545A CN201710767832.XA CN201710767832A CN107325545A CN 107325545 A CN107325545 A CN 107325545A CN 201710767832 A CN201710767832 A CN 201710767832A CN 107325545 A CN107325545 A CN 107325545A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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Abstract
One kind sustained release medicine-chest filled type slow-release material, Chinese medicine technical field of memory is prepared from the following components：Sepiolite powder, castor oil, sweet osmanthus freeze-dried powder, Radix agastaches freeze-dried powder, sodium citrate, konjac glucomannan, eucalyptus oil, sodium benzoate, polyglutamic acid, laruyl alcohol.The slow-release material of present invention sustained release medicine-chest is used as long acting vehicle using laruyl alcohol, sepiolite powder and castor oil, used by Natural anti-mildew composition and the collaboration for synthesizing mould proof composition, the antimildew function of Controlled-release filler can be increased, it has stronger killing ability to Penicillium notatum, melanomyces, rhizopus after tested, and anti-mold effect is lasting, go mouldy rate of the Chinese medicine in storage period can be reduced, so that the economic loss for the initiation that avoids going mouldy.
Description
Technical field：
The present invention relates to Chinese medicine technical field of memory, and in particular to one kind sustained release medicine-chest filled type slow-release material.
Background technology：
Chinese medicine refers to the medicine applied in the case where Han nationality's folk medicine is instructed.Chinese medicine is divided into Chinese patent drug, Chinese medicine by processing technology
Material.Chinese medicine is originating primarily from China, in addition to autonomic drug, animal drugs such as snake gall, bear gall, long-noded pit viper, pilose antler, deer horn etc.；It is situated between
Shell class such as pearl, concha meretricis seu cylinae；Mineral substance such as keel, magnetite etc. is all the Chinese medicine for curing the disease.A small number of Chinese medicines come from foreign country, such as west
American ginseng.
In general, medicinal material preferably puts preservation, particularly valuable medicinal in refrigerator, such as cordyceps, bird's nest both can insect prevention
It is again moistureproof.
Anti-moth-eating goes mouldy, and utilizes " antagonistic storage " reasonably combined medicinal material, such as has with Chinese prickly ash, anise, beautiful osmanthus pungent
The medicinal material of fragrance and some medicinal materials, which are put together, can play moth-proof and mould-proof effect, and such as Chinese prickly ash is with gekko, hippocampus with storage；The root bark of tree peony and Huaihe River
Mountain, the bighead atractylodes rhizome are with storage etc..
Protection against the tide, some medicinal materials first dry moisture removal, place into sealed bottle cap and are preserved, to prevent discoloration sick,
But astragali, dried orange peel, Radix Angelicae Sinensis, Chinese yam (Chinese yam) should not be exposed to the sun in the sun, astragali, Chinese yam, which are exposed to the sun, can make medicinal material change color, can
With
The method of " drying " is dried；Dried orange peel, Radix Angelicae Sinensis, which are exposed to the sun, can make medicinal material scent dissipation, preferably deposit in refrigerator.
But at present many shops of Chinese medicines be often made with when being stored to Chinese medicine simply wooden, plastics and
Metal container is preserved to medicinal material, is considered by strict humidity, temperature, some even go mouldy to insect pest
All do not carry out strict strick precaution, so may result in Chinese medicine can be gone mouldy after storage a period of time, it is shrivelled, fusing, raw
Worm etc. influence medicinal material is used and occurred the problem of drug effect, so as to cause substantial amounts of waste, some are even after generation lesion
Also patient is sold, is so undoubtedly a kind of injury to patient.
The content of the invention：
The technical problems to be solved by the invention are to overcome the defect of above-mentioned storage mode, and there is provided a kind of type slow-releasing medicine-chest
Interior slow-release material, the slow-release material has stronger killing ability, and anti-mold effect is persistently, can reduce Chinese medicine in storage
Rate of going mouldy during Tibetan, so that the economic loss for the initiation that avoids going mouldy.
