CN107308255B - Oral medicine and external medicine for treating acne and preparation method of oral medicine and external medicine - Google Patents

Oral medicine and external medicine for treating acne and preparation method of oral medicine and external medicine Download PDF

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CN107308255B
CN107308255B CN201710427098.2A CN201710427098A CN107308255B CN 107308255 B CN107308255 B CN 107308255B CN 201710427098 A CN201710427098 A CN 201710427098A CN 107308255 B CN107308255 B CN 107308255B
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acne
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treating acne
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CN107308255A (en
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田启旺
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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Abstract

The invention relates to the field of dermatological drugs, in particular to an oral drug and an external drug for treating acne and preparation methods of the oral drug and the external drug. The oral medicine for treating acne is prepared by grinding and mixing the following raw materials: fructus Kochiae, indigo naturalis, Scorpio, herba Hedyotidis Diffusae, Scutellariae radix, Coptidis rhizoma, fructus forsythiae, flos Lonicerae, flos Chrysanthemi Indici, herba Taraxaci, herba Schizonepetae, radix Saposhnikoviae, radix rehmanniae, Poria, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, Glycyrrhrizae radix, fructus Atriplicis Sibiricae and radix Puerariae. The external medicine for treating acne is prepared by infusing the following raw materials: scorpion, centipede, lightyellow sophora root, common cnidium fruit, honeycomb, szechwan chinaberry fruit, snake slough, sulfur and borneol. The cost of the oral medicine and the external medicine for treating the acne is low, and the medicine has obvious curative effect on the acne of adolescent men and women, is not easy to relapse and has no toxic or side effect. The preparation method of the oral medicine and the external medicine for treating the acne is simple.

Description

Oral medicine and external medicine for treating acne and preparation method of oral medicine and external medicine
Technical Field
The invention relates to the field of dermatological drugs, in particular to an oral drug and an external drug for treating acne and preparation methods of the oral drug and the external drug.
Background
Acne is also called comedo and whelk, is a common dermatosis of human body, and is commonly seen in the adolescent development stage of men and women. In adolescent development period, people like to eat spicy food due to irregular life, so that endocrine dyscrasia, stomach qi deficiency and skin immunity decline are caused, and acne is caused. Clinically, acne mainly appears on face, upper limbs, chest and neck, and symptoms are not uniform. Acne causes not only harm to the physical health of adolescent men and women, but also influences on the mental health of the adolescent men and women.
At present, the Chinese and western medicines for treating the skin diseases have a plurality of varieties, but the application range of the Chinese and western medicines for treating the skin diseases is less, and the treatment effect aiming at the acne also has respective defects. On the whole, western medicines generally have side effects and are easy to recur after recovery, and most of traditional Chinese medicines have unobvious curative effects.
Therefore, there is a need for an oral medicine, an external medicine and a preparation method thereof, which have low cost, obvious curative effect, difficult recurrence and no toxic or side effect and are used for treating acne in adolescent men and women.
Disclosure of Invention
Technical problem to be solved
In order to solve the problems in the prior art, the invention provides an oral medicine and an external medicine for treating acne, which have the advantages of low cost, obvious curative effect, difficult relapse and no toxic or side effect aiming at the acne of adolescent men and women, and a preparation method of the oral medicine and the external medicine.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that:
the invention provides an oral medicine for treating acne, which is prepared by grinding and mixing the following raw materials in parts by weight:
20-30 parts of belvedere fruit, 10-20 parts of indigo naturalis, 10-20 parts of scorpion, 5-15 parts of spreading hedyotis herb, 10-20 parts of baical skullcap root, 10-20 parts of goldthread root, 10-20 parts of weeping forsythia capsule, 10-20 parts of honeysuckle flower, 15-25 parts of wild chrysanthemum flower, 20-30 parts of dandelion, 10-20 parts of fineleaf schizonepeta herb, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of radix rehmanniae, 10-20 parts of poria cocos, 10-20 parts of Chinese angelica, 10-20 parts of szechuan lovage rhizome, 10-20 parts of liquorice, 20-30 parts of tribulus terrestris and 20-30 parts of.
