CN107319574A - It is a kind of to be beneficial to the protein modules food of burn trauma crowd's rehabilitation - Google Patents
It is a kind of to be beneficial to the protein modules food of burn trauma crowd's rehabilitation Download PDFInfo
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- CN107319574A CN107319574A CN201710654944.4A CN201710654944A CN107319574A CN 107319574 A CN107319574 A CN 107319574A CN 201710654944 A CN201710654944 A CN 201710654944A CN 107319574 A CN107319574 A CN 107319574A
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 37
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 37
- 235000013305 food Nutrition 0.000 title claims abstract description 34
- 208000014674 injury Diseases 0.000 title claims abstract description 21
- 230000008733 trauma Effects 0.000 title claims abstract description 21
- 230000009286 beneficial effect Effects 0.000 title claims abstract description 20
- 235000018102 proteins Nutrition 0.000 claims abstract description 36
- 241000251511 Holothuroidea Species 0.000 claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 19
- 108010073771 Soybean Proteins Proteins 0.000 claims abstract description 16
- 235000019710 soybean protein Nutrition 0.000 claims abstract description 16
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 9
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 6
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 5
- 239000005018 casein Substances 0.000 claims abstract description 5
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000021240 caseins Nutrition 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 5
- 239000011734 sodium Substances 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 3
- 230000007062 hydrolysis Effects 0.000 claims description 12
- 238000006460 hydrolysis reaction Methods 0.000 claims description 12
- 239000004365 Protease Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000004475 Arginine Substances 0.000 claims description 8
- 108091005804 Peptidases Proteins 0.000 claims description 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 235000019419 proteases Nutrition 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 7
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 6
- 239000008236 heating water Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 210000001835 viscera Anatomy 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000007781 pre-processing Methods 0.000 claims description 4
- 238000011160 research Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 241000965254 Apostichopus japonicus Species 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 3
- 229940088598 enzyme Drugs 0.000 claims description 3
- 229940055729 papain Drugs 0.000 claims description 3
- 235000019834 papain Nutrition 0.000 claims description 3
- 230000017854 proteolysis Effects 0.000 claims description 3
- 235000021251 pulses Nutrition 0.000 claims description 3
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 2
- 102000004407 Lactalbumin Human genes 0.000 claims 1
- 108090000942 Lactalbumin Proteins 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 12
- 208000027418 Wounds and injury Diseases 0.000 abstract description 12
- 230000036039 immunity Effects 0.000 abstract description 8
- 230000029663 wound healing Effects 0.000 abstract description 7
- 208000034657 Convalescence Diseases 0.000 abstract description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract description 2
- 230000036737 immune function Effects 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000001243 protein synthesis Methods 0.000 abstract description 2
- 230000014616 translation Effects 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract 1
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract 1
- 235000008434 ginseng Nutrition 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 description 8
- 230000035764 nutrition Effects 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 6
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- 244000068988 Glycine max Species 0.000 description 3
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- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
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- 230000002195 synergetic effect Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000004452 Arginase Human genes 0.000 description 1
- 108700024123 Arginases Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000003656 Electric Burns Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 208000034486 Multi-organ failure Diseases 0.000 description 1
- 208000010718 Multiple Organ Failure Diseases 0.000 description 1
- 206010071229 Procedural haemorrhage Diseases 0.000 description 1
- 101710089165 Protein white Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- -1 ammonia Acid amides Chemical class 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
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- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940071440 soy protein isolate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention, which is disclosed, a kind of is beneficial to the protein modules food of burn trauma crowd's rehabilitation, contain WPC, soy peptide powder, sea cucumber Gly-His-Lys, casein sodium, L glutamine, the soy peptide powder, ocean ginseng Gly-His-Lys are that soybean protein isolate and sea cucumber together digest gained through compound protein.Be conducive to the protein synthesis after wound, immunologic function to improve and wound healing, improve immunity of organisms, the final convalescence for accelerating fire victim, with very important social value.In addition, its preparation method is simple, it is adapted to the application of scale industrial production.