One kind sustained release medicine-chest filled type slow-release material, is prepared from the following components：Sepiolite powder, castor oil, sweet osmanthus
Freeze-dried powder, Radix agastaches freeze-dried powder, sodium citrate, konjac glucomannan, eucalyptus oil, sodium benzoate, polyglutamic acid, laruyl alcohol；
Above-mentioned slow-release material each component is according to the mass fraction：10-18 parts of sepiolite powder, 3-5 parts of castor oil, sweet osmanthus freeze
6-8 parts of powder, 3-5 parts of Radix agastaches freeze-dried powder, 2-5 parts of sodium citrate, 1-3 parts of konjac glucomannan, 3-5 parts of eucalyptus oil, sodium benzoate 1-5
Part, 3-5 parts of polyglutamic acid, 2-6 parts of laruyl alcohol；
The slow-release material is prepared from by following methods：
(1) sepiolite powder, castor oil are heated to 70-80 DEG C of insulation mixing 5-10min, add sodium citrate and bay
Alcohol, continues, in 70-80 DEG C of insulation mixing 5-10min, to produce long acting vehicle；
(2) ginkgo leaf freeze-drying, Radix agastaches freeze-dried powder and eucalyptus oil are added, grinding is uniform, stands and added after 10-15min
Konjac glucomannan and sodium benzoate, are sufficiently mixed, and produce mould proof composition；
(3) above-mentioned made long acting vehicle, mould proof composition, sodium benzoate and polyglutamic acid are added in kneader, mediated
Mixture is sent into freeze drier after 20-50minh, Controlled-release filler is produced after drying；
Using laruyl alcohol, sepiolite powder and castor oil as long acting vehicle, pass through Natural anti-mildew composition and the mould proof composition of synthesis
Collaboration use, the antimildew function of Controlled-release filler can be increased；
It has stronger killing ability to Penicillium notatum, melanomyces, rhizopus after tested, and anti-mold effect is persistently, energy
Enough reduction Chinese medicine storage period rate of going mouldy so that the economic loss for the initiation that avoids going mouldy；
Above-mentioned slow-release material is protected by being sustained medicine-chest centering medicine when in use, wherein using the slow of the slow-release material
Drug release case includes casing, case lid and the dividing plate being arranged in the middle of box house, and the casing is regular rectangular configuration, in casing
Bosom position be vertically installed with dividing plate box house be divided into two pieces of volumes and the equivalent region of structure, the case lid
The top of casing is mounted on, two pieces of down-set two pieces of region phases with box house are additionally provided with the bottom of case lid
The sealing gasket of matching, the tank wall of the casing is set to three layers, internal one layer be unsaturated zone, middle one layer be slow release layer, outside
One layer is separation layer；
Glass fibre silk screen is provided between the unsaturated zone, slow release layer and separation layer；
The dividing plate is fixedly installed on the bosom position of unsaturated zone, and box house is separated；
Further technology, uses physical connection, is fixed without using chemical jelly between dividing plate and unsaturated zone；
Well-regulated through hole is set on the unsaturated zone, and the diameter of through hole is arranged on 0.3-0.5 ㎜；
The slow release layer is formed by the braiding of glass fibre silk screen, and filled with slow-release material in slow release layer；
The separation layer is formed by the braiding of glass fibre silk screen, and is filled with separation layer isolation filler；
Different medicinal materials are put into the different zones of box house first when in use, case lid are then covered tightly i.e.