Further, the oral medicine for treating acne is prepared by grinding and mixing the following raw materials in parts by weight:
23-29 parts of fructus kochiae, 13-16 parts of indigo naturalis, 12-18 parts of scorpion, 6-12 parts of oldenlandia diffusa, 12-17 parts of scutellaria baicalensis, 11-16 parts of coptis chinensis, 13-18 parts of fructus forsythiae, 13-19 parts of honeysuckle, 19-23 parts of wild chrysanthemum flower, 22-28 parts of dandelion, 13-19 parts of schizonepeta, 12-17 parts of divaricate saposhnikovia root, 14-17 parts of radix rehmanniae, 11-17 parts of poria cocos, 13-16 parts of angelica sinensis, 14-16 parts of ligusticum wallichii, 12-19 parts of liquorice, 23-26 parts of tribulus terrestris and 23-29 parts of radix puerariae.
Further, the oral medicine for treating acne is prepared by grinding and mixing the following raw materials in parts by weight:
25 parts of broom cypress fruit, 15 parts of indigo naturalis, 15 parts of scorpion, 10 parts of spreading hedyotis herb, 15 parts of baical skullcap root, 15 parts of golden thread, 15 parts of weeping forsythia capsule, 15 parts of honeysuckle flower, 20 parts of wild chrysanthemum flower, 25 parts of dandelion, 15 parts of fineleaf schizonepeta herb, 15 parts of divaricate saposhnikovia root, 15 parts of rehmannia root, 15 parts of tuckahoe, 15 parts of angelica, 15 parts of szechuan lovage rhizome, 15 parts of liquorice, 25 parts of tribulus terrestris and 25 parts of kudzuvine.
The external medicine for treating acne provided by the invention is prepared by infusing the following raw materials in parts by weight:
10-20 parts of scorpion, 10-20 parts of centipede, 30-40 parts of radix sophorae flavescentis, 30-40 parts of fructus cnidii, 30-40 parts of honeycomb, 20-30 parts of szechwan chinaberry fruit, 10-20 parts of snake slough, 5-15 parts of sulfur and 5-15 parts of borneol.
Further, the external medicine for treating acne is prepared by infusing the following raw materials in parts by weight:
15 parts of scorpion, 15 parts of centipede, 35 parts of radix sophorae flavescentis, 35 parts of fructus cnidii, 35 parts of honeycomb, 25 parts of szechwan chinaberry fruit, 15 parts of snake slough, 10 parts of sulfur and 10 parts of borneol.
The preparation method of the oral medicine for treating acne provided by the invention comprises the following steps:
s1: selecting the raw materials of the oral medicine for treating acne, mixing and grinding the raw materials into powder to form a powdery semi-finished product for later use;
s2: stirring and mixing the powdery semi-finished product in the S1 to form the powdery oral medicine for treating acne, wherein the mixing speed is within the range of 120rpm-150rpm, and the mixing time is within the range of 5min-10 min.
Further, the preparation method of the oral medicine for treating acne of the present invention further comprises:
s3: and (4) filling the powder-shaped acne treatment oral medicine in the S2 into capsules to form the capsule-shaped acne treatment oral medicine.
Further, the preparation method of the oral medicine for treating acne of the present invention further comprises:
s3': the powder oral medicine for treating acne in the S2 is mixed with honey to prepare the pill oral medicine for treating acne.
The preparation method of the external medicine for treating acne provided by the invention comprises the following steps:
s1: selecting the raw materials of the external medicine for treating acne, and mixing to form a mixture for later use;
s2: soaking the mixture in S1 in 43-58% grain wine for 55-65 days.
Further, in S2, the mixture in S1 is infused in 50% grain liquor for 60 days.
(III) advantageous effects
The invention has the beneficial effects that:
in the oral medicine for treating acne, the belvedere fruit and the natural indigo are monarch drugs for promoting diuresis and excreting dampness, clearing away heat and toxic material, cooling blood and removing speckles;
radix scutellariae, rhizoma coptidis, fructus forsythiae, honeysuckle, wild chrysanthemum, dandelion, oldenlandia diffusa, radix rehmanniae, angelica and poria cocos are used as ministerial medicines for clearing heat, cooling blood and eliminating dampness;
herba Schizonepetae, radix Saposhnikoviae, radix Puerariae, and fructus Atriplicis Sibiricae have effects of dispelling pathogenic wind and eliminating dampness, calming endogenous wind, counteracting toxic substances, and resolving hard mass, and are used as adjuvant drugs;
ligusticum wallichii is used as a guiding drug for dispelling wind, activating blood and promoting qi circulation, and licorice is used for blending the raw materials;
the raw materials are common traditional Chinese medicines, so that on one hand, the cost is low; on the other hand, the combined action has the effects of clearing heat, promoting diuresis, cooling blood and removing toxicity, and the acne treatment composition is matched with an external medicament for treating acne, has obvious curative effect on the acne of adolescent men and women, is not easy to relapse, and has no toxic or side effect.