Description
Technical field
It is beneficial to the protein modules food of burn trauma crowd's rehabilitation the present invention relates to a kind of, is adapted to burn trauma crowd food
With.
Background technology
Burn refers to the infringement of skin caused by heating power or other tissues.Burn patient usually may be used due to the strike of wound
Cause the superelevation of body to be metabolized and cause nutritional deficiency, cause wound not more until the severe complication such as internal organ multiple organ failure.
On the one hand because metabolic rate increases, decompose vigorous, the surface of a wound oozes out and cut the reasons such as skin, skin-grafting, infection, operative hemorrhage, cause complete
Body consumption increases；On the other hand then because the burn patient disorders of digestion, appetite fall sharply, nutrient absorption is caused to have with supplement
It is difficult.Clinical observation shows, burns more serious, and the possibility for occurring dystrophia is bigger.Malnutrition can delay the surface of a wound to be cured
Close, reduce passive protective physical fitness and easy accompanying infection, have a strong impact on prognosis.
So, it is an important step in burn patient whole body therapeutic to maintain nutrition, rationally give dietary therapy.
But, different crowds, required nutrition differs greatly.And the food repaired in the market on the wound later stage
Product, are substantially the health food or medical food of full nutrition, different crowds are not finely divided.Related patent,
Such as, patent of invention " a kind of marine organism type enteral nutrition system for fire victim of Application No. 201610242367.3
Agent ", a kind of patent of invention " universal aquatic collagen protein peptide food of wound repair " of Application No. 201610314068.6, all
It is the wholefood that burn is repaired.Therefore its nutrition-allocated proportion and not reasonable, unsuitable all groups, blindly carry out nutrition and take the photograph
Optimal medical assistance effect can not be played by entering.
What wound or burnt degree most needed to repair is skin histology, and it is micromolecular collagen that skin, which is most needed, therefore wound
The demand for hindering patient to albumen is the most key.In addition, wound process can exist to lose blood simultaneously causes immunity of organism with tissue damage
The decline of power, this also determine the demand to albumen.
Therefore, a kind of special protein modules are developed, it is extremely important preferably to solve the above problems.
The content of the invention
It is beneficial to the protein modules food of burn trauma crowd's rehabilitation it is an object of the invention to provide a kind of, can be burnt
Sick and wounded people's whole body therapeutic link reasonable diet.
The technical scheme is that：It is a kind of to be beneficial to the protein modules food of burn trauma crowd's rehabilitation, the food
Composition by weight：WPC 8-12, soy peptide powder 5-7, sea cucumber Gly-His-Lys 2.5-5, casein sodium 0.1-0.3, L- paddy ammonia
Acid amides 0.8-1.2, the soy peptide powder, sea cucumber Gly-His-Lys are to be digested after soybean protein isolate and sea cucumber are mixed together through compound protein
Gained.
The ratio of soybean protein isolate and sea cucumber is 1 in the protein modules food:1-5:2.
Also contain arginine and proline in the protein modules food.
Final arginine and proline content are respectively 8-15% in the protein modules food.
In the proteolysis, enzyme used is trypsase and/or alkali protease and/or papain.
Proteolysis technique is：It is configured to 5-20% (w/v) soybean protein isolate, the sea cucumber aqueous solution (soybean separation protein
In vain:Sea cucumber=1:1-5:2), 90 DEG C of heating water bath 10-15min, are subsequently cooled to 50-55 DEG C.PH 6.8~8.0 is adjusted, is added
Trypsase and alkali protease, keep 45-60 DEG C of magnetic agitation 4-10h of hydrolysis temperature.