Can, because case lid bottom is provided with sealing gasket, so the sealing effectiveness of case lid is very well, it is logical additionally, due to being provided with cabinet wall
Gas-bearing formation, so the active ingredient inside slow release layer can be discharged by unsaturated zone, is effectively protected medicinal material, and in casing
Outermost layer is additionally provided with separation layer, and the separation layer can play isolation effect, and special due to separation layer and slow release layer
Material and structure, moreover it is possible to the effects such as playing damp proof, mould proof, effectively protect Chinese medicine not go bad；
The sealing gasket of wherein described case lid bottom is by granules of polystyrene, superfine powder of polytetrafluoroethylene, asbestos wool and epoxy
Soybean oil is molded after mixing banburying；
Wherein the isolation filler of filling is prepared from the following components in separation layer：Six hydrated chromium trichlorides, two hydration chlorine
Change copper, rilanit special, nickel powder, titanium valve, phenol, OBPA mould inhibitors, ceramic, trimethylolpropane trimethacrylate, six
Melamine methylol pregnancy ether, rice husk, corncob, quartz sand；
The mass fraction of above-mentioned isolation filler each component is：Six 2-4 parts of hydrated chromium trichlorides, 1-3 parts of Copper dichloride dihydrate,
1-2 parts of rilanit special, 3-4 parts of nickel powder, 1-2 parts of titanium valve, 5-10 parts of phenol, 10-15 parts of OBPA mould inhibitors, ceramic 3-5
Part, 2-3 parts of trimethylolpropane trimethacrylate, 1-2 parts of hexamethylolmelamine pregnancy ether, 2-5 parts of rice husk, corncob 3-
8 parts, 2-5 parts of quartz sand；
The preparation method of above-mentioned isolation filler is：
(1) six hydrated chromium trichlorides, Copper dichloride dihydrate are mixed and heated to 100-115 DEG C of insulation mixing 5-10min, then
Nickel powder, titanium valve are added, continues, in 100-115 DEG C of insulation mixing 15-30min, to stand 10-15min, be made and just expect；
(2) it will just expect and 120-125 DEG C of insulation mixing 15- be again heated to after being mixed with phenol and OBPA mould inhibitors
30min, after naturally cool to stand-by after room temperature；
(3) by rice husk, 90-98 DEG C of corncob hot pressing temperature, hot pressing pressure 1.3-2.5MPa, hot pressing time 0.5-1min/
Hot pressing under the conditions of mm, it is stand-by after naturally cool to 80-100 targeted fine powders are made using pulverizer after room temperature；
(4) fine powder just expected with prepared in step 3 is mixed into hydroxymethyl-propane triacrylate and kneading machine
135-140 DEG C kneads 4-8 minutes；
(5) hexamethylolmelamine pregnancy ether and ceramic and then after temperature is down to 110-115 DEG C are added and is added
Heat to 125-130 DEG C of insulation mixes 10-15min；
(6) ceramic and rilanit special are added, molten condition insulation mixing 10-15min is maintained, produces modified poly-
Ethylene glycol terephthalate；
(7) gained mixture is transferred in kneading machine, and 125-135 DEG C kneads 5-10 minutes, produces isolation filler.
Medicinal material is placed in equipment of the present invention and stored, then to medicinal material carry out coherent detection, and with it is other
Common wooden case and the medicinal material of canister storage carry out corresponding Experimental comparison, as a result as follows：
| Classification | Equipment shown in of the invention | Wooden case is stored | Canister is stored |
| Holding time | 5-8 | 3-5 | 3-6 |
| Go mouldy rate | 5-10% | 20-30% | 15-20% |
It can be seen that this storage device has the advantages that by upper table data：Utilize casing and the special knot of case lid
Configuration formula, and each structure functional effect, can be effectively protected Chinese medicine is not influenceed by the moist, factor such as go mouldy, and is had
The integrality of effect protection medicinal material；
By the preparation of separation layer and slow release layer special material and filler, protection can be played a part of to Chinese medicine, led to
The active ingredient of sustained release out slowly is crossed, medicinal material storage time can be extended by carrying out protection to medicinal material.
Brief description of the drawings：
Fig. 1 is internal structure schematic diagram of the invention；
Fig. 2 is body structure schematic diagram；
Fig. 3 cover structure schematic diagrames；
Fig. 4 is unsaturated zone structural scheme of mechanism；
Wherein：1- casings；2- case lids；3- dividing plates；4- unsaturated zones；5- separation layers；6- slow release layers；7- sealing gaskets.
Embodiment：
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, tie below
Conjunction is specifically illustrating and example, and the present invention is expanded on further.
Embodiment 1：One kind sustained release medicine-chest filled type slow-release material, is prepared from the following components：Sepiolite powder, castor-oil plant
Oil, sweet osmanthus freeze-dried powder, Radix agastaches freeze-dried powder, sodium citrate, konjac glucomannan, eucalyptus oil, sodium benzoate, polyglutamic acid, laruyl alcohol；
Each component is according to the mass fraction：15 parts of sepiolite powder, 4 parts of castor oil, 7 parts of sweet osmanthus freeze-dried powder, Radix agastaches are freezed
4 parts of powder, 3 parts of sodium citrate, 2 parts of konjac glucomannan, 4 parts of eucalyptus oil, 3 parts of sodium benzoate, 4 parts of polyglutamic acid, 5 parts of laruyl alcohol；
Wherein slow-release material is prepared from by following methods：
Sepiolite powder, castor oil are heated to 75 DEG C of insulation mixing 8min, sodium citrate and laruyl alcohol is added, continues
80 DEG C of insulation mixing 10min, produce long acting vehicle；
Ginkgo leaf freeze-drying, Radix agastaches freeze-dried powder and eucalyptus oil are added, grinding is uniform, and konjac glucomannan is added after standing 13min
And sodium benzoate, it is sufficiently mixed, produces mould proof composition；
Above-mentioned made long acting vehicle, mould proof composition, sodium benzoate and polyglutamic acid are added in kneader, 20- is mediated
Mixture is sent into freeze drier after 50minh, slow-release material is produced after drying.