In the preparation method of the oral medicine for treating acne, the oral medicine is prepared by grinding and mixing fructus kochiae, indigo naturalis, scorpion, oldenlandia diffusa, scutellaria baicalensis, coptis chinensis, fructus forsythiae, honeysuckle, wild chrysanthemum, dandelion, schizonepeta, radix sileris, radix rehmanniae, poria cocos, angelica sinensis, ligusticum wallichii, liquorice, tribulus terrestris and radix puerariae, and the preparation method is simple.
In the external medicine for treating acne, the scorpions and the centipedes are used as monarch medicines for calming endogenous wind and detoxifying, and eliminating stagnation and dredging collaterals;
the sophora flavescens, the common cnidium fruit and the szechwan chinaberry fruit are used as ministerial drugs for clearing heat, eliminating dampness, dispelling wind and removing toxicity;
snake slough and nidus Vespae can expel wind, kill parasites and relieve itching, and are used as adjuvant drugs;
sulfur and Borneolum Syntheticum are used as guiding drugs for killing parasites, treating sore, relieving swelling and pain, clearing heat and removing toxicity;
the raw materials are common traditional Chinese medicines, on one hand, the cost is low, on the other hand, the combined action has the effects of clearing heat, drying dampness, detoxifying and dissipating stagnation, and when the traditional Chinese medicine is used together with the oral medicine for treating acne, the traditional Chinese medicine is obvious in curative effect, not easy to relapse and free of toxic and side effects aiming at acne of adolescent men and women.
In the preparation method of the external medicine for treating acne, the external medicine is prepared by soaking scorpio, centipede, radix sophorae flavescentis, fructus cnidii, honeycomb, szechwan chinaberry fruit, snake slough, sulfur and borneol, and the preparation method is simple.
In conclusion, the internal medicine and the external medicine for treating the acne have low cost, have obvious curative effect on the acne of adolescent men and women, are not easy to relapse and have no toxic or side effect. The preparation method of the oral medicine and the external medicine for treating the acne is simple.
Detailed Description
For the purpose of better explaining the present invention, the present invention will be described in detail by way of specific embodiments for easy understanding.
Example 1
Selecting the following raw materials by mass: 25g of fructus kochiae, 15g of indigo naturalis, 15g of scorpion, 10g of oldenlandia diffusa, 15g of scutellaria baicalensis, 15g of coptis chinensis, 15g of fructus forsythiae, 15g of honeysuckle, 20g of wild chrysanthemum flower, 25g of dandelion, 15g of schizonepeta, 15g of divaricate saposhnikovia root, 15g of radix rehmanniae, 15g of poria cocos, 15g of angelica sinensis, 15g of ligusticum wallichii, 15g of liquorice, 25g of tribulus terrestris and 25g of radix puerariae.
Specifically, the preparation method of the oral medicine for treating acne of the embodiment comprises the following steps:
s1: selecting the raw materials of the oral medicine for treating acne in the above mass, mixing and grinding into powder to form a powdery semi-finished product for later use;
s2: and (4) stirring and mixing the powdery semi-finished product in the step S1 to form the powdery oral medicine for treating acne, wherein the mixing speed is 135rpm, and the mixing time is 8 min.
More specifically, the oral medicine for treating acne of the present embodiment may further include the steps of:
s3: and (4) filling the powder-shaped acne treatment oral medicine in the S2 into capsules to form the capsule-shaped acne treatment oral medicine.
Alternatively, the oral medicine for treating acne of this embodiment may further comprise the following steps:
s3': the powder oral medicine for treating acne in the S2 is mixed with honey to prepare the pill oral medicine for treating acne.
The oral medicine for treating acne in the form of capsule or pill prepared by the step S3 or S3' has no essential difference in the curative effect of treating acne from the oral medicine for treating acne in the form of powder prepared by the step S2.