It is a kind of to be beneficial to the protein modules food of burn trauma crowd's rehabilitation, the preparation method of the food, step：Sea cucumber is pre-
Processing：Fresh wall of sea cucumber Stichopus japonicus is rinsed well, with deionized water rinsing to pH be after removing the internal organs it is neutral, with deionized water with
1:4(m：V homogenate is smashed after) being well mixed；Enzymolysis：5-20% (w/v) soybean protein isolate, the sea cucumber aqueous solution are configured to, greatly
Beans protein isolate:Sea cucumber=1:1-5:2,90 DEG C of heating water bath 10min, are subsequently cooled to 50-55 DEG C, adjust pH 6.8~8.0,
Trypsase and alkali protease are added, 45 DEG C of magnetic agitation 4h of hydrolysis temperature are kept；After hydrolysis is good, using high-pressure pulse electric
Sterilization, 10-20KV/cm is filtrated to get filtrate afterwards；Dry：Above-mentioned solution is spray-dried, inlet temperature is set as 180 DEG C,
Outlet temperature is not less than 80 DEG C, and compressed air flow velocity is 460L/h, and the powder of acquisition is received and is fitted into hermetic bag, 4 DEG C are placed on
Stored in drier, for later stage research；It is dry-mixed：Spray drying gained powder is dry-mixed with remaining dosed powder progress, obtain
Finished product, is then packed.
The advantage of the invention is that：Soybean protein isolate and sea cucumber together digest, amino acid composition in gained enzymolysis product
It is more suitable for burn trauma crowd's rehabilitation.The arginine and proline ratio of the present invention, has collaboration in wound healing process
Effect.Glutamine and arginic combination, can regulate and control to be immunized, and body nutrition condition, enhancing immunity of organism work(are improved to reach
The effect of energy.Above-mentioned each component is combined by specific proportioning, mutual Synergistic, the comprehensive nutrition of reasonable supplement and sufficient energy
Amount, mitigates the physiological reaction that operative treatment is brought, and improves therapeutic effect, improves immunity of organisms, finally accelerate fire victim
Convalescence.
It is of the present invention it is a kind of be beneficial to the protein modules food of burn trauma crowd's rehabilitation, by marine organism type food materials
One of source as formula, by Synergistic between each component, the comprehensive nutrition of reasonable supplement and sufficient energy are conducive to
Protein synthesis after wound, immunologic function improve and wound healing, mitigate the physiological reaction that operative treatment is brought, and curative effect is controlled in improvement
Really, immunity of organisms, the final convalescence for accelerating fire victim, with very important social value are improved.In addition, it is prepared
Method is simple, is adapted to the application of scale industrial production.
Embodiment
With reference to embodiment, the present invention is further detailed explanation.
Embodiment 1
It is a kind of to be beneficial to contain WPC in the protein modules food of burn trauma crowd's rehabilitation, every part (20g)
10g, casein sodium, Glu 1g, arginine 3g, proline 2.5g, soybean protein isolate 7g, sea cucumber 2.8g
The preparation method of the above-mentioned protein modules food for being beneficial to burn trauma crowd's rehabilitation, is comprised the following steps that：
Sea cucumber preprocessing：Fresh wall of sea cucumber Stichopus japonicus is rinsed well, in being to pH with deionized water rinsing after removing the internal organs
Property, with deionized water with 1:4(m：V homogenate is smashed after) being well mixed.
Enzymolysis：5% (w/v) soybean separation protein white water solution is configured to, (soybean is mixed with pretreated sea cucumber solution
Protein isolate:Sea cucumber=1:1), 90 DEG C of heating water bath 10min, are subsequently cooled to 50-55 DEG C.Adjust (the enzymolysis of pH 6.8~8.0
Temperature), trypsase and alkali protease are added, 45 DEG C of magnetic agitation 4h of hydrolysis temperature are kept.
After hydrolysis is good, using high-pressure pulse electric sterilization, 10-20KV/cm is filtrated to get filtrate afterwards.