Embodiment 2：As Figure 1-4：One kind sustained release medicine-chest, including casing 1, case lid 2 and it is arranged on the bosom of casing 1
Dividing plate 3, casing 1 for rule rectangular configuration, dividing plate 3 is vertically installed with the bosom position of casing 1 by inside casing 1
Two pieces of volumes and the equivalent region of structure are divided into, case lid 2 is mounted on the top of casing 1, is also set up in the bottom of case lid 2
There is a sealing gasket 7 that two pieces of down-set two pieces of regions with inside casing 1 match, the tank wall of casing 1 is set to three layers, interior
One layer of portion be unsaturated zone 4, middle one layer be slow release layer 6, outside one layer be separation layer 5, wherein unsaturated zone 4, slow release layer 6 and isolation
Glass fibre silk screen is provided between layer 5；Dividing plate 3 is fixedly installed on the bosom position of unsaturated zone 4, inside casing 1
It is separated, physical connection is used between dividing plate 3 and unsaturated zone 4, is fixed without using chemical jelly, is set on unsaturated zone 4
Well-regulated through hole, the diameter of through hole is arranged on 0.3-0.5 ㎜, and slow release layer 6 is formed by the braiding of glass fibre silk screen, and in sustained release
Controlled-release filler is filled with layer 6, separation layer 5 is formed by the braiding of glass fibre silk screen, and isolation is filled with separation layer 5 and filled out
Material.
Embodiment 3：As Figure 1-4, different medicinal materials are put into casing 1 by a kind of sustained release medicine-chest first when in use
In internal different zones, case lid 2 is then covered tightly, because the bottom of case lid 2 is provided with sealing gasket 7, so the sealing of case lid 2
Effect very well, unsaturated zone 4 is provided with additionally, due in the inwall of casing 1, so the active ingredient inside slow release layer 6 can be by logical
Gas-bearing formation 4 is discharged, and is effectively protected medicinal material, and is additionally provided with separation layer 5 in the outermost layer of casing 1, and the separation layer 5 can
Isolation effect is played, and due to separation layer 5 and the special substance and structure of slow release layer 6, moreover it is possible to play the work(such as damp proof, mould proof
Effect, effectively protects Chinese medicine not go bad.
Embodiment 4：The isolation filler filled in the separation layer set on sustained release medicine-chest is prepared from the following components：Six
Hydrated chromium trichloride, Copper dichloride dihydrate, rilanit special, nickel powder, titanium valve, phenol, OBPA mould inhibitors, ceramic, three hydroxyls
Propane tri, hexamethylolmelamine pregnancy ether, rice husk, corncob, quartz sand；
The mass fraction of above-mentioned isolation filler each component is：Six 3 parts of hydrated chromium trichlorides, 2 parts of Copper dichloride dihydrate, hydrogenation
1 part of castor oil, 3 parts of nickel powder, 2 parts of titanium valve, 8 parts of phenol, 13 parts of OBPA mould inhibitors, 4 parts of ceramic, trimethylolpropane tris third
2 parts of olefin(e) acid ester, 1 part of hexamethylolmelamine pregnancy ether, 4 parts of rice husk, 5 parts of corncob, 3 parts of quartz sand；
The preparation method of above-mentioned isolation filler is：
(1) six hydrated chromium trichlorides, Copper dichloride dihydrate are mixed and heated to 115 DEG C of insulation mixing 5min, add nickel
Powder, titanium valve, continue, in 115 DEG C of insulation mixing 15min, to stand 13min, be made and just expect；
(2) it will just expect and 120 DEG C of insulation mixing 20min are again heated to after being mixed with phenol and OBPA mould inhibitors, treat certainly
So it is cooled to stand-by after room temperature；
(3) will be hot under the conditions of rice husk, 95 DEG C of corncob hot pressing temperature, hot pressing pressure 2.0MPa, hot pressing time 1min/mm
Pressure, it is stand-by after naturally cool to 90 targeted fine powders are made using pulverizer after room temperature；
(4) fine powder just expected with prepared in step 3 is mixed into hydroxymethyl-propane triacrylate and in kneading machine 140
DEG C mixing 5 minutes；
(5) hexamethylolmelamine pregnancy ether and ceramic and then after temperature is down to 110 DEG C are added and is heated to
130 DEG C of insulation mixing 10min；
(6) ceramic and rilanit special are added, molten condition insulation mixing 10min is maintained, produces modified poly- pair
PET；
(7) gained mixture is transferred in kneading machine, and 135 DEG C knead 5 minutes, produce isolation filler.