In the oral medicine for treating acne, the belvedere fruit has the effects of clearing heat, promoting diuresis, dispelling wind and relieving itching, and is used for treating rubella, eczema and skin pruritus;
indigo naturalis has effects of clearing heat-fire, cooling blood and removing toxic substance;
the scorpion stops endogenous wind, relieves spasm, counteracts toxin, removes stasis, unblocks collaterals and relieves pain, and is mainly used for treating stubborn rheumatism, pyocutaneous disease and scrofula;
oldenlandia diffusa has the effects of clearing heat and removing toxicity, relieving pain and dissipating stagnation, and inducing diuresis and removing dampness, and is especially good at treating various types of inflammation;
the scutellaria baicalensis clears heat and dries dampness, cools blood and prevents miscarriage, and detoxifies, and is mainly used for treating warm diseases, cough due to lung heat, damp-heat yellow gallbladder, carbuncle, swelling, furuncle and sore and other symptoms;
coptidis rhizoma has effects of clearing heat, eliminating dampness, purging pathogenic fire, and removing toxic substance, and can be used for treating damp-heat distention and fullness, heart fire hyperactivity, vexation, insomnia, carbuncle, furuncle, eczema, and eczema;
fructus forsythiae has effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogen accumulation, and can be used for treating superficial infection and lymphoid tuberculosis;
the flos Lonicerae has effects of dispelling pathogenic wind heat, and clearing away blood toxin, and can be used for treating various heat type diseases such as fever, rash, macula, and toxic heat sore and carbuncle;
wild chrysanthemum can disperse wind and heat, relieve swelling and remove toxicity, and treat diseases such as furuncle, carbuncle and swelling;
herba Taraxaci is effective in promoting urination and relieving diarrhea;
herba Schizonepetae has effects of eliminating phlegm, dispelling pathogenic wind, cooling blood, relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, eliminating sore, and stopping bleeding, and can be used for treating measles without adequate eruption;
exterior syndrome due to exogenous pathogenic factor of radix Saposhnikoviae, and can be used for treating rubella pruritus and rheumatalgia;
radix rehmanniae has effects of clearing heat and cooling blood, and can be used for treating warm disease with heat entering nutrient-blood, blood heat and toxic materials, and macula purple black;
poria has effects of promoting diuresis without damaging healthy qi, and can be used for treating dysuria, edema, fullness, phlegm, fluid, cough, and obstruction;
chinese angelica has the functions of enriching blood, promoting blood circulation, moistening dryness and lubricating intestines, and is mainly used for treating carbuncle, deep-rooted carbuncle, sore and ulcer;
the ligusticum wallichii is used for dispelling wind, activating blood and promoting qi circulation and treating carbuncle, cellulitis, sore and ulcer and the like;
the liquorice has the effects of clearing away heat and toxic materials, eliminating phlegm and relieving cough;
fructus Atriplicis Sibiricae has effects of suppressing hyperactive liver, resolving stagnation, dispelling pathogenic wind and improving eyesight, and can be used for treating skin pruritus;
radix Puerariae has the symptoms of fever, pain of neck and back, and measles without adequate eruption, and can be used for treating fever thirst, yin deficiency diabetes, spleen deficiency diarrhea.
In summary, the belvedere fruit and the natural indigo have the effects of promoting diuresis, eliminating dampness, clearing away heat and toxic materials, cooling blood and removing speckles, and are monarch drugs;
radix scutellariae, rhizoma coptidis, fructus forsythiae, honeysuckle, wild chrysanthemum, dandelion, oldenlandia diffusa, radix rehmanniae, angelica and poria cocos are used as ministerial medicines for clearing heat, cooling blood and eliminating dampness;
herba Schizonepetae, radix Saposhnikoviae, radix Puerariae, and fructus Atriplicis Sibiricae have effects of dispelling pathogenic wind and eliminating dampness, calming endogenous wind, counteracting toxic substances, and resolving hard mass, and are used as adjuvant drugs;
ligusticum wallichii is used as a guiding drug for dispelling wind, activating blood and promoting qi circulation, and licorice is used for blending the raw materials;
the raw materials are common traditional Chinese medicines, so that on one hand, the cost is low; on the other hand, the combined action has the effects of clearing heat, promoting diuresis, cooling blood and removing toxicity, and the acne treatment composition is matched with an external medicament for treating acne, has obvious curative effect on the acne of adolescent men and women, is not easy to relapse, and has no toxic or side effect.
The preparation method of the oral medicine for treating acne is simple.