Dry：Above-mentioned solution is spray-dried, inlet temperature is set as 180 DEG C, and outlet temperature is not less than 80 DEG C, and compression is empty
Gas velocity is 460L/h.The powder of acquisition is received and is fitted into hermetic bag, is placed in 4 DEG C of driers and stores, for later stage research.
It is dry-mixed：Spray drying gained powder is dry-mixed with remaining dosed powder progress, finished product is obtained, is then packed.
Embodiment 2
It is a kind of to be beneficial to contain WPC in the protein modules food of burn trauma crowd's rehabilitation, every part (20g)
10g, casein sodium, Glu 1g, arginase 12 .5g, proline-4 .5g, soybean protein isolate 5g, sea cucumber 5g
The preparation method of the above-mentioned protein modules food for being beneficial to burn trauma crowd's rehabilitation, is comprised the following steps that：
Sea cucumber preprocessing：Dried sea-cucumber body wall is rinsed well, with deionized water rinsing to pH be after removing the internal organs it is neutral, with
Deionized water is with 1:4(m：V homogenate is smashed after) being well mixed.
Enzymolysis：It is configured to 20% (w/v) soybean protein isolate, the marine fish fish scale aqueous solution (soybean protein isolate:Sea cucumber
=5:2), 90 DEG C of heating water bath 10min, are subsequently cooled to 50-55 DEG C.PH 6.8~8.0 (hydrolysis temperature) is adjusted, pancreas egg is added
White enzyme and papain, keep 45 DEG C of magnetic agitation 4h of hydrolysis temperature.After hydrolysis is good, conventional sterilization is filtrated to get filtrate.
Dry：Above-mentioned solution is spray-dried, inlet temperature is set as 180 DEG C, and outlet temperature is not less than 80 DEG C, and compression is empty
Gas velocity is 460L/h.The powder of acquisition is received and is fitted into hermetic bag, is placed in 4 DEG C of driers and stores, for later stage research.
It is dry-mixed：Spray drying gained powder is dry-mixed with remaining dosed powder progress, finished product is obtained, is then packed.
Embodiment 3
Analysis of amino acids
Determine the amino acid content pre-treating method of peptide in hydrolyzed soy protein isolate, sea cucumber:0.1g 1mL peptides are taken in water
Xie Guanzhong, adds 6mol/L hydrochloric acid 5mL, then using alcohol blast burner tube sealing, finally hydrolyze 24h in 110 DEG C of baking ovens.By water
Sample filtering constant volume is solved in 25mL volumetric flasks, the sample 1mL after constant volume is drawn and 60 DEG C of oven dryings, bottom is put into drying basin
Untill portion leaves a little solid or trace stain, 2mLpH5.0 sodium acetate buffers are added, after 0.22 μm of filter filtering, upper machine
Detection.
Table 1：Sample amino acid content and composition analysis mg/100mL
Note：* it is essential amino acid
Shown by the testing result to amino acid, soybean protein isolate of the present invention, the combined hydrolysis of sea cucumber, its finished product
Middle amino acid structure rationally, and is conducive to the recovery of wound mouthful, and the wherein arginine content in this product is higher, and arginine can
Promote wound healing, improve immunity function.
Embodiment 4：Clinical trial
To 45 severe burn inpatients, man 33, female 12, age 24-67 Sui, be averaged (38.2 ± 1.6) year；It is deep
Spend burn surface area average out to (28.7 ± 8.1) %；Burn cause：Flame burn 37, highly basic is burnt 5, electric burn 3.Institute
There is patient to be hospitalized for treatment in burnt degree 10h.Exclude the patients such as serious imbedibility wound, diarrhoea, shock property ulcer.In hospital just
Often treatment, after 40d, is randomly divided into 3 groups, determines immunoglobulin level and protein in body level, daily feed protein 90~
Immunoglobulin level and protein in body level are determined after 150g, 50d again.Wound healing time is recorded, and is counted.