Medicinal material is placed in the equipment shown in the present embodiment and stored, then to medicinal material progress coherent detection, and and its
Its common wooden case and the medicinal material of canister storage carry out corresponding Experimental comparison, as a result as follows：
| Classification | Embodiment 1 | Wooden case is stored | Canister is stored |
| Holding time | 8 years | 4 years | 56 years |
| Go mouldy rate | 6% | 25% | 18% |
It can be seen that this storage device has the advantages that by upper table data：Utilize casing and the special knot of case lid
Configuration formula, and each structure functional effect, can be effectively protected Chinese medicine is not influenceed by the moist, factor such as go mouldy, and is had
The integrality of effect protection medicinal material；
By the preparation of separation layer and slow release layer special material and filler, protection can be played a part of to Chinese medicine, led to
The active ingredient of sustained release out slowly is crossed, medicinal material storage time can be extended by carrying out protection to medicinal material.
The general principle and principal character and advantages of the present invention of the present invention has been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (5)
1. one kind sustained release medicine-chest filled type slow-release material, it is characterised in that：It is prepared from the following components：Sepiolite powder, castor
Sesame oil, sweet osmanthus freeze-dried powder, Radix agastaches freeze-dried powder, sodium citrate, konjac glucomannan, eucalyptus oil, sodium benzoate, polyglutamic acid, bay
Alcohol.
2. a kind of sustained release medicine-chest filled type slow-release material according to claim 1, it is characterised in that：Slow-release material each group
Divide and be according to the mass fraction：10-18 parts of sepiolite powder, 3-5 parts of castor oil, 6-8 parts of sweet osmanthus freeze-dried powder, Radix agastaches freeze-dried powder 3-5
Part, 2-5 parts of sodium citrate, 1-3 parts of konjac glucomannan, 3-5 parts of eucalyptus oil, 1-5 parts of sodium benzoate, 3-5 parts of polyglutamic acid, laruyl alcohol
2-6 parts.
3. a kind of according to claim 1 be sustained medicine-chest filled type slow-release material, it is characterised in that：By following methods system
It is standby to form：
(1) sepiolite powder, castor oil are heated to 70-80 DEG C of insulation mixing 5-10min, add sodium citrate and laruyl alcohol,
Continue, in 70-80 DEG C of insulation mixing 5-10min, to produce long acting vehicle；
(2) ginkgo leaf freeze-drying, Radix agastaches freeze-dried powder and eucalyptus oil are added, grinding is uniform, stands after a period of time, adds konjaku
Glue and sodium benzoate, are sufficiently mixed, and produce mould proof composition；
(3) above-mentioned made long acting vehicle, mould proof composition, sodium benzoate and polyglutamic acid are added in kneader, will after kneading
In mixture feeding freeze drier, Controlled-release filler is produced after drying.
4. a kind of according to claim 3 be sustained medicine-chest filled type slow-release material, it is characterised in that：The preparation of slow-release material
Time of repose is 10-15min in step (2).
5. a kind of according to claim 3 be sustained medicine-chest filled type slow-release material, it is characterised in that：The preparation of slow-release material
Kneading time in step (3) is 20-50min.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111493054A (en) * | 2020-04-23 | 2020-08-07 | 广东省粮食科学研究所 | Drug-applying slow-release device and production process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111493054A (en) * | 2020-04-23 | 2020-08-07 | 广东省粮食科学研究所 | Drug-applying slow-release device and production process thereof |
| CN111493054B (en) * | 2020-04-23 | 2022-01-11 | 广东省粮食科学研究所 | Drug-applying slow-release device and production process thereof |
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