Similar to the preparation process of example 1, examples 2 to 9 were prepared for oral administration for treating acne by adjusting the quality of each raw material in the preparation process, the mixing speed in S2 and the mixing time in S2. Examples 2-9 the preparation of oral formulations for the treatment of acne is shown in table 1.
Table 1: examples 2-9 preparation of oral medicine for treating acne
Figure BDA0001316454220000061
Figure BDA0001316454220000071
The oral medicine for treating acne prepared in the above examples 1 to 9 is matched with the external medicine for treating acne with the same component, and has obvious curative effect on treating acne. Among them, in examples 1 to 9, the oral drug for treating acne prepared in example 1 was combined with the same external drug for treating acne, and the best effect was obtained for treating acne.
Example 10
Selecting the following raw materials by mass: 15g of scorpion, 15g of centipede, 35g of radix sophorae flavescentis, 35g of fructus cnidii, 35g of honeycomb, 25g of szechwan chinaberry fruit, 15g of snake slough, 10g of sulfur and 10g of borneol.
Specifically, the preparation method of the external medicine for treating acne of the embodiment comprises the following steps:
s1: selecting the raw materials of the external medicine for treating acne in the above mass, and mixing to form a mixture for later use;
s2: soaking the mixture in S1 in 50% grain liquor for 60 days.
In the external medicine for treating acne, the scorpion stops endogenous wind, relieves spasm, counteracts toxin, removes stasis, dredges collaterals and relieves pain, and is mainly used for treating pyocutaneous disease and scrofula;
scolopendra has effects of calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain, and can be used for treating pyocutaneous disease and lymphoid tuberculosis;
radix Sophorae Flavescentis has effects of clearing heat, eliminating dampness, dispelling pathogenic wind, and removing toxic substance, and can be used for treating eczema, skin pruritus, and scabies;
fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, and killing parasite;
nidus Vespae has toxic materials removing, parasite killing, pathogenic wind expelling, and analgesic effects, and can be used for treating pyocutaneous disease, scrofula, and intractable tinea;
fructus Toosendan has effects of dispersing stagnated liver qi, promoting qi circulation, relieving pain, and expelling parasites;
periostracum Serpentis has effects of dispelling pathogenic wind, arresting convulsion, removing toxic substance, and eliminating nebula, and can be used for treating skin pruritus;
sulfur can kill parasites, relieve itching, sterilize, and scabies for external use;
borneol can dredge orifices, dispel stagnated fire, and relieve swelling and pain.
In summary, the scorpion and the centipede are used as monarch drugs for calming endogenous wind, detoxifying, dissipating stagnation and dredging collaterals in the external medicine for treating acne;
the sophora flavescens, the common cnidium fruit and the szechwan chinaberry fruit are used as ministerial drugs for clearing heat, eliminating dampness, dispelling wind and removing toxicity;
snake slough and nidus Vespae can expel wind, kill parasites and relieve itching, and are used as adjuvant drugs;
sulfur and Borneolum Syntheticum are used as guiding drugs for killing parasites, treating sore, relieving swelling and pain, clearing heat and removing toxicity;
the raw materials are common traditional Chinese medicines, on one hand, the cost is low, on the other hand, the combined action has the effects of clearing heat, drying dampness, detoxifying and dissipating stagnation, and when the traditional Chinese medicine is used together with the oral medicine for treating acne, the traditional Chinese medicine is obvious in curative effect, not easy to relapse and free of toxic and side effects aiming at acne of adolescent men and women.
The preparation method of the external medicine for treating acne is simple.
Similar to the preparation process of example 10, examples 11 to 18 were prepared for the external preparation for treating acne by adjusting the quality of each raw material in the preparation process, the alcohol content of grain in S2, and the brewing time in S2. Examples 11-18 the preparation of the external preparation for treating acne is specifically shown in Table 2.
Table 2: EXAMPLES 11-18 preparation of external preparations for treating acne
Figure BDA0001316454220000081
Figure BDA0001316454220000091
The external preparations for treating acne prepared in examples 10 to 18 above were combined with the internal preparation for treating acne of the same composition to have significant effects on the treatment of acne, wherein the external preparation for treating acne prepared in example 10 was combined with the internal preparation for treating acne of the same composition in examples 10 to 18 above to have the best effect on the treatment of acne.