Experimental group 1：The embodiment of the present invention 1
Experimental group 2：The embodiment of the present invention 2
Control group：General proteins powder
Table 2：Mouse serum antibody and cytokine levels compare in protein induced oral tolerance experiment
As a result visible, after albumen of the present invention, immunity of organism globulin quantity is significantly improved, and wound healing time is obvious
Shorten, protein in body level is also remarkably reinforced.Illustrate that protein modules of the present invention have the energy for promoting Wound healing, and can cooperate with
Immunity of organisms is improved, beneficial to the Health restoration of body.
Above-described is only some embodiments of the present invention.For the person of ordinary skill of the art, not
On the premise of departing from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention
Enclose.
Claims (7)
1. a kind of be beneficial to the protein modules food of burn trauma crowd's rehabilitation, it is characterised in that：The composition by weight of the food：It is dense
Contracting lactalbumin 8-12, soy peptide powder 5-7, sea cucumber Gly-His-Lys 2.5-5, casein sodium 0.1-0.3, Glu 0.8-1.2,
The soy peptide powder, sea cucumber Gly-His-Lys are through obtained by compound protein enzymolysis after soybean protein isolate and sea cucumber are mixed together.
2. it is beneficial to the protein modules food of burn trauma crowd's rehabilitation according to claim 1, it is characterised in that：The egg
The ratio of soybean protein isolate and sea cucumber is 1 in white component food:1-5:2.
3. it is beneficial to the protein modules food of burn trauma crowd's rehabilitation according to claim 1, it is characterised in that：The egg
Also contain arginine and proline in white component food.
4. it is beneficial to the protein modules food of burn trauma crowd's rehabilitation according to claim 1, it is characterised in that：The egg
Final arginine and proline content are respectively 8-15% in white component food.
5. according to claim 1 or claim 2 be beneficial to the protein modules food of burn trauma crowd's rehabilitation, it is characterised in that：Institute
State in proteolysis, enzyme used is trypsase and/or alkali protease and/or papain.
6. it is beneficial to the protein modules food of burn trauma crowd's rehabilitation according to claim 5, it is characterised in that：Protease
Solution technique is：It is configured to 5-20% (w/v) soybean protein isolate, the sea cucumber aqueous solution (soybean protein isolate:Sea cucumber=1:1-5:
2), 90 DEG C of heating water bath 10-15min, are subsequently cooled to 50-55 DEG C.PH 6.8~8.0 is adjusted, trypsase and alkalescence is added
Protease, keeps 45-60 DEG C of magnetic agitation 4-10h of hydrolysis temperature.
7. it is beneficial to the protein modules food of burn trauma crowd's rehabilitation according to claim 1, it is characterised in that：The food
Preparation method, step：Sea cucumber preprocessing：Fresh wall of sea cucumber Stichopus japonicus is rinsed well, deionized water rinsing is used after removing the internal organs
It is neutrality to pH, with deionized water with 1:4(m：V homogenate is smashed after) being well mixed；Enzymolysis：It is configured to the big of 5-20% (w/v)
Beans protein isolate, the sea cucumber aqueous solution, soybean protein isolate:Sea cucumber=1:1-5:2,90 DEG C of heating water bath 10min, are subsequently cooled to
50-55 DEG C, pH 6.8~8.0 is adjusted, trypsase and alkali protease is added, 45 DEG C of magnetic agitation 4h of hydrolysis temperature are kept；
After hydrolysis is good, using high-pressure pulse electric sterilization, 10-20KV/cm is filtrated to get filtrate afterwards；Dry：Above-mentioned solution is sprayed
Dry, inlet temperature is set as 180 DEG C, and outlet temperature is not less than 80 DEG C, and compressed air flow velocity is 460L/h, by the powder of acquisition
Receipts are fitted into hermetic bag, are placed in 4 DEG C of driers and store, for later stage research；It is dry-mixed：Gained powder will be spray-dried with surplus
Remaining dosed powder progress is dry-mixed, obtains finished product, then packs.
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