The taking method of the oral medicine for treating the acne comprises the following steps: the preparation is taken 3 times a day after meals, and the dosage of the preparation for each time contains 3-6g of raw materials; patients with mild disease and patients with early onset need to take the medicine for one to two treatment courses, and patients with long disease and patients with severe disease need to take the medicine for three to six treatment courses, wherein one treatment course is 30 days.
The application method of the external medicine for treating acne of the invention comprises the following steps: the first stage is erased once every 1 day, the second stage is erased once every 3 days, and the time of the first stage is equal to that of the second stage; patients with mild disease and patients with early onset need to be used for one to two treatment courses, and patients with long disease and patients with severe disease need to be used for three to six treatment courses, wherein one treatment course is 30 days.
The external medicine for treating the acne and the internal medicine for treating the acne are used simultaneously, and tea, tobacco, wine and spicy food are avoided during the application period.
The oral medicine for treating the acne and the external medicine for treating the acne are matched for use, and have better curative effects on symptoms such as acne, lung qi deficiency, spleen damp and hot excess, weak skin resistance and the like.
The clinical test results shown below are non-public clinical tests performed by the applicant in a specific area, and the pharmaceutical composition and the preparation method thereof were not disclosed to anyone before the filing date of the present application.
Clinical experiment one
126 cases of acne patients take the oral medicine for treating acne of the invention orally, and simultaneously are matched with the external medicine for treating acne of the invention externally, the specific conditions of treating acne by clinical experiments are as follows:
basic conditions of acne patients:
61 men and 65 women, the age is 15-30 years, the average age is 22.5 years, the disease course is shortest days and longest 10 years.
(II) diagnosis standard:
the main symptoms of acne are skin lesions such as acne, pimple, pustule, cyst, etc. on face, upper chest, back, etc. Wherein the content of the first and second substances,
acne: the initial stage is chestnut or pimple with pinhole size, which is semitransparent with embolism in hair follicle orifice and white head, and can be extruded;
pimples: the sebaceous gland orifice is completely blocked to form a papule, and the center of the sebaceous gland is provided with comedones which can form inflammatory or non-inflammatory papules;
pustule: infection is caused on the basis of papules, pustules appear on the tops of the papules, and viscous yellow pus flows out after the pustules are broken;
cyst: sebaceous cyst with different size is formed around the skin lesion, normal skin color or dark red, and bloody or colloidal secretion can be discharged when pressing;
and (3) nodule: when the inflammation is deep, the pus wall is thickened to form reddish or purplish red nodules, or the bulges are hemispherical or conical, which can exist for a long time and can be gradually absorbed, and also can cause pus and scar formation or sinus formation.
The skin lesions can exist simultaneously or can be mutually transformed, most patients are accompanied with seborrhea, have no subjective symptoms, and can cause pain and tenderness if inflammation is obvious.
(III) the use method of the medicine comprises the following steps:
is used according to the actual condition of the patient.
The oral medicine for treating acne is taken 3 times a day after meals, and the dosage of each time contains 3-6g of raw materials; patients with mild disease and patients with early onset need to take the medicine for one to two treatment courses, and patients with long disease and patients with severe disease need to take the medicine for three to six treatment courses, wherein one treatment course is 30 days.
The external medicine for treating acne is divided into two stages, wherein the first stage is erased once every 1 day, the second stage is erased once every 3 days, and the first stage and the second stage are equal in time; patients with mild disease and patients with early onset need to take one to two treatment courses, and patients with long disease and patients with severe disease need to take three to six treatment courses, wherein one treatment course is 30 days (the cautions are that the external medicine for treating acne is toxic to take, cannot be taken orally, and can only be taken externally).
During the period of taking the oral medicine for treating acne, all patients stop taking other medicines, and the patients are advised not to take tea, tobacco, wine and spicy food.
(IV) the criteria for efficacy assessment are shown in Table 3:
table 3: evaluation standard of curative effect of oral medicine and external medicine for treating acne
Cure of disease The symptoms disappear completely
Show effect The symptoms are obviously relieved
Is effective The symptoms are relieved and relieved, but not obvious enough
Invalidation Can not reach the effective standard after being continuously used for six months
In Table 3, all patients were examined with blood for further confirmation.
(V) the results of the drug use are shown in Table 4:
table 4: application results of oral medicine and external medicine for treating acne
Total up to
Number of patients before treatment 126
Number of cases of cured patients 116
Number of patients with significant effect 6
Effective patient case number 4
Number of invalid patients 0
Total effective rate 100％
Table 4 illustrates: in the first clinical experiment, after the 126 cases of acne patients take the oral medicine for treating acne of the present invention and are matched with the external medicine for treating acne of the present invention, all skin symptoms of the patients are effectively treated, the total effective rate reaches 100%, wherein 116 cases are cured, 6 cases are effective, 4 cases are effective, and the patient with the cure does not have the disease recurrence phenomenon in follow-up visits after one year.
The first clinical experiment mentioned above explains that: the oral medicine for treating the acne is taken, and the external medicine for treating the acne is externally applied, so that the acne treatment effect on adolescent men and women is obvious, the acne is not easy to relapse, and the acne treatment medicine has no toxic or side effect.
Clinical trial typical cases:
for a male with age of 18 years and suffering from facial acne for 2 years, the oral medicine for treating acne in the capsule form is taken, and the external medicine for treating acne is externally applied, so that the symptoms disappear after 4 treatment courses.
For a woman in age of 19 years, suffering from facial acne for more than one year, the oral medicine for treating acne in a capsule form is taken, and meanwhile, the external medicine for treating acne is externally applied, so that the total treatment period is 3, and the symptoms are completely disappeared.
For a woman in age of 30 years, suffering from facial acne and black spots for 10 years, the oral medicine for treating acne in a capsule form is taken, and meanwhile, the external medicine for treating acne is externally applied, so that 6 treatment courses are totally performed, and symptoms completely disappear.
For a woman in age of 29 years, suffering from facial acne for 2 years, the oral medicine for treating acne in a capsule form is taken, and meanwhile, the external medicine for treating acne is externally applied, so that 3 treatment courses are totally performed, and symptoms disappear.
For a male, the male is 24 years old, suffers from facial acne for 5 years, takes the oral medicine for treating acne in a capsule shape, and simultaneously externally applies the external medicine for treating acne of the invention, 5 treatment courses are totally counted, and the symptoms are completely disappeared.
When a male is 15 years old and suffers from face, chest and back acnes for 2 years, the oral medicine for treating acnes in a capsule form is taken, and simultaneously the external medicine for treating acnes is externally applied, so that 6 treatment courses are totally taken, and the symptoms are completely disappeared.
For a woman in 24 years old who suffers from facial acne for 3 years, the oral medicine for treating acne in a capsule form is taken, and the external medicine for treating acne is externally applied, so that the total of 4 treatment courses is achieved, and the symptoms are completely disappeared.
When a male is 19 years old and suffers from facial acne for 2 years, the oral medicine for treating the acne in the capsule form is taken, and the external medicine for treating the acne is externally applied, so that the total of 4 treatment courses is achieved, and the symptoms are completely disappeared.
The clinical trial representative cases further illustrate: the acne treatment oral medicine is taken and is matched with the external medicine for treating the acne, and the acne treatment effect on adolescent men and women is obvious.
In conclusion, the internal medicine and the external medicine for treating the acne have low cost, have obvious curative effect on the acne of adolescent men and women, are not easy to relapse and have no toxic or side effect. The preparation method of the oral medicine and the external medicine for treating the acne is simple.
The above description is only a preferred embodiment of the present invention, and for those skilled in the art, the present invention should not be limited by the description of the present invention, which should be interpreted as a limitation.

Claims (9)

1. A pharmaceutical composition for treating acne is characterized in that the pharmaceutical composition comprises an internal medicine and an external medicine; the oral medicine is prepared by grinding and mixing the following raw materials in parts by weight:
20-30 parts of belvedere fruit, 10-20 parts of indigo naturalis, 10-20 parts of scorpion, 5-15 parts of spreading hedyotis herb, 10-20 parts of baical skullcap root, 10-20 parts of golden thread, 10-20 parts of weeping forsythia capsule, 10-20 parts of honeysuckle flower, 15-25 parts of wild chrysanthemum flower, 20-30 parts of dandelion, 10-20 parts of fineleaf schizonepeta herb, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of radix rehmanniae, 10-20 parts of Indian buead, 10-20 parts of Chinese angelica, 10-20 parts of szechuan lovage rhizome, 10-20 parts of liquoric root, 20-30 parts of tribulus terrestris and 20-;
the external medicine is prepared by infusing the following raw materials in parts by weight:
10-20 parts of scorpion, 10-20 parts of centipede, 30-40 parts of radix sophorae flavescentis, 30-40 parts of fructus cnidii, 30-40 parts of honeycomb, 20-30 parts of szechwan chinaberry fruit, 10-20 parts of snake slough, 5-15 parts of sulfur and 5-15 parts of borneol;
the oral medicine and the external medicine are used together.
2. The pharmaceutical composition for treating acne according to claim 1, wherein the oral medicine is prepared by grinding and mixing the following raw materials in parts by weight:
23-29 parts of fructus kochiae, 13-16 parts of indigo naturalis, 12-18 parts of scorpion, 6-12 parts of spreading hedyotis herb, 12-17 parts of radix scutellariae, 11-16 parts of coptis chinensis, 13-18 parts of fructus forsythiae, 13-19 parts of honeysuckle, 19-23 parts of wild chrysanthemum flower, 22-28 parts of dandelion, 13-19 parts of schizonepeta, 12-17 parts of divaricate saposhnikovia root, 14-17 parts of radix rehmanniae, 11-17 parts of poria cocos, 13-16 parts of angelica sinensis, 14-16 parts of ligusticum wallichii, 12-19 parts of liquorice, 23-26 parts of tribulus terrestris and 23-29 parts of radix puerariae.
3. The pharmaceutical composition for treating acne according to claim 2, wherein the oral medicine is prepared by grinding and mixing the following raw materials in parts by weight:
25 parts of broom cypress fruit, 15 parts of indigo naturalis, 15 parts of scorpion, 10 parts of spreading hedyotis herb, 15 parts of baical skullcap root, 15 parts of golden thread, 15 parts of weeping forsythia capsule, 15 parts of honeysuckle flower, 20 parts of wild chrysanthemum flower, 25 parts of dandelion, 15 parts of fineleaf schizonepeta herb, 15 parts of divaricate saposhnikovia root, 15 parts of rehmannia root, 15 parts of tuckahoe, 15 parts of angelica, 15 parts of szechuan lovage rhizome, 15 parts of liquorice, 25 parts of tribulus terrestris and 25 parts of kudzuvine.
4. The pharmaceutical composition for treating acne as claimed in claim 1, wherein said external use medicine is prepared by infusing the following raw materials in parts by weight:
15 parts of scorpion, 15 parts of centipede, 35 parts of radix sophorae flavescentis, 35 parts of fructus cnidii, 35 parts of honeycomb, 25 parts of szechwan chinaberry fruit, 15 parts of snake slough, 10 parts of sulfur and 10 parts of borneol.
5. A pharmaceutical composition for the treatment of acne according to claims 1 to 3, characterized in that said oral drug is prepared by a process comprising the following steps:
s1: selecting the raw materials of the oral medicine for treating acne according to any one of claims 1-3, mixing and grinding into powder to form powdery semi-finished product for later use;
s2: stirring and mixing the powdery semi-finished product in the S1 to form the powdery oral medicine for treating acne, wherein the mixing speed is within the range of 120rpm-150rpm, and the mixing time is within the range of 5min-10 min.
6. The pharmaceutical composition for treating acne as claimed in claim 5, further comprising:
s3: and (4) filling the powder-shaped acne treatment oral medicine in the S2 into capsules to form the capsule-shaped acne treatment oral medicine.
7. The pharmaceutical composition for treating acne as claimed in claim 5, further comprising:
s3': the powder oral medicine for treating acne in the S2 is mixed with honey to prepare the pill oral medicine for treating acne.
8. The pharmaceutical composition for the treatment of acne as claimed in claim 1 or 4, wherein the preparation method of said external medicine comprises the following steps:
s1: selecting raw materials of the external medicine for treating acne as described in claim 1 or 4, and mixing to form a mixture for standby;
s2: soaking the mixture in S1 in 43-58% grain wine for 55-65 days.
9. The pharmaceutical composition for treating acne according to claim 8,
at S2, the mixture of S1 is infused in 50% grain liquor for 60 days.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102988648A (en) * 2011-09-09 2013-03-27 田启旺 Medicine for treating gastrointestinal diseases
CN106492186A (en) * 2017-01-11 2017-03-15 李惠学 A kind of medicine for treating acute and chronic tracheobronchitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102988648A (en) * 2011-09-09 2013-03-27 田启旺 Medicine for treating gastrointestinal diseases
CN106492186A (en) * 2017-01-11 2017-03-15 李惠学 A kind of medicine for treating acute and chronic tracheobronchitis

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